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高教学刊 2023年第21期9卷 8-11页

作者：陈思嘉杨婧媛 josémanuel cabello cotán 汕头大学广东汕头515063

该研究以汕头大学西班牙语专业为试验田,于2019—2020秋季学期在大一年级西班牙语精读课程进行中外教合作教学模式的探索与实践。在课程结束后利用问卷调查和访谈的方式收集学生们的反馈与改进意见。结果显示无论教师还是学生都对这种... 详细信息

该研究以汕头大学西班牙语专业为试验田,于2019—2020秋季学期在大一年级西班牙语精读课程进行中外教合作教学模式的探索与实践。在课程结束后利用问卷调查和访谈的方式收集学生们的反馈与改进意见。结果显示无论教师还是学生都对这种教学模式高度认可并且从中获益匪浅。该文将通过介绍合作的具体实施细节和学生们的反馈,为中外教合作教学模式未来的发展提供一定的参考与借鉴。

关键词：西班牙语合作教学中教外教教学实践

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Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration

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neural Regeneration Research 2023年第6期18卷 1196-1202页

作者： Instituto de Salud Carlos III Irene Villalón-García Suleva Povea-cabello MónicaÁlvarez-Córdoba Marta Talaverón-Rey Juan MSuárez-Rivero Alejandra Suárez-Carrillo manuel Munuera-Cabeza Diana Reche-López Paula Cilleros-Holgado Rocío Piñero-Pérez joséA.Sánchez-Alcázar Centro Andaluz de Biología del Desarrollo(CABD-CSIC-Universidad Pablo de Olavide de Sevilla) and Centro de Investigación Biomédica en Red:Enfermedades RarasInstituto de Salud Carlos IIISevillaSpain

Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases,such as Alzheimer’s,Parkinson’s,and Huntington’s diseases,or neurodegeneration with brain iron accumulation *** dysfunction,lipofuscin accumulation,autophagy disruption,and ferroptosis have been implicated as the critical pathomechanisms of lipid peroxidation and iron accumulation in these ***,the connection between lipid peroxidation and iron accumulation and the initial cause or consequence in neurodegeneration processes is *** this review,we have compiled the known mechanisms by which lipid peroxidation triggers iron accumulation and lipofuscin formation,and the effect of iron overload on lipid peroxidation and cellular *** vicious cycle established between both pathological alterations may lead to the development of ***,the investigation of these mechanisms is essential for exploring therapeutic strategies to restrict *** addition,we discuss the interplay between lipid peroxidation and iron accumulation in neurodegeneration,particularly in PLA2G6-associated neurodegeneration,a rare neurodegenerative disease with autosomal recessive inheritance,which belongs to the group of neurodegeneration with brain iron accumulation disorders.

关键词： 4-hidroxynonenal ferroptosis iron lipid peroxidation lipofuscin neurodegeneration neurodegeneration with brain iron accumulation oxidative stress PLA2G6-associated neurodegeneration

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Silk-ELR co-recombinamer covered stents obtained by electrospinning

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Regenerative Biomaterials 2019年第1期6卷 21-28页

作者： M.Putzu F.Causa manuel Parente Israel Gonza´lez de Torre J.C.Rodriguez-cabello P.A.netti Dipartimento di Ingegneria Chimica dei Materiali e della Produzione Industriale(DICMAPI)University“Federico II”Piazzale Tecchio 8080125 NaplesItaly Interdisciplinary Research Centre on Biomaterials(CRIB) University of Naples Federico IIPiazzale Tecchio 8080125 NapoliItaly Center for Advanced Biomaterials for Health Care@CRIB Istituto Italiano di TecnologiaLargo Barsanti e Matteucci 5380125 NapoliItaly Conic Vascular via Carlo Maderno 236901 LuganoSwitzerland Technical Proteins nanoBioTechnology S.L. Edificio CTTAPaseo de Belen9A47011 ValladolidSpain networking Research Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)ValladolidSpain Bioforge Lab University of ValladolidEdificio LUCIAPaseo de Belen1947011 ValladolidSpain

In the field of tissue engineering the choice of materials is of great importance given the possibility to use biocompatible polymers produced by means of biotechnology.A large number of synthetic and natural materials have been used to this purpose and processed into scaffolds using Electrospinning *** materials that could be used for the fabrication of scaffold and degradable membranes,natural polymers such as collagen,elastin or fibroin offer the possibility to design structures strictly similar to the extracellular matrix(ECM).Biotechnology and genetic engineering made possible the advent of a new class of biopolymers called protein-based *** example is represented by the silk-elastin-proteins that combine the elasticity and resilience of elastin with the high tensile strength of silk-fibroin and display engineered bioactive *** this work,we use electrospinning technique to produce a fibrous scaffold made of the corecombinamer *** fibres have been characterized from the morphological point of *** and morphology have been explored using Scanning Electron Microscopy.A thorough study regarding the influence of Voltage,flow rate and distance have been carried out to determine the appropriate parameters to obtain the fibrous mats without defects and with a good distribution of *** has also been in vitro *** the first time we use the co-recombinamer Silk-ELR for the fabrication of a 2.5 angioplasty balloon *** structure could be useful as a coated scaffold for the regeneration of intima layer of vessels.

关键词： electrospinning silk elastin-like-recombinamers tissue engineering

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