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Knowledge and Attitudes of Oncology Nurses Toward Clinical Trials-A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第1期8卷 209-221页

作者： Jin sil bae Jeong Hye Kim Department of Nursing Asan Medical CenterSeoulSouth Korea Department of Clinical Nursing University of UlsanSeoul 05505Korea

Purpose:The purpose of this study was to identify the knowledge and attitudes of oncology nurses toward clinical trials and to provide evidence for the development of clinical trial education programs for oncology ***:The study was conducted on 142 nurses who had more than six months of nursing experience working with cancer patients at a tertiary hospital in Seoul,Korea.A structured questionnaire was used to measure the knowledge and attitudes of oncology nurses toward clinical ***:The participants scored an average of 15.03±3.52 out of 19 in terms of knowledge about clinical *** terms of attitudes toward clinical trials,the participants scored an average of 5.91±1.37 out of *** was a significant positive correlation between the knowledge and attitudes of the participants toward clinical trials(r=0.23,P=0.007).Conclusion:This study found that there was a relationship between the knowledge and attitudes of oncology nurses toward clinical *** improve the competency of oncology nurses and provide high-quality care to patients participating in clinical trials,more systematic and sustainable education is required.

关键词： Clinical trial Nurses Knowledge Attitude Neoplasms

Infliximab vs adalimumab:Points to consider when selecting antitumor necrosis factor agents in pediatric patients with Crohn’s disease

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World Journal of Gastroenterology 2023年第18期29卷 2784-2797页

作者： Eun sil Kim ben Kang Department of Pediatrics Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea Department of Pediatrics School of MedicineKyungpook National UniversityDaegu 41944South Korea

biologic agents with various mechanisms against Crohn’s disease(CD)have been released and are widely used in clinical ***,two anti-tumor necrosis factor(TNF)agents,infliximab(IFX)and adalimumab(ADl),are the only biologic agents approved by the Food and Drug Administration for pediatric CD ***,in pediatric CD,the choice of biologic agents should be made more carefully to achieve the therapeutic *** are currently no headto-head trials of biologic agents in pediatric or adult *** is a lack of accumulated data for pediatric CD,which requires the extrapolation of adult data for the positioning of biologics in pediatric *** a pharmacokinetic point of view,IFX is more advantageous than ADl when the inflammatory burden is high,and ADl is expected to be advantageous over IFX in sustaining remission in the maintenance ***,we reviewed the safety profile,immunogenicity,preference,and compliance between IFX and ADl and provide practical insights into the choice of anti-TNF therapy in pediatric *** evaluation of clinical indications and disease behavior is essential when prescribing anti-TNF *** addition,factors such as the efficacy of induction and maintenance of remission,safety profile,immunogenicity,patient preference,and compliance play an important role in evaluating and selecting treatment options.

关键词： Anti-tumor necrosis factor Infliximab Adalimumab Crohn’s disease Pediatric

大隐静脉曲张射频闭合术后再通的影响因素分析

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中国基层医药 2024年第3期31卷 441-443页

作者：何思略万恒黄水传符方勇林智琪刘灏南方医科大学南方医院白云分院血管与介入科广州510080 南方医科大学南方医院血管与介入科广州510080

目的探讨大隐静脉曲张射频治疗术后再通的影响因素。方法采用病例对照研究,对南方医科大学南方医院白云分院和南方医科大学南方医院2021年10月至2022年2月射频闭合治疗的大隐静脉曲张患者40例的临床资料进行分析,依据术后康复情况分为... 详细信息

目的探讨大隐静脉曲张射频治疗术后再通的影响因素。方法采用病例对照研究,对南方医科大学南方医院白云分院和南方医科大学南方医院2021年10月至2022年2月射频闭合治疗的大隐静脉曲张患者40例的临床资料进行分析,依据术后康复情况分为对照组、观察组各20例。对照组为术后康复良好患者,观察组为术后再通患者。分析术后再通的影响因素。结果两组CEAP[临床(clinical)、病因(etiologic)、解剖(anatomic)、病理生理学(pathophysiologic)]分级、反流级别、职业因素、合并穿支静脉差异均无统计学意义(均P>0.05),对照组大隐静脉内径为(4.21±1.90)mm,小于观察组的(5.43±1.39)mm,差异有统计学意义(t=2.31,P=0.027)。结论静脉内径是影响大隐静脉曲张射频闭合术后再通的单一因素。

关键词：静脉曲张隐静脉导管消融术血管外科手术康复职业

How has the disease course of pediatric ulcerative colitis changed throughout the biologics era?A comparison with the IbSEN study

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World Journal of Gastroenterology 2022年第28期28卷 3666-3681页

作者： Yiyoung Kwon Eun sil Kim Yon Ho Choe Mi Jin Kim Department of Pediatrics Samsung Medical CenterSeoul 06351South Korea Department of Pediatrics Kangbuk Samsung Medical CenterSeoul 03181South Korea

bACKGROUND In Korea,infliximab was approved for use in children with ulcerative colitis(UC)in October *** To compare the clinical course of UC before and after the introduction of biological agents,and to compare with the IbSEN *** Patients under 18 years of age,who were diagnosed with UC and followed from January 2003 to October 2020,were included in the *** A(n=48)was followed for at least 2 years between January 2003 and October 2012,and Group b(n=62)was followed for at least 2 years between November 2012 and October *** compared endoscopic remission,drug composition,relapse rate,steroidfree period,and the quality of life of each *** plotted the clinical course of the included patients using the pediatric UC activity index score,and compared our patients with those in the IbSEN *** After 2 years of treatment,colonoscopy evaluation revealed different outcomes in the two treatment *** was confirmed in 14 patients(29.2%)of Group A,and in 31 patients(50.0%)of Group b(Plative corticosteroid-free period was 3.0 years in Group A and 4.4 years in Group ***-free period of Group b was significantly longer than that of Group A(Plly significant difference between the two groups in evaluation of the relapse rate during the observation period(Plotted clinical course graphs of Group A showed similar proportions to the graphs in the IbSEN ***,in Group b,the proportion of patients corresponding to curve 1(remission or mild severity after initial high activity)was high at 76%(47/62).CONClUSION The incidence of relapse has decreased and the steroid-free period has increased after the introduction of the biological *** clinical course also showed a different pattern from that of IbSEN *** active use of biological agents may change the long-term disease course in moderate to severe pediatric UC.

关键词： Colitis Ulcerative Children Infliximab Relapse Steroid

Effects of the Syzygium aromaticum l. extract on antioxidation and inhibition of matrix metalloproteinase in human dermal fibroblast

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Asian Pacific Journal of Tropical biomedicine 2019年第2期9卷 53-59页

作者： da Eun Kim Yeon sil Hwang bo Yoon Chang dae Sung Kim Hyoung Kwon Cho Sung Yeon Kim Institute of Pharmaceutical Research and Development College of PharmacyWonkwang University Hanpoong Pharm.CO. Ltd

Objective: To investigate cosmetic potential of Syzygium aromaticum l.(S. aromaticum l.) and to determine its antioxidant and anti-wrinkling effects. Methods: Using highperformance liquid chromatography, eugenol component was quantitated. The antioxidant activity of S. aromaticum l. was analyzed by 2,2-diphenyl-1-picrylhydrazyl radical scavenging and superoxide dismutase like activities. To determine cell viability, elastase and matrix metalloproteinase-1(MMP-1) activity, human dermal fibroblasts(HS68) were treated with S. aromaticum l. The inhibitory effect of S. aromaticum l. on tumor necrosis factor alpha induced MMPs expression in HS68 was analyzed by realtime-PCR. Results: The eugenol content was confirmed in S. aromaticum l. S. aromaticum l. was observed to have high 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and superoxide dismutase like activity. S. aromaticum l. had no cytotoxicity against the HS68 and dose-dependently increased elastase inhibition. Moreover, S. aromaticum l. significantly decreased MMP-1 content and inhibited gene levels of MMP-1, MMP-2, MMP-3 and MMP-9. Conclusions: The findings suggest that S. aromaticum l. has great potential as a cosmeceutical ingredient with antioxidant and antiwrinkling effects.

关键词： Syzygium aromaticum l Antioxidant Anti-aging Elastase Matrix metalloproteinase-1

Structure and Activity of Strigolactones： New Plant Hormones with a Rich Future

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Molecular Plant 2013年第1期6卷 38-62页

作者： binne Zwanenburg Tomás Pospísil Radboud University Nijmegen Institute for Molecules and Materials Cluster of Organic Chemistry Heyendaalseweg 135 6525AJ Nijmegen TheNetherlands Palacky University Faculty of Science Centre of the Region Haná for Biotechnological and Agricultural Research Department of Growth Regulators~lechtiteICJ 11 CZ-783 71 Olomouc Czech Republic

Strigolactones （Sls） constitute a new class of plant hormones which are active as germination stimulants for seeds of parasitic weeds of Striga, Orobanche, and Pelipanchi spp, in hyphal branching of arbuscular mycorrhizal （AM） fungi and as inhibitors of shoot branching. In this review, the focus is on molecular features of these Sls. The occurrence of Sls in root exudates of host plants is described. The naming protocol for Sl according to the International Union of Pure and Applied Chemistry （IUPAC） rules and the ＇at a glance＇ method is explained. The total synthesis of some natural Sls is described with details for all eight stereoisomers of strigol. The problems encountered with assign- ing the correct structure of natural Sls are analyzed for orobanchol, alectrol, and solanacol. The structure-activity relationship of Sls as germination stimulants leads to the identification of the bioactiphore of Sls. Together with a tentative mechanism for the mode of action, a model has been derived that can be used to design and prepare active Sl analogs. This working model has been used for the preparation of a series of new Sl analogs such as Nijmegen-1, and analogs derived from simple ketones, keto enols, and saccharine. The serendipitous finding of Sl mimics which are derived from the D-ring in Sls （appropriately substituted butenolides） is reported. For Sl mimics, a mode of action is proposed as well. Recent new results support this proposal. The stability of Sls and Sl analogs towards hydrolysis is described and some details of the mechanism of hydrolysis are discussed as well. The attempted isolation of the protein receptor for germination and the current status concerning the biosynthesis of natural Sls are briefly discussed. Some non-Sls as germinating agents are mentioned. The structure-activity relationship for Sls in hyphal branching of AM fungi and in repression of shoot branching is also analyzed. For each of the principle functions, a working model for the desi

关键词： germination stimulant hyphal branching AM fungi inhibition shoot branching plant hormones strigolac-tones structure-activity relationship.

Does weather affect the growth rate of COVID-19,a study to comprehend transmission dynamics on human health

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Journal of Safety Science and Resilience 2020年第1期1卷 3-11页

作者： Arjun sil Vanapalli Naveen Kumar Dept of Civil Engineering NIT SilcharAssam 788010India

The undefendable outbreak of novel coronavirus(SARS-COV-2)lead to a global health emergency due to its higher transmission rate and longer symptomatic duration,created a health surge in a short *** Nov 2019 the outbreak in China,the virus is spreading exponentially *** current study focuses on the relationship between environmental parameters and the growth rate of *** statistical analysis suggests that the temperature changes retarded the growth rate and found that-6.28℃ and+14.51℃ temperature is the favorable range for COVID-19 ***-Richter’s relationship is used to estimate the mean daily rate of exceedance of confirmed cases concerning the change in ***,temperature is the most influential parameter that reduces the growth at the rate of 13-17 cases/day with a 1℃ rise in temperature.

关键词： Covid-19 Pendemic Temperature Health risk

Muskingum equation based downstream sediment flow simulation models for a river system

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International Journal of Sediment Research 2016年第2期31卷 139-148页

作者： briti Sundar sil Parthasarathi Choudhury Department of Civil Engineering Tezpur University Department of Civil Engineering NIT Silchar

Applications of sediment transport and water flow characteristics based sediment transport simulation models for a river system are presented in this *** existing water-sediment model and a new sediment-water model are used to formulate the simulation models representing water and sediment movement in a river *** sediment-water model parameters account for water flow characteristics embodying sediment transport properties of a *** models are revised formulations of the multiple water inflows model describing water movement through a river system as given by the Muskingum *** models are applied to a river system in Mississippi River basin to estimate downstream sediment concentration,sediment discharge,and water *** system and the river section parameters are estimated using a revised and the original multiple water inflows models by applying the genetic *** models estimate downstream sediment transport rates on the basis of upstream sediment/water flow rates to a *** performance is evaluated by using standard statistical criteria;downstream water discharge resulting from the original multiple water inflows model using the estimated river system parameters indicate that the revised models satisfactorily describe water movement through a river *** obtained in the study demonstrate the applicability of the sediment transport and water flow characteristics-based simulation models in predicting downstream sediment transport and water flow rates in a river system.

关键词： Multiple rivers Sediment transport Modeling Estimation Muskingum model

brain metabolism in patients with vegetative state after post-resuscitated hypoxic-ischemic brain injury： statistical parametric mapping analysis of F-18 fluorodeoxyglucose positron emission tomography

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Chinese Medical Journal 2013年第5期126卷 888-894页

作者： Yong Wook Kim Hyoung Seop Kim Young-sil.an Department and Research Institute of Rehabilitation Medicine Yonsei University College of Medicine Seoul Republic of Korea Department of Physical Medicine and Rehabilitation NationalHealth Insurance Corporation Ilsan Hospital Gyonggi-doRepublic of Korea Department of Nuclear Medicine Ajou University School ofMedicine Suwon Republic of Korea

background Hypoxic-ischemic brain injury （HIbI） after cardiopulmonary resuscitation is one of the most devastating neurological conditions that causing the impaired consciousness. However, there were few studies investigated the changes of brain metabolism in patients with vegetative state （VS） after post-resuscitated HIbI. This study aimed to analyze the change of overall brain metabolism and elucidated the brain area correlated with the level of consciousness （lOC） in patients with VS after post-resuscitated HIbI. Methods We consecutively enrolled 17 patients with VS after HIbI, who experienced cardiopulmonary resuscitation. Overall brain metabolism was measured by F-18 fluorodeoxyglucose positron emission tomography （F-18 FDG PET） and we compared regional brain metabolic patterns from 17 patients with those from 15 normal controls using voxel-by-voxel based statistical parametric mapping analysis. Additionally, we correlated the lOC measured by the JFK-coma recovery scale-revised of each patient with brain metabolism by covariance analysis. Results Compared with normal controls, the patients with VS after post-resuscitated HIbI revealed significantly decreased brain metabolism in bilateral precuneus, bilateral posterior cingulate gyrus, bilateral middle frontal gyri, bilateral superior parietal gyri, bilateral middle occipital gyri, bilateral precentral gyri （PFEw correctecd 〈0.0001 ）, and increased brain metabolism in bilateral insula, bilateral cerebella, and the brainstem （PFEWcorrectecd 〈0.0001 ）. In covariance analysis, the lOC was significantly correlated with brain metabolism in bilateral fusiform and superior temporal gyri （P uncorrected 〈0.005）. Conclusions Our study demonstrated that the precuneus, the posterior cingulate area and the frontoparietal cortex, which is a component of neural correlate for consciousness, may be relevant structure for impaired consciousness in patient with VS after post-resuscitated HIbI. In post-resuscitated HIbI, measuremen

关键词： hypoxic-ischemic brain injury vegetative state brain metabolism