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Ductal carcinoma in situ within a fibroadenoma:A case report and review of literature

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World Journal of radiology 2024年第3期16卷 58-68页

作者： Yazmin Olivares-Antúnez Yesika Janett Dávila-Zablah joséra.l vázquez-ávila Gabriela Sofía Gómez-Macías María Teresa Mireles-Aguilar Margarita lilia Garza-Montemayor Department of Diagnostic Breast Imaging Center Hospital Zambrano HellionTecnológico de MonterreyNuevo León 66260Mexico Department of Patology Service Hospital San JoséTecnológico de MonterreyNuevo León 64710Mexico Department of Faculty of Medicine Hospital Universitario de la UANLNuevo León 64710Mexico. Department of Breast Surgery Center Hospital Zambrano HellionTecnológico de MonterreyNuevo León 66260Mexico

BACKGROUND Fibroadenoma(FA)is the most common tumor found in young women,although it can occur in any age *** carcinoma in situ(DCIS)that is confined in a FA is rare;it is most frequently reported as an incidental *** SUMMARY We report a case of DCIS within a FA in a 46-year-old female without cancerrelated personal and family *** patient was diagnosed with a breast conglomerate of nodules and was followed for 1 *** the current control image study,we found suspicious microcalcification,as a new finding,within one of the ***,a core biopsy of the tumor,which appeared hypoechoic,oval,and circumscribed,was *** pathological diagnosis was ductal carcinoma in situ within a fibroepithelial *** patient underwent breastconserving surgery and received radiotherapy as well as endocrine therapy(tamoxifen).CONClUSION We recommend a multidisciplinary approach for adequate treatment and followup.

关键词： Carcinoma in situ Fibroadenoma Mammography Ultrasound Magnetic resonance imaging radiology Case report

Hypothalamic circuits and aging:keeping the circadian clock updated

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Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa vázquez-lizarraga lucia Mendoza-viveros Carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-vázquez Ricardo Orozco-Solis Instituto Nacional de Medicina Genómica(INMEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overa.l quality of *** on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian *** circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during *** the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy *** brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

Chi-square automatic interaction detection(CHAID)analysis of the use of safety goggles and face masks as personal protective equipment(PPE)to protect against occupational biohazards

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Journal of Biosafety and Biosecurity

Journal of Biosafety and Biosecurity 2024年第2期6卷 125-133页

作者： ra.l Aguilar-Elena Juán joséAgún-González Universidad Internacional de valencia ValenciaSpain

Background:This study represents the first Spanish investigation to rigorously evaluate compliance with the use of safety goggles and face masks as essential personal protective equipment(PPE)in companies with workplaces involving exposure to biological ***:This study aimed to examine the degree of use of face masks and safety goggles as personal protective equipment(PPE),the factors that influence their use,and the profile of workers exposed to occupational biological agents in Spanish companies in the health sector,farming sector,meat industry,waste treatment plants,food industry,and veterinary ***:We conducted a cross-sectional descriptive study involving 590 Spanish workers from 51 *** developed a 34-item questionnaire to assess workers’perception of risk related to exposure to biological agents in their *** the questions,three were designed to measure the degree of use of key protective equipment in sectors with biological agent exposure:protective gloves,safety goggles or face *** only analyzed safety goggles and face *** performed various statistical analyses,including Cronbach’s alpha,frequency of endorsement,content validity ratio using lawshe’s method,varimax rotation,the Kaiser-Meyer-Olkin test,and Bartlett’s sphericity test,to assess the internal consistency and reliability of the ***,we employed a chi-square automatic interaction detection(CHAID)segmentation analysis,using workers’responses regarding their attitudes toward safety goggles and face mask usage as PPE for protection against biological risks,with demographic variables as independent ***:In the current study,CHAID analysis revealed that workers exposed to group 2 biological agents used more safety goggles and face shields compared with workers exposed to other groups of biological ***,workers in laboratories and the food industry used face masks more than workers of other ***

关键词： PPE Safety googles and breath mask CHAID Biological Agents Occupational Biosafety

A cleaner production strategy for acid mine drainage prevention of waste rock:A porphyry copper case

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International Journal of Mining Science and Technology 2024年第8期34卷 1163-1177页

作者： Yesica l.Botero Isabelle Demers luis A.Cisternas ArnoldoÁvila Mostafa Benzaazoua Departamento de Ingeniería Química y Procesos de Minerales Universidad de AntofagastaAntofagasta1240000Chile Research Institute on Mines and Environment Universitédu Québec en Abitibi-TémiscamingueRouyn-NorandaQC J9X5E4Canada Eriez Flotation Group Chile S.A. Santiago1240000Chile Geology and Sustainable Mining Institute University Mohammed Ⅵ PolytechnicLot 660 Hay Moulay RachidBen Guerir 43150Morocco

An in-process technology approach is proposed to identify the source of acid mine drainage(AMD)generation and prevent its formation in a porphyry copper waste rock(WR).Adopting actions before stockpiling the WR enables the establishment of potential contaminants and predicts the more convenient method for AMD prevention.A WR sample was separated into size fractions,and the WR’s net acidgenerating potential was quantified using chemical and mineralogical *** diameter of physical locking of sulfides(DPlS)was determined,and the fractions below the DPlS were desulfurized using ***,the WR fractions and tailing from the flotation test were submitted to acid-base accounting and weathering tests to evaluate their acid-generating *** show that the WR’s main sulfide mineral is pyrite,and the DPlS was defined as 850μm.A sulfide recovery of 91%was achieved using a combination of HydroFloat^(®)and Denver cells for a size fraction lower than *** grinding was *** results show that size fractions greater than DPlS and the desulfurized WR are unlikely to produce *** outcomes show that in-processing technology can be a more proactive approach and an effective tool for avoiding AMD in a porphyry copper WR.

关键词： Waste rock Porphyry copper ore Desulfurization Acid mine drainage HydroFloat^(®) In-process technology Cleaner production

Global paleobiogeography of Albian—Cenomanian(mid-Cretaceous)marine ostracods

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Journal of Palaeogeography 2024年第2期13卷 212-236页

作者： Bernardo vázquez-García Jorge villegas-Martín Gerson Fauth leonardo Borghi Aristóteles De Moraes Rios Netto Post-Graduate Program in Geology Unisinos UniversitySao LeopoldoRSBrazil Technological Institute of Paleoceanography and Climate Change-Itt Oceaneon Unisinos UniversitySao LeopoldoRSBrazil laboratory of Sedimentary Geology(lagesed) Department of GeologyInstitute of GeosciencesUFRJ-Federal Universityof Riode JaneiroBrazil labmicro Department of GeologyInstitute of GeosciencesUFRJ-Federal University of Rio de JaneiroBrazil

Despite their potential for providing important information for paleobiogeography,studies using ostracod assemblages compiled from global datasets have been scarce so *** this study,the paleogeographic implications of the relationship between different ostracod assemblages are analyzed and discussed for the Albian and *** compiled an ostracod dataset at the genus level,with 168 genera for the Albian and 174 for the Cenomanian,to which different multivariate statistical methods of grouping were *** affinity between different ostracod assemblages from different regions allowed for the delineation of 30 operational geographic units(OGUs)for the Albian,and 32 OGUs for the Cenomanian,grouped in three paleobiogeographic units(PBUs;Megatethys,Persia,and Austral)and one sub-unit(PBSU;Maghreb associated to the Megatethys).The Maghreb PBSU showed minor changes between the Albian and *** relationship among the OGUs grouped in each PBU is related to different factors,such as eustatic sea level events,similar climatic zones,and marine current circulation patterns.A relationship was observed between the Gabon and Nigeria OGUs with the Persia PBU,which suggests a direct east—west connection between them during the *** affinity observed in the Austral PBU between the South American,South African,and Australian regions during the Albian can be explained by their relative geographic isolation due to the Walvis Ridge *** eventual flooding of this barrier led to the relationship observed between the SE Brazilian and Bolivian regions with the Austral ***,the data also suggested that the separation of the Indian subcontinent from the Austral PBU took place during the Cenomanian.

关键词： Operational geographic units Paleobiogeographic units Albian Cenomanian Marine ostracods

Interindividual Age-Independent Differences in Human CX43 Impact ventricular Arrhythmic Risk

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Research 2024年第3期6卷 417-432页

作者： laura García-Mendívil María Pérez-Zabalza Antoni Oliver-Gelabert joséMaría vallejo-Gil Javier Fañanás-Mastral Manuel vázquez-Sancho Javier AndréBellido-Morales Alexánder Sebastián vaca-Núñez Carlos Ballester-Cuenca Emiliano Diez laura Ordovás Esther Pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para.la Investigación y el Desarrollo(AraID) Zaragoza 50018Spain. Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considera.ly among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

Machine learning based state-of-charge prediction of electrochemical green hydrogen production:Zink-Zwischenschritt-Elektrolyseur(ZZE)

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Energy and AI 2024年第2期16卷 269-276页

作者： Daniel vila Elisabeth Hornberger Christina Toigo STOFF2 GmbH–Gebäude H/Flughafen Tegel 1 13405 BerlinGermany University of Applied Sciences Upper Austria Stelzhamerstraße 23A-4600 WelsAustria Centre for Economic Research on Inclusivity and Sustainability at the University of Galway University RoadGalwayIreland

The intermittency of renewable energy is a key limiting factor for the successful decarbonization of both energy producing and consuming sectors. Green hydrogen has the potential to act as the central energy vector connecting hard-to-abate sectors to renewable power. However, combining energy storage and conversion for a holistic electrolyzer system remains challenging. Here, we show the innovative Zink-Zwischenschritt Elektrolyseur (ZZE), or Zinc Intermediate step Electrolyzer in English, that temporarily decouples the water splitting reaction and uses zinc to store electrical energy in chemical form. To perform optimal operation of a ZZE system, machine learning models were applied to predict the state of charge of a lab scale ZZE system. Using various models, we were able to determine the effectiveness of the prediction and contrast it to state of charge predictions of other energy storage systems. We show that a bi-directional long short-term memory neural network approach has the lowest error within the testing environment. This work serves to perform further ZZE development as well as state of charge prediction for other novel energy storage technologies.

关键词： Electrolyzer Battery ZZE Energy storage State of charge Machine learning Sequence-to-sequence model

Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-vázquez Cristina González-Barreira Paula Oreiro-Martínez Ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity Molecule magnet

Unravelling-based (auto)control of back-action in atomic Bose–Einstein condensate

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Frontiers of physics 2024年第4期19卷 287-295页

作者： v.A.Tomilin l.v.Il’ichov Institute of Automation and Electrometry SB raS 630090 NovosibirskRussia

We present a novel feedback control method for quantum *** does not affect the controlled system ***,it controls the unravelling of the quantum channel of interaction between the system and its *** interaction can be represented as a history of *** their informational content is changed,their back-action on the system is also *** action is trigged by the events,thus granting the system the degree of control over its own *** efficiency of the proposed scheme is demonstrated on the example of two-mode atomic Bose-Einstein condensate,with one of its modes subject to phase-contrast imaging in a Mach–Zehnder *** histories of photocounts in the output channels of the interferometer are used for *** capabilities of state engineering are studied for different settings of the feedback loop and different numbers of events in the recorded histories.

关键词： quantum feedback control quantum measurements twomode Bose-Einstein condensates