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Impacts of Climate Change on the Hydrology of a Small Brazilian Headwater Catchment Using the Distributed Hydrology-Soil-Vegetation Model

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American Journal of Climate Change 2018年第2期7卷 355-366页

作者： Lívia Alves Alvarenga Carlos Rogério de Mello Alberto Colombo Sin Chan Chou luz Adriana Cuartas Marcelo Ribeiro Viola Department of Engineering Federal University of Lavras Lavras Brazil National Institute for Space Research Cachoeira Paulista Brazil Center for Monitoring and Warning of Natural Disasters S&#227 o josé dos Campos Brazil

Climate change is one of the greatest issues for human society. The objective of this study is to assess the impacts of future climate change on seasonal average discharge and monthly water budget in a small headwater catchment, located on the Grande River basin, in Minas Gerais, Brazil. The assessment is carried out using the hydrology model, DHSVM. The atmospheric forcing to drive the Distributed Hydrology-Soil-Vegetation Model (DHSVM) is derived from the downscaling of the HadGEM2-ES projections by the Eta Regional Climate Model, at 5-km high resolution. The projections assume the RCP4.5 and RCP8.5 IPCC AR5 emission scenarios. Baseline period was taken between 1961 and 1990. The projections are assessed in three time slices (2011-2040, 2041-2070 and 2071-2099). The climate change is assessed in time slices of 30 years and in comparison against the baseline period to evaluate the hydrological changes in the catchment. The results showed differences in the hydrological behavior between the emission scenarios and though time slices. Reductions in the magnitude of the seasonal average discharge and monthly water budget may alter the water availability. Under the RCP4.5 scenario, results show greater reductions in the water availability in the first time slice, whereas under RCP8.5 scenario greater reductions are indicated in the third time slice.

关键词： Climate Changes RCP4.5 and RCP8.5 Scenarios Hydrological Model Discharge

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Liver transplant in patients with primary sclerosing cholangitis:A retrospective cohort from Northeastern Brazil

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World Journal of Hepatology 2023年第9期15卷 1033-1042页

作者： Louyse Teixeira de Souza Freitas Elodie Bomfim Hyppolito Victor Leonardo Barreto Luiz Humberto JataíCastelo Júnior Bianca Carneiro de Melo Jorge Frederico César Tahim de Sousa Brasil Háteras Malthus Barbosa Marzola Clébia Azevedo Lima Raquel Mendes Celedonio Gustavo Rêgo Coelho jose Huygens parente Garcia Liver Transplant Department Walter Cantídio Teaching HospitalFortaleza 60430270CearáBrazil School of Medicine University of FortalezaFortaleza 60811905CearáBrazil Hospital São josé CearáState Health DepartmentFortaleza 60455610CearáBrazil Department of Surgery Federal University of CearáFortaleza 60430140CearáBrazil Surgery Department São Carlos HospitalFortaleza 60130241CearáBrazil

BACKGROUND Primary sclerosing cholangitis(PSC)manifests within a broad ethnic and racial spectrum,reflecting different levels of access to health *** To evaluate the clinical profile,complications and survival rates of patients with PSC undergoing liver transplantation(LTx)at a Brazilian reference *** All patients diagnosed with PSC before or after LTx were *** medical records were reviewed for demographic and clinical variables,including outcomes and *** level of statistical significance was set at P<*** Our cohort represented 1.6%(n=34)of the 2113 patients receiving liver grafts at our service over the past two *** were male(n=19;56%).The average age(40±14 years)was similar for men and women(P=0.347).The mean follow-up time from diagnosis to LTx was 68 *** patients had the classic form of *** women had PSC/autoimmune hepatitis overlap syndrome,and one patient had small-duct *** phosphatase levels at diagnosis and pre-LTx model for end-stage liver *** were significantly higher in *** bowel research(IBD)was investigated by colonoscopy in 26/34(76%)and was present in most cases(18/26;69%).IBD was less common in women than in men(44.4%vs.55.6%)(P=0.692).Cholangiocarcinoma(CCA)was diagnosed in 2/34(5.9%)patients by histopathology of the explant(survival:3 years 6 mo,and 4 years 11 mo).Two patients had complications requiring a second LTx(one after 7 d due to hepatic artery thrombosis and one after 17 d due to primary graft dysfunction).Five patients(14.7%)developed biliary *** overall median post-LTx survival was 66 *** deaths occurred in the first year(infection n=2,primary liver graft dysfunction n=3,unknown cause n=1).The 1-year and 5-year survival rates of this cohort were 82.3%and 70.6%,respectively,matching the mean overall survival rates of LTx patients at our center(87.1%and 69.43%,respectively)(P=0.83).CONCLUSION Survival after 1 and 5 years was simil

关键词： Primary sclerosing cholangitis Epidemiology Liver transplantation Survivor Clinical associations Pathological features

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Correction to“Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil”

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World Journal of Experimental Medicine 2023年第3期13卷 47-49页

作者： Fabrício Freire de Melo Lilian Martins Oliveira Diniz joséNélio Januário João Fernando Gonçalves Ferreira Rafael Santos Dantas Miranda Dórea Breno Bittencourt de Brito Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva luz Samuel Luca Rocha Pinheiro Gifone Aguiar Rocha Dulciene Maria de Magalhães Queiroz Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Departamento de Pediatria Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Departamento de Clínica Médica Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Correction to“Freire de Melo F,Martins Oliveira Diniz L,Nélio Januário J,Fernando Gonçalves Ferreira J,Dórea RSDM,de Brito BB,Marques HS,Lemos FFB,Silva luz M,Rocha Pinheiro SL,de Magalhães Queiroz *** of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in *** J Exp Med 2022;12(5):100-103[PMID:36196438 DOI:10.5493/wjem.v12.i5.100]”.In this article,we identified an issue with the“Acknowledgments”***,we then provide a recognition section for our supporting institutions.

关键词： Correction COVID-19 serological testing Serologic tests Rapid diagnostic

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Metastatic hormone-sensitive prostate cancer:How should it be treated?

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World Journal of Clinical Oncology 2021年第2期12卷 43-49页

作者： Fernando López-Campos Carmen González-San Segundo Antonio joséConde-Moreno Felipe Couñago Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology HGU Gregorio MarañonComplutense UniversityMadrid 28007Spain Department of Radiation Oncology Hospital Universitario y Politécnico La Fe.CEU Cardenal Herrera UniversityValencia 46026Spain Department of Radiation Oncology Hospital Universitario Quirón Salud MadridHospital La LuzUniversidad Europea de Madrid(UEM)Madrid 28223Spain

The number of treatment options for metastatic hormone-sensitive prostate cancer has increased substantially in recent *** classic treatment approach for these patients—androgen-deprivation therapy alone—is now considered *** randomized phase III clinical trials have demonstrated significant clinical benefits—including significantly better overall survival and quality of life—for treatments that combine androgen-deprivation therapy with docetaxel,abiraterone acetate,enzalutamide,apalutamide,and/or radiotherapy to the primary *** a result,these approaches are now included in treatment guidelines and considered standard of ***,the different treatment strategies have not been directly compared,and thus treatment selection remains at the discretion of the individual physician or,ideally,a multidisciplinary *** the range of available treatment approaches with varying toxicity profiles,treatment selection should be individualized based on the patient’s clinical characteristics and preferences,which implies active patient participation in the decision-making *** the present document,we discuss the changing landscape of the management of patients with metastatic hormonesensitive prostate cancer in the context of several recently-published landmark randomized *** addition,we discuss several unresolved issues,including the optimal sequencing of systemic treatments and the incorporation of local treatment of the primary tumour and metastases.

关键词： Metastatic hormone-sensitive prostate cancer Androgen-receptor signaling inhibitors Abiraterone acetate Enzalutamide Apalutamide Docetaxel

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GOECP/SEOR radiotherapy guidelines for small-cell lung cancer

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World Journal of Clinical Oncology 2021年第3期12卷 115-143页

作者： Felipe Couñago Carolina de la Pinta Susana Gonzalo Castalia Fernández Piedad Almendros Patricia Calvo Begoña Taboada Antonio Gómez-Caamaño joséLuis López Guerra Marisa Chust joséAntonio GonzálezFerreira AnaÁlvarez González Francesc Casas Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223MadridSpain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario La PrincesaMadrid 28006Spain Department of Radiation Oncology GenesisCare MadridMadrid 28043Spain Department of Radiation Oncology Hospital General UniversitarioValencia 46014Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology Hospital Universitario Virgen del RocíoSevilla 41013Spain Department of Radiation Oncology Fundación Instituto Valenciano de OncologíaValencia 46009Spain Department of Radiation Oncology GenesisCare-SpainSevilla 41092Spain Department of Radiation Oncology HGU Gregorio MarañónMadrid 28007Spain Department of Radiation Oncology Thoracic UnitHospital ClinicBarcelona 08036Spain

Small cell lung cancer(SCLC)accounts for approximately 20%of all lung *** main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to *** cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic *** 5-year OS rate in patients with limited-stage disease(non-metastatic)is slightly higher than 30%,but less than 5%in patients with extensive-stage disease(metastatic).The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis,planning,and treatment of *** guidelines emphasise treatment fields,radiation techniques,fractionation,concomitant treatment,and the optimal timing of Ch and ***,we discuss the main indications for reirradiation in local recurrence.

关键词： Small cell lung cancer Chemotherapy Hyperfractionated radiation therapy Prophylactic brain irradiation Brain metastases Reirradiation

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Watch and wait approach in rectal cancer:Current controversies and future directions

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World Journal of Gastroenterology 2020年第29期26卷 4218-4239页

作者： Fernando López-Campos Margarita Martín-Martín Roberto Fornell-Pérez Juan Carlos García-Pérez Javier Die-Trill Raquel Fuentes-Mateos Sergio López-Durán joséDomínguez-Rullán Reyes Ferreiro AlejandroRiquelme-Oliveira Asunción Hervás-Morón Felipe Couñago Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiology Hospital Universitario de BasurtoBilbao 48013VizcayaSpain Department of Surgery Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Medical Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Gastroenterology and Hepatology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Medical Oncology Hospital Infanta CristinaMadrid 28034Spain Department of Radiation Oncology Hospital Universitario QuirónsaludMadrid 28003Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Universidad Europea de Madrid(UEM) Madrid 28223Spain

According to the main international clinical guidelines,the recommended treatment for locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by ***,doubts have been raised about the appropriate definition of clinical complete response(cCR)after neoadjuvant therapy and the role of surgery in patients who achieve a *** resection is associated with significant morbidity and decreased quality of life(QoL),which is especially relevant given the favourable prognosis in this patient subset. Accordingly, therehas been a growing interest in alternative approaches with less morbidity,including the organ-preserving watch and wait strategy, in which surgery isomitted in patients who have achieved a cCR. These patients are managed with aspecific follow-up protocol to ensure adequate cancer control, including the earlyidentification of recurrent disease. However, there are several open questionsabout this strategy, including patient selection, the clinical and radiologicalcriteria to accurately determine cCR, the duration of neoadjuvant treatment, therole of dose intensification (chemotherapy and/or radiotherapy), optimal followupprotocols, and the future perspectives of this approach. In the present review,we summarize the available evidence on the watch and wait strategy in thisclinical scenario, including ongoing clinical trials, QoL in these patients, and thecontroversies surrounding this treatment approach.

关键词： Watch and wait Rectal cancer Clinical complete response Organ preservation Dose intensification

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Implications of the New Operational Rules for Cantareira Water System: Re-Reading the 2014-2016 Water Crisis

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Journal of Water Resource and Protection 2020年第4期12卷 261-274页

作者： Karinne Reis Deusdará-Leal luz Adriana Cuartas Rong Zhang Guilherme S. Mohor Luíz Valério de Castro Carvalho Carlos Afonso Nobre Eduardo Mario Mendiondo Elisangela Broedel Marcelo Enrique Seluchi Regina Célia dos Santos Alvalá Brazilian Center for Monitoring and Early Warning of Natural Disaster-Cemaden Sao José dos Campos Brazil Department of Hydrology and Water Resources Nanjing Hydraulic Research Institute (NHRI) under the Ministry of Water Resources The Ministry of Transport and National Energy Administration Nanjing China University of Potsdam Potsdam Germany Universidade de Taubaté Taubaté Brazil Institute of Advanced Studies University of Sao Paulo Sao José dos Campos Brazil Sao Carlos School of Engineering University of Sao Paulo USP Sao Carlos Brazil Center for Education & Research of Disasters of Sao Paulo CEPED Sao Paulo Brazil

During the 2014-2016 water shortage crisis, the Metropolitan Area of Sao Paulo (MASP) water supply system extracted pumping volume from the Cantareira System. Before the crisis, between 1984 and 2013, the reservoir’s average water extraction flow was 29.6 m3·s-1. During the period of pumping volume usage, the average extraction flow was 16.2 m3·s-1. Following the crisis, two new mitigation policies were implemented: a water extraction Resolution (in 2017) and a Resolution for water reallocation from another basin (in 2018). This study provides a novel investigation of the Cantareira System water crisis by assessing the mitigation policies impacts on storage level dynamics. The system storage level was evaluated using the reservoir simulation module of PDM-Cemaden hydrological model, assuming that the new policies had already been implemented prior to the crisis. A control simulation was run with observed in- and out-flow and operationally-practiced extraction flow. The storage level dynamics impacts were evaluated under 4 water mitigation policies scenarios varying the policies implementation starting date, the extraction flow range and including the water reallocation variable. Results showed that pumping volume would only need extraction during a short period (Scenarios I, III and IV), and considering the water reallocation, pumping volume extraction would not have been necessary (Scenario II). Although the pumping volume would still have been extracted during a short period, water shortage impact would have been lessened, had the policies been already implemented before the crisis. The water mitigation policies implementation supports the reservoirs storage management but does not guarantee that MASP water demand is fully met. Therefore, in order to effectively improve water security, further policies and practices to reduce water demand and enhance supply should be considered.

关键词： Cantareira System Drought Sao Paulo Brazil Dead Storage Water Crisis

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Empathy Levels of Dental Students of Central America and the Caribbean

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Health 2015年第12期7卷 1678-1686页

作者： Víctor Patricio Díaz-Narváez Ana María Erazo Coronado Jorge Luis Bilbao Farith González Mariela Padilla Madeline Howard Guadalupe Silva Joel Arboleda Mirian Bullen Robert Utsman Elizabeth Fajardo luz Marina Alonso Marcos Cervantes Facultad de Odontología Universidad San Sebastián Santiago Chile Universidad Autónoma de Chile Santiago Chile Universidad Metropolitana Barranquilla Colombia Facultad de Medicina Universidad Libre Seccional Barranquilla y Fundación Universitaria San Martín Sede Puerto Colombia Barranquilla Colombia Facultad de Odontología Universidad de Cartagena Cartagena Colombia Universidad Latinoamericana de Ciencia y Tecnología San José Costa Rica Facultad de Odontología Universidad de Costa Rica San José Costa Rica Universidad Central del Este San Pedro de Macorís República Dominicana Facultad de Odontología Universidad de Panamá Ciudad de Panamá República de Panamá Faculty of Health Sciences Universidad del Tolima Ibagué Colombia División de Salud Universidad del Norte Barranquilla Colombia Facultad de Ciencias Sociales Universidad del Norte Barranquilla Colombia

Objective: The aim of this study is to check whether there are differences in the distribution of empathy levels in dental students from nine faculties of dentistry Colombia, Panama, Costa Rica and Dominican Republic. Methods: The levels of empathy and matrices of empathy construct matrices are estimated dental students by using the Jefferson Scale of Physician Empathy, the Spanish version for students (S version) culturally validated in Colombia, Panama, Costa Rica and Dominican Republic measured by arbitrator criteria. Cronbach α is estimated. Data of empathic orientation of the studied factors between faculties are analyzed and compared by ANOVA and Duncan test and matrices of empathy construct using discriminant analysis. Results: We find that there are differences in levels of empathy between universities, courses, gender and interaction between the Dental Faculty (University) and Course. The comparison between matrices shows unexplained variances and differences observed between the levels of empathy in student populations. Conclusions: Variability in empathy is observed in the studied factors and among student populations. The variability is an empirical finding, but is not possible in this work, to explain why.

关键词： Empathy Jefferson Scale of Physician Empathy (JSPE) Levels of Empathy

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New perspectives in the management of small cell lung cancer

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World Journal of Clinical Oncology 2022年第6期13卷 429-447页

作者： Cristina Pangua Jacobo Rogado Gloria Serrano-Montero joséBelda-Sanchís BeatrizÁlvarez Rodríguez Laura Torrado Nuria Rodríguez De Dios Xabier Mielgo-Rubio Juan Carlos Trujillo Felipe Couñago Department of Medical Oncology Hospital Universitario Infanta LeonorMadrid 28031Spain Department of Thoracic Surgery Hospital de la Santa Creu i Sant Pau&Hospital de MarUniversitat Autònoma de BarcelonaBarcelona 08041CataloniaSpain Department of Radiation Oncology Hospital Universitario HM SanchinarroHM HospitalesHM CIOCC Centro Integral Oncológico Clara CampalMadrid 28050Spain Department of Radiation Oncology Hospital Universitario Lucus Augusti&Instituto de Investigación Sanitaria Santiago de Compostela(IDIS)Lugo 27003Spain Department of Radiation Oncology Hospital Del Mar&Hospital Del Mar Medical Research Institute(IMIM)&Pompeu Fabra UniversityBarcelona 08003CataloniaSpain Department of Medical Oncology Alcorcón Foundation University HospitalAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu i Sant PauBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

The treatment of small cell lung cancer(SCLC)is a challenge for all specialists *** treatments have been added to the therapeutic armamentarium in recent months,but efforts must continue to improve both survival and quality of *** in surgery and radiotherapy have resulted in prolonged survival times and fewer complications,while more careful patient selection has led to increased staging *** in the field of systemic therapy have resulted in changes to clinical guidelines and the management of patients with advanced disease,mainly with the introduction of *** this article,we describe recent improvements in the management of patients with SCLC,review current treatments,and discuss future lines of research.

关键词： Small cell lung cancer Whole-brain radiotherapy Prophylactic cranial irradiation Stereotactic body radiotherapy Immunotherapy Atezolizumab Durvalumab

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GOECP/SEOR radiotherapy guidelines for thymic epithelial tumours

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World Journal of Clinical Oncology 2021年第4期12卷 195-216页

作者： Mikel Rico Sonia Flamarique Cristina Casares Tamara García Miriam López Maribel Martínez Javier Serrano Manuel Blanco Raúl Hernanz Lourdes de Ingunza-Barón Francisco joséMarcos Felipe Couñago Department of Radiation Oncology Complejo Hospitalario de NavarraPamplona 31008NavarraSpain Health Research Institute of Navarre(IdiSNA) Navarra BiomedPamplona 31008NavarraSpain Department of Radiation Oncology University Hospital Miguel ServetZaragoza 50009AragónSpain Department of Radiation Oncology University Hospital of CaceresCáceres 10004ExtremaduraSpain Department of Radiation Oncology Hospital Universitario de FuenlabradaFuenlabrada 28942MadridSpain Department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009AragónSpain Department of Radiation Oncology Clínica Universidad de NavarraMadrid 28027Spain Department of Radiation Oncology Hospital Universitario TorrecárdenasAlmería 04009AndalucíaSpain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario Puerta del MarCádiz 11009AndalucíaSpain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

Thymic epithelial tumours(TET)are rare,heterogeneous neoplasms that range from resectable indolent tumours to aggressive thymic carcinomas with a strong tendency to *** pathological diagnosis is complex,in part due to the management of TETs is scant and mainly based on non-randomised studies and retrospective ***,the clinical management of TETs tends to be highly heterogenous,which makes it difficult to improve the evidence *** role of technological advances in the field of radiotherapy and new systemic therapies in the treatment of TETs has received little attention to *** the present clinical guidelines,developed by the GOECP/SEOR,we review recent developments in the diagnosis and classification of *** also present a consensus-based therapeutic strategy for each disease stage that takes into consideration the best available *** guidelines focus primarily on the role of radiotherapy,including recent advances,in the management of *** main aim of this document is to promote the standardisation of clinical practice and lay the foundations for future studies to clarify the main unresolved questions related to the optimal management of TET.

关键词： Targeted therapies Thymic epithelial tumors Radiotherapy Reirradiation Guidelines Chemotherapy

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