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Cellular & Molecular Immunology 2018年第4期15卷 353-366页

作者： Laura Gómez-Jaramillo Raquel Romero-García Gema Jiménez-Gómez Lisa Riegle Ana Belén Ramos-Amaya joséantonio brieva Marie Kelly-Worden antonio Campos-Caro Unidad de Investigación Hospital Universitario Puerta del MarCádizSpain Department of Biology Ball State UniversityMuncieINUSA

The production and secretion of antibodies by human plasma cells(PCs)are two essential processes of humoral *** secretion process relies on a group of proteins known as soluble N-ethylmaleimide-sensitive factor attachment protein receptors(SNAREs),which are located in the plasma membrane(t-SNAREs)and in the antibody-carrying vesicle membrane(v-SNARE),and mediate the fusion of both *** have previously shown that SNAP23 and STX4 are the t-SNAREs responsible for antibody ***,using human PCs and antibody-secreting cell lines,we studied and characterized the expression and subcellular distribution of vesicle associated membrane protein(VAMP)isoforms,demonstrating that all isoforms(with the exception of VAMP1)are expressed by the referenced ***,the functional role in antibody secretion of each expressed VAMP isoform was tested using *** results show that VAMP2 may be the v-SNARE involved in vesicular antibody *** further support this conclusion,we used tetanus toxin light chain to cleave VAMP2,conducted experiments to verify co-localization of VAMP2 in antibody-carrying vesicles,and demonstrated the coimmunoprecipitation of VAMP2 with STX4 and SNAP23 and the in situ interaction of VAMP2 with *** together,these findings implicate VAMP2 as the main VAMP isoform functionally involved in antibody secretion.

关键词： exocytosis human immunoglobulin plasma cells VAMP proteins

Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Effect of rhenium on the microstructure and mechanical behavior of Fe–2.25Cr–1.6W–0.25V-0.1C bainitic steels

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Journal of Materials Science & Technology 2017年第12期33卷 1487-1493页

作者： josé antonio Jiménez Manuel Carsí Oscar antonio Ruano Department of Physical Metallurgy Centro Nacional de lnvestigaciones MetalurgicasC.S.I.CAvda.Gregorio del Amo 828040 MadridSpain

A new ferritic creep resistant steel has been developed by eliminating Nb and adding 1.5 mass % Re to a ferritic steel grade T/P23 with the aim of enhancing its mechanical properties at high *** ingots of both steels, new grade and ASTM T/P 23, were hot rolled at 900℃ and then submitted to a thermal treatment consisting of solubilization at 1050℃ and tempering at 700℃. Tempered bainitic microstructures obtained contain second phases reinforcing carbide particles, mainly M_6C and M_（23）C_6 at the boundaries of both, prior austenite grains and bainitic ferrite laths, as well as MC within the grains. Mechanical properties at temperatures ranging from 540 to 600℃ were studied by strain-ratechange tests in compression at strain rates between 10^（-7） and 10^（-4）s^（-1）. These tests showed high stress exponents（n ≥ 20） and activation energies（Q ≈ 400 k J/mol） for both alloys, which were associated with a dislocation movement mechanism with a strong interaction between dislocations and precipitates. On the other hand, a creep exponent of 5 was derived for the stress dependence of minimum creep rate from conventional-type creep tests at 600℃. Although this stress exponent is usually related to a dislocation climb controlled creep mechanism, remarkable microstructural degradation observed with increasing creep time makes difficult to elucidate the true deformation mechanism controlling creep.

关键词： Creep resistant steel T/P23 Thermal treatment Tempered bainite High temperature mechanical properties Creep

A Proof of Wedderburn＇s Theorem

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Algebra Colloquium 2015年第4期22卷 603-606页

作者： josé antonio Cuenca Mira Departamento de álgebra Geometría y Topología Facultad de Ciencias Universidad de Málaga 29071 Málaga Spain

In this note we first introduce the finite weak Herstein condition, which is a property that holds for every finite field. For a field F satisfying the finite weak Herstein condition, we then characterize whether all the finite-dimensional division F-algebras are commutative. This gives an alternate proof of Wedderburn＇s Theorem.

关键词： division algebra finite-dimensional algebra finite field Galois extension

Gravitational waves from compact objects

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Research in Astronomy and Astrophysics 2010年第11期10卷 1071-1099页

作者： josé antonio de Freitas Pacheco University of Nice-Sophia Antipolis Observatoire de la Cote d'Azur Laboratoire Cassiopée-UMR 6202 BP 4229-F606304-Nice Cedex 4-France

Large ground-based laser beam interferometers are presently in operation both in the USA （LIGO） and in Europe （VIRGO） and potential sources that might be detected by these instruments are revisited. The present generation of detectors does not have a sensitivity high enough to probe a significant volume of the universe and, consequently, predicted event rates are very low. The planned advanced generation of interferometers will probably be able to detect, for the first time, a gravitational sig- nal. Advanced LIGO and EGO instruments are expected to detect few （some）： binary coalescences consisting of either two neutron stars, two black holes or a neutron star and a black hole. In space, the sensitivity of the planned LISA spacecraft constellation will allow the detection of the gravitational signals, even within a ＂pessimistic＂ range of possible signals, produced during the capture of compact objects by supermassive black holes, at a rate of a few tens per year.

关键词： gravitational waves -- neutron stars -- black holes

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

Evaluation of the effectiveness of horizontal subsurface flow constructed wetlands for different media

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Journal of Environmental Sciences 2010年第6期22卷 820-825页

作者： antonio Albuquerque josé Oliveira Sabrina Semitela Leonor Amaral Department of Civil Engineering and Architecture and C-MADE University of Beira Interior Municipality of Penamacor Department of Sciences and Environmental Engineering Faculty of Sciences and TechnologyNew University of Lisbon

Two media bed （gravel and Filtralite NR） were tested in a mesocosm to evaluate the removal of organic matter （as chemical oxygen demand （COD））, ammonia （NH4-N）, nitrite, nitrate and solid matter （as total suspended solids （TSS）） for a synthetic wastewater （acetate-based） and a domestic wastewater. The use of Filtralite allowed average removal rates （6--16.8 g COD/（m^2·day）, 0.8-1.1 g NH4-N/（m^2·day） and 3.1 g TSS/（m^2·day）） and removal efficiencies （65%-93%, 57%-85% and 78% for COD, NH4-N and TSS, respectively）, higher than that observed in the experiments with gravel. The applied loads of COD, ammonia, nitrate and TSS seem to influence the respective removal rates but only for the treatment of domestic wastewater with nigher correlation coefficients for Filtralite. Regardless the type of media bed and the type of wastewater, nitrate was completely removed for nitrogen loading rates up to 1.3 g NO3-N/（m^2·day）. There was no evidence of the influence of nitrate loads on the removal of organic matter.

关键词： media bed constructed wetlands pollutants removal rates

Parameter Estimation for Hot-spot Thermal Model of Power Transformers Using Unscented Kalman Filters

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 634-642页

作者： MiguelÁngel González-Cagigal joséantonio Rosendo-Macías antonio Gómez-Expósito Department of Electrical Engineering University of SevilleSevilleSpain ENGREEN Laboratory of Engineering for Energy and Environmental Sustainability SevilleSpain

This paper presents a parameter estimation technique for the hot-spot thermal model of power *** proposed technique is based on the unscented formulation of the Kalman filter,jointly considering the state variables and parameters of the dynamic thermal model.A two-stage estimation technique that takes advantage of different loading conditions is developed,in order to increase the number of parameters which can be *** results are presented,which show that the observable parameters are estimated with an error of less than 3%.The parameter estimation procedure is mainly intended for factory testing,allowing the manufacturer to enhance the thermal model of power transformers and,therefore,its customers to increase the lifetime of these *** proposed technique could be additionally considered in field applications if the necessary temperature measurements are available.

关键词： Parameter estimation power transformer unscented Kalman filter thermal model

Miscibility of Poly(hydroxybutyrate)/Poly(vinyl alcohol)Melt Blends Plasticized With Glycerol

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Journal of Renewable Materials 2019年第4期7卷 325-333页

作者： Deliane da Silva Cabral antonio joséFelix Carvalho Department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloAv.João Dagnone110013563-120São Carlos-SP-Brazil

Poly(hydroxybutyrate)/poly(vinyl alcohol)(PHB/PVA)blends plasticized with glycerol were prepared by melt blending of PHB and glycerol plasticized *** PHB/PVA-glycerol compositions were 90:10,75:25 and 50:50 w/w,being the concentration of glycerol in the PVA mixture of 10 wt%.The blends were characterized by infrared spectroscopy,dynamic-mechanical thermal analysis,and scanning electron microscope of the fragile fractured *** results showed one single phase blend,indicating miscibility corroborated by the presence of a single glass transition *** blending method proved to be an efficient way to tune PHB properties keeping its biodegradable nature since both PVA and glycerol are fully biodegradable materials.

关键词： Blend miscibility melt processing poly(hydroxybutyrate) poly(vinyl alcohol)