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Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly

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World Journal of Stem Cells 2020年第12期12卷 1667-1690页

作者： Marta Camacho-Cardenosa josémanuel quesada-gómez Alba Camacho-Cardenosa Alejo Leal gabrielDorado Bárbara Torrecillas-Baena Antonio Casado-Díaz Facultad Ciencias del Deporte Universidad De ExtremaduraCáceres 10003Spain CIBER De Fragilidad Y Envejecimiento Saludable(CIBERFES) Unidad De Gestión Clínica De Endocrinología Y NutriciónInstituto Maimónides De Investigación Biomédica De CórdobaHospital Universitario Reina SofíaCórdoba 14004Spain Servicio de Traumatología Hospital de CáceresCáceres 10004Spain Departamento Bioquímica y Biología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de Córdoba-CIBERFES14071 CórdobaSpain

BACKgROUND Mesenchymal stem cells(MSC)of bone marrow are the progenitor of osteoblasts and *** tend to differentiate into adipocytes,instead of osteoblasts,with *** favors the loss of bone mass and development of *** induces hypoxia inducible factor 1αgene encoding transcription factor,which regulates the expression of genes related to energy metabolism and *** allows a better adaptation to low O2 *** hypoxia has negative effects on bone metabolism,favoring bone ***,surprisingly,cyclic hypoxia(CH),short times of hypoxia followed by long times in normoxia,can modulate MSC differentiation and improve bone health in *** To evaluate the CH effect on MSC differentiation,and whether it improves bone mineral density in *** MSC cultures were induced to differentiate into osteoblasts or adipocytes,in CH(3%O2 for 1,2 or 4 h,4 d a week).Extracellular-matrix mineralization and lipid-droplet formation were studied in MSC induced to differentiate into osteoblast or adipocytes,*** addition,gene expression of marker genes,for osteogenesis or adipogenesis,have been quantified by quantitative real time polymerase chain *** in vivo studies with elderly(>75 years old;n=10)were carried out in a hypoxia chamber,simulating an altitude of 2500 m above sea level,or in normoxia,for 18 wk(36 CH sessions of 16 min each).Percentages of fat mass and bone mineral density from whole body,trunk and right proximal femur(femoral,femoral neck and trochanter)were assessed,using dual-energy X-ray *** CH(4 h of hypoxic exposure)inhibited extracellular matrix mineralization and lipid-droplet formation in MSC induced to differentiate into osteoblasts or adipocytes,***,both parameters were not significantly affected by the other shorter hypoxia times *** longest periods of hypoxia downregulated the expression of genes related to extracellular matrix

关键词： Normobaric cyclic hypoxia Mesenchymal stem cells Cellular differentiation Osteoblasts Adipocytes Bone health

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Influence of olive oil and its components on mesenchymal stem cell biology

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World Journal of Stem Cells 2019年第12期11卷 1045-1064页

作者： Antonio Casado-Díaz gabriel Dorado jose manuel quesada-gómez CIBER de Fragilidad y Envejecimiento Saludable(CIBERFES) Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC)Hospital Universitario Reina SofíaCórdoba 14004Spain Departement Bioquímica y Biología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de CórdobaCIBERFESCórdoba 14071Spain Unidad de gestión Clínica de Endocrinología y Nutrición CIBER de Fragilidad y Envejecimiento Saludable(CIBERFES)Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC)Hospital Universitario Reina SofíaCórdoba 14004Spain

Extra virgin olive oil is characterized by its high content of unsaturated fatty acid residues in triglycerides,mainly oleic acid,and the presence of bioactive and antioxidant *** consumption is associated with lower risk of suffering chronic diseases and unwanted processes linked to aging,due to the antioxidant capacity and capability of its components to modulate cellular signaling *** of olive oil can alter the physiology of mesenchymal stem cells(MSCs).This may explain part of the healthy effects of olive oil consumption,such as prevention of unwanted aging *** date,there are no specific studies on the action of olive oil on MSCs,but effects of many components of such food on cell viability and differentiation have been *** objective of this article is to review existing literature on how different compounds of extra virgin olive oil,including residues of fatty acids,vitamins,squalene,triterpenes,pigments and phenols,affect MSC maintenance and differentiation,in order to provide a better understanding of the healthy effects of this ***,most studies have shown a positive effect of these compounds on *** collective findings support the hypothesis that at least part of the beneficial effects of extra virgin olive oil consumption on health may be mediated by its effects on MSCs.

关键词： Olive oil Mesenchymal stem cells Cellular differentiation Aging Cellular niche Mediterranean diet

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Numerical Results on an SIMVW Epidemic Model with Feedback Vaccination

Numerical Results on an SIMVW Epidemic Model with Feedback V...

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作者： josu FERNANDEZ-PEREDA manuel DE LA SEN Santiago ALONSO-quesada Department of Electricity and Electronics ⅡDP EHU/UPV

A new epidemic model refereed to with the acronym SIMVW is proposed, where S, I, M, V and W are, respectively, the subsequent subpopulations: susceptible human, infectious human, susceptible vector, infectious vector and vaccinated human. The equilibrium steady states are examined and a set of typical endemic and disease.-free situations are tested for a malaria case study in the absence and presence of vaccination efforts.

关键词： Epidemic model Vaccination effort Simulation

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Periodic equilibrium states in a SEIR mathematical model of an infectious non-lethal disease

Periodic equilibrium states in a SEIR mathematical model of ...

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第25届中国控制与决策会议

作者： Raul Nistal manuel de la Sen Santiago Alonso-quesada Asier Ibeas Department of Electricity and Electronics Faculty of Science and Technology Basque Country University Dpt. de Telecomunicacio i Enginyeria de Sistemes Universitat Autonoma de Barcelona

ISBN: (纸本)9781467355339

The periodic regime in a SEIR model with a delay is studied in this paper. The model is studied first under a simple set of constant parameters and then a more complex solution is proposed, depending on a set of periodic parameters related to the variable risk of contracting the disease and the different vaccination strategies applied in order to prevent it. Both the periodic parameters and the subpopulations obtained in the periodic solution proposed are defined as generic Fourier series, so the solution is valid for any possible periodic parameters. The stability of such periodic regimes are studied. A complementary numerical simulation of this model under periodic parameters is also included.

关键词： Periodic Solutions Epidemic threshold Vaccination control

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Increased incidence of and microbiologic changes in pyogenic liver abscesses in the Mexican population

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World Journal of Hepatology 2020年第10期12卷 816-828页

作者： Juanita Pérez-Escobar Wagner Ramirez-quesada Daniel Alejandro Calle-Rodas Luis Alberto Chi-Cervera Nalu Navarro-Alvarez Jorge Aquino-Matus Juan Pablo Ramírez-Hinojosa Carlos Moctezuma-Velázquez Aldo Torre Department of gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Department of Internal Medicine Hospital General Dr.Manuel Gea GonzálezMexico City 14080Mexico

BACKgROUND Pyogenic liver abscess(PLA)is a rare disease with an estimated incidence that varies widely across the globe,being as high as 115.4/100000 habitants in Taiwan and as low as 1.1-1.2/100000 habitants in Europe and *** though there are multiple microorganisms capable of producing an abscess in the liver,including Entamoeba histolytica,fungi,and viruses,most abscesses are derived from bacterial *** epidemiology of PLA in Mexico is currently *** To describe the clinical,demographic and microbiologic characteristics of PLA in *** This is a retrospective study carried out in two centers,and included patients seen between 2006 and 2018 with the diagnosis of pyogenic *** collected demographic,clinical,and microbiological information,treatment,complications,and outcomes.A logistic regression analysis was used to determine the association between different variables and mortality *** A total of 345 patients were included in this study.233(67.5%)had confirmed PLA,133(30%)patients had no positive culture and negative serology and 9(2.5%)had mixed *** mean age was 50 years(ranging from 16-97 years)and 63%were female.65%of the patients had positive cultures for Extended Spectrum Beta-Lactamases(ESBL)-Escherichia coli and Klebsiella *** was administered in 60%of *** most common sources of infection were ascending cholangitis and cholecystitis in 34(10%)and 31(9%),*** median length of hospital stay was 14 d.165 patients underwent percutaneous catheter *** inpatient mortality rate was 63%.Immunocompromised state[OR 3.9,95%CI:1.42-10.46],ESBL-Escherichia coli[OR 6.7,95%CI:2.7-16.2]and Klebsiella pneumoniae[OR 4-8,95%CI:1.6-14.4]predicted inpatient mortality by multivariate *** The prevalence of PLA is increasing in Mexico and has a very high mortality ***-Escherichia coli and Klebsiella pneumoniae are the most common microorganisms causing PLA

关键词： Liver abscess Pyogenic Mexican population Epidemiology Complications Outcomes Mortality

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