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World Journal of Gastroenterology 2014年第29期20卷 10137-10143页

作者： Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María josé Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado Department of Surgery Reina Sofia Hospital Department of Pediatric Surgery Reina Sofia Hospital Department of Pediatric Oncology Reina Sofia Hospital

AIM:To report our experience with long-term outcomes after multimodal management ***:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to ***,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were ***:The median age at surgery was 14.4 mo,with a male to female ratio of 4:*** staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 *** pretreatment tumor volume was 735 *** out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 *** volume and alphafetoprotein levels significantly dropped after neoadjuvant *** procedures performed included hemihepatectomies,segmentectomies and atypical *** patients received chemotherapy after *** postoperative hospital stay was 8 *** patients were alive and disease-free after a median follow-up period of 23 *** regards to the literature review,seventeen articles were found that were related to our ***:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results.

关键词： Liver tumors Chemotherapy Liver surgery Multimodal

Do Cytokines Play a Role in Predicting Some Features and Outcome in Infective Endocarditis?

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Advances in Infectious Diseases 2013年第2期3卷 115-119页

作者： Maria Carmo Pereira Nunes Izabella Rodrigues de Araújo Andréa Teixeira de Carvalho Letícia Alves Andrade Marcio Henrique Lima Resende josé Luiz Padilha da Silva Teresa Cristina Abreu Ferrari Universidade Federal de Minas Gerais Faculdade de Medicina Departamento de Clínica Médica Belo Horizonte Brazil

Objective: This study aimed to measure the serum concentrations of several cytokines in patients with infective endocarditis (IE), and correlate them with the C-reactive protein serum levels, echocardiographic findings and infecting microorganisms. Methods: Forty-five patients with definite IE according to the Duke’s criteria were included in the study. Ten healthy blood donors formed the control group. Serum levels of interleukin (IL) 1β, IL-6, IL-8, IL-10, IL-12 and tumor necrosis factor-α (TNF-α) were measured and compared between the groups, and also with some clinical and laboratory parameters of IE. Results: Patients with IE had significantly higher serum concentrations of the inflammatory mediators than the control patients. Median IL-12 and IL-1β levels were higher in staphylococcal than streptococcal IE. Except for TNF-α, the levels of all the other cytokines correlated with the C-reactive protein concentrations. In multivariate analysis, IL-10 and IL-12 serum levels remained as independent factors associated with the C-reactive protein concentrations. There was a significant correlation between IL-10 concentration and vegetation length. Conclusion: The inflammatory serum cytokines levels were elevated in IE in comparison to healthy controls. C-reactive protein concentrations correlated with cytokines levels. IL-1β and IL-12 serum concentrations were higher in staphylococcal when compared to streptococcal IE. IL-10 levels were associated with vegetation size.

关键词： Infective Endocarditis Inflammatory Cytokines C-Reactive Protein

Bilateral Gluteal Reconstruction with Double Flap Secondary to Biopolymers Injection

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Journal of Biosciences and Medicines 2021年第7期9卷 174-183页

作者： Miguel Ángel Sánchez-Morán garcía Carlos I. Navarro-Delgadillo Pamela Sánchez-Morán Pérez Rogelio Cordova-López Vanessa Moreno-Diaz Oscar Pérez-Osorio Donovan Magaña-Vega Willian Bautista-Santos Providence Medical Clinic Ciudad de México México

The injection of adjuvant substances for aesthetic purposes is a public health problem, for 40 years this problem has been described throughout our continent, the vast majority of women patients are affected by the infiltration of silicon, mineral oils, automotive oil, methyl methacrylate, cement and various oily substances. This is a 54-year-old female patient who for about 30 years for cosmetic purposes was injected with mineral oil (quantity unknown) in both glutei with the aim of buttock augmentation. Physical examination was observed an important deformity in each buttock, hyperkeratosis with discoloration in both buttocks, loss of bilateral projection, right buttock with a secondary tumor of 22 cm × 11 cm and left 22 cm × 10 cm, stony appearance, local hyperthermia, painful on manipulation, with diffuse nodular lesions measuring 2 cm × 2 cm, without evidence of loss of continuity that would condition secretion leakage. Surgical planning is based on the very important size of the initial defect that we would have to reconstruct, so that the rotation of two wide-based flaps could guarantee better survival and occlusion of the defect, since the realization of a graft would cause a significant deformity, and the realization of a microsurgical flap in a fibrous tissue would inevitably result in its necrosis. The pathophysiology of the adjuvant disease is extremely complex, therefore it must be addressed by a multidisciplinary group with extensive experience.

关键词： Gluteal Reconstruction Biopolymers Foreign Materials Biomaterials Modelants

Antiprotozoal Activity of a <i>Thymus vulgaris</i>Methanol Extract and Its Fractions

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Health 2017年第7期9卷 1081-1094页

作者： Jesús Norberto Garza-González Javier Vargas-Villarreal Ma Julia Verde-Star Catalina Rivas-Morales Azucena Oranday-Cárdenas Magda E. Hernandez-garcía Laura De La Garza-Salinas Francisco González-Salazar Department of Chemistry Phytochemistry and Analytical Chemistry Lab Faculty of Biological Sciences University Autonomous of Nuevo Leon San Nicolas de los Garza Mexico Department of Basic Sciences Division of Health Sciences University of Monterrey San Pedro Garza Garcia Mexico Laboratory of Biochemistry and Cell Physiology Division of Cellular and Molecular Biology Center for Biomedical Research of the Northeast Mexican Social Security Institute Monterrey Mexico Mexican Social Security Institute Nuevo Leon Delegation Monterrey Mexico

Introduction: Thymus vulgaris is used in traditional medicine to treat gastrointestinal diseases because of its antifungal, antibacterial, and antispasmodic activity. Objective: To verify whether Thymus vulgaris also has antiprotozoal activity against Trichomonas vaginalis, Giardia lamblia and Entamoeba histolytica trophozoites. Materials and methods: Conventional cultures of parasites were measured on the third day during the logarithmic growth phase. The antiprotozoal activity of the methanol extract and its fractions were evaluated comparing growth in cultures with and without extracts. Next, the extract was fractionated by polarity-based partitioning. Then, the purity of each fraction was determined by thin layer chromatography (TLC). The percentage of growth inhibition was calculated with respect to untreated controls. The 50% inhibitory concentration (IC50) of each extract was calculated by PROBIT analysis. Results: We found that a methanol extract of the aerial parts of Thymus vulgaris, at 300 μg/mL, inhibited the in vitro growth of G. lamblia and T. vaginalis, while E. histolytica growth was poorly inhibited. The methanol extract was further separated into mixtures of ursolic, oleanolic, and betulinic acids. The IC50 values of ursolic acid against G. lamblia and T. vaginalis were 8.12 μg/mL and 5.51 μg/mL, respectively. Conclusions: The methanol extract fraction containing ursolic acid obtained from Thymus vulgaris has antiprotozoal activity against G. lamblia and T. vaginalis trophozoites.

关键词： Thymus vulgaris Trichomonas vaginalis Giardia lamblia Entamoeba histolytica Antiprotozoal Agents

Emerging Water Quality Issues along Rio de la Sabana, Mexico

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Journal of Water Resource and Protection 2018年第7期10卷 621-636页

作者： Daniel Pineda-Mora Jeiry Toribio-Jiménez Teresa Leal-Ascencio Ma Ana Laura Juárez-López Justiniano González-González Jesús Carlos Ruvalcaba-Ledezma Ramón Alberto Batista-garcía Paul Alexander Arp Local Development Science Center Autonomous University of Guerrero Acapulco Mexico Faculty of Chemistry and Biological Science Autonomous University of Guerrero Chilpancingo Mexico Faculty of Chemistry Science University of Veracruz Xalapa Mexico Health Science Institute Autonomous University of Hidalgo Pachuca Mexico Cell Dynamics Research Center Autonomous University of Morelos Cuernavaca Mexico Faculty of Forestry and Environmental Management University of New Brunswick Fredericton Canada

The basin of Rio de la Sabana is the largest tributary of the Tres Palos coastal lagoon in Southwest Mexico, east of Acapulco. This lagoon and its upstream basin areas have become a high priority area for the preservation of coastal and marine environments. To obtain information about water quality as affected by urban expansion since 2002, fourteen physicochemical parameters (temperature, pH, electrical conductivity, dissolved oxygen, ammonium, nitrate, nitrite, sulphate, phosphate), biochemical (biological and chemical oxygen demand, methylene blue active substances) and bacteriological parameters (total and fecal coliforms) were determined. This sampling was done for dry and rainy season conditions at seven locations (S1, S2, S3, …, S7) along the river, spaced 3 to 6 km apart to a total of 30.4 km. The results were grouped into four zones: (Z1) reference, (Z2) transition, (Z3) polluted, (Z4) recovery. The Alborada (S5) and Tunzingo (S6) sites, adjacent to dense high-class residential areas (Z3), had the greatest pollution charges in both seasons, while the La Poza (S7) site near the Tres Palos lagoon (Z4) showed a decrease in pollution. All parameters correlated with increasing head- to down-river sampling distance by following linear (pH, DO) or curvilinear patterns (all other parameters). Using sampling location and dry versus rainy sampling season as multivariate regression (predictor) variables led to least-squares capturing: 1) 66% to 95% of the T(°C), pH, DO, and PO3-4 variations, and 2) 57% to 96% of the log-linear variations of the other parameters. Among the parameters, T(°C), DO, and PO3-4 were not significantly affected by sampling season, while pH became so after deleting two higher than usual pH values at the S5 and S6 locations during the dry season.

关键词： Rio de la Sabana Urban Developments Water Pollution Sampling Locations Dry/Rainy Season Multivariate Analyses

Toxoplasma gondii causes death and plastic alteration in the jejunal myenteric plexus

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World Journal of Gastroenterology 2015年第16期21卷 4829-4839页

作者： Eduardo joséde Almeida Araújo Larissa Marchi Zaniolo Suellen Laís Vicentino Marcelo Biondaro Góis Jacqueline Nelisis Zanoni Aristeu Vieira da Silva Débora de Mello Goncales Sant'Ana Departamento de Histologia Centro de Ciencias BiológicasUniversidade Estadual de Londrina Programa de Pós-graduacao em Ciencia Animal Universidade Paranaense Departamento de Ciencias Morfológicas.Universidade Estadual de Maringa Departamento de Biologia Universidade Estadual de Feira de Santana

AIM:To assess the effects of ME-49 Toxoplasma gondii(***) strain infection on the myenteric plexus and external muscle of the jejunum in ***:Thirty rats were distributed into two groups:the control group(CG)(n = 15) received 1 m L of saline solution orally, and the infected group(IG)(n=15)inoculated with 1 m L of saline solution containing500 oocysts of M-49 *** strain *** 36 d of infection,the rats were *** with *** was confirmed by blood samples collected from all rats at the beginning and end of the *** jejunum of five animals was removed and submitted to routine histological processing(paraffin)for analysis of external muscle *** remaining jejunum from the others animals was used to analyze the general population and the NADH-diaphorase,VIPergic and nitrergic subpopulations of myenteric neurons;and the enteric glial cells(S100-IR).RESULTS:Serological analysis showed that animals from the IG were infected with the *** affecting jejunal muscle thickness was observed in the IG rats(77.02±42.71)in relation to the CG(51.40±12.34),P<*** addition,31.2%of the total number of myenteric neurons died(CG:39839.3±5362.3;IG:26766.6±2177.6;P<0.05);hyperplasia of nitrergic myenteric neurons was observed(CG:7959.0±1290.4;IG:10893.0±1156.3;P<0.05);general hypertrophy of the cell body in the remaining myenteric neurons was noted[CG:232.5(187.2-286.0);IG:248.2(204.4-293.0);P<0.05];hypertrophy of the smallest varicosities containing VIP neurotransmitter was seen(CG:0.46±0.10;IG:0.80±0.16;P<0.05)and a reduction of 25.3%in enteric glia cells(CG:12.64±1.27;IG:10.09±2.10;P<0.05)was observed in the infected ***:It was concluded that infection with oocysts of ME-49 *** strain caused quantitative and plastic alterations in the myenteric plexus of the jejunum in rats.

关键词： Enteric nervous system Infectious diseases Glial cells Nitric oxide Neuronal plasticity Smallintestine Toxoplasmosis Vasoactive intestinal peptide

Review of the treatment of liver hydatid cysts

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World Journal of Gastroenterology 2015年第1期21卷 124-131页

作者： Concepción Gomez i Gavara Rafael López-Andújar Tatiana Belda Ibáez josé M Ramia ngel ngel Moya Herraiz Francisco Orbis Castellanos Eugenia Pareja Ibars Fernando San Juan Rodríguez Hepatobiliopancreatic Surgery and Transplantation Unit La Fe University Hospital46026 ValenciaSpain Digestive Surgery Virgen de los Lirios HospitalAlcoy03804 ValenciaSpain General Hospital Guadalajara Hepatobiliopancreatic Surgery Unit19002 GuadalajaraSpain

A review was carried out in Medline,LILACS and the Cochrane *** database search strategy included the following terms: "hydatid cyst","liver","management","meta-analysis" and "randomized controlled trial".No language limits were used in the literature *** latest electronic search date was the 7th of January *** and exclusion criteria: all relevant studies on the assessment of therapeutic methods for hydatid cysts of the liver were considered for *** from editorials,letters to publishers,low quality review articles and studies done on animals were excluded from ***,well-structured abstracts from relevant articles were selected and accepted for *** forms were designed for data extraction; two investigators entered the data on patient demographics,methodology,recurrence of HC,mean cyst size and number of cysts per *** hundred and fourteen articles were identified using the previously described search *** applying the inclusion and exclusion criteria detailed above,57 articles were selected for final analysis: one meta-analysis,9 randomized clinical trials,5 non-randomized comparative prospective studies,7 non-comparative prospective studies,and 34 retrospective studies(12 comparative and 22 noncomparative).Our results indicate that antihelminthic treatment alone is not the ideal treatment for liver hydatid *** studies in the literature support the effectiveness of radical treatment compared with conservative *** surgery with omentoplasty is effective in preventing postoperative complications.A laparoscopic approach is safe in some *** drainage with albendazole therapy is a safe and effective alternative treatment for hydatid cysts of the *** surgery with preand post-operative administration of albendazole is the best treatment option for liver hydatid cysts due to low recurrence and complication rates.

关键词： Hydatid Liver Cyst Echinococcosis PAIR Cystectomy

Hepatoprotective effect of silymarin

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World Journal of Hepatology 2014年第3期6卷 144-149页

作者： Nancy Vargas-Mendoza Eduardo Madrigal-Santillán ngel Morales-González Jaime Esquivel-Soto Cesar Esquivel-Chirino Manuel garcía-Luna y González-Rubio Juan A Gayosso-de-Lucio josé A Morales-González Institute of Health Sciences Autonomous University of Hidalgo State Laboratorio Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico NacionalAv.Juan de Dios Bátiz s/n esquina Miguel Othón de MendizabalUnidad Profesional Adolfo López Mateos Faculty of Dentistry UNAM

The use of medicinal plants in treating illnesses has been reported since ancestral *** the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic *** is a natural compound derived from the species Silybum marianum,which is commonly known as Milk *** plant contains at least seven flavoligands and the flavonoid *** hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol,acetaminophen,and carbon *** generation of free radicals is known to damage cellular membranes and cause *** enhances hepatic glutathione and may contribute to the antioxidant defense of the *** has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity.A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls.

关键词： Silybum marianum Hepatoprotector Lipoperoxidation Silymarin

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一种环境友好的鞣制工艺

皮革与化工 2014年第4期31卷 19-23页

作者： Anna Bacardit Stefan vander Burgh Jordi Armengol luis Ollé 孙海云金博

研制一种新的鞣制工艺(亮湿革),用此工艺可以生产出一种合格的汽车内饰浅色革。此工艺是无铬、无醛、无有机溶剂挥发的绿色工艺。工艺的重点是使用了凯米拉公司提供的无毒、无害、绿色、安全的鞣剂。与传统的铬鞣革和醛鞣革相比,新工艺... 详细信息

研制一种新的鞣制工艺(亮湿革),用此工艺可以生产出一种合格的汽车内饰浅色革。此工艺是无铬、无醛、无有机溶剂挥发的绿色工艺。工艺的重点是使用了凯米拉公司提供的无毒、无害、绿色、安全的鞣剂。与传统的铬鞣革和醛鞣革相比,新工艺无论对环境或在经济上考虑都有很大的优势,具体来说,与传统的铬鞣革相比,可使废水中化学需氧量(COD)降低60%,悬浮液体降低61%,氮含量降低65%,此外这种工艺生产出的亮湿革的挥发性化合物比蓝湿革降低43%,比白湿革降低8%,更为重要的是,真正地做到了无铬废水排放。

关键词：汽车内饰革鞣制亮湿革蓝湿革白湿革

改进间接电弧焊过程中电磁交互作用对7075铝合金显微组织和耐腐蚀性能的影响（英文）

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Transactions of Nonferrous Metals Society of China 2019年第3期29卷 473-484页

作者： J.S.REYNA-MONTOYA M.A.garcíA-RENTERíA V.L.CRUZ-HERNáNDEZ F.F.CURIEL-LóPEZ L.R.DZIB-PéREZ L.A.FALCóN-FRANCO Faculty of Metallurgy Autonomous University of Coahuila Instituto de Investigación en Metalurgia y Materiales Universidad Michoacana de San Nicolás de Hidalgo Centre for Corrosion Research Autonomous University of Campeche

研究低强度电磁交互作用(EMILI)对改进间接电弧(MIEA)焊7075-T651铝合金板(厚度为13 mm)的显微组织和耐腐蚀性能的影响。焊接过程为单道次,热输入约为1.5k J/mm。通过测量显微硬度和电化学阻抗谱分别研究EMILI对局部力学性能和天然海水... 详细信息

研究低强度电磁交互作用(EMILI)对改进间接电弧(MIEA)焊7075-T651铝合金板(厚度为13 mm)的显微组织和耐腐蚀性能的影响。焊接过程为单道次,热输入约为1.5k J/mm。通过测量显微硬度和电化学阻抗谱分别研究EMILI对局部力学性能和天然海水中耐蚀性的影响,并将其与焊缝的显微组织观察结果相关联。焊缝的显微组织表征表明,在电磁搅拌作用下,3mT的EMILI使焊缝金属的晶粒细化。此外,扫描电镜观察表明,热影响区(HAZ)的富铜相析出和共晶偏析也因受到EMILI的影响而减少。使用3 mT的EMILI焊接可以减少7075-T651焊缝在天然海水中的腐蚀溶解性和热影响区的过时效程度。因此,EMILI结合MIEA技术可使焊接接头具有更好的显微组织特征,能改善热影响区的力学性能,降低电化学活性。

关键词： 7075-T651铝合金改进间接电弧焊显微组织表征耐腐蚀性电磁交互作用