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Alterations in blink and masseter reflex latencies in older adults with neurocognitive disorder and/or diabetes mellitus

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World Journal of Clinical Cases 2022年第1期10卷 177-188页

作者： Jaime Alberto Bricio-barrios Eder Ríos-Bracamontes Mónica Ríos-Silva Miguel Huerta Walter Serrano-Moreno joséenrique barrios-navarro Genaro Gabriel Ortiz Miguel Huerta-Trujillo joséGuzmán-Esquivel Xóchitl Trujillo Faculty of Medicine University of ColimaColima 28040ColimaMexico General Hospital Zone#1 Mexican Social Security InstituteVilla de Alvarez 28983ColimaMexico University Biomedical Research Center University of ColimaColima 28045ColimaMexico University Biomedical Research Center CONACYTColima 28045ColimaMexico Department of Philosophical and Methodological Disciplines University Health Sciences CenterUniversity of GuadalajaraGuadalajara 44340JaliscoMexico

BACKGROUND Blink and masseter reflexes provide reliable,quantifiable data on the function of the central nervous system:Delayed latencies have been found in patients with neurocognitive disorder(ND)and type 2 diabetes mellitus(T2DM),but this has not been studied in patients with both *** To investigate if older adults with ND plus T2DM have prolonged latencies of blink and masseter-reflex and if they were associated with disease *** This cross-sectional study included 227 older adults(>60 years)from Colima,*** disorder was identified by a neuropsychological battery test,and T2DM identified by medical history,fasting glucose,and glycosylated *** in the early reflex(R1),ipsilateral late(R2),and contralateral late(R2c)components of the blink reflex were analyzed for all subjects,and 183 subjects were analyzed for latency of the masseter *** In 20.7%of participants,ND was *** 37%,T2DM was *** in R1,R2,and R2c were significantly prolonged for groups with ND plus T2DM,ND,and T2DM,compared with the control group(P<0.0001).The masseter reflex was only prolonged in older adults(regardless of T2DM status)with ND vs controls(P=0.030).In older adults with ND and without T2DM,the more the cognitive impairment progressed,the more prolonged latencies in R2 and R2c presented(P<0.01).CONCLUSION These findings suggest that blink and masseter reflexes could be used to evaluate possible changes in brainstem circuits in older adults with ND and T2DM.

关键词： Blink reflex Masseter reflex Brainstem reflexes Neurocognitive disorder Type 2 diabetes mellitus Older adults

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia Jiménez-Díaz Juan D.navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Deforestation and fragmentation trends of seasonal dry tropical forest in Ecuador: impact on conservation

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Forest Ecosystems 2021年第3期8卷 615-627页

作者： Carlos A.Rivas joséGuerrero-Casado Rafael M.navarro-Cerillo Instituto de Ciencias Básicas Universidad Técnica de ManabíPortoviejoManabíEcuador Department of Forest Engineering Laboratory of DendrochronologySilviculture and Global Change–DendrodatLab–ERSAFUniversity of CordobaCampus de RabanalesCrta.IVkm.396E-14071 CordobaSpain Departamento de Medicina Veterinaria Facultad de Ciencias VeterinariasUniversidad Técnica de ManabíPortoviejoManabíEcuador Department of Zoology University of CordobaCampus de Rabanales14071 CordobaSpain

Background:Fragmentation and deforestation are one of the greatest threats to forests,and these processes are of even more concern in the tropics,where the seasonal dry forest is possibly one of the most threatened ecosystems with the least remaining surface ***:The deforestation and fragmentation patterns that had occurred in Ecuadorian seasonal dry forests between 1990 and 2018 were verified,while geographic information systems and land cover shapes provided by the Ecuadorian Ministry of the Environment were employed to classify and evaluate three types of seasonal dry forests:deciduous,semi-deciduous,and *** study area was tessellated into 10 km2 hexagons,in which six fragmentation parameters were measured:number of patches,mean patch size,median patch size,total edge,edge density and reticular fragmentation index(RFI).The RFI was also measured both outside and inside protected natural areas(unprotected,national protected areas and protected forest).Moreover,the areas with the best and worst conservation status,connectivity and risk of disappearance values were identified by means of a Getis-Ord Gi*statistical ***:The deforestation of seasonal dry forests affected 27.04%of the original surface area still remaining in 1990,with an annual deforestation rate of−1.12%between 1990 and *** RFI has increased by 11.61%as a result of the fact that small fragments of forest have tended to disappear,while the large fragments have been fragmented into smaller *** semi-deciduous forest had the highest levels of fragmentation in *** three categories of protection had significantly different levels of fragmentation,with lower RFI values in national protected areas and greater values in protected ***:The seasonal dry forest is fragmenting,deforesting and disappearing in some *** increased protection and conservation of the Ecuadorian seasonal dry forest is,therefore,necessary owing to the fact that not all prot

关键词： Deciduous forest Semi-deciduous forest Remnant forest Patch isolation Habitat loss Protected areas

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Minimization of methabenzthiazuron residues in leaching water using amended soils and photocatalytic treatment with TiO_2 and ZnO

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Journal of Environmental Sciences 2014年第4期26卷 757-764页

作者： jos Fenoll Pilar Flores Pilar Hellín Joaquín Hern'andez Simón navarro Department of Food Quality Murcia Institute of Agri-Food Research and Development Department of Agricultural Chemistry Geology and Pedology School of Chemistry University of Murcia Campus Universitario de Espinardo

In the present work, potential groundwater pollution by methabenzthiazuron （MTBU） and the effect of three different amendments （composted sheep manure, composted pine bark and spent coffee grounds） on its mobility were investigated under laboratory conditions. The efficiency of ZnO and TiO2 suspensions in the photocatalytic degradation of MTBU in leaching water was also investigated. The relative and cumulative breakthrough curves were obtained from disturbed soil columns. The presence and/or addition of organic matter drastically reduced the movement of the herbicide. On other hand, photocatalytic experiments showed that the addition of ZnO and TiO2 strongly enhances the degradation rate of this herbicide compared with the results of photolytic experiments under artificial light. ZnO appeared to be more effective in MTBU oxidation than TiO2. The results obtained point to the interest of using organic wastes and heterogeneous photocatalysis for reducing the pollution of groundwater by pesticide drainage.

关键词： groundwater pollution organic amendment pesticide movement photocatalytic oxidation semiconductor oxides

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Generating oligodendroglia from adult mesenchymal cells for transplantation:cell reprogramming or direct lineage conversion?

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Neural Regeneration Research 2023年第7期18卷 1493-1494页

作者： Jorge Pascual-Guerra joséA.Rodríguez-navarro Carlos L.Paíno Service of Neurobiology-Research Ramón y Cajal University Hospital-IRYCISMadridSpain Department of Cellular Biology Complutense UniversityMadridSpain

Cell replacement therapy has long been proposed as a treatment for the damaged nervous *** of the most challenging aspects of such a strategy,however,is finding sources of donor cells for *** neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be *** possibility would be sourcing precursor or differentiated cells from fetal tissues;however,aside from ethical issues,heterologous cells are at risk of immunological rejection in the long *** improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.

关键词： neural programming removed

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Rock mass structural recognition from drill monitoring technology in underground mining using discontinuity index and machine learning techniques

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International Journal of Mining Science and Technology 2023年第5期33卷 555-571页

作者： Alberto Fernández joséA.Sanchidrián Pablo Segarra Santiago Gómez Enming Li Rafael navarro Universidad Politécnica de Madrid–ETSI Minas y Energía Spain Universidad de Salamanca–GIR Charrock Spain

A procedure to recognize individual discontinuities in rock mass from measurement while drilling(MWD)technology is developed,using the binary pattern of structural rock characteristics obtained from in-hole images for *** from two underground operations with different drilling technology and different rock mass characteristics are considered,which generalizes the application of the methodology to different sites and ensures the full operational integration of MWD data *** approaches are followed for site-specific structural model building:a discontinuity index(DI)built from variations in MWD parameters,and a machine learning(ML)classifier as function of the drilling parameters and their *** prediction ability of the models is quantitatively assessed as the rate of recognition of discontinuities observed in borehole *** between the parameters involved in the models for each site,and differences in their weights,highlight the site-dependence of the resulting *** ML approach offers better performance than the classical DI,with recognition rates in the range 89%to 96%.However,the simpler DI still yields fairly accurate results,with recognition rates 70%to 90%.These results validate the adaptive MWD-based methodology as an engineering solution to predict rock structural condition in underground mining operations.

关键词： Drill monitoring technology Rock mass characterization Underground mining Similarity metrics of binary vectors Structural rock factor Machine learning

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Disturbance and forest recovery in the Monarch Butterfly Biosphere Reserve,Mexico

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Journal of Forestry Research 2020年第5期31卷 1551-1566页

作者： jose Lopez-Garcıa Rafael M.navarro-Cerrillo Instituto de Geografıa Universidad Nacional Autonoma de MexicoCiudad UniversitariaC.P.04510 CoyoacanDFMexico Departamento de Ingenierıa Forestal Universidad de CordobaCampus de RabanalesCarretera Nacional IV km 39614014 CordobaSpain

Analysis of the change in forest cover is important to determine stand dynamics and the processes involved in disturbance and *** of the core zone of the Monarch Butterfly Biosphere Reserve were studied using photo interpretation techniques,considering biennial changes between 1999 and 2013 and changes over the whole period of study 1999–*** matrices were elaborated to determine the processes of change involved in both recovery and *** biennial changes for the whole period amounted to 2274 ha;343 ha accounted as degraded in more than one biennial *** total changes in forest cover between 1999 and 2013 involved 4902 ha,out of which,2912 ha were affected by disturbance,and 1990 ha were *** density and 2013 vegetation cover maps,the overall accuracy was 95.6%and 90.2%,*** combining both maps,gradual processes were revealed that were not evident in separate *** methodology is useful for the management and conservation of natural protected areas.

关键词： Illegal logging Forest density change Forest recovery Conifer forests Monarch Butterfly Biosphere Reserve

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Classification of Some Nilpotent Class of Leibniz Superalgebras

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Acta Mathematica Sinica,English Series 2010年第5期26卷 799-816页

作者： Luisa M.CAMACHO josé R.GóMEZ Rosa M.navarro Bakhrom A.OMIROV Dpto. Matemática Aplicada I Universidad de Sevilla Dpto. de Matemáticas Universidad de Extremadura Institute of Mathemátics and Information Technologues Uzbekistan Academy of Science

The aim of this work is to present the description of Leibniz superalgebras up to isomorphism with characteristic sequence （n｜m - 1, 1） and nilindex n ＋ m.

关键词： Lie superalgebras Leibniz superalgebras nilindex charasteristic sequence

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In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

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Acta Pharmaceutica Sinica B 2021年第4期11卷 989-1002页

作者： Ana LMartínez-López Carlos JGonzález-navarro Paula Aranaz joséLVizmanos Juan MIrache NANO-VAC Research Group Department of Chemistry and Pharmaceutical TechnologySchool of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Center for Nutrition Research School of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Department of Biochemistry&Genetics School of ScienceUniversity of NavarraPamplona 31080Spain Navarra Institute for Health Research(IdiSNA) Pamplona 31080Spain

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of *** nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,displayed a size of 260 nm with a negative surface charge and an insulin payload of 77 mg/*** intestinal pig mucus,the diffusivity of these nanoparticles(PPA-NPs)was found to be 20-fold higher than bare nanoparticles(NPs).These results were in line with the biodistribution study in rats,in which NPs remained trapped in the mucus,whereas PPA-NPs were able to cross this layer and reach the epithelium *** therapeutic effcacy was evaluated in Caenorhabditis elegans grown under high glucose *** this model,worms treated with insulin-loaded in PPA-NPs displayed a longer lifespan than those treated with insulin free or nanoencapsulated in *** finding was associated with a signifcant reduction in the formation of reactive oxygen species(ROS)as well as an important decrease in the glucose and fat content in *** effects would be related with the mucus-permeating ability of PPA-NPs that would facilitate the passage through the intestinal peritrophic-like dense layer of worms(similar to mucus)and,thus,the absorption of insulin.

关键词： Nanoparticles Oral delivery Mucus-permeating Biodistribution Insulin Caenorhabditis elegans ROS

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Unpaved rural roads as source areas of sediment in a watershed of the Brazilian semi-arid region

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International Journal of Sediment Research 2019年第5期34卷 475-485页

作者： Teresa Raquel Lima Farias Pedro Henrique Augusto Medeiros Joaquín navarro-Hevia josé Carlos de Araújo Federal Institute of Education Science and Technology of Ceará University of Valladolid Campus La Yutera Federal University of Ceará Department of Agricultural Engineering Campus do Pici

Approximately 80% of the road network in Brazil is unpaved and shows evidences of a high erosion potential. In the semi-arid Caatinga Biome in the northeast of the country, a monitoring programme has been done for two years in order to analyze runoff and sediment production from unpaved rural roadways and from embankments. Sediment production ranged from 0.30 to 0.92 Mg/ha yr, higher than in undisturbed areas, but generally lower than that reported for unpaved roads in other regions. However,this is a semi-arid area with low rainfall and runoff and, hence, with a limited hydrological connectivity and sediment production. Sediment production on an embankment with no vegetation was around ten times higher than on an embankment with vegetation. On the road surface, annual sediment production(normalized for gradient) in a section with traffic was three times higher than for a road surface without traffic. In addition, events that occurred after roadway maintenance activities generated peaks of sediment concentration of over 5000 mg/L. These results suggest that sediment production from roads and embankments with bare surfaces is at least one order of magnitude higher than in undisturbed catchment areas. Maintenance activity and vehicle traffic contribute to an increase in sediment availability and impact on the sediment concentration, but less intensely on sediment loads, which depend on the runoff magnitude of the events occurring after roadway maintenance. It was also found that the natural vegetation of the semi-arid region potentially captures sediment on roadway embankments; thereby playing an important role in breaking connectivity between the sediment flow from unpaved roads and the natural drainage system of the catchment.

关键词： Sediment production Caatinga vegetation Road maintenance Embankment

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