检索结果-南通市图书馆

A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells

引用

Cellular & Molecular Immunology 2023年第12期20卷 1499-1512页

作者： Leticia Martín-Cruz Marcos Viñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-Phillips Irene Real-Arévalo Francisco Javier Cañada joséignacio tudela Luis Moltó Jesús Moreno-Sierra joséLuis Subiza Oscar Palomares Department of Biochemistry and Molecular Biology School of ChemistryComplutense University of MadridMadridSpain Inmunotek Alcaláde HenaresMadridSpain Fundación Investigación Hospital Clínico San Carlos Martin Lagos s/n28040MadridSpain Centro de Investigaciones Biológicas Margarita Salas CSICRamiro de Maetzu 928040MadridSpain CIBER de Enfermedades Respiratorias(CIBERES)Avda Monforte de Lemos3-528029MadridSpain Servicio de Urología Hospital Clínico San CarlosUniversidad Complutense de MadridMartín Lagos s/n28040MadridSpain

Functional Tregs play a key role in tumor development and progression,representing a major barrier to anticancer immunity.The mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely understood.Herein,by using NMR,chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses,we demonstrate that the tumoral carbohydrate A10(Ca10),a cell-surface carbohydrate derived from Ehrlich’s tumor(ET)cells,is a heparan sulfate-related proteoglycan that enhances glycolysis and promotes the development of tolerogenic features in human DCs.Ca10-stimulated human DCs generate highly suppressive Tregs by mechanisms partially dependent on metabolic reprogramming,PD-L1,IL-10,and IDO.Ca10 also reprograms the differentiation of human monocytes into DCs with tolerogenic features.In solid ET-bearing mice,we found positive correlations between Ca10 serum levels,tumor size and splenic Treg numbers.Administration of isolated Ca10 also increases the proportion of splenic Tregs in tumor-free mice.Remarkably,we provide evidence supporting the presence of a circulating human Ca10 counterpart(Ca10H)and show,for the first time,that serum levels of Ca10H are increased in patients suffering from different cancer types compared to healthy individuals.Of note,these levels are higher in prostate cancer patients with bone metastases than in prostate cancer patients without metastases.Collectively,we reveal novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in cancer.The discovery of this novel structural-functional relationship may open new avenues of research with important clinical implications in cancer treatment.

关键词： Tumoral carbohydrate A10 Heparan sulfate-related proteoglycan Cancer immunology Dendritic cell Regulatory T cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tribological performance of novel nickel-based composite coatings with lubricant particles

引用

Friction 2019年第2期7卷 169-180页

作者： ignacio tudela Andrew J.COBLEY Yi ZHANG Daido Metal Co. Ltd.European Technical Centre UKResearch & Development Department Functional Materials Research Centre for Manufacturing and Materials EngineeringFaculty of EngineeringEnvironment and ComputingCoventry University

The present study is focused on the evaluation of the tribological performance of novel Ni/h BN and Ni/WS_2 composite coatings electrodeposited from an additive-free Watts bath with the assistance of ultrasound. Lubricated and non-lubricated scratch tests were performed on both novel composite coatings and on standard Ni deposits used as a benchmark coating to have an initial idea of the effect of the presence of particles within the Ni matrix. Under lubricated conditions, the performance of the Ni/h BN composite coating was very similar to the benchmark Ni coating, whereas the Ni/WS_2 behaved quite differently, as the latter did not only show a lower coefficient of friction, but also prevented the occurrence of stick-slip motion that was clearly observed in the other coatings. Under non-lubricated conditions, whereas the tribological performance of the Ni/hBN composite coating was again very similar to that of the benchmark Ni coating, the Ni/WS_2 composite coatings again showed a remarkable enhancement, as the incorporation of the WS_2 particles into the Ni coating not only resulted in a lower coefficient of friction, but also in the prevention of coating failure.

关键词： nickel tungsten disulphide hexagonal boron nitride composite coatings solid lubricant tribology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用原子和光合成扭曲双层材料（英文）

引用

Science Bulletin 2023年第6期68卷 557-558页

作者： Alejandro González-tudela Institute of Fundamental Physics IFF-CSIC

Sometimes, an apparently naive approach can have a large impact on physics. That was the case when Geim, Novoselov, and coworkers isolated graphene for the first time by exfoliating sheets from graphite using Scotch tape. The isolation of this wonder material led to a revolution in condensed-matter physics and eventually earned them the 2010 Nobel Prize in Physics. Fourteen years later,

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

现在和未来如何进行虚构文学创作——华文作家与西语作家圆桌对话

引用

世界华文文学论坛 2024年第1期 84-100页

作者：赵彦罗茜奥·奥维耶多史志龙(翻译) 不详马德里康普顿斯大学文学系西班牙拉美文学研究协会尼加拉瓜西班牙语学院北美西班牙语学院

主持人语:在作家们几乎已穷尽了虚构文学所有创新方面的今天,我们面临了如何用新手段来写我们的新故事。除了作家们本人自觉在文本创作上面的积极探索和努力尝试外,社交媒体的多手段、即时更新和瞬息变化也给我们作家的文学创作发展提... 详细信息

主持人语:在作家们几乎已穷尽了虚构文学所有创新方面的今天,我们面临了如何用新手段来写我们的新故事。除了作家们本人自觉在文本创作上面的积极探索和努力尝试外,社交媒体的多手段、即时更新和瞬息变化也给我们作家的文学创作发展提供了一些可能是消极也可能是积极的新手段,换句话说,现在它们也成了我们文本创新的一种工具。当然,这种“新的写作工具”也带来了一定程度上的困惑,甚至有可能对文学本身会造成一种伤害。

关键词：华文作家文本创作即时更新社交媒体虚构文学文学创作文本创新写作工具

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用原子和光合成扭曲双层材料

引用

Science Bulletin 2023年第6期68卷 557-558,M0003页

作者： Alejandro González-tudela Institute of Fundamental Physics IFF-CSIC Calle Serrano 113bMadrid 28006Spain

关键词：光合成 eventually earned

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cost Optimisation for Minimizing the Visual Impact of Ornamental Stone Quarrying. A Case Study in Murcia Region

引用

Journal of Geoscience and Environment Protection 2018年第2期6卷 74-88页

作者： josé Molina-Ruiz María josé Martínez-Sánchez Carmen Pérez-Sirvent Mari Luz García-Lorenzo María Luz tudela-Serrano Department of Geography Faculty of Geography University of Murcia Campus de la Merced Murcia Spain Department of Agricultural Chemistry Geology and Pedology Faculty of Chemistry University of Murcia Campus de Espinardo Murcia Spain Department of Mineralogy and Petrology Faculty of Geology University Complutense of Madrid Madrid Spain

Quarrying of ornamental stone has adverse effects that are both visual and environmental. This paper aims to develop a methodology for minimising the costs associated with reducing the visual impact of ornamental stone quarrying. This study uses digital topographical maps of the study zone and a GPS and GIS application to calculate the extent of the area affected by quarrying activities for each altitude designated in the work plan and to calculate the extent of the potential visual impact. The results obtained applying the proposed methodology for the selected area suggested that the potential visual impact is minimal for an altitude of 520 metres, this being the optimal point for the observer. When altitude increases, the potential visual impact increases and the optimal point for the observer diminishes until the highest impact altitude (740 m) is readied. The optimal point that the exploitation should reach is that at which the values of the diagram generated by the (%) area of potential visual impact and area of exploitation (%) intersect. The methodology allows the optimal altitude to be determined for mining exploitations and helps assess the viability of a given exploitation from an environmental point of view.

关键词： Restoration Costs Ornamental Stone Visual Impact Limestone Quarrying

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Social and Personal Determining Factors in the Results on Contents of Food Handlers’ Formation Plans

引用

Food and Nutrition Sciences 2011年第6期2卷 560-574页

作者： Esteban Pérez António Raposo Luis tudela Conrado Carrascosa Esther Sanjuán Rafael Millán 不详

This study has two main objectives: on one hand, the evaluation of food items related to the food training courses in order to know which ones require better explanations from trainers and a further development and refinement by food handlers. It is also a goal of this work to appreciate the level of general knowledge of food handlers before receive any training session and then see if there was some improvement after the course. On the other hand, identifying potential social and personal factors of food handlers that influence on the results of the evaluation. To this end, two tests were performed (one before the training and at the end) and evaluated the results per modules. In general, knowledge levels both initially and after taking the course proved to be satisfactory. Personal and social factors determined better or worse scores on the basis of these.

关键词： Food Handlers Social Personal Training Evaluation HACCP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：