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Prognostic performance of an index based on lactic dehydrogenase and transaminases for patients with liver steatosis and COVID-19

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World Journal of Gastroenterology 2022年第37期28卷 5444-5456页

作者： Ricardo Ulises Macías-Rodríguez Alberto Adrián Solís-Ortega Victoria J Ornelas-Arroyo Astrid ruiz-Margáin Maria Sarai González-Huezo Nestor A Urdiales-Morán Berenice M Román-Calleja Juan M Mayorquín-Aguilar jos.A González-Regueiro Alejandro Campos-Murguía Israel Vicente Toledo-Coronado Mónica Chapa-Ibargüengoitia Bernardo Valencia-Peña Carlos Fernando Martínez-Cabrera Nayelli C Flores-García Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Department of Gastroenterology Centro Médico ISSEMYMToluca 52140Mexico Department of Radiology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico

BACKGROUND Metabolic associated fatty liver disease(MAFLD)is associated with complications and mortality in patients with coronavirus disease 2019(COVID-19).However,there are no prognostic scores aimed to evaluate the risk of severe disease specifically in patients with MAFLD,despite its high *** dehydrogenase,aspartate aminotransferase and alanine aminotransferase have been used as markers of liver ***,we propose an index based on lactate dehydrogenase,aspartate aminotransferase and alanine aminotransferase for the prediction of complications and mortality in patients with MAFLD and *** To evaluate the prognostic performance of an index based on lactate dehydrogenase and transaminases(aspartate aminotransferase/alanine aminotransferase)in patients with COVID-19 and MAFLD[liver fibrosis and nutrition(LNF)-COVID-19 index].METHODS In this retrospective cohort study,two cohorts from two different tertiary centers were *** first was the derivation cohort to obtain the score cutoffs,and the second was the validation *** included hospitalized patients with severe COVID-19 and *** steatosis was evaluated by computed tomography *** under the receiver operating characteristic(ROC)curve analysis and survival analysis were *** In the derivation cohort,44.6%had MAFLD;ROC curve analysis yielded a LFN-COVID-19 index>1.67 as the best cutoff,with a sensitivity of 78%,specificity of 63%,negative predictive value of 91%and an area under the ROC curve of *** the multivariate analysis,the LFN-COVID-19 index>1.67 was independently associated with the development of acute kidney injury(odds ratio:1.8,95%confidence interval:1.3-2.5,P<0.001),orotracheal intubation(odds ratio:1.9,95%confidence interval:1.4-2.4,P<0.001),and death(odds ratio:2.86,95%confidence interval:1.6-4.5,P<0.001)in both *** LFN-COVID-19 index has a good performance to predict prognosis in patients with MAFLD and COVID-19,which

关键词： COVID-19 Metabolic associated fatty liver disease Lactate dehydrogenase Transaminases Prognosis Nonalcoholic fatty liver disease

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GOECP/SEOR clinical guidelines on radiotherapy for malignant pleural mesothelioma

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World Journal of Clinical Oncology 2021年第8期12卷 581-608页

作者： Javier Luna Andrea Bobo Joaquín jos. Cabrera-Rodriguez María Pagola Margarita Martín-Martín María Ángeles González ruiz Miguel Montijano Aurora Rodríguez Lira Pelari-Mici Almudena Corbacho Marta Moreno Felipe Couñago Department of Radiation Oncology Institute of OncohealthFundación Jiménez DíazMadrid 28040Spain Department of Radiation Oncology Institution of Ruber Internacional HospitalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario de BadajozBadajoz 06080Spain Department of Radiation Oncology Institution of Onkologikoa/Hospital Universitario DonostiaSan Sebastián 20014Spain Department of Radiation Oncology Institution of Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology Institution of Hospital Universitario Virgen de la MacarenaSevilla 41009Spain Department of Radiation Oncology Institution of Genesis care SpainMadrid 28005Spain Department of Radiation Oncology Institution of Hospital de MéridaMérida 06800Spain Department of Oncology Institution of University NavarraClinical UniversityPamplona 31008Spain Department of Radiation Oncology Institution of Hospital Universitario Quirónsalud and Hospital LaLuzEuropean University of MadridMadrid 28028Spain

Malignant pleural mesothelioma(MPM)is a rare tumor with poor prognosis and rising *** care is common in MPM as radical treatment with curative intent is often not possible due to metastasis or extensive locoregional *** therapeutic advances have been made in recent years,including the use of less aggressive surgical techniques associated with lower morbidity and mortality(e.g.,pleurectomy/decortication),technological advancements in the field of radiotherapy(intensity-modulated radiotherapy,image-guided radiotherapy,stereotactic body radiotherapy,proton therapy),and developments in systemic therapies(chemotherapy and immunotherapy).These improvements have had as yet only a modest effect on local control and *** in the management of MPM and standardization of care are hampered by the evidence to date,limited by high heterogeneity among studies and small sample *** this clinical guideline prepared by the oncological group for the study of lung cancer of the Spanish Society of Radiation Oncology,we review clinical,histologic,and therapeutic aspects of MPM,with a particular focus on all aspects relating to radiotherapy,including the current evidence base,associations with chemotherapy and surgery,treatment volumes and planning,technological advances,and reradiation.

关键词： Malignant pleural mesothelioma Chemotherapy Surgery Radiotherapy Radiation techniques Reradiation

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Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

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Translational Neurodegeneration 2019年第1期8卷 111-125页

作者： jos. Aguareles Juan Paraíso-Luna Belén Palomares Raquel Bajo-Grañeras Carmen Navarrete Andrea ruiz-Calvo Daniel García-Rincón Elena García-Taboada Manuel Guzmán Eduardo Muñoz Ismael Galve-Roperh Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS) Ctra.Colmenar Viejokm9100 MadridSpain Departamento de Bioquímica y Biología Molecular and Instituto Universitario de Investigación Neuroquímica Universidad ComplutenseMadridSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) MadridSpain Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC) CórdobaSpain Departamento de Biología Celular Fisiología e InmunologíaUniversidad de CórdobaCórdobaSpain Hospital Universitario Reina Sofía CórdobaSpain Emerald Health Pharmaceuticals San DiegoUSA

Background:The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular *** cannabinoid actions in the nervous system are mediated by CB1 receptors,which can elicit psychotropic effects,but other targets devoid of psychotropic activity,including CB2 and nuclear PPARγreceptors,can also be the target of specific ***:We investigated the pro-neurogenic potential of the synthetic cannabigerol derivative,VCE-003.2,in striatal neurodegeneration by using adeno-associated viral expression of mutant huntingtin in vivo and mouse embryonic stem cell differentiation in ***:Oral administration of VCE-003.2 protected striatal medium spiny neurons from mutant huntingtin-induced damage,attenuated neuroinflammation and improved motor ***-003.2 bioavailability was characterized and the potential undesired side effects were evaluated by analyzing hepatotoxicity after chronic ***-003.2 promoted subventricular zone progenitor mobilization,increased doublecortin-positive migrating neuroblasts towards the injured area,and enhanced effective ***,we demonstrated the proneurogenic activity of VCE-003.2 in embryonic stem ***-003.2 was able to increase neuroblast formation and striatal-like CTIP2-mediated ***:The cannabigerol derivative VCE-003.2 improves subventricular zone-derived neurogenesis in response to mutant huntingtin-induced neurodegeneration,and is neuroprotective by oral administration.

关键词： Cannabinoid Huntingtin Neurodegeneration Neurogenesis PPAR

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Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy

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World Journal of Gastroenterology 2014年第43期20卷 15992-16013页

作者： Maria Victoria Preciado Pamela Valva Alejandro Escobar-Gutierrez Paula Rahal Karina ruiz-Tovar Lilian Yamasaki Carlos Vazquez-Chacon Armando Martinez-Guarneros Juan Carlos Carpio-Pedroza Salvador Fonseca-Coronado Mayra Cruz-Rivera Laboratorio de Biología Molecular División PatologíaHospital de Ni?os "Ricardo Gutiérrez"Buenos Aires C1425EFDArgentina Instituto de Diagnóstico y Referencia Epidemiológicos Mexico 01480Mexico Department of Biology Institute of BioscienceLanguage and Exact ScienceS?o Paulo State UniversityS?o José do Rio PretoSP 13560-970Brazil Laboratorio de Inmunobiología de Enfermedades Infecciosas Unidad de Investigación MultidisciplinariaFacultad de Estudios Superiores CuautitlánUniversidad Nacional Autónoma de MéxicoCuautitlán IzcalliEstado de México 54714Mexico Departmento de Microbiología y Parasitología Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico City 04510Mexico

Hepatitis C virus(HCV)infection represents an important public health problem *** of HCV morbidity and mortality is a current challenge owned to several viral and host *** molecular evolution plays an important role in HCV transmission,disease progression and therapy *** high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and *** evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging *** advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against *** a result,superior sustained viral responses have been *** rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era.

关键词： Hepatitis C virus Evolution Phylogenetics Drug resistance Clinical outcome

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气候波动与土地利用变化对西班牙比利牛斯山脉中部径流影响的评价

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AMBIO－人类环境杂志 2003年第4期32卷 283-286页

作者： Santiago Beguería Juan I.López-Moreno Adrián Lorente Manuel Seeger jos. M.García-ruiz 闵庆文比利牛斯生态研究所大学地理学

在地中海国家扩大灌溉土地的面积,应当考虑气候与土地利用变化对水资源的影响。本文利用降水和温度资料,分析了20世纪中叶以来西班牙比利牛斯山脉中部流域径流的变化趋势。降水与径流之间关系的年变化表明,径流在所研完期间的后半时段... 详细信息

在地中海国家扩大灌溉土地的面积,应当考虑气候与土地利用变化对水资源的影响。本文利用降水和温度资料,分析了20世纪中叶以来西班牙比利牛斯山脉中部流域径流的变化趋势。降水与径流之间关系的年变化表明,径流在所研完期间的后半时段相对较低,这一趋势与土地利用变化一致。在月水平上,降水量在10月、4月和7月明显增加,而在3月则有下降:温度在1月和2月有所增加,而在4月则趋于下降。但过去50年间径流在大部分月份中呈显著下降趋势,土地利用和植被覆盖的变化是解释年平均径流下降大约30%的惟一非气候因素。

关键词：气候波动土地利用西班牙比利牛斯山脉径流植被覆盖

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秘鲁人面部形态特征的全基因组关联分析

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基因组学与应用生物学 2021年第7期40卷 2810-2818页

作者：宋春波 Macarena Fuentes-Guajardo Kaustubh Adhikari 孙畅张曼菲李晴杨光睿 Rolando Gonzalez-jos. Lavinia Schüler-Faccini Maria-Cátira Bortolini Victor Acuña-Alonzo Samuel Canizales-Quinteros Carla Gallo Giovanni Poletti Gabriel Bedoya Francisco Rothhammer Andrés ruiz-Linares 复旦大学生命科学学院现代人类学教育部重点实验室上海200438

人类面部形态由神经外胚层发育而来,是区别个体的最显著特征之一。研究人面部特征的遗传机制可为生物医学、司法鉴定等应用领域提供依据。虽然目前已经在正常人群和患病人群中发现了一些与面部特征相关的基因,但是还有许多面部特征的基... 详细信息

人类面部形态由神经外胚层发育而来,是区别个体的最显著特征之一。研究人面部特征的遗传机制可为生物医学、司法鉴定等应用领域提供依据。虽然目前已经在正常人群和患病人群中发现了一些与面部特征相关的基因,但是还有许多面部特征的基因有待发现。本研究基于拉美人群进化和多样性研究联合会(consortium for the analysis of the diversity and evolution of Latin America,CANDELA)队列中的1140个秘鲁健康人群,通过标定其面部的47个特征点来计算中部和下部脸部面积,并计算47个特征点之间的欧式距离,以其结果作为表型;与约七十万个单核苷酸多态性(single nucleotide polymorphisms,SNPs)的全基因组分型数据进行全基因组关联分析(genome-wide association study,GWAS),并在CANDELA队列中的384个巴西和智利的独立健康人群中进行结果验证。本研究用一个加性遗传模型来进行线性回归关联检验,其中因变量为表型的数量性状,协变量为年龄、性别、身体质量指数(body mass index,BMI)及基因组群体分层分析中的前5个主成分(principal components,PCs)。研究结果表明,位于LD基因区(EDAR,LIMS1,RANBP2,SULT1C4,CCDC138,GCC2)的17个单核苷酸多态性与7个数量表型有很强的相关性;其中EDAR作为影响头面发育的一因多效性基因,在本研究中影响中部颅面形态。

关键词：面部形态特征全基因组关联分析加性遗传模型 EDAR LIMS1

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel ruiz-Mateos jos.Miguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez jos.Manuel Lomas Claudio Bueno Rosario Amaya jos.Antonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén jos.Molina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?

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World Journal of Hepatology 2015年第17期7卷 2119-2126页

作者： Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey Eli García-ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria jos. María Remes-Troche Servicio de Gastroenterología Instituto de Investigaciones Médico-Biológicas de la Universidad VeracruzanaHospital Juárez de México Laboratorio de Fisiología Digestiva Instituto de Investigaciones Médico-Biológicas de la Universidad Veracruzana

AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality.

关键词： Alcoholic hepatitis Model for end-stageliver disease-Na Maddrey Mortality

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在阳光下,在自然中

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现代装饰（家居） 2015年第8期 112-119页

作者： Ana Llobet Borja Garcia Francesco Sillitti Gandiablasco jos. A Gandía-Blasco Mario ruiz Mariana Lerma Nendo Neri&Hu Odosdesign Ramón Esteve Romero Vallejo Stefan Diez 伏平范嘉苑

大自然在创造了人类的同时，也赋予了我们温暖的阳光和美丽的风光。在自然中，文人墨客从绿水青山、疏枝密叶中找到点亮思绪的明灯，于是有了“两个黄鹂鸣翠柳，一行白鹭上青天”的闲情；有了“采菊东篱下，悠然见南山”的雅致；有了“... 详细信息

大自然在创造了人类的同时，也赋予了我们温暖的阳光和美丽的风光。在自然中，文人墨客从绿水青山、疏枝密叶中找到点亮思绪的明灯，于是有了“两个黄鹂鸣翠柳，一行白鹭上青天”的闲情；有了“采菊东篱下，悠然见南山”的雅致；有了“似曾相识燕归来，小园香径独徘徊”的丝丝惆怅。在自然中，敏感热情的艺术家从纤枝细叶的纹路里找到了色彩与音符的灵感，无论是贝多芬的《田园交响曲》、德彪西的《新世界交响曲》。还是斯美塔那的《我的祖国》都会将我们带入奇妙的音乐世界。尽显山河田园之美。

关键词：大自然阳光艺术家贝多芬世界温暖南山塔

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Comprehensive Left Ventricular Mechanics Analysis by Speckle Tracking Echocardiography in COVID-19

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World Journal of Cardiovascular Diseases 2021年第2期11卷 113-125页

作者： Francisco J. González-ruiz Emmanuel A. Lazcano-Díaz Zuilma Y. Vásquez-Ortiz Fernanda Bernal-Ceballos Rodrigo Gopar-Nieto Consuelo Orihuela-Sandoval jos. P. Hernández-Reyes Edgar García-Cruz Eduardo Bucio-Reta Ángel Ramos-Enríquez Luis A. Cota-Apodaca Luis Efren-Santos Blanca Estela Broca-García Daniel Manzur-Sandoval Efrén Melano-Carranza Fernandez de la Reguera Guillermo Gustavo Rojas-Velasco Francisco Baranda-Tovar Department of Cardiovascular Critical Care National Institute of Cardiology “Dr. Ignacio Chávez” México City México Department of Echocardiography National Institute of Medical Science and Nutrition “Dr. Salvador Zubirán” México City México PhD Program National University of Mexico (UNAM) México City México Cardiovascular Diseases Department National Institute of Cardiology “Dr. Ignacio Chávez” México City México

Background: Cardiac involvement and the consequences of inflammation induced by SARS-CoV2 infection could have catastrophic long-term consequences. Left ventricular mechanics could identify a specific pattern of myocardial fiber damage in patients infected with COVID-19. To our knowledge there are no publications referring to the global description of ventricular mechanics in patients with COVID-19. Objective: To describe left ventricular mechanics in hospitalized patients with COVID-19. Methods: In this cross-sectional study, we included 40 hospitalized patients with confirmed diagnostic of COVID-19, from April 11, 2020, to September 6, 2020. Demographic and laboratory data, clinical and echocardiographic characteristics were collected, as well as events during hospitalization. Left ventricular deformation was analyzed and reported. Results: Subclinical dysfunction was observed in 82.5% (left ventricular longitudinal strain [LVGLS] -17.05% and global circumferential strain [GCS] -18.6%) of the patients, likewise, the mean twist and apical rotation were preserved, and even increased as part of the compensating mechanism to maintain the ejection fraction. Conclusion: In patients hospitalized with COVID-19, despite having a normal left ventricular ejection fraction, subclinical myocardial damage was found, manifested by a decrease in Global Longitudinal Strain (GLS) and Global Circumferential Strain (GCS). This behavior is similar to that of cardiomyopathies in the early stage of the disease, and given the pathophysiological mechanisms involved in the disease, its long-term consequences should be monitored and evaluated.

关键词： COVID-19 Speckle Tracking Echocardiography Myocarditis Cardiomyopa-thy Cardiac Mechanics Strain Myocardial Damage Deformation Imaging Myocardial Strain

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