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Metabolic profiling of four synthetic stimulants,including the novel indanyl-cathinone 5-PPDi,after human hepatocyte incubation

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Journal of Pharmaceutical Analysis 2020年第2期10卷 147-156页

作者： David fabregat-safont marie mardal Juan v.sancho Félix Hernández Kristian Linnet maría Ibánez Research Institute for Pesticides and Water University Jaume IAvda.Sos Baynat s/n12071CastellónSpain Department of Forensic Medicine Section of Forensic ChemistryFaculty of Health and Medicinal SciencesUniversity of CopenhagenFrederik V's vej 112100KФbenhavnФDenmark Department of Occupational and Environmental Medicine University Hospital of Northern NorwaySykehusvegenTromsoeNorway

synthetic cathinones are new psychoactive substances that represent a health risk *** most of the 130 reported compounds,information about toxicology and/or metabolism is not available,which hampers their detection(and subsequent medical treatment)in intoxication *** principles of forensic analytical chemistry and the use of powerful analytical techniques are indispensable for stab-lishing the most appropriate biomarkers for these *** metabolic fate of synthetic cathinones can be assessed by the analysis of urine and blood obtained from authentic consumers;however,this type of samples is limited and difficult to *** this work,the metabolic behaviour of three synthetic cathinones(4-CEC,4-CPrC and 5-PPDi)and one amphetamine(3-FEA)has been evalu-ated by incubation with pooled human hepatocytes and metabolite identification has been performed by high-resolution mass *** in vitro approach has previously shown its feasibility for obtaining excretory human metabolites.4-CEC and 3-FEA were not metabolised,and for 4-CPrC only two minor metabolites were *** the contrary,for the recently reported 5-PPDi,twelve phase I metabolites were *** to our knowledge,this is the first metabolic study of an *** reported in this paper will allow the detection of these synthetic stimulants in intoxi-cation cases,and will facilitate future research on the metabolic behaviour of other indanyl-based cathinones.

关键词： synthetic cathinones 5-PPDi Metabolite identification In vitro metabolism Hepatocyte incubation High resolution mass spectrometry

Effect of initial microstructure on austenite formation kinetics in high-strength experimental microalloyed steels

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International Journal of Minerals,Metallurgy and Materials 2015年第12期22卷 1304-1312页

作者： Edgar López-martínez Octavio vázquez-Gómez Héctor javier vergara-Hernández Bernardo Campillo faculty of Chemistry Metallurgical Engineering Department Autonomous National University of Mexico National Council for science and Technology Metallurgy science Postgraduate Programme Morelia Institute of Technology Institute of Physical sciences Autonomous National University of Mexico

Austenite formation kinetics in two high-strength experimental microalloyed steels with different initial microstructures comprising bainite-martensite and ferrite-martensite/austenite microconstituents was studied during continuous heating by dilatometric analysis. Austenite formation occurred in two steps：（1） carbide dissolution and precipitation and （2） transformation of residual ferrite to austenite. Dilatometric analysis was used to determine the critical temperatures of austenite formation and continuous heating transformation diagrams for heating rates ranging from 0.03°C.s^-1 to 0.67°C.s^-1. The austenite volume fraction was fitted using the Johnson-Mehl-Avrami-Kolmogorov equation to determine the kinetic parameters k and n as functions of the heating rate. Both n and k parameters increased with increasing heat- ing rate, which suggests an increase in the nucleation and growth rates of austenite. The activation energy of austenite formation was determined by the Kissinger method. Two activation energies were associated with each of the two austenite formation steps. In the first step, the austenite growth rate was controlled by carbon diffusion from carbide dissolution and precipitation; in the second step, it was controlled by the dissolution of residual ferrite to austenite.

关键词： non-isothermal kinetics microalloyed steel austenite heating dilatometry

Exploiting the diversity of tomato:the development of a phenotypically and genetically detailed germplasm collection

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Horticulture Research 2020年第1期7卷 1941-1954页

作者： Estefanía Mata-Nicolás javier Montero-Pau Esther Gimeno-Paez víctor Garcia-Carpintero Peio Ziarsolo Naama Menda Lukas A.Mueller joséBlanca Joaquín Cañizares Esther van der Knaap maría joséDíez Instituto Universitario de Conservación y Mejora de la Agrodiversidad valenciana.COMAv.Universitat Politècnica de valència ValenciaSpain Department of Biochemistry and Molecular Biology Universitat de ValènciaValenciaSpain Boyce Thompson Institute IthacaNYUSA Institute of Plant Breeding Genetics and GenomicsUniversity of GeorgiaGeorgiaGAUSA Department of Horticulture University of GeorgiaGeorgiaGAUSA

A collection of 163 accessions,including solanum pimpinellifolium,solanum lycopersicum *** and solanum lycopersicum ***,was selected to represent the genetic and morphological variability of tomato at its centers of origin and domestication:Andean regions of Peru and Ecuador and *** collection is enriched with *** *** from the Amazonian region that has not been analyzed previously nor used *** collection has been morphologically characterized showing diversity for fruit,flower and vegetative *** genomes were sequenced in the varitome project and are publicly available(***/projects/varitome).The identified sNPs have been annotated with respect to their impact and a total number of 37,974 out of 19,364,146 sNPs have been described as high impact by the snpEeff *** has shown associations for different traits,demonstrating the potential of this collection for this kind of *** have not only identified known QTLs and genes,but also new regions associated with traits such as fruit color,number of flowers per inflorescence or inflorescence *** speed up and facilitate the use of this information,F2 populations were constructed by crossing the whole collection with three different *** F2 collection is useful for testing sNPs identified by GWAs,selection sweeps or any other candidate *** data is available on solanaceae Genomics Network and the accession and F2 seeds are freely available at COMAv and at TGRC *** these resources together make this collection a good candidate for genetic studies.

关键词： germplasm collection traits

Alcoholic liver disease:Utility of animal models

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World Journal of Gastroenterology 2018年第45期24卷 5063-5075页

作者： Arantza Lamas-Paz Fengjie Hao Leonard J Nelson maria Teresa vázquez santiago Canals manuel Gómez del Moral Eduardo martínez-Naves Yulia A Nevzorova Francisco javier Cubero Department of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for Bioengineering(IBioE) School of EngineeringFaraday BuildingThe University of EdinburghEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Human Anatomy and Embryology Complutense University School of MedicineMadrid 28040Spain Instituto de Neurociencias Consejo Superior de Investigaciones CientíficasUniversidad Miguel HernándezSan Juan de Alicante 03550Spain Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain Department of Genetics Physiology and MicrobiologyFaculty of BiologyUniversidad ComplutenseMadrid 28040Spain Department of Internal Medicine Ⅲ University Hospital RWTH AachenAachen 52062Germany

Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.

关键词： steatohepatitis Cirrhosis Hepatocellular carcinoma Alcoholic liver disease Reactive oxygen species

Ophiolite hosted chromitite formed by supra-subduction zone peridotite–plume interaction

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Geoscience Frontiers 2020年第6期11卷 2083-2102页

作者： Júlia farré-de-Pablo Joaquín A.Proenza josémaría González-Jiménez Thomas Aiglsperger Antonio Garcia-Casco javier Escuder-viruete vanessa Colás Francisco Longo Departament de Mineralogia Petrologia i Geologia AplicadaUniversitat de BarcelonaC/Martíi Franquess/n08028BarcelonaSpain Departamento de Mineraloga y Petrologa Universidad de GranadaFacultad de CienciasFuentenueva s/n18002GranadaSpain Department of Civil Engineering and Natural Resources LuleåUniversity of TechnologySE 97187LuleåSweden Instituto Andaluz de Ciencias de la Tierra(CsIC-UGR) Avda.de las Palmeras 4E-18100ArmillaGranadaSpain Instituto Geologico y Minero de Espana C/La Calera 1Tres Cantos28760MadridSpain Instituto de Geología Universidad Nacional Autonoma de MéxicoCiudad Universitaria04510Ciudad de MéxicoMexico facultad de Ingeniería Universidad Catòlica de CibaoLa VegaDominican Republic

Chromitite bodies hosted in peridotites typical of suboceanic mantle(***)are found in the northern and central part of the Loma Caribe peridotite,in the Cordillera Central of the Dominican *** chromitites are massive pods of small size(less than a few meters across)and veins that intrude both dunite and ***,they are high-Cr chromitites[Cr#=Cr/(Cr+Al)atomic ratio=0.71-0.83]singularly enriched in TiO2(up to 1.25 wt.%),Fe2 O3(2.77-9.16 wt.%)as well as some trace elements(Ga,v,Co,Mn,and Zn)and PGE(up to 4548 ppb in whole-rock).This geochemical signature is unknown for chromitites hosted in oceanic upper mantle but akin to those chromites crystallized from mantle plume derived ***,the melt estimated to be in equilibrium with such chromite from the Loma Caribe chromitites is similar to basalts derived from different source regions of a heterogeneous Caribbean mantle *** mantle plume is responsible for the formation of the Caribbean Large Igneous Province(CLIP).Dolerite dykes with back-arc basin basalt(BABB)and enriched mid-ocean ridge basalt(E-MORB)affinities commonly intrude the Loma Caribe peridotite,and are interpreted as evidence of the impact that the Caribbean plume had in the off-axis magmatism of the back-arc basin,developed after the Caribbean island-arc extension in the Late *** propose a model in which chromitites were formed in the shallow portion of the back-arc mantle as a result of the metasomatic reaction between the supra-subduction zone(ssZ)peridotites and upwelling plume-related melts.

关键词： Chromitite Ophiolite Plume Mantle Back-arc basin Dominican Republic

2-Cys Peroxiredoxins Participate in the Oxidation of Chloroplast Enzymes in the Dark

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Molecular Plant 2018年第11期11卷 1377-1388页

作者： valle Ojeda Juan manuel Perez-Ruiz Francisco javier Cejudo Instituto de Bioquimica vegetaly Fotosintesis Universidad de Sevilla and Consejo Superior de lnvestigaciones CientificasAvenida Americo Vespucio 4941092SevillaSpain

Most redox-regulated chloroplast enzymes are reduced during the day and oxidized during the *** the reduction mechanism of light-dependent enzymes is well known,the mechanism mediating their oxidation in the dark remains *** thiol-dependent peroxidases,2-Cys peroxiredoxins (Prxs),play a key role in light-dependent reduction of chloroplast *** transfer reducing equivalents of thiols to hydrogen peroxide,suggesting the participation of these peroxidases in enzyme oxidation in the ***,we have addressed this issue by analyzing the redox state of well-known redox-regulated chloroplast enzymes in response to darkness in Arabidopsis thaliana mutants deficient in chloroplastlocalized Prxs (2-Cys Prxs A and B,Prx ⅡE,and Prx Q).Mutant plants lacking 2-Cys Prxs A and B,and plants overexpressing NADPH-dependent thioredoxin (Trx) reductase C showed delayed oxidation of chloroplast enzymes in the *** contrast,the deficiencies of Prx ⅡE or Prx Q exerted no *** vitro assays allowed the reconstitution of the pathway of reducing equivalents from reduced fructose 1,6-bisphosphatase to hydrogen peroxide mediated by Trxs and 2-Cys *** together,these results suggest that 2-Cys Prxs participate in the short-term oxidation of chloroplast enzymes in the dark.

关键词： chloroplast enzyme oxidation peroxiredoxin thioredoxin hydrogen peroxide darkness

short-term outcomes of robotic liver resection: An initial singleinstitution experience

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World Journal of Hepatology 2022年第1期14卷 224-233页

作者： manuel Durán javier Briceño Ana Padial Ferdinando Massimiliano Anelli Juan manuel sánchez-Hidalgo maría Dolores Ayllón Rafael Calleja-Lozano Carmen García-Gaitan Unit of Hepatobiliary surgery and Liver Transplantation General and Digestive Surgery DepartmentReina Sofia University HospitalCordoba 14004Spain GC18 Translational Research in surgery of solid Organ Transplantation Maimonides Biomedical Research InstituteCórdoba 14004Spain GE09 Research in Peritoneal and Retroperitoneal Oncological surgery Maimonides Biomedical Research InstituteCórdoba 14004Spain Department of Anesthesiology and Resuscitation Reina Sofia University HospitalCordoba 14004Spain

BACKGROUND Liver surgery has traditionally been characterized by the complexity of its procedures and potentially high rates of morbidity and mortality in inexperienced *** robotic approach has gradually been introduced in liver surgery and has increased notably in recent ***,few centers currently perform robotic liver surgery and experiences in robot-assisted surgical procedures continue to be limited compared to the laparoscopic *** To analyze the outcomes and feasibility of an initial robotic liver program implemented in an experienced laparoscopic hepatobiliary *** A total of forty consecutive patients underwent robotic liver resection(da vinci Xi,***,United states)between June 2019 and January *** were prospectively followed and retrospectively *** characteristics and perioperative and short-term outcomes were *** are expressed as mean and standard *** study was approved by the Institutional Review *** The mean age of patients was 59.55 years,of which 18(45%)were *** mean body mass index was 29.41 kg/m^(2).Nine patients(22.5%)were *** were divided by type of resection as follows:Ten segmentectomies,three wedge resections,ten left lateral sectionectomies,six bisegmentectomies(two vvI bisegmentectomies and four Ivb-v bisegmentectomies),two right anterior sectionectomies,five left hepatectomies and two right *** lesions occurred in twenty-nine(72.5%)of the *** mean operative time was 258.11 min and two patients were transfused intraoperatively(5%).Inflow occlusion was used in thirty cases(75%)and the mean total clamping time was 32.62 *** was a single conversion due to uncontrollable *** postoperative complications(Clavien–Dindo>Ⅲb)occurred in three patients(7.5%)and mortality in one(2.5%).No patient required readmission to the *** mean hospital stay was 5.6 *** Althou

关键词： Robotics Hepatectomy Minimally invasive surgery Liver surgery Da vinci

sintering study of Ti6Al4v powders with different particle sizes and their mechanical properties

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International Journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1389-1401页

作者： joséLuis Cabezas-villa joséLemus-Ruiz Didier Bouvard Omar Jiménez Héctor javier vergara-Hernández Luis Olmos University Michoacana of san Nicolás of Hidalgo IIMMMorelia 58060México University Grenoble Alpes CNRSSIMaPGrenoble 38000France University of Guadalajara Departamento de Ingeniería de ProyectosZapopan 45100México National Technological Institute of Mexico I.T.MoreliaMorelia 58120México University Michoacana of san Nicolás of Hidalgo INICITMorelia 58060México

Ti6Al4v powders with three different particle size distributions(0–20, 20–45, and 45–75 μm) were used to evaluate the effect of the particle size distribution on the solid-state sintering and their mechanical properties. The sintering kinetics was determined by dilatometry at temperatures from 900 to 1260°C. The mechanical properties of the sintered samples were evaluated by microhardness and compression tests. The sintering kinetics indicated that the predominant mechanism depends on the relative density irrespective of the particle size used. The mechanical properties of the sintered samples are adversely affected by increasing pore volume fraction. The elastic Young's modulus and yield stress follow a power law function of the relative density. The fracture behavior after compression is linked to the neck size developed during sintering, exhibiting two different mechanisms of failure: interparticle neck breaking and intergranular cracking in samples with relative densities below and above of 90%, respectively. The main conclusion is that relative density is responsible for the kinetics, mechanical properties, and failure behavior of Ti6 Al4 v powders.

关键词： Ti6Al4v powders dilatometry microhardness sintering kinetics compression failure behavior

Q-switching of waveguide lasers based on graphene/Ws_2 van der Waals heterostructure

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Photonics Research 2017年第5期5卷 406-410页

作者： ZIQI LI CHEN CHENG NINGNING DONG CAROLINA ROMERO QINGMING LU JUN WANG javier RODRíGUEZ vázquez DE ALDANA YANG TAN FENG CHEN school of Physics State Key Laboratory of Crystal Materials Shandong University Key Laboratory of Materials for High-Power Laser Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Laser Microprocessing Group Facultad Ciencias Universidad de Salamanca school of Chemistry and Chemical Engineering Shandong University

We report on the operation of passively Q-switched waveguide lasers at 1 μm wavelength based on a graphene∕Ws_2 heterostructure as a saturable absorber(sA). The gain medium is a crystalline Nd:YvO_4 cladding waveguide produced by femtosecond laser writing. The nanosecond waveguide laser operation at 1064 nm has been realized with the maximum average output power of 275 m W and slope efficiency of 37%. In comparison with the systems based on single Ws_2 or graphene sA, the lasing Q-switched by a graphene∕Ws_2 heterostructure sA possesses advantages of a higher pulse energy and enhanced slope efficiency, indicating the promisingapplications of van der Waals heterostructures for ultrafast photonic devices.

关键词： Ws Q-switching of waveguide lasers based on graphene/Ws2 van der Waals heterostructure der