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Synthesis and Radiation Dosimetry of [68Ga]-Ga-Lys1, Lys3-DOTA-Bombesin (1,14) Antagonist for PET-Imaging, as a Potential Theragnostic Tracer in Oncology

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Journal of Encapsulation and Adsorption Sciences 2020年第2期10卷 29-41页

作者： Juan C. Manrique-Arias Quetzali Pitalua-Cortes Roberto Pedrero-Piedras Géiser Rodríguez-Mena Tessy López Cristian cabezas-Ortiz Osvaldo García-Pérez Departamento de Medicina Nuclear Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología México City México Cancer Center Cyclotron Department Doctors Hospital Monterrey México Departamento de Atención a la Salud Universidad Autónoma Metropolitana-Xochimilco México City México

This Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinomas, but not in advanced stages. Therefore, there is a need to develop effective tracers for the accurate and specific detection of this disease. The objective of this study was to evaluate Lys1, Lys3-DOTA-BBN (1,14) analog with the radiolabeled positron emitter [68Ga]-Ga-BBN for receptor imaging with PET, and to determine its biodistribution and radiation dosimetry using whole-body (WB) PET scans in healthy volunteers. The highest uptake was in the pancreas, followed by urinary bladder. The critical organ was pancreas with a mean absorbed dose of 206 ± 0.7, 210 ± 0.7, 120 ± 0.9, 390.23 ± 0.6 μGy/MBq and the effective doses were estimated as 73.2 ± 0.6, 49.8 ± 0.3 μGy/MBq (women and men, respectively).

关键词： Radiation Dosimetry Biodistribution PET Imaging Radiopharmaceutical Lys1 Lys3-DOTA-BBN (1 14) Bombesin Analogs

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冻融法纯化水稻胚乳RNA及稻米品质重要相关基因表达谱研究

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中国水稻科学 2005年第2期19卷 105-110页

作者：张海燕董海涛姚海根向跃武谭学林方永启邓晔金庆超 cabezas DANIEL 姜玉新戴承恩阎文昭李德葆浙江大学农业与生物技术学院生物信息与基因网络研究组浙江杭州310029 嘉兴市农业科学研究院浙江嘉兴314016 四川省农业科学院生物技术核技术研究所四川成都610066 云南农业大学稻作研究所云南昆明650201

提出了一种从水稻胚乳组织中快速分离总RNA的方法,可以简便地去除RNA中存在的淀粉等多糖类杂质,所获的胚乳总RNA其质量可满足Northern印迹、微阵列制备等分子生物学实验要求。将从966个水稻品种的胚乳中分离所得的RNA制备RNA阵列,用于... 详细信息

提出了一种从水稻胚乳组织中快速分离总RNA的方法,可以简便地去除RNA中存在的淀粉等多糖类杂质,所获的胚乳总RNA其质量可满足Northern印迹、微阵列制备等分子生物学实验要求。将从966个水稻品种的胚乳中分离所得的RNA制备RNA阵列,用于稻米品质重要基因Wx基因的表达谱分析,结果证实:水稻Wx基因表达丰度总体上与水稻胚乳的直链淀粉含量呈正相关;应用于Northern印迹实验,表明在水稻胚乳组织中,淀粉分支酶Rbe1具有两个长度不同的同源基因,其中一个分子量大的为胚乳特异表达,分子量小的则在水稻各组织中共表达。

关键词：胚乳水稻品种 Wx基因稻米品质淀粉分支酶总RNA 直链淀粉含量特异表达分子生物学实验同源基因

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Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects

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Open Journal of Immunology 2013年第3期3卷 82-92页

作者： V. Wallace McCarlie James K. Hartsfield Jr Janice S. Blum Carlos González-cabezas Judith R. Chin George J. Eckert Lorri A. Morford Mark D. Pescovitz Henry Rodriguez Margherita Fontana Richard L. Gregory Center for Oral Health Research Division of Orthodontics Department of Oral Health Science and Department of Microbiology Immunology and Molecular Genetics Colleges of Dentistry and Medicine University of Kentucky Lexington USA Center for Oral Health Research Division of Orthodontics Department of Oral Health Science College of Dentistry University of Kentucky Lexington USA Department of Biostatistics Schools of Medicine and Public Health Indiana University Indianapolis USA Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan Ann Arbor USA Department of Microbiology and Immunology School of Medicine Indiana University Indianapolis USA Department of Pediatric Dentistry and Orthodontics School of Dental Medicine East Carolina University Greenville USA Department of Pediatric Dentistry School of Dentistry Indiana University Indianapolis USA Department of Pediatrics College of Medicine University of South Florida Tampa USA Departments of Oral Biology and Preventive and Community Dentistry and Department of Pathology and Laboratory Medicine Schools of Dentistry and Medicine Indiana University Indianapolis USA Departments of Surgery and Microbiology and Immunology School of Medicine Indiana University Indianapolis USA

Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to Streptococcus mutans antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential influence of immune responses to I/II. However, it was not known whether secretory IgA (SIgA) responses to the selected epitopes from HLA-DRB1*04 positive subjects were different compared to controls, or across other caries-related factors such as total IgA (TIgA). Thirty-two total subjects were matched according to HLA type, gender, ethnicity and age. HLA genotyping, oral bacterial, immunoglobulin and antibody analyses were performed. A large observed difference emerged with regard to the natural immune reservoir of TIgA in HLA-DRB1*04 positive subjects, specifically, a 27.6% reduction compared to controls. In contrast to all other epitopes studied, HLA-DRB1*04 positive subjects also exhibited reduced reactivity to I/II epitope 834-853. HLA-DRB1*04 positive subjects exhibited lower specific SIgA activity/TIgA to 834-853 and also a lower specific reactivity to 834-853/whole cell S. mutans UA159. Furthermore, HLA-DRB1*04 positive subjects exhibited lower responses to I/II in its entirety. The large observed difference in TIgA and the 834-853 reactivity pattern across multiple measures suggest potentially important connections pertaining to the link between HLA-DRB1*04 and caries.

关键词： Dental Caries Streptococcus mutans I/II IgA Immunomodulation Immunogenetics HLA-II DRB1 DRB1*04

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