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Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez mónica g mendoza-rodríguez Omar R Alemán Fernando A Candanedo-gonzález miriam rodríguez-Sosa Juan jos.montesinos-montesinos mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

Federated Network Intelligence Orchestration for Scalable and Automated FL-Based Anomaly Detection in B5g Networks

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Computers, materials & Continua 2024年第7期80卷 163-193页

作者： Pablo Fernández Saura jos. m.Bernabé murcia Emilio garcía de la Calera molina Alejandro molina Zarca Jorge Bernal Bernabé Antonio F.Skarmeta gómez Department of Information and Communications Engineering University of MurciaMurcia30100Spain University Center of Defense Spanish Air Force AcademySan Javier30720Spain

The management of network intelligence in Beyond 5g(B5g)networks encompasses the complex challenges of scalability,dynamicity,interoperability,privacy,and *** are essential steps towards achieving the realization of truly ubiquitous Artificial Intelligence(AI)-based analytics,empowering seamless integration across the entire Continuum(Edge,Fog,Core,Cloud).This paper introduces a Federated Network Intelligence Orchestration approach aimed at scalable and automated Federated Learning(FL)-based anomaly detection in *** leveraging a horizontal Federated learning approach based on the FedAvg aggregation algorithm,which employs a deep autoencoder model trained on non-anomalous traffic samples to recognize normal behavior,the systemorchestrates network intelligence to detect and prevent *** into a B5g Zero-touch Service management(ZSm)aligned Security Framework,the proposal utilizes multi-domain and multi-tenant orchestration to automate and scale the deployment of FL-agents and AI-based anomaly detectors,enhancing reaction capabilities against *** proposed FL architecture can be dynamically deployed across the B5g Continuum,utilizing a hierarchy of Network Intelligence orchestrators for real-time anomaly and security threat *** includes FL enforcement operations for interoperability and extensibility,enabling dynamic deployment,configuration,and reconfiguration on *** validation of the proposed solution was conducted through dynamic orchestration,FL,and real-time anomaly detection processes using a practical test *** of key performance metrics,leveraging the 5g-NIDD dataset,demonstrates the system’s capability for automatic and near real-time handling of anomalies and attacks,including real-time network monitoring and countermeasure implementation for mitigation.

关键词： Federated learning 6g orchestration anomaly detection security policy

Taurine as a possible therapy for immunosenescence and inflamm.ging

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Cellular & molecular Immunology 2024年第1期21卷 3-5页

作者： jos.m.Izquierdo Centro de Biología molecular Severo Ochoa(CBmSO).Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent Science article,Singh et *** taurine as an endogenously produced anti-inflammatory,anti-immunosenescence,and anti-aging *** authors also show that restoring taurine to its“youthful”levels prevents in... 详细信息

关键词： Taurine inflam

Secondary metabolites of Entomopathogenic Fungi, Biological Alternative for the Control of Agricultural Pests and Disease: Present and Perspectives

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Advances in Enzyme Research 2024年第1期12卷 1-15页

作者： Nallely San Juan-maldonado Silvia rodríguez-Navarro Alejandro Angel-Cuapio jos. Norberto Vásquez Bonilla Juan Esteban Barranco-Florido Departamento de Producció n Agr&#237cola y Animal Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico Divisió n de Ingenier&#237a Qu&#237mica y Bioqu&#237mica Tecnol&#243gico Nacional de M&#233xico/TES de Ecatepec Ecatepec de Morelos M&#233xico Departamento de Sistemas Bioló gicos Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico

The use of entomopathogenic fungi (EF) in recent years has been highly effective against the different orders of insects considered pests of agricultural importance and their conidia have been commonly applied, but it has been reported that these are sensitive to the environmental conditions. For this reason, biopesticides products have been formulated based on secondary metabolites, recently. These biomolecules participate as biological control agent, such as: cyclic depsipeptides, amino acids, polyketides, polyphenols and terpenoids, affecting their morphology, life cycle and insect behavior. The use of secondary metabolites of entomopathogenic fungi opens the possibility of application in a more efficient way for the control of agricultural pests in a compatible with the environment and human health;therefore, it is important to know, analyzing the type of molecules, their effects, and their different methods of application.

关键词： Secondary metabolites Entomopathogenic Fungi Biological Control Agent

mitochondria–cgAS–STINg axis is a potential therapeutic target for senescence-dependent inflamm.ging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： jos.m.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Does enhanced recovery after surgery programs improve clinical outcomes in liver cancer surgery?

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World Journal of gastrointestinal Oncology 2024年第2期16卷 255-258页

作者： Belinda Sánchez-Pérez jos.m Ramia Department of general Digestive and Transplantation SurgeryUniversity Regional HospitalMálaga 29010MálagaSpain Department of Surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Enhanced recovery after surgery(ERAS)programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in *** surgery is usually performed in oncological patients(liver metastasis,hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver surgery ERAS programs in oncological outcomes is not clearly *** advantages of ERAS programs are:ERAS decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes;a better and faster posto-perative recovery should let oncologic teams begin chemotherapeutic regimens on time;prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving ***,ERAS could be another way to improve our oncological *** will discuss the literature about liver surgery ERAS focusing on its oncological implications and future investigations projects.

关键词： Enhanced recovery after surgery programs Liver surgery Key components Long-term oncological outcomes Enhanced recovery after surgery compliance

gut microbiota in preterm infants receiving breast milk or mixed feeding

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World Journal of Clinical Pediatrics 2024年第2期13卷 135-145页

作者： Sandra gabriela Sánchez-gonzález Bárbara gabriela Cárdenas-del-Castillo Elvira garza-gonzález gerardo R Padilla-Rivas Isaías rodríguez-Balderrama Consuelo Treviño-garza Fernando Félix montes-Tapia gerardo C Palacios-Saucedo Anthony gutiérrez-rodríguez manuel Enrique de-la-O-Cavazos Department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Departamento de Bioquímica y medicina molecular Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Biochemistry and molecular medicine Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Pediatric Surgery Hospital Universitario"Dr.JoséEleuterio González"Monterrey 64460Nuevo LeónMéxico

BACKgROUND Preterm birth is the leading cause of mortality in newborns,with very-low-birthweight infants usually experiencing several *** milk is considered the gold standard of nutrition,especially for preterm infants with delayed gut colonization,because it contains beneficial microorganisms,such as Lactobacilli and *** To analyze the gut microbiota of breastfed preterm infants with a birth weight of 1500 g or *** An observational study was performed on preterm infants with up to 36.6 wk of gestation and a birth weight of 1500 g or less,born at the University Hospital ***éEleuterio gonzález at monterrey,mexico.A total of 40 preterm neonates were classified into breast milk feeding(Bm)and mixed feeding(mF)groups(21 in the Bm.group and 19 in the mF group),from October 2017 to June *** samples were collected before they were introduced to any feeding *** full enteral feeding was achieved,the composition of the gut microbiota was analyzed using 16S rRNA gene *** variables were compared using Student’s t-test or using the mann–Whitney U test for nonparametric ***,evenness,equitability,margalef’s index,Fisher’s alpha,Chao-1 index,and Shannon’s diversity index were also *** No significant differences were observed at the genus level between the *** comparison indicated higher counts of Alphaproteobacteria and Betaproteobacteria in the initial compared to the final sample of the Bm.group(Pgher counts of gammaproteobacteria were detected in the final than in the initial sample(P=0.040).According to the margalef index,Fisher’s alpha,and Chao-1 index,a decrease in species richness from the initial to the final sample,regardless of the feeding type,was observed(Pminant phyla were Bacteroidetes,Actinobacteria,Firmicutes,and Proteobacteria,with Proteobacteria being the most ***,no significant differences were

关键词： gut microbiota Human milk Preterm infant Proteobacteria Very low birth weight 16S rRNA

Permeability Estimation of Shale Oil Reservoir with Laboratory-derived Data: A Case Study of the Chang 7 member in Ordos Basin

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Applied geophysics 2024年第3期21卷 440-455,616页

作者： Zhang Lin gao Li Ba Jing Zhang meng-Bo jos.m.Carcione Liu Wei-Hua School of Earth Sciences and Engineering Hohai UniversityNanjingJiangsu211000 Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an Shanxi710018 National Institute of Oceanography and Applied geophysics(OgS) SgonicoTrieste 34010 Sinopec geophysical Research Institute NanjingJiangsu211103

The shale oil reservoir within the Yanchang Formations of Ordos Basin harbors substantial oil and gas resources and has recently emerged as the primary focus of unconventional oil and gas exploration and *** to its complex pore and throat structure,pronounced heterogeneity,and tight reservoir characteristics,the techniques for conventional oil and gas exploration and production face challenges in comprehensive implementation,also indicating that as a vital parameter for evaluating the physical properties of a reservoir,permeability cannot be effectively *** study selects 21 tight sandstone samples from the Q area within the shale oil formations of Ordos *** systematically conduct the experiments to measure porosity,permeability,ultrasonic wave velocities,and resistivity at varying confining *** reveal that these measurements exhibit nonlinear changes in response to effective *** using these experimental data and effective medium model,empirical relationships between P-and S-wave velocities,permeability and resistivity and effective pressure are established at logging and seismic ***,relationships between P-wave impedance and permeability,and resistivity and permeability are determined.A comparison between the predicted permeability and logging data demonstrates that the impedance–permeability relationship yields better results in contrast to those of resistivity–permeability *** relationships are further applied to the seismic interpretation of shale oil reservoir in the target layer,enabling the permeability profile predictions based on inverse P-wave *** predicted results are evaluated with actual production data,revealing a better agreement between predicted results and logging data and productivity.

关键词： shale oil reservoir P-wave impedance resistivity permeability rock physics experiment

Venopulmonary ECmO Improved Hypoxemia and Supported the Right Ventricle in a Patient with Decompensated Eisenmenger Syndrome

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World Journal of Cardiovascular Surgery 2024年第1期14卷 7-19页

作者： Daniel manzur-Sandoval gian manuel Jiménez-rodríguez Edgar garcía-Cruz Ramón Espinosa-Soto Erika Yamali Ramirez-marcano Yessenia máyory Téllez-López jos. Luis Elizalde-Silva gustavo Rojas-Velasco Cardiovascular Critical Care Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Adult Congenital Heart Disease Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Cardiology Department Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico

mechanical circulatory and/or respiratory assistance with extracorporeal membrane oxygenation (ECmO) has become a standard of care for patients with circulatory (venoarterial) and/or respiratory (venovenous) failure refractory to standard therapies. Adult patients with congenital heart disease are an increasingly recognized and growing population and include various groups, such as undiagnosed cases in childhood and palliated and/or corrected cases, which require subsequent care because of residual lesions, cardiac arrest/insufficiency, and arrhythmias, among other conditions. In addition, these patients are prone to developing pathologies that are typical of adulthood with a generally increased risk of morbidity and mortality because of their low reserves and organic dam.ge associated with the underlying heart disease, which makes them candidates for ECmO. These patients represent an additional challenge in this therapy because malformations and the presence of a shunt can generally affect the usual cannulation methods and hemodynamic and oximetry monitoring. Thus, the configuration decision must be made on a case-by-case basis. Here, we present a cannulation method, venopulmonary artery ECmO, which provides hemodynamic and respiratory support, and may be ideal for patients with shunts and/or right ventricular dysfunction. To our knowledge, this is the first report of this configuration in patients with congenital heart diseases.

关键词： Eisenmenger Syndrome Venopulmonary Artery ECmO Refractory Hypoxemia Right Ventricular Dysfunction