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Atmospheric and Climate Sciences 2021年第3期11卷 486-507页

作者： Marcos Figueiredo Salviano Augusto josé Pereira Filho Felipe Vemado Geological Survey of Brazil S&#227 o Paulo Brazil Departamento de Ciências Atmosféricas Instituto de Astronomia Geofísica e Ciências Atmosféricas Universidade de S&#227 o Paulo S&#227 o Paulo Brazil

This study consists of hydrological simulations of the Muriaé river watershed with the topography-based hydrological model (TOPMODEL) and available stream gauge and rain measurements between 2009 and 2013 for two subbasins, namely Carangola and Patrocínio do Muriaé. The simulations were carried out with the Climate Prediction Center morphing method (CMORPH) precipitation estimates and rain gauge measurements integrated into CM- ORPH by the Statistical Objective Analysis Scheme (SOAS). TOPMODEL calibration was performed with the shuffled complex evolution (SCE-ua) method with Nash-Sutcliffe efficiency (NSE). The best overall results were obtained with CMORPH (NSE ~ 0.6) for both subbasins. The simulations with SOAS resulted in an NSE ~ 0.2. However, in an analysis of days with high- level stages, SOAS simulations resulted in a better hit rate (23%) compared to CMORPH (10%). CMORPH simulations underestimated the flows at the flood periods, which indicates the importance to use multi-sensor precipitation data. The results with TOPMODEL allow an estimate of future discharges, which allows for better planning of a flood warning system and discharge measurement schedule.

关键词： Hydrologic Model CMORPH Statistical Objective Analysis Scheme (SOAS) TOPMODEL Muriaé River

Exercise training in the management of patients with resistant hypertension

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World Journal of Cardiology 2015年第2期7卷 47-51页

作者： Fernando Ribeiro Rui Costa josé Mesquita-Bastos School of Health Sciences University of Aveiro Portugal and CINTESIS.UA 3810-193 Aveiro Portugal School of Health Sciences University of Aveiro3810-193 Aveiro Portuga

Hypertension is a very prevalent risk factor for cardiovascular disease. The prevalence of resistant hypertension, i.e., uncontrolled hypertension with 3 or more antihypertensive agents including 1 diuretic, is between 5% and 30% in the hypertensive population. The causes of resistant hypertension are multifactorial and include behavioral and biological factors, such as nonadherence to pharmacological treatment. All current treatment guidelines highlight the positive role of physical exercise as a non-pharmacological tool in the treatment of hypertension. This paper draws attention to the possible role of physical exercise as an adjunct non-pharmacological tool in the management of resistant hypertension. A few studies have investigated it, employing different methodologies, and taken together they have shown promising results. In summary, the available evidence suggests that aerobic physical exercise could be a valuable addition to the optimal pharmacological treatment of patients with resistant hypertension.

关键词： Exercise training Resistant hypertension Blood pressure Non-pharmacological Cardiovascular disease

Hydrometeorological Modeling of Limpopo River Basin in Mozambique with TOPMODEL and Remote Sensing

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Open Journal of Modern Hydrology 2022年第2期12卷 55-73页

作者： Tomásio Eduardo Januário Augusto josé Pereira Filho Marcos Figueiredo Salviano Department of Atmospheric Sciences Institute of Astronomy Geophysics and Atmospheric Sciences University of S&#227 o Paulo S&#227 o Paulo Brazil Geological Survey of Brazil S&#227 o Paulo Brazil

The Limpopo River basin (LRB) is known for its vulnerability to floods, high rates of evapotranspiration, and droughts that cause significant losses to the local community. The present study aimed to perform simulations of flood events occurring in two Mozambican sub-basins of LRB, namely Chókwè and Xai-Xai from 2000 to 2015 with TOPography-based hydrological MODEL (TOPMODEL) and satellite remote sensing data. As input in TOPMODEL, data from two high-resolution global satellite-based precipitation products: Climate Prediction Center MORPHing technique (CMORPH) and Integrated Multi-Satellite Retrievals for the Global Precipitation Mission (GPM) algorithm (IMERG), 8-day MOD16 evapotranspiration product and surface runoff data estimated by Global Land Data Assimilation System (GLDAS) were used. The sensitivity tests of TOPMODEL parameters were applied using the Monte Carlo simulation. Calibration and validation of the model were performed by the Shuffled Complex Evolution (SCE-ua) method and were evaluated with the Kling-Gupta Efficiency (KGE) index. The results indicated that simulations with the GPM-IMERG (KGE: 0.59 and 0.65) tended to underestimate the stream flows, while with the CMORPH product the performance was much better (KGE: 0.66 and 0.77) in both sub-basins. Thus, TOPMODEL can help to develop flood monitoring systems from satellite remotely sensed data in similar regions of Mozambique.

关键词： Floods Simulations Limpopo River TOPMODEL CMORPH IMERG

Selective Fetal Growth Restriction in Monochorionic Diamniotic Twins: Diagnosis and Management

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Maternal-Fetal Medicine 2022年第4期4卷 268-275页

作者： Alicia Mazer Zumaeta Maria Mar Gil Miguel Rodriguez-Fernandez Pilar Carretero joséHector Ochoa Maria Cristina Casanova Francisca Sonia Molina Department of Obstetrics and Gynecology Hospital Universitario Clinico San CecilioGranada 18016Spain Department of Obstetrics and Gynecology Hospital Matemo Provincial Dr.Raul Felipe LuciniCordoba 500oArgentina Diagnus SA Prenatal Diagnosis and Fetal Medicine CenterCordoba 5000Argentina Obstetrics and Gynecology Department Hospital Universitario de TorrejonTorrejon de Ardoz 28223MadridSpain School of Medicine Universidad Francisco de VitoriaPozuelo de Alarcon 28223MadridSpain Instituto de Investigacion Biosanitaria lbs.GRANADA Granada 18016Spain

Selective fetal growth restriction (sFGR) is a severe condition that complicates 10% to 15% of all monochorionic diamniotic (MCDA) twin pregnancies. Pregnancies complicated with sFGR are at high risk of intrauterine demise or adverse perinatal outcome for the twins. Three clinical types have been described according to the umbilical artery (ua) Doppler pattern observed in the smaller twin: type I, when the ua Doppler is normal;type II, when there is persistent absent or reversed end-diastolic blood flow in the ua Doppler;and type III, when there is intermittent absent and/or reversed end-diastolic blood flow in the ua Doppler. Clinical evolution and management options mainly depend on the type of sFGR. Type I is usually associated with a good prognosis and is managed conservatively. There is no consensus on the management of types II and III, but in earlier and more severe presentations, fetal interventions such as selective laser photocoagulation of placental anastomoses or selective fetal cord occlusion of the smaller twin may be considered. This review aims to provide updated information about the diagnosis, evaluation, follow-up, and management of sFGR in MCDA twin pregnancies.

关键词： Twins Monochorionic diamniotic twins Selective fetal growth restriction Birthweight discordance Fetal therapy Placenta

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fabien Chantegreil Florian Nachon Xavier Brazzolotto Anna Skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia Binda Francisco López-Muoz Stanislav Gobec joséMarco-Contelles University of Ljubljana Faculty of PharmacyLjubljana 1000Slovenia Laboratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of Biology and Biotechnology University of PaviaPavia 27100Italy Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal Anatomy and Preclinical Sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of Biochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of Translational Neurobiology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain Biotechnology and Vegetal Biology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hMAO-A/B)for the therapy of neurodegenerative *** identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available *** 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h MAO-B(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding,which was further studied by enzyme *** 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19.

关键词： Quinolylnitrone Butyrylcholinesterase Monoamine oxidase B Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task Novel object recognition

Microhabitat heterogeneity associated with Vanilla *** its influences on the microbial community of leaf litter and soil

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Soil Ecology Letters 2020年第3期2卷 195-208页

作者： Gabriela Montes de Oca-Vasquez Frank Solano-Campos Bernal Azofeifa-Bolanos Amelia Paniagua-Vasquez jose Vega-Baudrit Antonio Ruiz-Navarro Ruben Lopez-Mondejar Felipe Bastida National Nanotechnology Laboratory National Center for High Technology10109 PavasSan JoseCosta Rica School of Biological Sciences Universidad NacionalCampus Omar Dengo86-3000 HerediaCosta Rica Asociacion Nacional de Vainilleros Unidos San JoseCosta Rica Instituto de Investigacion y Servicios Forestales Universidad Nacional86-3000 HerediaCosta Rica Laboratory of Polymer Science and Technology School of ChemistryUniversidad NacionalCampus Omar Dengo86-3000 HerediaCosta Rica CEBAS-CSIC Department of Soil and Water ConservationCampus Universitario de Espinardo30100MurciaSpain Laboratory of Environmental Microbiology Institute of Microbiology of the CASVidenska 1083Praha 414220Czech Republic

The impact of forest microhabitats on physiochemical properties of the soil and that of microbial communities on tropical soils remain poorly *** elucidate the effect of tropical forest stand on leaf litter and soil microbial communities,we studied enzyme activities,microbial biomass,and diversity in three distinct microhabitats in terms of plant richness,diameter at breast height(DBH),and physiochemical properties of soil and litter,each associated with a different Vanilla *** the soil,positive correlations were found between electrical conductivity(EC)and total organic carbon(TOC)with phosphatase activity,and between nitrogen(N)and water-soluble carbon(WSC)content with urease activity(ua).In the litter,the water content was positively correlated with bacterial and fungal biomass,and N and WSC contents were positively correlated with fungal *** correlations were found between plant richness and ua in the soil,plant richness and fungal biomass in the soil and litter,and DBH and fungal biomass in the *** sequencing revealed differences between microhabitats in the relative abundance of some fungal and bacterial taxa and in the bacterial community composition of both litter and *** richness and diversity were different between microhabitats,and,in litter samples,they were negatively correlated with DBH and plant richness,*** contrast,none of the soil and litter physiochemical properties were significantly correlated with microbial *** results show that significant shifts in enzyme activity,microbial biomass,and diversity in the microhabitats were driven by key abiotic and biotic factors depending on the soil or litter sample type.

关键词： Tropical rainforest Enzyme activity Microbial community composition Microbial biomass Plant richness