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Design multifunctional Mg–Zr coatings regulating Mg alloy bioabsorption

Journal of Magnesium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohra Benzarti Sandesh Itani josédavid castro Sandra Carvalho Ana Sofia Ramos University of Coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Laboratory of Multifunctional Materials and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magnesium(Mg)alloys are widely used for temporary bone implants due to their favorable biodegradability,cytocompatibility,hemocompatibility,and close mechanical properties to ***,rapid degradation and inadequate strength limit their *** overcome this,the direct current magnetron sputtering technique is employed for surface coating in Mg-based alloys using various zirconium(Zr)*** approach presents a promising strategy for simultaneously improving corrosion resistance,maintaining biocompatibility,and enhancing strength without compromising *** leveraging Mg’s inherent biodegradability,it has the potential to minimize the need for secondary surgeries,thereby reducing costs and *** paper is a systematic study aimed at understanding the corrosion mechanisms of Mg–Zr coatings,denoted Mg-xZr(x=0–5 at.%).Zr-doped coatings exhibited columnar growth leading to denser and refined structures with increasing Zr *** analysis confirmed the presence of the Mg(00.2)basal plane,shifting towards higher angles(1.15°)with 5 at.%Zr doping due to lattice parameter changes(i.e.,decrease and increase of“c”and“a”lattice parameters,respectively).Mg–Zr coatings exhibited“liquidphilic”behavior,while Young’s modulus retained a steady value around 80 GPa across all ***,the hardness has significantly improved across all samples’coating,reaching the highest value of(2.2±0.3)GPa for 5 at.%*** testing in simulated body fluid(SBF)at 37℃ revealed a significant enhancement in corrosion resistance for Mg–Zr coatings containing 1.0–3.4 at.%*** with the 5 at.%Zr coating which exhibited a corrosion rate of 32 mm/year,these coatings displayed lower corrosion rates,ranging from 1 to 12 mm/*** synergistic enhancement in mechanical properties and corrosion resistance,achieved with 2.0–3.4 at.%Zr,suggests potential ability for reducing stress shielding and controlled degradation performance,and consequentl

关键词： Mg-Zr coatings Magnetron sputtering Nanoindentation Corrosion resistance Bone implants

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Prehospital critical care drug-therapy and 30-day mortality in patients with acute respiratory disease

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World Journal of Emergency Medicine 2025年第1期16卷 43-50页

作者： Jesús Jurado-Palomo joséLuis Martín-Conty Begoña Polonio-López Cristina Rivera Picón Raúl López-Izquierdo Carlos del Pozo Vegas Pedro Ángel de Santos castro Ancor Sanz-García Francisco Martín-Rodríguez Technological Innovation Applied to Health Research Group(ITAS) Faculty of Health SciencesCastilla-La Mancha UniversityTalavera de la Reina 45600Spain Nuestra Señora del Prado General Hospital Talavera de la Reina 45600Spain Emergency Department Rio Hortega University HospitalValladolid 47012Spain CIBER of Respiratory Diseases(CIBERES) Institute of Health Carlos ⅢMadrid 28029Spain Faculty of Medicine University of ValladolidValladolid 470003Spain Emergency Department University Clinical HospitalValladolid 47003Spain Prehospital Emergency Medical Services(SACYL) Valladolid 47007Spain

BACKGROUND: Prehospital medication is a reality, and the role of these therapies must be explored to assess their validity, especially for acute respiratory diseases, which are usually associated with increased morbidity. The aim of this study was to examine the association of prehospital medication use with mortality in patients with acute respiratory ***: A prospective, multicenter, emergency medical service(EMS) delivery cohort study was carried out in adults with unselected respiratory diseases managed by EMS who were transferred to the emergency department. From January 1, 2019, to October 31, 2023, six advanced life support units, thirty-eight basic life support units, and four hospitals in Spain participated in the study. Demographic data, vital signs, use of mechanical ventilation, prehospital respiratory diagnosis, and prehospital medication were collected. The primary outcome was 30-day in-hospital ***: A total of 961 patients were included, with a mortality rate of 17.5%(168 patients). Age, an increasing number of comorbidities, the use of invasive mechanical ventilation(IMV), the use of major analgesics, hypnotics, and bicarbonate were risk factors. In contrast, elevated systolic blood pressure and Glasgow Coma Scale scores were found to be protective factors against mortality. The predictive capacity of the model reached an area under the curve(AUC) of 0.857(95% confidence interval [95% CI] 0.827–0.888).CONCLUSION: Our data revealed that IMV, major analgesics, hypnotics and bicarbonate administration were associated with elevated mortality. Adding prehospital drug therapy information to demographic variables and vital signs could improve EMS decision-making, allowing a better characterization of patients at risk of clinical worsening.

关键词： Drug-therapy Medication Prehospital Mortality Emergency medical services

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A simple method for automatic recreation of railway horizontal alignments

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Railway Engineering Science 2025年第1期33卷 62-78页

作者： Alberte castro Gerardo Casal Duarte Santamarina Miguel E.Vázquez‑Méndez Transportation and Infrastructure Engineering Universidade de Santiago de CompostelaEPSERúa Benigno Ledo27002 LugoSpain Department of Applied Mathematics Universidade de Santiago de CompostelaEPSERúa Benigno Ledo27002 LugoSpain CITMAga Rúa de Constantino Candeira15782 Santiago de CompostelaSpain

This paper deals with the problem of recreating horizontal alignments of existing railway *** main objective is to propose a simple method for automatically obtaining optimized recreated alignments located as close as possible to an existing *** on a previously defined geometric model,two different constrained optimization problems are *** first problem uses only the information provided by a set of points representing the track centerline while the second one also considers additional data about the existing *** proposed methodology consists of a two-stage process in which both problems are solved consecutively using numerical *** main results obtained applying this methodology are presented to show its performance and to prove its practical usefulness:an academic example used to compare with other methods,and a case study of a railway section located in Parga(Spain)in which the geometry of its horizontal alignment is successfully recovered.

关键词： Railway horizontal alignment Geometrical model Constrained optimization problem Numerical resolution

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Green synthesis of glycolic acid through the electrocatalytic reduction of oxalic acid over black TiO_(2): An experimental and theoretical study

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Journal of Energy Chemistry 2025年第1期100卷 544-556页

作者： Hugo Olvera-Vargas Oscar Andrés Jaramillo-Quintero Luis Darío Alarcón León Orlando castro-Ocampo Christian A.Celaya Marina E.Rincón Jesús Muñiz Instituto de Energías Renovables Universidad Nacional Autónoma de México(IER-UNAM)Priv.Xochicalco s/nCol.CentroTemixcoMorelos.CP 62580Mexico Centro de Nanociencias y Nanotecnología Universidad Nacional Autónoma de México(UNAM)Km 107Carretera Tijuana-EnsenadaEnsenadaB.C.C.P.22800Mexico

Herein,we present the electrocatalytic four-electron hydrogenation of oxalic acid into glycolic acid using black TiO_(2)as an *** acid is an abundant compound found in several sources of organic *** results showed a high selectivity of black TiO_(2)toward glycolic acid,with the formation of glyoxylic acid being the rate-limiting step (glyoxylic acid is the two-electron intermediate).The highest Faradaic efficiency (FE) of 69.6%±8.3% was achieved at 10.2 mA cm^(-2)in 4 h of electrolysis using an H-type cell operated at room temperature,with 50.2%±3.8% of oxalic acid conversion (degradation kinetic constant k=0.0042±0.0001 min-1),58.8%±7.0%of reaction yield and 1.2±0.18 g L-1of glycolic acid production.A theoretical model of black TiO_(2)coming from anatase TiO_(2)was implemented by introducing Ti3+defects,which gave black TiO_(2)the theoretical capability to easily transform oxalic acid into glycolic acid as experimentally *** reaction mechanism was supported and described in detail by density functional theory calculations,which revealed that surface Ti^(3+)states were the main catalytic *** is the first time that a detailed step-by-step mechanism at the atomic level has been proposed for this electrocatalytic reaction,which represents a valuable contribution to the understanding of this process of high energy/environmental *** is also the first time that black TiO_(2)has been used as an electrocatalyst for this sustainable process.

关键词： Chemical energy storage Electrochemical hydrogenation Density functional theory Renewable energy Oxalic acid

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Aptamers as new promising entities for therapeutics:our experience from the neurological diseases

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Neural Regeneration Research 2025年第12期20卷 3523-3524页

作者： Macarena Hernández-Jiménez Fernando de castro Neurovascular Research Unit Pharmacology and Toxicology DepartmentComplutense UniversityMadridSpain AptaTargets S.L. Avda.Cardenal Herrera OriaMadridSpain Instituto de Investigación Hospital 12 de Octubre MadridSpain Instituto Cajal-CSIC MadridSpain

Based on data from Global Burden of Disease,Injuries,and Risk Factors(2024),disorders of the central nervous system(CNS)are an important cause of death or long-term disability,representing the top-ranked contributor to global disability adjusted life *** group of pathological conditions includes congenital and neurodevelopmental disorders,cerebrovascular diseases,and neurodegenerative diseases,and induce the disruption of brain growth,brain and/or spinal cord damage,and cognitive,sensory,or motor function ***,despite the huge impact of these diseases on the lives of patients,there is a lack of available therapeutic options and the investigation in the field represents real interest in the scientific community nowadays.

关键词： diseases congenital impairment

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alcohol drinking and mammary cancer: pathogenesis and potential dietary preventive alternatives

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World Journal of Clinical Oncology 2014年第4期5卷 713-729页

作者： Gerardo Daniel castro josé A castro Centro de Investigaciones Toxicológicas CITEDEF B1603ALO Villa Martelli province of Buenos Aires Argentina Instituto de Investigación e Ingeniería Ambiental Universidad Nacional de General San Martín B1650ANQ San Martín province of Buenos Aires Argentina

Alcohol consumption is associated with an increased risk of breast cancer, increasing linearly even with a moderate consumption and irrespectively of the type of alcoholic beverage. It shows no dependency from other risk factors like menopausal status, oral contraceptives, hormone replacement therapy, or genetic history of breast cancer. The precise mechanism for the effect of drinking alcohol in mammary cancer promotion is still far from being established. Studies by our laboratory suggest that acetaldehyde produced in situ and accumulated in mammary tissue because of poor detoxicating mechanisms might play a role in mutational and promotional events. Additional studies indicated the production of reactive oxygen species accompanied of decreases in vitamin E and GSH contents and of glutathione transferase activity. The resulting oxidative stress might also play a relevant role in several stages of the carcinogenic process. There are reported in literature studies showing that plasmatic levels ofestrogens significantly increased after alcohol drinking and that the breast cancer risk is higher in receptor ERpositive individuals. Estrogens are known that they may produce breast cancer by actions on ER and also as chemical carcinogens, as a consequence of their oxidation leading to reactive metabolites. In this review we introduce our working hypothesis integrating the acetaldehyde and the oxidative stress effects with those involving increased estrogen levels. We also analyze potential preventive actions that might be accessible. There remains the fact that alcohol drinking is just one of the avoidable causes of breast cancer and that, at present, the suggested acceptable dose for prevention of this risk is of one drink per day.

关键词： Alcohol Ethanol Acetaldehyde Free radicals Mammary cancer Oxidative stress Estrogens Polyphenols

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COMBINING SINGULAR SPECTRUM ANALYSIS AND PAR(p) STRUCTURES TO MODEL WIND SPEED TIME SERIES

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Journal of Systems Science & Complexity 2014年第1期27卷 29-46页

作者： MENEZES Moises Lima de SOUZA Reinaldo castro PESSANHA jos Francisco Moreira Department of Statistics Fluminense Federal University ( UFI~ Brazil. Email: moisesAima@msn.com.SOUZA Reinaldo Castro Electrical Engineering Department: Pontifical Catholic University of Rio de Janeiro (PUC-Rio) Brazil. Institute of Mathematics and Statistics State University of Rio de Janeiro (UERJ) Brazil.

Singular spectrum analysis （SSA） is a technique that decomposes a time series into a set of components, such as, trend, harmonics, and residuals. Leaving out the residual components and adding up the others, the time series can be smoothed. This procedure has been used to model Brazilian electricity consumption and flow series. The PAR（p）, periodic autoregressive models, has been broadly used in modelling energy series in Brazil. This paper presents an approach of this decomposition method, by fitting the PAR（p）, considering its multivariate version known as multivariate SSA （MSSA）. The method was applied to a vector of two wind speed series recorded at two locations in the Brazilian Northeast region. The obtained results, when compared to the univariate decomposition of each series, were far superior, showing that the spatial correlation between the two series were considered by MSSA decomposition stage.

关键词： MSSA periodic autoregressive model SSA wind speed series.

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King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

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Lifestyles of Older Adults in Castilla-La Mancha(Spain):Influence of Sex,Age,and Habitat

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 313-335页

作者： Esther Portal Martínez Juan Lirio castro david Alonso González joséLuis Gómez Ramos University of Castilla-La Mancha Talavera de la ReinaSpain Complutense University MadridSpain

This paper presents the quantitative research results of a comprehensive study titled“Current Profle of Older Adults in Castilla-La Mancha(Spain).”The study aims to understand and describe the characteristics of individuals aged 65 and above within this autonomous region,with a focus on the variables of sex,age,and habitat.A cross-sectional approach was employed,utilizing quantitative methods to collect *** gather information,a customized questionnaire was developed to address the study objectives,covering various aspects such as sociodemographic factors,living conditions,leisure activities,social participation,and cultural *** survey was conducted via telephone,ensuring representation by employing gender quotas,age-group stratifcation,and considerations for habitat size.A representative sample of 1,065 participants was included in the *** fndings reveal a degree of homogeneity in the lifestyles of older adults,with discernible variations infuenced by factors such as sex,habitat,and *** results shed light on the diverse habits and experiences of older adults,emphasizing the signifcance of habitat conditions,social participation,and the aging process.

关键词： Lifestyle habits Older adults Habitat conditions Social participation Aging experience

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DNA metabarcoding the diet of Podarcis lizards endemic to the Balearic Islands

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Current Zoology 2023年第5期69卷 514-526页

作者： Iris Alemany Ana Pérez-Cembranos Valentín Pérez-Mellado joséAurelio castro Antònia Picornell Cori Ramon joséA Jurado-Rivera Deptartment of Biology Universitat de les Illes BalearsCtra.Valldemossa km 7’5Palma de Mallorca07122Balearic IslandsSpain and Department of Animal Biology Universidad de SalamancaCampus Miguel de Unamuno s/n37007SalamancaSpain

Dietary studies are essential to unravel the functioning of ecosystems and ultimately to understand *** task,which at first may seem simple,becomes especially complex in those cases of omnivorous species with highly variable *** this regard,the emergence of next-generation DNA sequencing methodologies represents a powerful tool to address the *** we implement a high-throughput metabarcoding strategy based on the analysis of four molecular markers aimed at sequencing both mitochondrial(animal prey)and chloroplast(diet plants)genome fragments from fecal samples of two lizard species endemic to the Balearic Archipelago(Podarcis lilfordi and ***)obtained through non-invasive *** results allowed for the characterization of their diets with a high degree of taxonomic detail and have contributed a large number of new trophic *** reported diets are based mainly on the consumption of arthropods,mollusks and plants from a diversity of taxonomic orders,as well as carrion and marine *** analyses also reveal inter-and intra-specific differences both in terms of seasonality and geographical distribution of the sampled lizard *** molecular findings provide new insights into the trophic interactions of these threatened endemic lizards in their unique and isolated ecosystems.

关键词： Balearic archipelago COI metabarcoding Podarcis lilfordi Podarcis pityusensis psbA-trnH rbcL trophic ecology

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