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Management of hepatitis B virus infection after liver transplantation

World Journal of Gastroenterology 2015年第42期21卷 12083-12090页

作者： miguel Jiménez-Pérez Rocío González-Grande josé Mostazo Torres Carolina González Arjona Francisco Javier Rando-Mu?oz Liver Transplantation and Hepatology Unit UGC de Aparato Digestivo Hospital Regional Universitario Department of Abdominals Diseases Hospital Nij Smellinghe Ziekenhuis

Chronic hepatitis B virus(HBV) infection is responsible for up to 30% of cases of liver cirrhosis and up to 53% of cases of hepatocellular carcinoma. Liver transplantation(LT) is the best therapeutic option for patients with end-stage liver failure caused by HBV. The success of transplantation, though, depends on receiving prophylactic treatment against post-transplant viral reactivation. In the absence of prophylaxis, liver transplantation due to chronic hepatitis B(CHB) is associated with high rates of viral recurrence and poor survival. The introduction of treatment with hepatitis B immunoglobulins(HBIG) during the 1990 s and later the incorporation of oral antiviral drugs have improved the prognosis of these patients. Thus, LT for CHB is now a universally accepted option, with an estimated 5 years survival of around 85% vs the 45% survival seen prior to the introduction of HBIG. The combination of lamivudine plus HBIG has for many years been the most widely used prophylactic regimen. However, with the appearance of new more potent oral antiviral agents associated with less resistance(e.g., entecavir and tenofovir) for the treatment of CHB, new prophylactic strategies are being designed, either in combination with HBIG or alone as a monotherapy. These advances have allowed for more personalized prophylaxis based on the individual risk profile of a given patient. In addition, the small pool of donors has required the use of anti-HBc-positive donors(with the resulting possibility of transmitting HBV from these organs), which has been made possible by suitable prophylactic regimens.

关键词： Hepatitis B virus Liver tra nsplantation Recurrence Prophylaxis Hepatitis B immunoglobulin

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Checking procalcitonin suitability for prognosis and antimicrobial therapy monitoring in burn patients

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Burns & Trauma 2018年第1期6卷 39-48页

作者： Luís Cabral Vera Afreixo Rita Meireles miguel Vaz Catarina Chaves Marisa Caetano Luís Almeida joséArtur Paiva Department of Plastic Surgery and Burns Unit Unidade de QueimadosCoimbra University Hospital Centre(CHUC)Av.Bissaya Barreto s/n3000-075 CoimbraPortugal Autonomous Section of Health Sciences(SACS) University of AveiroAveiroPortugal CIDMA-Center for Research and Development in Mathematics and Applications iBiMEDInstitute for BiomedicineUniversity of AveiroAveiroPortugal Clinical Pathology Department Coimbra University Hospital Centre(CHUC)CoimbraPortugal Pharmacy Department Coimbra University Hospital Centre(CHUC)CoimbraPortugal MedinUP Department of Pharmacology and TherapeuticsFaculty of MedicineUniversity of PortoPortoPortugal Department of Emergency and Intensive Care Medicine Centro Hospitalar Sao JoaoPortoPortugal Faculty of Medicine University of PortoGrupo de Infeccao e SépsisPortoPortugal.

Background: Due to greater infection susceptibility, sepsis is the main cause of death in burn patients. Quick diagnosis and patient stratification, early and appropriated antimicrobial therapy, and focus control are crucial for patients’survival. On the other hand, superfluous extension of therapy is associated with adverse events and arousal of microbial resistance. The use of biomarkers, necessarily coupled with close clinical examination, may predict outcomes, stratifying patients who need more intensive care, and monitor the efficacy of antimicrobial therapy, allowing faster de-escalation or stop, reducing the development of resistance and possibly the financial burden, without increasing mortality. The aim of this work is to check the suitability of procalcitonin (PCT) to fulfill these goals in a large sample of septic burn patients. Methods: One hundred and one patients, with 15% or more of total body surface area (TBSA) burned, admitted from January 2011 to December 2014 at Coimbra Burns Unit (CBU), in Portugal were included in the sample. All patients had a diagnosis of sepsis, according to the American Burn Association (ABA) criteria. The sample was factored by survival (68 survivors and 33 non-survivors). The maximum value of PCT in each day was used for statistical analysis. Data were summarized by location measures (mean, median, minimum, maximum, quartiles) and dispersion measures (standard error and range measures). Statistical analysis was performed with SPSS?23.0 IBM? for Windows?. Results: There were statistically significant differences between PCT levels of patients from the survivor and non-survivor groups during the first and the last weeks of hospitalization as well as during the first week after sepsis suspicion, being slightly higher during this period. During the first 7 days of antimicrobial therapy, PCT was always higher in the non-survivor, still without reaching statistical significance, but when the analysis was extended till the 15th

关键词： Burns Sepsis Procalcitonin Prognosis Antimicrobial stewardship

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Propagation and Confinement of Electric Field Waves along One-Dimensional Porous Silicon Hybrid Periodic/Quasiperiodic Structure

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Optics and Photonics Journal 2013年第2期3卷 1-12页

作者： josé Escorcia-García miguel Eduardo Mora-Ramos Centro de Investigación en Energía Universidad Nacional Autónoma de México Temixco Morelos México Física Teórica y Aplicada Escuela de Ingeniería de Antioquia Sede Las Palmas Envigado Antioquia Colombia

Selective spatial confinement of the electric field intensity is theoretically obtained for the light propagation along hybrid structures conformed by periodic and Fibonacci quasiperiodic dielectric multilayers. Sandwich-like configurations featuring periodic-quasiperiodic-periodic as well as quasiperiodic-periodic-quasiperiodic designs exhibit spatial localization of a large percent of the optical signal within specific zones of the hybrid system. Such a feature might be of interest in the pursuing of lasing devices based on porous silicon. It is found that the electric field confinement does not only depend on the quality of the defect or a particular transmission mode observed in the reflectivity spectra. We show that it is possible to enhance the electric field confinement solely varying the angle of incidence. The possibility of realizing finite photonic crystals with reduced size and very well defined band gap by means of a quasiperiodic-periodic-quasiperiodic hybrid multilayer is also revealed.

关键词： Optical Properties Electric Field Multilayers Hybrid Structures

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Imaging evaluation of the liver in oncology patients:A comparison of techniques

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World Journal of Hepatology 2021年第12期13卷 1936-1955页

作者： Patrícia S Freitas Catarina Janicas joséVeiga António P Matos Vasco Herédia miguel Ramalho Department of Radiology Centro Hospitalar Universitário de Lisboa CentralLisbon 1150-199Portugal Department of Radiology Centro Hospitalar de Lisboa OcidentalLisbon 1449-005Portugal Department of Radiology Hospital Garcia de OrtaEPEAlmada 2805-267Portugal Department of Radiology Hospital CUF TejoLisbon 1350-352Portugal Department of Radiology Hospital Espírito Santo deÉvora-EPEÉvora 7000-811Portugal Department of Radiology Hospital da LuzLisbon 1500-650Portugal

The liver is commonly affected by metastatic ***,it is essential to detect and characterize liver metastases,assuming that patient management and prognosis rely on *** imaging techniques that allow non-invasive assessment of liver metastases include ultrasonography,computed tomography(CT),magnetic resonance imaging(MRI),positron emission tomography(PET)/CT,and PET/*** this paper,we review the imaging findings of liver metastases,focusing on each imaging modality’s advantages and potential *** also assess the importance of different imaging modalities for the management,follow-up,and therapy response of liver *** date,both CT and MRI are the most appropriate imaging methods for initial lesion detection,follow-up,and assessment of treatment *** MRI is frequently used as a problem-solving technique for liver lesions and has evolved substantially over the past decade,including hardware and software developments and specific intravenous contrast *** studies have shown that MRI performs better in small-sized metastases and moderate to severe liver steatosis *** state-of-the-art MRI shows a greater sensitivity for detecting and characterizing liver metastases,CT remains the chosen *** also present the controversial subject of the"economic implication"to use CT over MRI.

关键词： Liver metastases Magnetic resonance imaging Computed tomography Oncology Ultrasound Follow-up

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Graphene quantum dots: From efficient preparation to safe renal excretion

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Nano Research 2021年第3期14卷 674-683页

作者： Caroline Hadad josémiguel González-Domínguez Silvia Armelloni Deborah Mattinzoli Masami Ikehata Akcan Istif Adrian Ostric Francesco Cellesi Carlo Maria Alfieri Piergiorgio Messa Belén Ballesteros Tatiana Da Ros Centre of Excellence for Nanostructured Materials(CENMAT) INSTMDepartment of Chemical and Pharmaceutical SciencesUniversity of TriesteVia L.Giorgieri 134127TriesteItaly Laboratoire LG2A-CNRS UMR 7378 Universitéde Picardie Jules Verne33 rue Saint Leu-UFR des Sciences80039AmiensFrance Instituto de Carboquímica(CSIC) C/Miguel Luesma Castán 4E-50018ZaragozaSpain Renal Research Laboratory-Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico via Pace 920122MilanItaly Dipartimento di Chimica Materiali ed Ingegneria Chimica“G.Natta”Politecnico di MilanoVia Mancinelli 720131MilanItaly Unit of Nephrology Dialysis and Renal Transplant Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinicovia della commenda 420122MilanItaly Department of Clinical Sciences and Community Health University of Milan20122MilanItaly Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and the Barcelona Institute of Science and TechnologyCampus UABBellaterra08193BarcelonaSpain

Carbon nanomaterials offer excellent prospects as therapeutic agents,and among them,graphene quantum dots(GQDs)have gained considerable interest thanks to their aqueous solubility and intrinsic fluorescence,which enable their possible use in theranostic approaches,if their biocompatibility and favorable pharmacokinetic are *** prepared ultra-small GQDs using an alternative,reproducible,top-down synthesis starting from graphene oxide with a nearly 100%*** materials were tested to assess their safety,demonstrating good biocompatibility and ability in passing the ultrafiltration barrier using an in vitro *** leads to renal excretion without affecting the ***,we studied the GQDs in vivo biodistribution confirming their efficient renal clearance,and we demonstrated that the internalization mechanism into podocytes is ***,considering the reported characteristics,it appears possible to vehiculate compounds to kidneys by means of GQDs,overcoming problems related to lysosomal degradation.

关键词： graphene quantum dots podocytes biodistribution uptake pathway renal clearance nanocarrier

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Ultrasound-Guided Infraclavicular Axillary Vein Cannulation

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International Journal of Clinical Medicine 2017年第4期8卷 227-235页

作者： miguel A. García-Díaz Manuel ruiz-Castro Department of Anesthesia University Hospital Príncipe de Asturias Madrid Spain

Background and Objective: Percutaneous central venous cannulation is a common invasive procedure. In comparison with an external landmark technique, the advantages of ultrasound-guided venous access include direct visualization of the anatomy and in vivo visualization of venous cannulation. Methods: We evaluated an ultrasound-guided technique for infraclavicular axillary vein cannulation, focusing on its ease of use, success rate and complications rate. One hundred and twenty patients who submitted to central venous catheter placement were punctured using our technique. The patients were positioned so that their ipsilateral upper limb was abducted at 90° to the longitudinal axis, which makes it possible to visualize the infraclavicular vessels due to the elevation of the clavicle, thereby improving accessibility. Results: Cannulation was successful in all patients. The median time from the start of the first puncture (of the skin) until the aspiration of blood was 15 s (range 7 - 135 s). Both infraclavicular axillary veins were cannulated, and the vein was punctured successfully at the first attempt in 95% of the patients, without complications during the procedure. Conclusion: We propose an ultrasound-guided infraclavicular approach of the axillary vein, with a high success rate and no complications in the present cohort.

关键词： Ultrasonography Catheterization Central Venous Central Venous Catheter Ultrasound-Guided Technique Infraclavicular Axillary Vein

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Prevalence of meeting 24-Hour Movement Guidelines from pre-school to adolescence: A systematic review and meta-analysis including 387,437 participants and 23 countries

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Journal of Sport and Health Science 2022年第4期11卷 427-437页

作者： miguel Angel Tapia-Serrano Javier Sevil-Serrano Pedro Antonio Sanchez-miguel jose Francisco Lopez-Gil Mark STremblay Antonio Garcıa-Hermoso Department of Didactics of Musical Plastic and Body ExpressionFaculty of Teaching TrainingUniversity of ExtremaduraAvenida de la UniversidadS/NCaceres 10071Spain Department of Physical Activity and Sport Faculty of Sport ScienceUniversity of Murcia(UM)San Javier 30720Spain Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario(CHEO)Research InstituteOttawaON K1H 8L1Canada Navarrabiomed Public University of Navarra(UPNA)Health Research Institute of Navarra(IdiSNA)Navarra Hospital Complex(CHN)Pamplona 310008Spaia

Background:Meeting the 24-Hour Movement Guidelines(physical activity,screen time,and sleep duration) has been associated with positive health ***,there are no previous meta-analyses that have examined the overall adherence to the 24-Hour Movement Guidelines from pre-school to adolescence across the ***,the main purpose of this systematic review and meta-analysis was to examine the overall(non)adherence to the 24-Hour Movement Guidelines among preschoolers,children,and adolescents ***:Four electronic databases(MEDLINE,Scopus,Web of Science,and Cochrane Database of Systematic Reviews) were searched for quantitative studies published in Spanish and English between January 2016 and May *** that were conducted with apparently healthy participants and reported the overall(non)adherence to the 24-Hour Movement Guidelines in preschoolers and/or children and/or adolescents were ***:Sixty-three studies comprising 387,437 individuals(51% girls) aged 3-18 years from 23 countries were ***,7.12%(95%confidence interval(95%CI):6.45%-7.78%) of youth met all three 24-Hour Movement Guidelines,and 19.21%(95%CI:16.73%-21.69%)met none of the 3 *** sex,adherence to all recommendations was significantly lower in girls(3.75%,95%CI:3.23%-4.27%) than in boys(6.89%,95%CI:5.89%-7.89%)(p <0.001).However,there were no sex differences regarding adherence to any of the 3 individual recommendations(girls,15.66%,95%CI:8.40%-22.92%;boys,12.95%,95%CI:6.57%-19.33%).In terms of age group,adherence to the 3 recommendations was 11.26%(95%CI:8.68%-13.84%),10.31%(95%CI:7.49%-13.12%),and 2.68%(95%CI:1.78%-3.58%) in preschoolers,children,and adolescents,***,8.81%(95%CI:5.97%-11.64%) of preschoolers,15.57%(95%CI:11.60%-19.54%) of children,and 28.59%(95%CI:22.42%-34.75%) of adolescents did not meet any of the *** America was the region with the lowest adherence(all:2.93%;none:3

关键词： Exercise Lifestyle Movement behaviors Sedentary behaviors Youth

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Improving outcomes in pancreatic cancer: Key points in perioperative management

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World Journal of Gastroenterology 2014年第39期20卷 14237-14245页

作者： josé M álamo Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Lydia Barrera miguel A Gómez Jordi Muntané Francisco J Padillo Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREH o Ciberehd) Instituto de Salud Carlos Ⅲ 28029 Madrid Spain Francisco J Padillo Department of General Surgery Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla 41013 Seville Spain

This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neo-adjuvant therapy. Preoperative biliary drainage is recommended only in patients with severe jaundice, as it can lead to infectious cholangitis, pancreatitis and delay in resection, which can lead to tumor progression. The development of a phase III clinical trial is mandatory to clarify the role of neo-adjuvant radiochemotherapy in pancreatic adenocarcinoma. Venous resection does not adversely affect postoperative mortality and morbidity, therefore, the need for venous resection should not be a contraindication to surgical resection in selected patients. The data on arterial resection alone, or combined with vascular resection at the time of pancreatectomy are more heterogeneous, thus, patient age and comorbidity should be evaluated before a decision on operability is made. In patients undergoing R0 resection, arterial resection can also be performed.

关键词： Pancreatic cancer Obstructive jaundice Preoperative drainage Neo-adjuvant therapy Vascular resection

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Antifungal Potential of Beauveria bassiana on Solanum lycopersicum L. Infected with Fusarium oxysporum f. sp. lycopersici

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Phyton-International Journal of Experimental Botany 2023年第4期92卷 1235-1255页

作者： Henry López-López Nancy ruiz-Lau Rocío Meza-Gordillo Víctor Manuel ruiz-Valdiviezo joseph Galthier Robledo-Luchetti Carlos Alberto Lecona-Guzmán Juan joséVillalobos-Maldonado Luc Dendooven Joaquín Adolfo Montes-Molina Laboratorio de Biotecnología vegetal Tecnológico Nacional de Mexico/Campus Tuxtla GutiérrezTuxtla Gutiérrez29050Mexico CONACYT-Tecnológico Nacional de Mexico/Campus Tuxtla Gutiérrez Tuxtla Gutiérrez29050México ABACUS CinvestavCiudad de México07360México

The objective of this work was to evaluate the effect of Beauveria bassiana(Bb 1205)on controlling Fusarium oxysporum ***(Fol 17108)in tomato plants in greenhouse *** of Bb 1205 was the most promising among the agronomic variables and expression of the activity of the enzymesβ-1,3-glucanases and *** of Bb 1205 occurred at a concentration of 1×108 conidia·mL−1,which was administered onto the leaves,directly into the soil and via *** with Fol 17108 occurred with 1×106 spores·mL−1,which were added directly to the *** was used for measuring agronomic parameters,namely activity of chitinases andβ-1,3-glucanases in foliage and *** Bb 1205 was added to the soil,the chlorophyll index and aerial part length showed significant *** addition,it was determined that root length,fresh weight of foliage,flower,and fruit count increased 82 days after inoculation(dai).Chitinase activity induced by Bb 1205 in leaves and roots of tomato plants infected with Fol 17108 was observed when injected into the stem at 32 dai(41.8 and 11.6-fold,respectively).Inoculation on the foliage showed a 10-fold increase ofβ-1,3-glucanases in the roots after 82 *** for leaves,a 3.8-fold increase was found when the stem was *** the different in vivo applications,Bb 1205 activated its defenses by expressing the chitinase enzymes andβ-1,3-glucanase,thus reducing the damage caused by Fol 17108,demonstrating increase plant growth thereafter.

关键词： Mycoparasitism agronomic parameters chitinases β-1,3-glucanases

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Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency

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Journal of Animal Science and Biotechnology 2018年第1期9卷 228-232页

作者： Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida Alexandre miguel Henrique Santana Francisco joséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme joséBento Sterman Ferraz Heidge Fukumasu Departmento de Zootecnia Universidade Federal dos Vales do Jequitinhonha e MucuriDiamantinaMG 39100 000Brazil Faculdade de Ciencias Agrarias e Veterinarias Universidade Estadual Paulista JaboticabalSP 14884 900Brazil Departamento de Medicina Veterinaria Faculdade de Zootecnia e Encjenharia de AlimentosUniversidade de Sao PauloAM.Duque de Caxias Norte n225Pirassununcja 13635 900SPBrazil Departmento de Zootecnia e Desenvolvimento Acjrossocioambiental Sustentavel Faculdade de VeterinariaUniversidade Federal FluminenseNiteroiRJ 24230 340Brazil Departamento de Zootecnia Faculdade de Zootecnia e Engenharia de AlimentosUniversidade de Sao PauloPirassununga 13635-900SPBrazil

Background： Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the *** this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake（DMI） and average daily gain（ADG） of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake（RFI） and select 20 animals for the high feed efficient（LRFI） and 20 for the low feed efficient（HRFI） groups. Blood samples were collected on d 56 and at slaughter（80 d） to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression ***： DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter（P = 0.0049）. Gene expression of leptin were greater in LRFI animals（P = 0.0022） in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene ***： These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake.

关键词： Beef cattle Energy homeostasis Fat depositon Residual feed intake

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