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Advanced glycation end product:A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study

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World Journal of Gastroenterology 2021年第29期27卷 4913-4928页

作者： Evelyn Nunes Goulart da silva Pereira Daniela Polessa Paula Beatriz Peres de Araujo Maria de jesus Mendes da Fonseca Maria de Fátima Haueisen Sander Diniz Anissa Daliry Rosane Harter Griep Laboratory of Cardiovascular Investigation Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil National School of Statistical Sciences Brazilian Institute of Geography and StatisticsRio de Janeiro 20231-050Brazil department of Epidemiology and Quantitative Methods in Health Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil Faculty of Medicine Universidade Federal de Minas GeraisMinas Gerais 31270-901Brazil Laboratory of Health and Environment Education Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil

BACKGROUND Liver diseases are associated with the excess formation of advanced glycation end products(AGEs),which induce tissue inflammation and oxidative ***,the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease(NAFLD)is *** To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil *** In 305 individuals at baseline ELSA-Brasil,NAFLD-associated steatosis was classified by ultrasound hepatic *** participants were grouped according to the severity of steatosis:mild and moderate/severe *** measurement of serum fluorescent AGE concentrations was based on spectrofluorimetric *** AGE content and clinical and laboratory characteristics of the participants were compared between *** correlation between serum AGE levels and the grade of steatosis was *** regression analysis was used to investigate the relationship between serum AGE levels and steatosis severity.A P valuedered statistically *** According to the steatosis severity spectrum in NAFLD,from mild to moderate/severe,individuals with the most severe steatosis grade had a higher incidence of metabolic syndrome(63%vs 34%,P≤0.001),diabetes mellitus(37%vs 14%,P≤0.001),and high cholesterol levels(51%vs 33%,Pdex,systolic and diastolic blood pressure,fasting blood glucose,glycated hemoglobin,insulin,triglycerides,alanine aminotransferase,gamma-glutamyl transferase,C-reactive protein,and uric acid levels and lower high-density *** serum AGE content was present in the moderate/severe group of individuals than in the mild group(P=0.008).In addition,the serum AGE levels were correlated with the steatosis grade in the overall sample(rho=0.146,P=0.010).Logistic regres

关键词： Advanced glycation end products Non-alcoholic fatty liver disease Steatosis ELSA-Brasil study Spectroscopy

Cutaneous Tuberculosis and AIDS Diagnosis: A Case Report

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Case Reports in Clinical Medicine 2018年第2期7卷 126-130页

作者： Gisela Borges Maria de jesus silva Internal Medicine department Hospital Pulido Valente Lisbon Portugal

The incidence of extrapulmonary tuberculosis has been increasing especially among immunocompromised patients. Mycobacterium tuberculosis skin infection is rare, accounting for 1.5% of all forms of the disease. We present a clinical case of 38 years old woman, Brazilian;with sexual risk behaviours that develops a sudden thoracoabdominal tumefaction of 4 - 5 cm. The investigation confirmed a metastatic tuberculous abscess in a patient with acquired immunodeficiency syndrome.

关键词： Cutaneous Tuberculosis Metastatic Tuberculous Abscess Tuberculous Gumma Extrapulmonary Tuberculosis Acquired Immunodeficiency Syndrome

Multi-objective forest harvesting under sustainable and economic principles

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林业研究:英文版 2023年第5期34卷 1379-1394页

作者： Talles Hudson Souza Lacerda Luciano Cavalcante de jesus Franca Isáira Leite e Lopes Sammilly Lorrayne Souza Lacerda Evandro OrfanóFigueiredo Bruno Henrique Groenner Barbosa Carolina Souza Jarochinski e silva Lucas Rezende Gomide Suzano SA Sao JoséDos CamposSao PauloBrazil Institute of Agricultural Sciences Federal University of Uberlandia–UFUMonte CarmeloMinas GeraisBrazil department of Forest Sciences Federal University of Lavras–UFLALavrasMinas GeraisBrazil Brazilian Agricultural Research Corporation–EMBRAPA Rio BrancoAcreBrazil department of Systems and Automation Federal University of Lavras–UFLALavrasMinas GeraisBrazil

Selective logging is well-recognized as an effective practice in sustainable forest ***,the ecological efficiency or resilience of the residual stand is often in *** time depends on operational variables,diversity,and forest *** logging is excellent but is open to *** may be resolved by mathematical programming and this study integrates the economic-ecological aspects in multi-objective function by applying two evolutionary *** function maximizes remaining stand diversity,merchantable logs,and the inverse of distance between trees for harvesting and log landings *** Brazilian rainforest database(566 trees)was used to simulate our 216-ha *** log landing design has a maximum volume limit of 500 *** nondominated sorting genetic algorithm was applied to solve the main optimization *** parallel,a sub-problem(p-facility allocation)was solved for landing allocation by a genetic *** frontier analysis was applied to distinguish the gradientsα-economic,β-ecological,andγ-*** expected,the solutions have high diameter changes in the residual stand(average removal of approximately 16 m^(3) ha^(-1)).All solutions showed a grouping of trees selected for harvesting,although there was no formation of large clearings(percentage of canopy removaldemographic rates of the remaining *** methodology should support projects of reduced impact logging by using spatial-diversity information to guide better practices in tropical forests.

关键词： Amazon rainforest management Computational intelligence Multi-objective functions Evolutionary computing

Analysis of the Identification of Local Agriculture Products in the Municipality of Aileu, Manufahi, and Ainaro That Have Potential for Export and Attract Foreign Investments in Agricultural Sector

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Agricultural Sciences 2023年第2期14卷 145-153页

作者： Vicente de Paulo Correia josé Nelson Salsinha Oscar Da silva Carlos Da Conceição de deus Mateus de jesus Gomes Graciano Soares Gomes decio R. Sarmento National Center for Scientific Research (CNIC) National University of Timor Lorosa’e (UNTL) Dili Timor-Leste Lecturers of Agriculture Faculty National University of Timor Lorosa’e (UNTL) Dili Timor-Leste TradeInvest Dili Timor-Leste

The objective of this study is to identify and collect information on local agriculture products and identify local potential agriculture and livestock that can attract foreign investments. Used Stratified Random Sampling and data was collected from both primary and secondary data (both quantitative and qualitative data. The data analyzed used qualitative and quantitative analysis. The supply chain analysis was carried out to develop a description of the value chain to identify potential high-value market areas and current and potential products in the domestic and export markets. The results of the study revealed that most farmers in the research location grow different types of crops and livestock. In particular for Aileu and Ainaro where most of the areas are up-land, therefore, horticulture crops (mustard, cabbage, carrots, and tomato) and coffee are dominated in these areas. For Manufahi, some parts are lowland areas, where most crops grown are maize, cassava, and paddy rice. The study reveals that local potential agriculture products and livestock in the municipalities of Aileu, Ainaro, and Manufahi are vegetable, coffee, maize, and paddy rice, banana, shallot, tangerine, cabbage, carrot, cattle, mung-bean, and banana. To accelerate economic growth, in these municipalities, there is a need to modernize agricultural production, requiring markets for both inputs supply and for the sale of output products. Opportunities to increase the productivity of these products are feasible and this can be done through the use of high-variety seeds and better farm management, and the government and private sector can play an important role in improving productivity as this will have a further implication in improving food security.

关键词： Potential Product Investment Agriculture Livestock Market

Obesity in people with diabetes in COVID-19 times: Important considerations and precautions to be taken

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World Journal of Clinical Cases 2021年第20期9卷 5358-5371页

作者： Adriano Alberti Fabiana Schuelter-Trevisol Betine Pinto Moehlecke Iser Eliane Traebert Viviane Freiberger Leticia Ventura Gislaine Tezza Rezin Bruna Becker da silva Fabiana Meneghetti Dallacosta Leoberto Grigollo Paula Dias Gracielle Fin josiane Aparecida de jesus Fabiane Pertille Carina Rossoni Ben Hur Soares Rudy joséNodari Júnior Clarissa Martinelli Comim Research Group in Neurodevelopment of Childhood and Adolescence Laboratory of Experimental NeurosciencePostgraduate Program in Health SciencesUniversity of South Santa Catarina(Unisul)Palhoça88137-270Santa CatarinaBrazil Brazil Clinical Research Center Postgraduate Program in Health SciencesUniversity of Southern Santa Catarina at TubarãoTubarão88704-900Santa CatarinaBrazil Postgraduate Programme in Health Sciences University of Southern Santa CatarinaPalhoça88137-270Santa CatarinaBrazil Postgraduate Program in Biosciences and Health University of the West of Santa CatarinaJoaçaba89600-000Santa CatarinaBrazil department of Physical Education University of the West of Santa CatarinaJoaçaba89600-000Santa CatarinaBrazil Environmental Health Institute of the Faculty of Medicine of the University of Lisbon Lisboa1649-029Portugal Health Science University of Passo FundoPasso Fundo99052-900Rio Grande do SulBrazil Research department Salus DermatoglifiaLuzerna89609-000Santa CatarinaBrazil

At the end of 2019,a new disease with pandemic potential appeared in *** was a novel coronavirus called coronavirus disease 2019(COVID-19).Later,in the first quarter of 2020,the World Health Organization declared the outbreak of this disease a *** people,people with comorbidities,and health care professionals are more vulnerable to *** has been growing exponentially worldwide,affecting several age *** is a morbidity that is associated with genetic,epigenetic,environment factors and/or interaction between *** is associated with the development of several diseases including diabetes mellitus,mainly type *** affects a significant portion of the global *** and diabetes are among the main risk factors for the development of severe symptoms of COVID-19,and individuals with these conditions constitute a risk *** on a literature review on obesity in people with diabetes in the framework of the COVID-19 pandemic,this study presents updated important considerations and care to be taken with this population.

关键词： Obesity Diabetes COVID-19 Population World Disease

Bayesian modeling of COVID-19 cases with a correction to account for under-reported cases

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Infectious Disease Modelling 2020年第1期5卷 699-713页

作者： Anderson Castro Soares de Oliveira Lia Hanna Martins Morita Eveliny Barroso da silva Luiz Andre Ribeiro Zardo Cor jesus Fernandes Fontes Daniele Cristina Tita Granzotto departamento de Estatística Universidade Federal de Mato Grosso-UFMTCEP:78060-900CuiabaMTBrazil departamento de Estatística Universidade Estadual de Maringa-UEMCEP:87020-900MaringaPRBrazil Faculdade de Medicina Universidade Federal de Mato Grosso-UFMTCEP:78060-900CuiabaMTBrazil

The novel of COVID-19 disease started in late 2019 making the worldwide governments came across a high number of critical and death cases,beyond constant fear of the collapse in their health *** the beginning of the pandemic,researchers and authorities are mainly concerned with carrying out quantitative studies(modeling and predictions)overcoming the scarcity of tests that lead us to under-reporting *** address these issues,we introduce a Bayesian approach to the SIR model with correction for underreporting in the analysis of COVID-19 cases in *** proposed model was enforced to obtain estimates of important quantities such as the reproductive rate and the average infection period,along with the more likely date when the pandemic peak may *** under-reporting scenarios were considered in the simulation study,showing how impacting is the lack of information in the modeling.

关键词： COVID-19 Under-reporting SIR model Bayesian aproach

Characterization of the Sexual Self- and Cross-Compatibility in Genotypes of Cacao

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American Journal of Plant Sciences 2018年第9期9卷 1794-1806页

作者： Samuel Martins de jesus Branco Daniela Viana da silva Uilson Vanderlei Lopes Ronan Xavier Corrêa Universidade Estadual de Santa Cruz Ilhéus Brazil Centro de Pesquisas do Cacau (CEPEC/CEPLAC) Ilheus Brazil

Cacao is a tree crop of high economic importance and the subject of several studies aiming the genetic improvement of the species with the incorporation of characteristics that are agronomically important to create superior genotypes. In this context, this study aimed to characterize 22 genotypes of cacao for sexual compatibility, which is a trait that is strongly associated with yield. Additionally, we identify genotypes incompatible with clone TSH-1188 through controlled intercrosses, due to the great importance of this clone in cocoa breeding. Fifteen genotypes were characterized as self-incompatible and other seven as self-compatible, considering the retention index (20%) of self-pollinated flowers. Nine genotypes were characterized for the first time: CCN-16, COCA-3310, COCA-3370/5, EB-1017, IMC-119, IMC-97, LCTEEN-37A, NA-45, and UF-612. Cacao genotypes showed flower retention index ranging from 0.0% to 55.1% after 15 days of self-pollinations. The number of retained flowers varied after self-pollination of cacao genotypes at 1, 5 and 15 days after pollination. CCN-51, Catongo, CCN-10 and P-4B, were the genotypes with minor losses of flowers after 15 days of pollination, while IMC-119 and TSH-516 had 100% of loss of flowers between 1 and 5 days after pollination. Moreover, the flower retention index 15 days after cross-pollination with TSH-1188 ranged from 0.0% to 87.5% among the tested genotypes. The results of cross-pollinations identified two genotypes that are incompatibles, EB-1017 and IMC-119. This result is important for future allelic studies of incompatibility in cacao, because it might indicate that these genotypes share the same self-incompatibility allele(s). We conclude, therefore, that this study enable the characterization of this working collection of cocoa germplasm for sexual compatibility and this information is important for subsequent crosses between cacao genotypes.

关键词： Breeding System Pollination Retention Index Cocoa Germplasm Theobroma cacao

Physicochemical and Sensory Characterization of Banana and Aracá-Boi Jam

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Food and Nutrition Sciences 2014年第8期5卷 733-741页

作者： Eliseth de Souza Viana Jaciene Lopes de jesus Ronielli Cardoso Reis Marcos Vinícius silva de Andrade Celio Kersul do Sacramento Brazilian Agricultural Research Corporation EMBRAPANational Cassava&Fruits Research CenterCruz das AlmasBrazil Federal University of Reconcavo Baiano Cruz das AlmasBrazil State University of Santa Cruz IlhéusBrazil

This study evaluated the physicochemical and sensory properties of mixed jam elaborated with banana and ara?á-boi. Four banana extract (BE) and ara?á-boi (AB) jams were prepared using the following proportions: F1 (70% BE:30% AB), F2 (60% BE:40% AB), F3 (40% BE:60% AB) and F4 (30% BE:70% AB). The jams were analyzed for physicochemical and sensory properties. The sensory acceptance test was performed by 50 panelists who were asked to indicate how much they liked/ disliked the jams based on the following attributes: color, aroma, flavor and texture. The formulations that contained more BE (F1 and F2) showed a lower titratable acidity (TA), higher ratio (SS/TA) and higher total sugar. A global analysis of the internal preference mapping verified that formulations F1 and F2 were preferred for flavor and had good acceptance levels for the other evaluated attributes, which indicated that the consumers favored jams with lower concentrations of AB and higher concentrations of BE. The formulation F1 was considered the most accepted for all attributes evaluated and showed high purchase intent (68%), and was therefore appropriate for industrialization and consumption.

关键词： Musa spp. Eugenia stipitata Acceptance Preference Mapping Fruits Processing

The Behavior of Recycled Concrete through the Application of an Isotropic Damage Model

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Open Journal of Civil Engineering 2015年第3期5卷 339-351页

作者： Marcelo Pedreira da silva Magno Teixeira Mota Anderson de Souza Matos Gadea Monica Batista Leite Koji de jesus Nagahama Civil and Environmental Engineering Post-Graduate Program State University of Feira de SantanaFeira de SantanaBrazil

The main goal of this paper is to describe the mechanical behavior of the CDW recycled concrete in compression, using an isotropic damage model adapted to the variation of the replacement rate of natural aggregates by recycled ones. The isotropic model by Mazars was used as a constitutive equation for the CDW concrete and its adjustment parameters, A and B, were written as quadratic polynomials according to the aggregates replacement rate. The model was evaluated for conventional and recycled concretes. For the latter ones, the aggregates replacement ratios evaluated were 50% and 100%. The results show good approximation between the analytical and numerical values obtained with the adapted isotropic damage model and experimental concrete results for both compressive and flexural strength.

关键词： Recycled Concrete Construction and demolition Waste Isotropic Damage Mazars Isotropic Model