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Trauma outcomes in nonfatal road traffic accidents:a Portuguese medico-legal approach

Forensic Sciences Research 2022年第3期7卷 528-539页

作者： Flávia Cunha-Diniz Tiago Taveira-Gomes joséManuel teixeira Teresa Magalhães CINTESIS—Faculty of Medicine University of PortoPortoPortugal IINFACTS—Institute of Research and Advanced Training in Health Sciences and Technologies Department of SciencesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal fernando Pessoa University PortoPortugal Porto Healthcare Unity—Accidents Fidelidade—Insurance CompanyPortoPortugal

The objective of this study was to compare the outcomes of nonfatal road traffic accidents by the victims’age group and *** used the Portuguese medico-legal rules for personal injury assessment,in the scope of the Civil Law in that country,which includes a three-dimensional *** was a retrospective study including 667 victims of road traffic accidents aged 3–94 years *** final medico-legal reports all used the Portuguese methodology for personal injury *** were analysed by the victims’age group(children,working-age adults,and older people)and *** traffic accidents were generally serious(ISS mean 9.5),with higher severity in children and older *** most frequent body sequelae were musculoskeletal(64.8%),which were associated with functional and situational *** damage resulted in an average length of impairment of daily life of 199.6 days,171.7 days to return to work,and an average degree of quantum doloris(noneconomic damage related to physical and psychological harm)of 3.7/*** average permanent damage was 7.3/100 points for Permanent Functional Deficit,0.43/3 for Permanent Professional Repercussion,2/7 for Permanent Aesthetic Damage,3.9/7 for Permanent Repercussion on Sexual Activity and 3.2/7 for Permanent Repercussion on Sport and Leisure ***,19%of people became permanently dependent(10.6%needed third-party assistance).The medico-legal methodology used,considering victims’real-life situation,allows a comprehensive *** were several significant differences among the three age groups but none between *** differences and the impact of the more severe cases justify further detailed medico-legal studies in these specific situations on children,older people,and severely injured victims.

关键词： Forensic sciences traffic accident trauma injury damage outcome assessment legal medicine

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Nutritional supplements use in high-performance athletes is related with lower nutritional inadequacy from food

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Journal of Sport and Health Science 2016年第3期5卷 368-374页

作者： Mónica Sousa Maria J.Fernandes Pedro Carvalho josé Soares Pedro Moreira Vitor Hugo teixeira Centre of Research Education Innovation and Intervention in Sport Faculty of Sport University of Porto Faculty of Nutrition and Food Sciences University of Porto Research Centre on Physical Activity Health and Leisure Faculty of Sport University of Porto

Background: The use of nutritional supplements(NS) among athletes is widespread. However, little is known about the relationship between nutritional adequacy and NS usage. The aims of this study were to evaluate the NS usage and to compare the nutritional intake from food and prevalence of micronutrient inadequacy(PMI) between NS users and ***: Portuguese athletes from 13 sports completed an NS usage questionnaire and a semi-quantitative food-frequency questionnaire assessing information over the previous 12 months. The estimated average requirement cut-point method was used to calculate PMI. General linear models were used to compare nutritional intake and NS usage. Chi-squared tests and logistic regression were performed to study, respectively,relationships and associations between PMI and NS ***: From the 244 athletes(66% males, 13–37 years), 64% reported NS usage. After adjustment, NS users showed a higher intake from food(p < 0.05), for at least 1 gender, for energy, and for 7 of the 17 studied nutrients. The highest PMI were seen for vitamins D and E, calcium, folate,and magnesium. After adjustment, NS users, irrespective of gender, reported lower PMI for calcium(OR = 0.28, 95%CI: 0.12–0.65), and female users for magnesium(OR = 0.06, 95%CI: 0.00–0.98).Conclusion: Athletes using NS reported a higher nutritional intake from food, and a lower PMI for several nutrients. Perhaps, those who were taking NS were probably the ones who would least benefit from it.

关键词： Carbohydrates Minerals Proteins Sport Vitamins

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Pork Meat Quality of Preto Alentejano and Commercial Largewhite Landrace Cross

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Journal of Integrative Agriculture 2013年第11期12卷 1961-1971页

作者： Alfredo teixeira Sandra Rodrigues Veterinary and Animal Reserch Centre (CECAV) Agrarian School of Polytechnic Institute of BraganaCampus Sta Apolónia Apt.1172Bragan a 5301-855Portugal Mountain Research Centre(CIMO) Agrarian School of Polytechnic Institute of BraganaCampus Sta Apolónia Apt.1172Bragan a 5301-855Portugal

This work aimed to evaluate the physical-chemical characteristics of pork from a local breed （Portuguese black pork called Preto Alentejano） and a commercial breed. Sixteen animals were used, 4 females and 4 males from each breed. Animals had 80-100 kg of live weight. The longissimus muscle between the 5th thoracic vertebra and the 10th lumbar vertebra was used in the analysis. Samples were analysed for protein, fat, pigments, ashes, dry mater, water-holding capacity, and texture. Results of fat and pigments contents indicate signiifcant （P〈0.05 and P〈0.01） differences for all treatments. For protein, ashes, dry mater, water-holding capacity and texture, no signiifcant differences were found for sex. In the analysis of fatty acids composition, ten were detected, being the main ones C16：0, C18：0, C16：1, C18：1, C18：2. There was a predominance of monounsaturated fatty acids （MUFA）, followed by saturated （SFA） and polyunsaturated （PUFA）. Differences were signiifcant for sex （P〈0.01） and breed （P〈0.01）. Preto Alentejano breed and females presented the higher percentages of SFA （P〈0.01） and MUFA （P〈0.001） fatty acids. Differences between breeds might be due to breed production system and feed differences.

关键词： breed sex pork meat quality

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Oxidative stress in N88S seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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Neural Regeneration Research 2023年第8期18卷 1719-1720页

作者： Vítor Costa Vitor teixeira i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoPortoPortugal Yeast Signalling Networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal ICBAS Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

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Acupuncture Treatment for Idiopathic Trigeminal Neuralgia:A Longitudinal Case-Control Double Blinded Study

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Chinese Journal of Integrative Medicine 2017年第11期23卷 829-836页

作者： Michelle Cristina Ichida Mariana Zemuner Jorge Hosomi Hong Jin Pai Manoel Jacobsen teixeira joséTadeu Tesseroli de Siqueira Silvia R D T de Siqueira Neurology Department Medical SchoolUniversity of Sao PauloSao Paulo(05403-010)Brazil Group of Acupuncture Interdisciplinary Pain Group of the Neurology DivisionClinical HospitalMedical SchoolUniversity of Sao PauloSao Paulo(05403-010)Brazil Interdisciplinary Pain Center of Hospital das Clinicas Neurology DepartmentMedical SchoolUniversity of Sao PauloSao Paulo(05403-010)Brazil Neurosurgery Division Psychiatry InstituteClinical HospitalMedical SchoolUniversity of Sao PauloS&o Paulo(05403-010)Brazil Orofacial Pain Team Dentistry DivisionClinical HospitalMedical SchoolUniversity of Sao PauloSao Paulo(05403-010)Brazil Group of Oral Medicine and Neuroscience of the Dentistry Division Psychiatry InstituteClinical HospitalMedical SchoolUniversity of Sao PauloSao Paulo(05403-010)Brazil School of Arts Science and HumanitiesUniversity of Sao PauloSao Paulo(05403-010)Brazil

Objective： To evaluate the treatment effect of acupuncture on patients with idiopathic trigeminal neuralgia（ITN） by case-control longitudinal blinded study. Methods： Sixty ITN patients and 30 healthy subjects were included. The ITN patients were randomly assigned to acupuncture group（15 cases）, sham-acupuncture group（15 cases） and carbamazepine group（30 cases）, respectively. Clinical orofacial evaluation（including pain intensity and medication doses）, research diagnostic criteria for temporomandibular disorders（RDC/TMD） and Helkimo indexes（for functional evaluation of the masticatory system）, and quantitative sensory testing for sensory thresholds（gustative, olfactory, cold, warm, touch, vibration and superficial and deep pain） were evaluated before treatment, immediately after treatment, and 6 months after treatment. Results： The mean pain intensity by the Visual Analogue Scale only decreased in the acupuncture group at the last evaluation（P=0.012）. Patients in the sham-acupuncture group had an increase in carbamazepine doses according to the prescriptions（P〈0.01）. There was a reduction in secondary myofascial pain and mandibular limitations at the acupuncture and sham-acupuncture groups, however only the acupuncture group kept the changes after 6 months（P〈0.01, P=0.023）. There was a decrease in mechanical thresholds in the acupuncture group（tactile, P〈0.01; vibration, P=0.027） and an increase in deep pain thresholds in both acupuncture and sham-acupuncture groups（P=0.013）. Conclusion： Acupuncture can be an option in the treatment of ITN due to its analgesic effect in both ITN and secondary myofascial pain associated with it.

关键词： acupuncture idiopathic trigeminal neuralgia orofacial pain temporomandibular disorders quantitative sensory testing case-control study

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Nutrient variability and its influence on nitrogen processes in a highly turbid tropical estuary(Bangpakong, Gulf of Thailand)

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Journal of Environmental Sciences 2016年第7期28卷 131-142页

作者： Adriano A.Bordalo Kashane Chalermwat Catarina teixeira Laboratory of Hydrobiology and Ecology Institute of Biomedical Sciences University of Porto Centre of Marine and Environmental Research University of Porto Department of Aquatic Sciences Burapha University

Estuarine ecosystems in SE Asia have been poorly studied when compared to other tropical environments. Important gaps exist particularly in the understanding of their biogeochemical function and contribution to global change. In this work we looked into N-turnover in the water column and sediments of the Bangpakong estuary（13°N）. A seasonal sampling program was performed along the salinity gradient covering different stretches of the estuary（68 km）.Key physical and chemical characteristics were also monitored in order to unravel possible environmental controls. Results showed the occurrence of active denitrification in sediments（5.7–50.9 nmol N-N2/（cm3·hr））, and water column（3.5–1044 pmol N-N2/（cm3·hr））. No seasonal or spatial variability was detected for denitrification potential in sediment samples. However, in the water column, the denitrification activity peaked during the transition season in the downstream sites coinciding with high turbidity levels. Therefore, in that period of the year, the water column compartment may be an important contributor to nitrate reduction within the estuary. The rather low nitrification rates detected were not always measurable, probably due to the reduced oxygen content and high siltation. This study is one of the few dealing simultaneously with sediments and water column processes in a highly turbid tropical ***, it emerges as a valuable contribution for the understanding of the dynamics of the nitrogen cycle in tropical environments by exploring the role of estuarine N microbial activity in reducing the effects of increased nitrogen loads.

关键词： Nutrients Denitrification Nitrification Tropical estuary Bangpakong River

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Current role and future perspectives of cardiac rehabilitation in coronary heart disease

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World Journal of Cardiology 2021年第12期13卷 695-709页

作者： Eduardo M Vilela Ricardo Ladeiras-Lopes Ana Joao Joana Braga Susana Torres Sofia Viamonte josé Ribeiro Madalena teixeira josé P Nunes Ricardo Fontes-Carvalho Department of Cardiology Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal Department of Surgery and Physiology Cardiovascular Research Unit(UnIC)Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Centro de Reabilitação do Norte Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4405-565Portugal Faculty of Medicine University of PortoPorto 4200-319Portugal

Ischaemic heart disease(IHD)is a major cause of morbidity and mortality *** there have been major advances in this field,these patients are still a higher risk *** such,strategies to mitigate risk and tailor secondary prevention measures are of the utmost *** rehabilitation(CR),encompassing several domains including exercise training,cardiovascular risk factor optimization,nutritional and psychological assessments,as well as other ancillary interventions has shown to be one of the pillars in the contemporary management of patients with ***,CR is associated with several benefits in this population,ranging from functional capacity to improvements in *** this,there are still several issues concerning the optimal application of CR which are still not fully ascertained,such as lack of referral and completion,as well as questions related to programme design(particularly among patients with multiple comorbidities).In this review,we aim at presenting a pragmatic overview on the current role of CR in the management of individuals with IHD,while also discussing some of the caveats in the current data,as well as future concepts which could help improve the uptake and personalization of this pivotal time-tested intervention.

关键词： Cardiac rehabilitation Secondary prevention Myocardial infarction Ischaemic heart disease Cardiovascular diseases

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Multivariate Optimization of Volatile Compounds Extraction in Chardonnay Wine by Headspace-Solid Phase Micro Extraction and Gas Chromatography Coupled with Tandem Mass Spectrometry

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American Journal of Analytical Chemistry 2016年第10期7卷 712-723页

作者： Sabrina de Bona Sartor Marla Sganzerla josé teixeira Filho Helena teixeira Godoy Food Analysis Laboratory Department of Food Science Faculty of Food Engineering University of Campinas (UNICAMP) Campinas Brazil Facvest University (UNIFACVEST) Lages Brazil Hydrology Laboratory Faculty of Agricultural Engeneering University of Campinas (UNICAMP) Campinas Brazil

A method for optimization of extraction of volatile compounds in Chardonnay wine was developed using headspace-solid phase microextraction (HS-SPME) and gas chromatography coupled with triple quadrupole tandem mass spectrometry (GC-MS/MS). Optimization of the HS-SPME conditions, temperature (T, °C) and extra-ction time (t, minutes), was carried out using a 22 factorial central composite rota- tional design (CCRD). Total area of chromatographic peaks of nineteen compounds was monitored in order to identify the best response and the data was collected on multiple reaction monitoring (MRM) mode. The mathematical model that describes the response surface for the CCRD was validated using the analysis of variance (ANO VA) with 95% of confidence level. This model showed a lack of fit based on mean square pure error ratios for each response, in which Fcalculated was 2.23 higher than Ftabulated. Even though the models cannot be rigorously used to make quantitative predictions, the coefficients of the model, especially the linear ones, are useful for understanding systematic behaviour of the response values as a function of the factor levels. Multivariate statistical design can be used in optimization of HS-SPME extraction parameters with reduced number of experiments and can be useful in sampling method of volatile compounds of Chardonnay wines analysis by CG-MS/MS. The optimal condition achieved in this method was 30°C and 45 minutes of extraction.

关键词： Chardonnay GC-MS/MS HS-SPME Multivariate Optimization Volatile Compounds

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Is there a window of opportunity to optimize trastuzumab cardiac monitoring?

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World Journal of Cardiology 2022年第7期14卷 403-410页

作者： Bruno Henrique Rala de Paula Maria Eduarda teixeira Ferro Costa Carlos Augusto Moreira de Sousa joséBines Sarah Cannon Research Institute London W1G 6ADUnited Kingdom Department of Cardiology Hospital do Câncer III-Instituto Nacional de CâncerRio de Janeiro 20560-121Brazil Departamento de Tecnologias da Informação e Educação em Saúde(DTIES) da Faculdade de Ciências Médicas(FCM)na Universidade do Estado do Rio de Janeiro(UERJ)Rio de Janeiro 20550-170Brazil Department of Medical Oncology Instituto Nacional de CâncerRio de Janeiro 20560-121Brazil

BACKGROUND It remains unclear whether the current arbitrary screening recommendations of trastuzumab-related cardiotoxicity provides an adequate balance between preventing heart damage and curtailing a curative *** To determine the incidence rate and consequences of trastuzumab-induced cardiotoxicity as adjuvant treatment in a real-world *** We present a retrospective analysis of cardiac function measured by echocardiogram at baseline and every 3 mo during trastuzumab *** was defined as a drop in left ventricular ejection fraction(LVEF)≥10%from baseline and/or any drop<50%.RESULTS Between January 2011 and December 2014,407 patients were ***(93.6%)were treated with an anthracycline followed by a taxane-based regimen and trastuzumab for 12 *** patients(9.8%)had *** of them were symptomatic,and 28(72.5%)completely recovered *** happened early as shown by LVEF measured on echocardiogram 2 to 4 as compared to 5 to 7(odds ratio=2.47,95%confidence interval:1.09,5.63,P=0.024).There were 54 deaths(13.3%)during the 70-mo follow-up period;1(0.2%)was attributed to late cardiotoxicity(4 years after treatment).The absence of symptomatic cardiotoxicity during trastuzumab treatment and moreover the early occurrence on the treatment period may translate into a strategy to evaluate less *** We observed a 10%rate of asymptomatic cardiotoxicity,which mirrors the results from the large adjuvant *** being transient,an LVEF drop led to frequent treatment delays and *** remains unclear whether LVEF decline is predictive of late cardiotoxicity,and treatment efficacy is compromised.

关键词： Cardiac toxicity Ventricular Dysfunction Heart failure Trastuzumab Breast cancer

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Morphological and kinetic parameters of the absorption of nitrogen forms for selection of Eucalyptus clones

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Journal of Forestry Research 2021年第4期32卷 1599-1611页

作者： Matheus Severo de Souza Kulmann Betania Vahl de Paula Paula Beatriz Sete Wagner Squizani Arruda Gabriel Alberto Sans Camila Peligrinotti Tarouco Luciane Almari Tabaldi fernando teixeira Nicoloso Gustavo Brunetto Soil Science Department Federal University of Santa MariaSanta MariaRS 97105-900Brazil Federal University of Santa Catarina Admar Gonzaga Highway1346FlorianópolisSC 88034-001Brazil Biology Department Natural and Exact Sciences CenterFederal University of Santa MariaSanta MariaRS 97105-900Brazil

Eucalyptus clones are selected according to productivity,wood quality,rooting capacity,and resistance to drought,frost and ***,kinetic and morphological parameters that determine the absorption efficiency of nutrients such as nitrate(NO_(3)^(-)) and ammonium(NH_(4)^(+))are often not considered in breeding *** objective of this study was to evaluate the morphological,physiological and kinetic parameters of nitrogen uptake by clones of Eucalyptus saligna(32,864) and Eucalyptus grandis(GPC23).Morphological parameters in shoot and root systems,biomass and N concentrations in different organs,photosynthetic pigment concentrations,parameters of chlorophyll a fluorescence and photosynthetic rates were *** parameters,maximum absorption velocity(V_(max)),Michaelis-Menten constant(K_(m)),minimum concentration(C_(min)) and influx(I) were calculated for NO_(3)^(-)and NH_(4)^(+) in the two *** clone was more efficient in the uptake of NO_(3)^(-)and NH_(4)^(+),and showed lower K_(m) and C_(min)values,allowing for the absorption of nitrogen at low concentrations due to the high affinity of the absorption sites of clone roots to NO_(3)^(-)and NH_(4)^(+).Higher root lengths,area and volume helped the *** clone in absorption efficiency and consequently,resulted in higher root and shoot *** *** clone had higher K_(m) and Cmin for NO_(3)^(-)and NH_(4)^(+),indicating adaptation to environments with higher N *** results of NO_(3)^(-)and NH_(4)^(+) kinetic parameters indicate that they can be used in Eucalyptus clone selection and breeding programs as they can predict the ability of clones to absorb NO_(3)^(-)and NH_(4)^(+) at different concentrations.

关键词： Ammonium and nitrate Eucalyptus saligna Eucalyptus grandis Root system architecture Nitrogen influx Maximum absorption velocity(V_(max)) Michaelis–Menten constant(K_(m)) Minimum concentration(C_(min))

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