检索结果-南通市图书馆

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Past,present,and future of long-term treatment for hepatitis B virus

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第25期29卷 3964-3983页

作者： Teresa Broquetas josé A Carrión Liver Section Gastroenterology DepartmentHospital del MarBarcelona 08003Spain Institut Hospital del Mar D’Investigacions Mèdiques PSMARBarcelona 08003Spain Universitat Pompeu Fabra Facultat de Ciències de la Salut i de la VidaBarcelona 08003Spain

The estimated world prevalence of hepatitis B virus(HBV)infection is 316 *** infection was identified in 1963 and nowadays is a major cause of cirrhosis and hepatocellular carcinoma(HCC)despite universal vaccination programs,and effective antiviral ***-term administration of nucleos(t)ide analogues(nA)has been the treatment of choice for chronic hepatitis B during the last *** nA has shown a good safety profile and high efficacy in controlling viral replication,improving histology,and decreasing the HCC incidence,decompensation,and ***,the low probability of HBV surface antigen seroclearance made necessary an indefinite *** knowledge,in recent years,about the different phases of the viral cycle,and the new insights into the role of the immune system have yielded an increase in new therapeutic ***,several clinical trials evaluating combinations of new drugs with different mechanisms of action are ongoing with promising *** integrative literature review aims to assess the knowledge and major advances from the past of hepatitis B,the present of nA treatment and withdrawal,and the future perspectives with combined molecules to achieve a functional cure.

关键词： Hepatitis B Therapy Antigen Functional cure Antiviral agents Drug development

Minimization of methabenzthiazuron residues in leaching water using amended soils and photocatalytic treatment with TiO_2 and ZnO

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2014年第4期26卷 757-764页

作者： jos Fenoll Pilar Flores Pilar Hellín Joaquín Hern'andez Simón navarro Department of Food Quality Murcia Institute of Agri-Food Research and Development Department of Agricultural Chemistry Geology and Pedology School of Chemistry University of Murcia Campus Universitario de Espinardo

In the present work, potential groundwater pollution by methabenzthiazuron （MTBU） and the effect of three different amendments （composted sheep manure, composted pine bark and spent coffee grounds） on its mobility were investigated under laboratory conditions. The efficiency of ZnO and TiO2 suspensions in the photocatalytic degradation of MTBU in leaching water was also investigated. The relative and cumulative breakthrough curves were obtained from disturbed soil columns. The presence and/or addition of organic matter drastically reduced the movement of the herbicide. On other hand, photocatalytic experiments showed that the addition of ZnO and TiO2 strongly enhances the degradation rate of this herbicide compared with the results of photolytic experiments under artificial light. ZnO appeared to be more effective in MTBU oxidation than TiO2. The results obtained point to the interest of using organic wastes and heterogeneous photocatalysis for reducing the pollution of groundwater by pesticide drainage.

关键词： groundwater pollution organic amendment pesticide movement photocatalytic oxidation semiconductor oxides

Coping with drought? The hidden microhabitat selection and underground movements of amphisbaenians under summer drought conditions

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2024年第5期70卷 647-658页

作者： joséMartín Gonzalo Rodríguez-Ruiz joséJavier Cuervo Departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain

Habitat selection is a dynamic process that depends on many environmental variables that can vary with weather *** is important because,within a context of global change,extreme weather events,such as severe droughts,are predicted to become more *** examined the patterns of microhabitat selection and underground movements(using PIT-tag telemetry)of a strictly fossorial reptile,the north African checkboard amphisbaenian Trogonophis wiegmanni,during the summer drought *** aimed to test whether changes in strategies of habitat use and movements could allow this amphisbaenian to cope with unfavorable *** found that during the summer drought period,*** did not use the microhabitats in relationship to their availability,but particularly selected sites with high abundance of rocks but also areas under a high cover of bushes,where environmental conditions were more *** also found,using PIT-tag telemetry,that the numbers of *** individuals located under rocks and their activity(number of days with movements)decreased largely in ***,the animals were not entirely inactive,but,especially males were active below the ground under bushes and made some relatively long underground hidden movements between favorable areas.

关键词： arid environments fossoriality habitat selection movement ecology Trogonophis wiegmanni weather conditions

new strategies for ischemic stroke: internal photobiomodulation therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neural Regeneration Research 2020年第9期15卷 1658-1659页

作者： Ramón Iglesias-Rey josé Castillo Clinical neurosciences Research Laboratory (LInC) Health Research Institute of Santiago de Compostela (IDIS) Clinical University Hospital Universidade de Santiago de Compostela

Epidemiology and physiopathology of ischemic stroke:Every year, around 15 million of people suffer a stroke event all around the world. Among those, around 6.7 million will die, and most of the survivors will suffer s... 详细信息

关键词： pathology Epidemiology ischemic

Appraising trapping efficiency of vegetative barriers in agricultural landscapes:Strategy based on a probabilistic approach based on a review of available information

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2024年第3期12卷 615-634页

作者： josé-Antonio Muñoz Gema Guzmán María-Auxiliadora Soriano josé A.Gómez Institute for Sustainable Agriculture(IAS)-CSIC Cordoba14004Spain Andalusian Institute of Agricultural and Fisheries Research and Training(IFAPA) Granada18004Spain Agronomy Department(DAUCO) University of CordobaCordoba14071Spain

Vegetative barriers have proven their effectiveness in controlling water erosion and enhancing other ecosystem services in agricultural *** characteristic has led to the conservation and promotion of vegetative barriers as landscape elements by the Common Agricultural Policy and other policy *** reviews have dealt with the trapping efficiency of vegetated barriers,although they usually focus on studies from humid climates where their implantation and survival are more ***,vegetated barriers are also an attractive alternative in arid and semi-arid *** limit competition for water and nutrients with crops to a reduced area compared to other best management practices,such as cover *** study presents a review of trapping efficiency of sediment,runoff,and nutrients(P and n)by vegetative barriers in regions of humid and arid,and semi-arid,climates,and a strategy based on sediment trapping efficiency probability,which in turn is based on the results obtained from our *** types of independent variables were grouped and identified for the review:related to the vegetative barrier dimension(buffer width,slope of the plot,and buffer area ratio),and related to the experimental conditions(type of vegetation in the buffer,soil protection of the non-buffered area,type of climate,type of experimental measurement and origin of rainfall).An explor-atory analysis evaluated the significance of the experimental variables,which identified the need to focus on experiments under natural rainfall since those carried out with simulated rainfall presented statis-tically significant *** general,average trapping efficiencies for runoff and sediment were 40.1 and 62.6%,*** nutrients,values of trapping efficiencies had an average of 44.9%for phosphorus and 38.4%for *** and sediment trapping efficiency in arid and semi-arid re-gions tended to be higher than in humid *** dimensional

关键词： Connectivity Sediment transport Runoff nutrients Experimental plots Buffer strip

How does anodization time affect morphological and photocatalytic properties of iron oxide nanostructures?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第3期38卷 159-169页

作者： Bianca Lucas-Granados Rita Sánchez-Tovar Ramón MFernández-Domene joséMaría Estívalis-Martínez joséGarcía-Antón Ingeniería Electroquímica y Corrosión(IEC).Instituto Universitario de Seguridad Industrial Radiofísica y Medioambiental(ISIRYM)Universitat Politècnica de ValènciaCamino de Vera s/n46022ValenciaSpain Departmento de Ingeniería Química Universitat de ValènciaAv de les Universitatss/n46100 BurjassotSpain

Iron oxide nanostructures are promising materials to be used as photocatalysts in different photoelectrochemical applications. There are different techniques in order to synthesize these nanostructures, but one of the most inexpensive and simple method is electrochemical anodization. This method can lead to different nanostructures by controlling its parameters. Anodization time is one of the most critical parameters since it considerably affects the properties of the obtained nanostructures. In this work, different anodization times(5, 10, 15, 30 and 60 min) were studied. The resulting nanotubes were characterized by field emission scanning electron microscopy, Raman laser confocal microscopy, water splitting measurements, Mott-Schottky analysis and electrochemical impedance spectroscopy, in order to test their viability for being used as photocatalysts in photoelectrochemical applications. Results showed that the best photocurrent density values in water splitting tests(0.263 m A m-2) were achieved for the sample anodized for 10 min under hydrodynamic conditions.

关键词： Iron oxide Metallic nanostructures Photoelectrochemistry Anodization Time

Visual grading criteria for Japanese larch ( Larix kaempferi ) structural timber from Spain

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2020年第6期31卷 2605-2614页

作者： Mari-jose Barriola josé-Ramón Aira Edgar Lafuente Tknika LHri Aplikatutako Ikerketa eta Berrikuntzako EAEko zentroaZamalbide Auzoa z/g20100 ErrenteriaGipuzkoaSpain Escuela de Ingeniería de la Industria Forestal Agronómica y de la BioenergíaUniversidad de ValladolidUVa-Campus Duques de Sorias/n42005 SoriaSpain Cesefor Centro de Servicios y Promoción Forestal y de su Industria de Castilla y LeónCalle C42005 SoriaSpain

Larch wood is structurally classifi ed in many countries as one of conifers with the highest load-bearing capacity(strength class of C30).The Spanish visual classifi cation regulation only assigns a strength class to 4 pine woods:Laricio pine(Pinus nigra ***),Silvestre pine(Pinus sylvestris L.),Radiata pine(Pinus radiata ***),and Pinaster pine(Pinus pinaster Ait.).This work adds to the number of structurally characterised species by creating a visual classifi cation table for Japanese larch wood(Larix kaempferi(Lamb.)Carr.)which diff erentiates between 2 visual classes,MEG-1 and *** strength values were calculated for each class(fk,MEG-1=31.80 MPa,f k,MEG-2=24.55 MPa),mean module of elasticity(E 0,mean,MEG-1=13,082 MPA,E 0,mean,MEG-2=12,320 MPA)and density(ρk,MEG-1=456.6 kg m−3,ρk,MEG-2=469.1 kg m−3),before fi nally assigning a strength class of C30 to visual class MEG-1,and a strength class of C24 to visual class MEG-2.

关键词： Japanese larch wood Visual grading Strength class Mechanical properties Density

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid