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Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

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Research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María Pérez-Zabalza Antoni Oliver-Gelabert joséMaría Vallejo-Gil Javier Fañanás-Mastral Manuel Vázquez-Sancho Javier Andrébellido-Morales Alexánder Sebastián Vaca-Núñez Carlos ballester-Cuenca Emiliano diez Laura Ordovás Esther Pueyo biomedical Signal Interpretation and Computational Simulation group(bSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain bSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and biology of Cuyo(IMbECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. biomedical Research Networking Center in bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

Impact of device resistances in the performance of graphene-based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期 89-99页

作者： óscar Castelló Sofía M.López baptista Kenji Watanabe Takashi Taniguchi Enrique diez Jesús Enrique Velázquez-Pérez Yahya M.Meziani josé M.Caridad Juan A.Delgado-Notario Department of Applied Physics University of Salamanca Unidad de Excelencia en Luz y Materia Estructurada(LUMES) University of Salamanca Research Center for Electronic and Optical Materials National Institute for Materials Science Research Center for Materials Nanoarchitectonics National Institute for Materials Science Nanotechnology Group USAL–Nanolab University of Salamanca

In recent years, graphene field-effect-transistors(GFETs) have demonstrated an outstanding potential for terahertz(THz) photodetection due to their fast response and high-sensitivity. Such features are essential to enable emerging THz applications, including 6G wireless communications, quantum information, bioimaging and security. However, the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device, so-called access or parasitic resistances. In this work, we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET detectors. Such dual-gate architectures allow us to fine tune(decrease) the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector, respectively. Our results can be well understood by a series resistance model, as shown by the excellent agreement found between the experimental data and theoretical calculations. These findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

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Document Clustering with Evolutionary Systems through Straight-Line Programs “<i>slp</i>”

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Journal of Intelligent Learning Systems and Applications 2012年第4期4卷 303-318页

作者： josé Luis Castillo Sequera josé Raúl Fernández del Castillo diez León Gonzalez Sotos Department of Computer Science University of Alcala Madrid Spain.

In this paper, we show a clustering method supported on evolutionary algorithms with the paradigm of linear genetic programming. “The Straight-Line Programs (slp)”, which uses a data structure which will be useful to represent collections of documents. This data structure can be seen as a linear representation of programs, as well as representations in the form of graphs. It has been used as a theoretical model in Computer Algebra, and our purpose is to reuse it in a completely different context. In this case, we apply it to the field of grouping library collections through evolutionary algorithms. We show its efficiency with experimental data we got from traditional library collections.

关键词： Clustering Genetic Algorithm Data Mining Straight Line Programs

Double balloon device compared to oxytocin for induction of labour after previous caesarean section

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 212-216页

作者： Estefanía Rodríguez Ferradas Izaskun Lasa Alvarado Miren Arrue Gabilondo Irene diez-Itza josé García-Adanez Departament of Obstetrics and Gynecology Asturias Central Hospital Oviedo Spain Departament of Obstetrics and Gynecology Donostia Hospital San Sebastián Spain

Objective: To assess cervical changes, duration of oxytocin infusion, mode of delivery and complications after cervical ripening using a double balloon device in women with a previous caesarean section. Methods: Longitudinal study including 80 women with a previous caesarean section, no previous vaginal delivery and an unfavourable cervix (bishop

关键词： Double balloon Device Induction Labor Vaginal birth after Caesarean Cervical Ripening

SARS-CoV-2 outbreak impact on a trauma unit

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World Journal of Orthopedics 2021年第10期12卷 751-759页

作者： Sarah Mills Aitor Ibarzábal-Gil josé M Martínez-diez Javier Pallarés-Sanmartín Carlos Kalbakdij-Sánchez Juan C Rubio-Suárez Itsaso Losantos-García E Carlos Rodríguez-Merchán Department of Orthopedic Surgery La Paz University HospitalMadridSpain Department of biostatistics La Paz University HospitalMadrid 28046Spain Osteoarticular Surgery Research Hospital La Paz Institute for Health Research–IdiPAZ(La Paz University Hospital–Autonomous University of Madrid)MadridSpain

bACKGROUND From February 2020 onwards,our country has been hit by the coronavirus severe acute respiratory syndrome-2(SARS-CoV-2)*** a glance,hospitals became overrun and had to reformulate all the assistance guidelines,focusing on the coronavirus disease *** year after the start of the pandemic,we present the results of a morbimortality *** To analyze how our department was affected by the outbreak in terms of morbimortality,and to analyze demographic data,admission to hospital-related data,and subgroups analyses for patients with hip fractures and *** We designed a study comparing data from patients who were admitted to our unit due to a lower limb fracture or a high energy trauma during the pandemic(from March to April 2020)to those admitted during the same period in 2019 before the *** the pandemic *** cohorts completed a minimum of 6 mo of *** The number of patients admitted to hospital in 2020 was nearly half of those in *** fractures in the elderly represented 52 out of 73 of the admitted *** patients had a positive test result for SARS-CoV-2 *** with SARS-CoV-2 infection were admitted to the hospital for a longer time than the non-infected(P<0.001),and had a higher mortality rate during hospitalization and follow-up(P=0.02).Patients with a hip fracture associated with a severe respiratory syndrome were mostly selected for conservative treatment(P=0.03).CONCLUSION Mortality and readmission rates were higher in the 2020 cohort and during follow-up,in comparison with the cohort in 2019.

关键词： Trauma department COVID-19 pandemic SARS-CoV-2 outbreak Hip fractures Morbimortality Polytraumatic patients

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

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Acta Pharmaceutica Sinica b 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fabien Chantegreil Florian Nachon Xavier brazzolotto Anna Skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia binda Francisco López-Muoz Stanislav Gobec joséMarco-Contelles University of Ljubljana Faculty of PharmacyLjubljana 1000Slovenia Laboratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of biology and biotechnology University of PaviaPavia 27100Italy Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal Anatomy and Preclinical Sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of biochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of Translational Neurobiology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain biotechnology and Vegetal biology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h bChE)and monoamine oxidases(hMAO-A/b)for the therapy of neurodegenerative *** identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available *** 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h bChE(IC50=1.06±0.31 nmol/L)and h MAO-b(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hbChE and hMAO-b provided the structural basis for potent binding,which was further studied by enzyme *** 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19.

关键词： Quinolylnitrone butyrylcholinesterase Monoamine oxidase b Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task Novel object recognition

华北地区晚二叠世-早三叠世植物群演变及极端环境的指示

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华北地区晚二叠世-早三叠世植物群演变及极端环境的指示

中国古生物学会孢粉学分会十届二次学术年会

作者：舒文超喻建新童金南 josé bienvenido diez 史骁楚道亮黄其胜 barry Lomax 中国地质大学(武汉)地球科学学院生物地质与环境地质国家重点实验室 Facultad de Ciencias del Mar. Universidad de VigoCampus As Lagoas 吉林大学地球科学学院 The School of biosciences The University of NottinghamSutton Bonington Campus

二叠纪-三叠纪之交发生了显生宙历史上最大的生物大灭绝事件,同时伴随着环境的强烈波动,如高温事件,酸雨事件,野火事件,陆地风化增强,强烈的火山活动以及紫外辐射增强。现有的工作主要集中于海相地层的研究,而这个时期陆地生态系统的演... 详细信息

二叠纪-三叠纪之交发生了显生宙历史上最大的生物大灭绝事件,同时伴随着环境的强烈波动,如高温事件,酸雨事件,野火事件,陆地风化增强,强烈的火山活动以及紫外辐射增强。现有的工作主要集中于海相地层的研究,而这个时期陆地生态系统的演变研究程度较低。我国华北地区发育十分连续的上二叠统至中三叠统地层,是全国乃至全球研究该重要时期陆地生态系统的极好研究区之一。同时陆地植物在陆地生态系统中占据着不可或缺的地位,因此华北地区二叠纪-三叠纪之交陆地植物的演变过程及其对极端响应的研究将为陆地生态系统的崩解提供一定的思路。本研究从华北不同区域选取了5条主干剖面结合古孢粉化石和古植物大化石开展,化石主要产自上石盒子组顶部、孙家沟组下部、刘家沟组上部及和尚沟组下部,共建立了两个主要的古孢粉化石组合及四个古植物大化石组合。综合古孢粉化石及古植物大化石来看,晚二叠世植物群主要以裸子植物为主导,尤以松柏类植物占绝对优势,孢粉化石以无肋双气囊类、Lueckisporites spp.、一些松柏类的单气囊类为主,其次为种子蕨类植物（具肋纹双气囊类）,蕨类植物的孢子极少,植物大化石也是以松柏类的营养枝为主及少量雄性球果、雌性的苞麟种鳞复合体等,还可见一些楔叶类植物化石（如Neocalamites）,苏铁类植物化石（如Pterophyllum）等。在二叠纪三叠纪之交,生物大灭绝事件也导致了华北地区晚二叠世这套松柏类植物为主导的植物群几乎消失,而据古孢粉化石记录,早三叠世以具腔类石松类三缝孢及苏铁类花粉为主导,伴随少量种子蕨类的具肋纹类花粉出现,早三叠世晚期植物大化石记录才逐渐开始出现,同时记录了在这次大灭绝事件之后华北地区陆地植物群的重现过程。此外,在华北地区晚二叠世最晚期松柏植物为主的植物群消失前夕,出现了大量的异常花粉及孢子四分体,这些异常现象往往与地表紫外辐射（UV-b）增强有关,同时说明可能是当时强烈的西伯利亚大火山岩省的频繁巨量活动极大地破坏大气臭氧层,形成了大规模的臭氧层空洞,从而导致了植物群崩塌瓦解。

关键词：二叠纪-三叠纪之交生物大灭绝古孢粉化石古植物化石紫外辐射UV-b增强

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在阳光下,在自然中

现代装饰（家居） 2015年第8期 112-119页

作者： Ana Llobet borja Garcia Francesco Sillitti Gandiablasco josé A Gandía-blasco Mario Ruiz Mariana Lerma Nendo Neri&Hu Odosdesign Ramón Esteve Romero Vallejo Stefan diez 伏平范嘉苑

大自然在创造了人类的同时，也赋予了我们温暖的阳光和美丽的风光。在自然中，文人墨客从绿水青山、疏枝密叶中找到点亮思绪的明灯，于是有了“两个黄鹂鸣翠柳，一行白鹭上青天”的闲情；有了“采菊东篱下，悠然见南山”的雅致；有了“... 详细信息

大自然在创造了人类的同时，也赋予了我们温暖的阳光和美丽的风光。在自然中，文人墨客从绿水青山、疏枝密叶中找到点亮思绪的明灯，于是有了“两个黄鹂鸣翠柳，一行白鹭上青天”的闲情；有了“采菊东篱下，悠然见南山”的雅致；有了“似曾相识燕归来，小园香径独徘徊”的丝丝惆怅。在自然中，敏感热情的艺术家从纤枝细叶的纹路里找到了色彩与音符的灵感，无论是贝多芬的《田园交响曲》、德彪西的《新世界交响曲》。还是斯美塔那的《我的祖国》都会将我们带入奇妙的音乐世界。尽显山河田园之美。

关键词：大自然阳光艺术家贝多芬世界温暖南山塔