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Measuring disturbance at swift breeding colonies due to the visual aspects of a drone:a quasi-experiment study

Current Zoology 2021年第2期67卷 157-163页

作者： Geison P.MESQUITA joséd.rodríguez-teijeiro Serge A.WICH Margarita MULERO-PÁZMÁNY department of Animal Biology Plant Biology and EcologyFaculty of BioscienceAutonomous University of BarcelonaBarcelona 08193Spain Institut de Recerca de la Biodiversitat University of BarcelonaBarcelona 08193Spain department of Evolutionary Biology Ecology and Environmental SciencesFaculty of BiologyBiodiversity Research Institute(IRBio)University of BarcelonaBarcelona 08193Spain School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L35UGUK Institute for Biodiversity and Ecosystem dynamics University of AmsterdamAmsterdam 1012 WXThe Netherlands

There is a growing body of research indicating that drones can disturb ***,it is usu-ally unclear whether the disturbance is due to visual or auditory ***,we examined the effect of drone flights on the behavior of great dusky swifts Cypseloides senex and white collared swifts Streptoprocne zonaris in 2 breeding sites where drone noise was obscured by environmental noise from waterfalls and any disturbance must be largely *** performed 12 experimental flights with a multirotor drone at different vertical,horizontal,and diagonal distances from the *** all flights,17%causedds to temporarily a bandon the breeding site,50%caused half to abandon,and 33%caused more than half to *** found that the diagonal distance explained 98.9%of the variability of the disturbance percentage and while at distances>50 m the disturbance percentage does not exceed 20%,atdisturbance percentage increase to>60%.We recommend that flights with a multirotor drone during the breeding period should be con-ducted at a distance of>50 m and that recreational flights should be discouraged or conducted at larger distances(e.g.100 m)in nesting birds areas such as waterfalls,canyons,and caves.

关键词： Cypseloides senex disturbance drones multirotors Streptoprocne zonaris unmanned aircraft systems

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Wear protection assessment of ultralow viscosity lubricants in high-power-density engines:A novel wear prediction algorithm

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Friction 2024年第8期12卷 1785-1800页

作者： Javier BLANCO-rodrÍguez Jacobo PORTEIRO joséA.LÓPEZ-CAMPOS MartíCORTAdA-GARCÍA Silvia FERNÁNdEZ-CASTEJÓN CINTECX Universidade de VigoLagoas-Marcosende s/nVigo 36310Spain Repsol SA MadridSpain

durability and reliability have been studied for decades through intensive trial-error ***,there are numerous fields of application where the costs associated with this approach are not *** lubricated machines with severe dynamic loads,such as high-power-density engines,simulation tools offer clear advantages over intensive *** and multiple scenarios can be cost-effectively simulated to assess different lubricants and engine *** work presented here details the study of wear based on a validated elastohydrodynamic(EHd)simulation model of the connecting rod journal *** model accounts for elastic deformation through a connecting rod finite element model(FEM).In addition,multiple lubricant rheological and tribological dependences,determined by specific experimental tests,are applied in the model through their interaction with the simulation ***,a novel wear algorithm is proposed to predict wear depth over time evolution along a proposed wear cycle based on the typical working ranges of high-performance engines.A final assessment is presented to compare 4 different ultralow-viscosity lubricants in their protective performance under severe *** results show the evolution of the wear load and wear depth over the wear *** evaluation is key to describing a lubricant selection procedure for high-power-density engines.

关键词： wear modelling finite element modelling mixed lubrication elastohydrodynamic(EHd) internal combustion engines bearings

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Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： damián Sánchez-Ramírez Mónica G Mendoza-rodríguez Omar R Alemán Fernando A Candanedo-González Miriam rodríguez-Sosa Juan joséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(dR)that has been inversely associated with poor prognosis;less dR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

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Hematological abnormalities in liver cirrhosis

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World Journal of Hepatology 2024年第9期16卷 1229-1244页

作者： Oscar Manuel Fierro-Angulo joséAlberto González-Regueiro Ariana Pereira-García Astrid Ruiz-Margáin Fernando Solis-Huerta Ricardo Ulises Macías-rodríguez department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico department of Hematology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Hematological abnormalities are common in cirrhosis and are associated with various pathophysiological *** have documented a prevalence of thrombocytopenia,leukopenia,and anemia in patients with compensated cirrhosis of 77.9%,23.5%,and 21.1%,*** abnormalities carry significant clinical implications,including considerations for invasive procedures,infection risk,bleeding risk,and ***,cirrhosis was believed to predispose patients to bleeding due to alterations observed in classical coagula-tion tests such as prothrombin time,partial thromboplastin time,international normalized ratio,and ***,this understanding has evol-ved,and cirrhosis patients are now also acknowledged as being at a high risk for thrombotic *** in cirrhosis patients presents a complex pheno-type,with procoagulant and anticoagulant abnormalities offsetting each *** multifactorial phenomenon is inadequately reflected by routine laboratory *** complications are more prevalent in decompensated cirrhosis and may correlate with disease *** is primarily associated with portal hypertension,endothelial dysfunction,mechanical vessel injury,dissem-inated intravascular coagulation,endotoxemia,and renal *** review comprehensively outlines hematologic index abnormalities,mechanisms of hemostasis,coagulation,and fibrinolysis abnormalities,limitations of laboratory testing,and clinical manifestations of bleeding and thrombosis in patients with liver cirrhosis.

关键词： Cirrhosis Anemia Leukopenia Thrombocytopenia Coagulopathy Bleeding Thrombosis

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Risk Assessment of an Environmental Liability in the Commercialization of Hydrocarbons-A Secondary Publication

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Journal of World Architecture 2024年第2期8卷 108-117页

作者： Yamila Navarro Sosa joséCarlos Rojas Acosta Lester Rivas Trasancos Carlos C.Cañete Pérez Yuletsis díaz rodríguez Center for Petroleum Research(CEINPET) HavanaCuba Technological University of Havana joséAntonio Echeverría HavanaCuba

The risk analysis evaluates the probability of occurrence with the impact of said *** the hydrocarbon sector,an environmental liability is an improperly abandoned facility,soil contaminated by spills or *** objective of this work is to define a risk management *** characterization of the residue and the area was carried *** events were identified:overflow spill,soil contamination by infiltration,as well as radiant heat and suffocating and toxic fumes from a *** matrix method was applied considering the probability of occurrence against *** danger of infiltration implied a high level of *** risk management plan was drawn up,its main action being the liquidation of the pool and the sanitation of the area.

关键词： Hazardous events Environmental liability Waste Risk Vulnerability

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Comparing Fine-Tuning, Zero and Few-Shot Strategies with Large Language Models in Hate Speech detection in English

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2849-2868页

作者： Ronghao Pan joséAntonio García-díaz Rafael Valencia-García departamento de Informática y Sistemas Universidad de MurciaCampus de EspinardoMurcia30100Spain

Large Language Models(LLMs)are increasingly demonstrating their ability to understand natural language and solve complex tasks,especially through text *** of the relevant capabilities is contextual learning,which involves the ability to receive instructions in natural language or task demonstrations to generate expected outputs for test instances without the need for additional training or gradient *** recent years,the popularity of social networking has provided a medium through which some users can engage in offensive and harmful online *** this study,we investigate the ability of different LLMs,ranging from zero-shot and few-shot learning to *** experiments show that LLMs can identify sexist and hateful online texts using zero-shot and few-shot approaches through information ***,it is found that the encoder-decoder model called Zephyr achieves the best results with the fine-tuning approach,scoring 86.811%on the Explainable detection of Online Sexism(EdOS)test-set and 57.453%on the Multilingual detection of Hate Speech Against Immigrants and Women in Twitter(HatEval)***,it is confirmed that the evaluated models perform well in hate text detection,as they beat the best result in the HatEval task *** error analysis shows that contextual learning had difficulty distinguishing between types of hate speech and figurative ***,the fine-tuned approach tends to produce many false positives.

关键词： Hate speech detection zero-shot few-shot fine-tuning natural language processing

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Secondary Metabolites of Entomopathogenic Fungi, Biological Alternative for the Control of Agricultural Pests and disease: Present and Perspectives

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Advances in Enzyme Research 2024年第1期12卷 1-15页

作者： Nallely San Juan-Maldonado Silvia rodríguez-Navarro Alejandro Angel-Cuapio josé Norberto Vásquez Bonilla Juan Esteban Barranco-Florido departamento de Producció n Agr&#237cola y Animal Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico divisió n de Ingenier&#237a Qu&#237mica y Bioqu&#237mica Tecnol&#243gico Nacional de M&#233xico/TES de Ecatepec Ecatepec de Morelos M&#233xico departamento de Sistemas Bioló gicos Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico

The use of entomopathogenic fungi (EF) in recent years has been highly effective against the different orders of insects considered pests of agricultural importance and their conidia have been commonly applied, but it has been reported that these are sensitive to the environmental conditions. For this reason, biopesticides products have been formulated based on secondary metabolites, recently. These biomolecules participate as biological control agent, such as: cyclic depsipeptides, amino acids, polyketides, polyphenols and terpenoids, affecting their morphology, life cycle and insect behavior. The use of secondary metabolites of entomopathogenic fungi opens the possibility of application in a more efficient way for the control of agricultural pests in a compatible with the environment and human health;therefore, it is important to know, analyzing the type of molecules, their effects, and their different methods of application.

关键词： Secondary Metabolites Entomopathogenic Fungi Biological Control Agent

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detection of Progesterone Receptor as a Method of diagnosing Mammary Cancer in Female dogs

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Open Journal of Veterinary Medicine 2024年第8期14卷 217-227页

作者： josé de Jesús Vázquez Pérez Angel Ramses Figueroa Hernandez Jorge Peregrina Sandoval Guillermo Nolasco rodríguez Manuel Rosales Cortés department of Veterinary Medicine University Center of Biological and Agricultural Sciences University of Guadalajara Zapopan Mexico department of Cellular and Molecular Biology University Center for Biological and Agricultural Sciences University of Guadalajara Zapopan Mexico

Introduction: Canine mammary gland tumor is the most common type of neoplasia in non-ovariectomized bitches. Approximately 50% of tumors are malignant. Neoplasms originating from the mammary gland represent the most common neoplastic disease in canines in Veterinary Medicine. Aim: Relate the expression of the receptor to progesterone (PR) with the tumor stage of canine mammary carcinoma. Material and Methods: Analytical-cross-sectional study, samples of paraffinized tumor tissue obtained from 30 canine patients with breast cancer were used. The expression of PR was performed by immunohistochemical labeling, using murine anti-PR (anti-PR Biocare brand). A descriptive analysis was carried out with the results using the SPSS program. Results: The predominant histological subtype of breast cancer was tubular carcinoma with 12 patients, followed by papillary cystic carcinoma with 6 patients, solid carcinoma 5, carcinosarcoma 4 and comedocarcinoma 3. There was a significant trend between breast cancer subtypes, histological grade G1. Among the histopathological findings, the degree of invasion is related to the presence of tumor cells in adjacent lymph nodes, which is why it is a prognostic indicator. The expression of PR in the tumor tissue samples it was 42.8% positive versus 57.14% negative, of which 75% correspond to G1, 8.3% to G2 and 16.6% to G3. With respect to the relationship of the expression of PR vs type of tumor, it was found that 50% correspond to tubular carcinoma, 33.3% to papillary cystic carcinoma, 8.3% to solid carcinoma and 8.3% to comedocarcinoma. Conclusion: The hormone receptor was negative in more than half of the patients and histological grade is significantly associated with tumor subtypes, this study emphasizes the need to introduce receptor testing into our routine clinical practice to offer the best treatment for breast cancer.

关键词： Cancer Mammary Gland Progesterone Immunohistochemistry Progesterone Membrane Receptor Component 1 (PGRMC 1)

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Presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan joséPérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSP)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSP,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(Parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSP.

关键词： reticulum endoplasmic

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Gut microbiota in preterm infants receiving breast milk or mixed feeding

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World Journal of Clinical Pediatrics 2024年第2期13卷 135-145页

作者： Sandra Gabriela Sánchez-González Bárbara Gabriela Cárdenas-del-Castillo Elvira Garza-González Gerardo R Padilla-Rivas Isaías rodríguez-Balderrama Consuelo Treviño-Garza Fernando Félix Montes-Tapia Gerardo C Palacios-Saucedo Anthony Gutiérrez-rodríguez Manuel Enrique de-la-O-Cavazos department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico departamento de Bioquímica y Medicina Molecular Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico department of Biochemistry and Molecular Medicine Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico department of Pediatric Surgery Hospital Universitario"Dr.JoséEleuterio González"Monterrey 64460Nuevo LeónMéxico

BACKGROUNd Preterm birth is the leading cause of mortality in newborns,with very-low-birthweight infants usually experiencing several *** milk is considered the gold standard of nutrition,especially for preterm infants with delayed gut colonization,because it contains beneficial microorganisms,such as Lactobacilli and *** To analyze the gut microbiota of breastfed preterm infants with a birth weight of 1500 g or *** An observational study was performed on preterm infants with up to 36.6 wk of gestation and a birth weight of 1500 g or less,born at the University Hospital ***éEleuterio González at Monterrey,Mexico.A total of 40 preterm neonates were classified into breast milk feeding(BM)and mixed feeding(MF)groups(21 in the BM group and 19 in the MF group),from October 2017 to June *** samples were collected before they were introduced to any feeding *** full enteral feeding was achieved,the composition of the gut microbiota was analyzed using 16S rRNA gene *** variables were compared using Student’s t-test or using the Mann–Whitney U test for nonparametric ***,evenness,equitability,Margalef’s index,Fisher’s alpha,Chao-1 index,and Shannon’s diversity index were also *** No significant differences were observed at the genus level between the *** comparison indicated higher counts of Alphaproteobacteria and Betaproteobacteria in the initial compared to the final sample of the BM group(Pddition,higher counts of Gammaproteobacteria were detected in the final than in the initial sample(P=0.040).According to the Margalef index,Fisher’s alpha,and Chao-1 index,a decrease in species richness from the initial to the final sample,regardless of the feeding type,was observed(Pdominant phyla were Bacteroidetes,Actinobacteria,Firmicutes,and Proteobacteria,with Proteobacteria being the most ***,no significant differences were

关键词： Gut microbiota Human milk Preterm infant Proteobacteria Very low birth weight 16S rRNA

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