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Antioxidant Protective Effects of the Resveratrol on the Cardiac and Vascular Tissues from Renal Hypertensive Rats

Open Journal of Medicinal Chemistry 2012年第3期2卷 61-71页

作者： Joyce Cristina de Oliveira Carla Renata Kitanish Antonietto Angélica Cristina Scalabrini Talita Sanches Marinho Larissa Pernomian joséwilson ncorrêa Carolina Baraldi Araujo Restini School of Nutrition University of Ribeirao PretoRibeirao PretoBrazil School of Pharmaceutical Sciences University of Ribeirao PretoRibeirao PretoBrazil Department of Physics and Chemistry Faculty of Pharmaceutical Sciences from Ribeirao PretoLaboratory of PharmacologyUniversity of Sao PauloRibeirão PretoBrazil Federal University of Amazonas ManausBrazil School of Medicine Animal Experimental LaboratoryUniversity of Ribeirao PretoRibeirao PretoBrazil

Background: Accumulating reactive oxygen species (ROS) is involved in cellular signaling and function disturbances due to the oxidative stress, which contributes to several diseases. The consequences of ROS activity represent an im-portant mechanism on the pathogenesis of vascular diseases, such as hypertension. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Resveratrol, a polyphenolic compound primarily found in red wine, has many biological and pharmacological proper-ties. Considering the antioxidant properties of resveratrol, the present study was aimed to investigate the effects of the chronic treatment with resveratrol on cardiovascular system from renal hypertensive rats. Results: 2K-1C hypertension presented increased blood pressure, which was reduced at the end of the fifth week of resveratrol treatment. The cardiac hypertrophy index and the basal levels of ROS in rat aortic rings were also reduced by resveratrol treatment. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the car-diac growth and the vascular ROS generation in renal hypertension.

关键词： Hypertension Aorta Superoxide Resveratrol Phenylephrine Reactive Species of Oxygen(ROS)

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Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Touristic urbanization and greening of coastal dune fields:A long-term assessment of a temperate sandy barrier of Argentina

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Journal of Geographical Sciences 2025年第1期35卷 206-230页

作者： GARZO Pedro Andrés DADON josé Roberto ISLA Federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.Schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world. However, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization practices were considered necessary. The systematic introduction of fast-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. This complex region includes urban resorts, afforestation zones, and protected areas. A GIS-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. Furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native plant communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Anther and pollen development:A conserved developmental pathway

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Journal of Integrative Plant Biology 2015年第11期57卷 876-891页

作者： josé Fernndez Gmez Behzad Talle Zoe A wilson School of Biosciences University of NottinghamSutton Bonington Campus

Pollen development is a critical step in plant development that is needed for successful breeding and seed formation. Manipulation of male fertility has proved a useful trait for hybrid breeding and increased crop yield. However, although there is a good understanding developing of the molecular mechanisms of anther and pollen anther development in model species, such as Arabidopsis and rice, little is known about the equivalent processes in important crops. Nevertheless the onset of increased genomic information and genetic tools is facilitating translation of information from the models to crops, such as barley and wheat; this will enable increased understanding and manipulation of these pathways for agricultural improvement.

关键词： Anther Arabdiopsis cereals comparative biology pollen

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez joséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Ultrastructural analysis of the loss of desiccation tolerance in germinating Eremanthus erythropappus seeds

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Journal of Forestry Research 2019年第4期30卷 1331-1336页

作者： Rayana S.Martins Anderson C.josé josé Marcio R.Faria wilson V.S.Pereira Department of Forest Sciences Federal University of Lavras(UFLA)

Eremanthus erythropappus(DC.)MacLeish is an important forest species native to the Brazilian savanna biome,an environment with well-defined rainy and dry *** seeds are desiccation tolerant,non-dormant and dispersed at the end of dry *** exposes them to the first sporadic rains that can trigger germination but the subsequent dry days can compromise survival of the newly germinated *** study evaluates if the damages caused by drying of germinating *** seeds,at the stage when they have lost desiccation tolerance,are *** percentage of normal seedlings was evaluated when seeds with different imbibition times were dried to their initial water content and then pre-humidified and *** tolerance was fully lost after 0.5 mm of hypocotyl-radicle protrusion(approximately 72 h)when the radicle had root hairs,a possible indicator of sensitivity to *** of cell contents and ultrastructural damage to the seeds subjected to drying were observed by electron scanning *** hairs disappeared after drying,reappearing after pre-humidification,possibly an attempt to increase the surface area of the radicle for water ***,the hypocotylradicle axis became darkened,probably by antioxidant system failure,causing seed death.

关键词： Candeia Drying Desiccation tolerant seeds Rehydration Scanning electron microscopy

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Driving factors of tree biomass and soil carbon pool in xerophytic forests of northeastern Argentina

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Ecological Processes 2023年第1期12卷 916-928页

作者： Silvana María joséSione Marcelo Germán wilson Silvia Gabriela Ledesma Emmanuel Adrián Gabioud joséDaniel Oszust Leandro Javier Rosenberger Centro de Investigación Científica y de Transferencia Tecnológica a la Produc-ción(CICyTTP-CONICET) España 149(3105)DiamanteEntre RíosArgentina Facultad de Ciencias Agropecuarias(FCA-UNER) Universidad Nacional de Entre RíosRuta 11 Km 10.5(3101)Oro VerdeEntre RíosArgentina Instituto Nacional de Tecnología Agropecuaria(INTA) EEA ParanáRuta 11 Km 12.5(3101)Oro VerdeEntre RíosArgentina

Background The conversion of forests into agricultural lands can be a threat because the forests carbon stored could be a source of emissions. The capacity to improve the predictions on the consequences of land use change depends on the identification of factors that influence carbon pools. We investigated the key driving factors of tree biomass and soil carbon pools in xerophytic forests in northeastern Argentina. Based on analyses of forest structure variables and abiotic factors (topography and soil properties) from 18 mature forests, we evaluated carbon pools using uniand multivariate (redundancy analysis) methods. Results The total carbon pool was estimated at 102.4 ± 24.0 Mg ha−1. Soil organic carbon storage is the single largest carbon pool relative to tree biomass, representing 73.1% of total carbon. Tree canopy cover and basal area were positively correlated with biomass carbon pool (r = 0.77 and r = 0.73, p < 0.001, respectively), proving to be significant drivers of carbon storage in this compartment. Slope, soil clay content and cation-exchange capacity had a better explanation for the variability in soil carbon pools, and all showed significant positive correlations with soil carbon pools (r = 0.64, 0.60 and 0.50;p < 0.05, respectively). The vertisols showed a 27.8% higher soil carbon stock than alfisols. Conclusions The relevance of our study stems from a dearth of information on carbon pools and their drivers in xerophytic forests, and in particular, the importance of this ecosystems’ type for Argentina, because they cover 81.9% of native forest area. Basal area and tree canopy cover exert a strong effect on the carbon pool in tree biomass but not in the soil. The results suggests that there is a potentially major SOC accumulation in forests located in slightly sloping areas and soils with higher topsoil clay content, such as vertisols. This could provide an important reference for implementing forestry carbon sink projects.

关键词： Carbon pool Forest biomass Soil parameters Ecosystem services

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Analysis of Viscous Heating in a Micro-Rocket Flow and Performance

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Journal of Thermal Science 2008年第2期17卷 116-124页

作者： josé A.Moríigo josé Hermida Quesada Dept.of Space Programmes National Institute for Aerospace Technology Dept.of Aerodynamics and Propulsion National Institute for Aerospace Technology

Micro-rockets for propulsion of small spacecrafts exhibit significant differences with regard to their macroscale counterparts,mainly caused by the role of the viscous dissipation and heat transfer processes in the micron-sized *** goal of this work is to simulate the transient operation of a micro-rocket to investigate the effects of viscous heating on the flow and performance for four configurations of the expanding gas and wafer *** modelling follows a multiphysics approach that solves the fluid and solid regions fully coupled.A contin- uum-based description that incorporates the effects of gas rarefaction through the micro-nozzle,viscous dissipa- tion and heat transfer at the solid-gas interface is ***-equilibrium is addressed with the implementa- tion of a 2nd-order slip-model for the velocity and temperature at the *** results stress that solid-fluid cou- pling exerts a strong influence on the flowfield and performance as well as the effect of the wafer during the first instants of the transient in micro-rockets made of low and high thermal conductivity materials.

关键词： Micronozzles propulsion MEMS slip flow viscous heating

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Multiphysics Simulation of a Novel Concept of MEMS-based Solid Propellant Thruster for Space Propulsion

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Journal of Thermal Science 2011年第6期20卷 527-533页

作者： josé A.Moríigo josé Hermida-Quesada Dept.of Space Programmes National Institute for Aerospace Technology Ctra.Ajalvir km.4Torrejón de Ardoz 28850 MadridSpain Propulsion EngineerPh.D. Dept.of Aerodynamics and Propulsion National Institute for Aerospace Technology Ctra.Ajalvir km.4Torrejón de Ardoz 28850 MadridSpain

This work analyzes a novel MEMS-based architecture of submillimeter size thruster for the propulsion of small spacecrafts,addressing its preliminary characterization of *** architecture of microthruster comprises a setup of miniaturized channels surrounding the solid-propellant reservoir filled up with a high-energetic *** channels guide the hot gases from the combustion region towards the nozzle entrance located at the opposite side of the *** simulations of the transient response of the combustion gases and wafer heating in thruster firings have been conducted with FLUENT under a multiphysics modelling that fully couples the gas and solid parts *** approach includes the gas-wafer and gas-polymer thermal exchange,burnback of the polymer with a simplified non-reacting gas pyrolysis model at its front,and a slip-model inside the nozzle portion to incorporate the effect of gas-surface and rarefaction onto the gas ***,accurate characterization of thruster operation requires the inclusion of the receding front of the polymer and heat transfer in the moving gas-solid *** study stresses the improvement attained in thermal management by the inclusion of lateral micro-channels in the *** particular,the temperature maps reveal the significant dependence of the thermal loss on the instantaneous surface of the reservoir wall exposed to the heat flux of hot ***,the simulations stress the benefit of implementing such a pattern of micro-channels connecting the exit of the combustion reservoir with the *** results prove that hot gases flowing along the micro-channels exert a sealing action upon the heat flux at the reservoir wall and partly mitigate the overall thermal loss at the inner-wall vicinity during the *** analysis shows that propellant decomposition rate is accelerated due to surface preheating and it suggests that a delay of the flame extinction into the reservoir

关键词： micronozzles spacecraft micropropulsion solid propellant thrusters

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