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Phenolic metabolism and molecular mass distribution of polysaccharides in cellulose-deficient maize cells

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Journal of Integrative Plant Biology 2017年第7期59卷 475-495页

作者： María de Castro Romina Martínez-Rubio josé L.Acebes antonio Encina Stephen C.Fry Penélope García-Angulo área de Fisiología Vegetal.Dpto.Ingenieríay Ciencias Agrarias.Facultad de Biologíay Ciencias Ambientales.Universidad de León The Edinburgh Cell Wall Group Institute of Molecular Plant Sciences School of Biological Sciences Daniel Rutherford BuildingThe King's Buildings

As a consequence of the habituation to low levels of dichlobenil （DCB）, cultured maize cells presented an altered hemicellulose cell fate with a lower proportion of strongly wall-bound hemicelluloses and an increase in soluble extracellular polymers released into the culture medium. The aim of this study was to investigate the relative molecular mass distributions of polysaccharides as well as phenolic metabolism in cells habituated to low levels of DCB （1.5 μM）. Generally, cell wall bound hemicelluloses and sloughed polymers from habituated cells were more homogeneously sized and had a lower weight-average relative molecular mass. In addition, polysaccharides underwent massive cross-linking after being secreted into the cell wall, but this cross-linking was less pronounced in habituated cells than in non-habituated ones. However, when relativized, ferulic acid and p-coumaric acid contents were higher in this habituated cell line. Feasibly, cells habituated to low levels of DCB synthesized molecules with a lower weight-average relative molecular mass, although cross-linked, as a part of their strategy to compensate for the lack of cellulose.

关键词： Phenolic metabolism and molecular mass distribution of polysaccharides in cellulose-deficient maize cells were for

Is there a place for cellular therapy in depression?

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World Journal of Psychiatry 2021年第9期11卷 553-567页

作者： Pedro antonio Schmidt do Prado-Lima Zaquer Suzana Munhoz Costa-Ferro Bruno solano de Freitas Souza Ivana Beatrice Manica da Cruz Biogenomics Lab Brain Institute of Rio Grande do Sul(BraIns) Pontifical Catholic University of Rio Grande do SulPorto Alegre 90610-000Rio Grande do SulBrazil Center for Biotechnology and Cell Therapy Sao Rafael HospitalSalvador 41253-190BahiaBrazil D’Or Institute for Research and Education(IDOR) Salvador 41253-190BahiaBrazil Laboratory of Tissue Engineering and Immunopharmacology Gonçalo Moniz InstituteFiocruzSalvador 40296-710BahiaBrazil Health Sciences Center Federal University of Santa MariaSanta Maria 97105900RSBrazil

Although efforts have been made to improve the pharmacological treatment of depression,approximately one-third of patients with depression do not respond to conventional therapy using *** potential non-pharmacological therapies have been studied in the last years,including the use of mesenchymal stem cell therapies to treat *** therapies are reviewed here since it is clinically relevant to develop innovative therapeutics to treat psychiatric *** data corroborate that mesenchymal stem cell therapy could be considered a potential treatment for depression based on its antiinflammatory and neurotrophic ***,some clinical trials involving treatment of depression with stem cells are in progress,but with no published *** studies and other future clinical investigations will be crucial to define how much mesenchymal stem cells can effectively be used in psychiatric clinics as a strategy for supporting depression treatment.

关键词： Mood disorders Stem cells transplant Mesenchymal stem-cells transplant Inflammation Immunomodulation Depression

Relational coordination and healthcare management in lung cancer

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World Journal of Clinical Cases 2014年第12期2卷 757-768页

作者： josé antonio Vinagre Romero Juan Del Llano Se?arís Carmen De Pablos Heredero Mark Nuijten Clinical Management Business Organization Entrepreneurship Health Administration Business Organization Universidad Rey Juan Carlos Respiratory Unit at La Paz University Hospital28046 Madrid Spain Community Health Gaspar Casal Foundation Universidad Pompeu Fabra-CRES 28006 Madrid Spain Economics Rey Juan Carlos University School of Social Sciences Doctoral Program in Business Organization and Entrepreneurship 28032 Madrid Spain Rotterdam School of Management Erasmus University University of Maastricht the University of Groningen 3062 PA Rotterdam The Netherlands

In the current socio-economic scenario characterized by a growing shortage of resources and progressive budget constraints, the need to better coordinate processes in health institutions appears as a relevant aspect to ensure the future sustainability of system. In this sense, Relational Coordination(RC) provides a valuable opportunity for the reconfiguration of clinical guidelines concerning isolated single-level considerations. In this research the RC model has been applied to explain best results in the process of diagnosing and offering clinical treatments for lung cancer. Lung cancer presents the higher rates of tumor's mortality worldwide. Through unstructured and informal interviews with clinicians at both levels(Primary/Specialist Care), a diagnosis of the situation in relation to joint management of lung cancer is provided. Solutions of continuity in terms of coordination are explained due to the observation of lack of effective knowledge transfer between the two levels. It is this disconnection which justifies the introduction of a modified model of RC for the study and implementation of transfer relations between the knowledge holders, in order to structure consolidated and cooperative evidence-based models that lead to a substantial shortening in the response times with a marked outcomes improvement. To our knowledge, the application of this model to a Public Health problem bringing together both levels of care, hasn't been made till now.

关键词： Relational Coordination Lung cancer Clinical pathway Dialogic practices High performance work systems Healthcare performance

T-cell allorecognition of donor glutathione S-transferase T1 in plasma cell-rich rejection

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World Journal of Hepatology 2017年第27期9卷 1115-1124页

作者： María josé Martínez-Bravo Berta Sánchez josé Manuel Sousa María josé Acevedo Miguel Angel Gómez-Bravo antonio Núnez-Roldán Isabel Aguilera Immunology Service Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla Digestive Diseases Service Hospital Universitario Virgen del Rocío Liver Transplant Unit Hospital Universitario Virgen del Rocío

AIM To investigate the role of glutathione S-transferase T1 donor-specific T lymphocytes in plasma cell-rich rejection of liver *** The study group included 22 liver transplant patients. Among them, 18 patients were mismatched for the glutathione S-transferase T1(GSTT1) alleles(don+/rec-), and 4 were matched(don+/rec+). Seven of the mismatched patients produced anti-GSTT1 antibodies and developed plasma cell-rich rejection(former de novo immune hepatitis). For the detection of specific Tlymphocytes, peripheral blood mononuclear cells were collected and stored in liquid nitrogen. The memory T cell response was studied by adding to the cell cultures to a mix of 39 custom-made, 15-mer overlapping peptides, which covered the entire GSTT1 amino acid sequence. The specific cellular response to peptides was analyzed by flow cytometry using the markers CD8, CD4, IL-4 and IFNγ.RESULTS Activation of CD8^+ T cells with different peptides was observed exclusively in the group of patients with plasma-cell rich rejection(3 out of 7), with production of IL-4 and/or IFNγ at a rate of 1%-4.92% depending on the peptides. The CD4^+ response was most common and not exclusive for patients with the disease, where 5 out of 7 showed percentages of activated cells from 1.24% to 31.34%. Additionally, two patients without the disease but with the mismatch had cells that became stimulated with some peptides(1.45%-5.18%). Highly unexpected was the finding of a double positive CD4^+CD8^(low) T cell population that showed the highest degree of activation with some of the peptides in 7 patients with the mismatch, in 4 patients with plasma cell-rich rejection and in 3 patients without the disease. Unfortunately, CD4^+CD8^(low) cells represent 1% of the total number of lymphocytes, and stimulation could not be analyzed in 9 patients due to the low number of gated cells. Cells from the 4 patients included as controls did not show activation with any of the peptides. CONCLUSION Patients

关键词： Donor-specific glutathione S-transferase T1 antibodies Indirect presentation Glutathione S-transferase T1-memory T cells De novo immune hepatitis Donor/recipient mismatch

Development and validation of a coastal ocean forecasting system for Puerto Rico and the *** islands

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Journal of Ocean Engineering and Science 2018年第3期3卷 223-236页

作者： M.solano M.Canals S.Leonardi Naval Research Laboratory Stennis Space Center MS 39529-5004 Center for Ocean Science and Engineering Department of engineering Sciences and MaterialsCaribbean Coastal Ocean Observing SystemUniversity of Puerto Rico at Mayaguez Dept.Mechanical Engineering The University of Texas at DallasTX USA

An ocean forecasting system has been developed for the coastal area of Puerto Rico and the *** *** paper presents the development and validation of the Puerto Rico Operational Regional Ocean Modeling System(PRO-ROMS)developed by the Caribbean Coastal Ocean Observing System(CARICOOS),which aims at improving currently available short-term forecasts of ocean currents for this region,and to resolve sub-mesoscale variability absent from the currently operational regional *** coastal ocean forecasting system is based on the Regional Ocean Modeling System(ROMS),and provides a 3-day forecast of ocean currents,water levels,temperature and *** and lateral boundary conditions are derived from the *** Oceanographic Office(NAVOCEANO)operational AmSeas forecasting system,a 3.6-km resolution application of the regional Navy Coastal Ocean Model(NCOM)that encompasses the Gulf of Mexico and Caribbean *** conditions are interpolated from the Navy’s Coupled Ocean-Atmosphere Mesoscale Prediction System(COAMPS)with the exception of surface stresses,which are computed from a 2-km application of the Weather Research and Forecasting(WRF)model used by National Centers for Environmental Protection’s(NCEP)National Digital Forecast Database(NDFD).Tidal variability is imposed using ROMS spectral forcing by specifying the harmonic phases and amplitudes from the TPXO global inverse tide solutions at the boundaries and sub-tidal conditions are imposed by filtering out high frequencies of barotropic variables from the lateral boundary conditions interpolated from *** results of sea surface height are validated with NOAA tide gauges,ocean currents are validated with Acoustic Doppler Current Profilers(ADCP)and High Frequency Radars(HFR).Computed statistics show improvement of the ocean current forecast in PRO-ROMS compared to AmSeas,especially at higher frequencies dominated by the tides and in small channels where the bathymetry is

关键词： Ocean modeling Operational oceanography Forecasting

Characterization of Gromov Hyperbolic Short Graphs

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Acta Mathematica Sinica,English Series 2014年第2期30卷 197-212页

作者： josé Manuel RODRIGUEZ Departamento de Matemticas Universidad Carlos III de MadridAvenida de la Universidad 30

To decide when a graph is Gromov hyperbolic is,in general,a very hard *** this paper,we solve this problem for the set of short graphs（in an informal way,a graph G is r-short if the shortcuts in the cycles of G have length less than r）：an r-short graph G is hyperbolic if and only if S9r（G）is finite,where SR（G）：=sup{L（C）：C is an R-isometric cycle in G}and we say that a cycle C is R-isometric if dC（x,y）≤dG（x,y）＋R for every x,y∈C.

关键词： Short graph Gromov hyperbolicity Gromov hyperbolic graph infinite graphs geodesics

Association of accelerometer-derived step volume and intensity with hospitalizations and mortality in older adults:A prospective cohort study

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Journal of Sport and Health Science 2022年第5期11卷 578-585页

作者： Asier Manas Borja del Pozo Cruz Ulf Ekelund joséLosa Reyna Irene Rodríguez Gómez joséantonio Carnicero Carreno Leocadio Rodríguez Manas Francisco J.García García Ignacio Ara GENUD Toledo Research Group University of Castilla-La ManchaToledo 45071Spain CIBER of Frailty and Healthy Aging(CIBERFES) Madrid 28029Spain Motivation and Behaviour Research Program Institute for Positive Psychology and EducationFaculty of Health SciencesAustralian Catholic UniversitySydneyNSW 2060Australia Department of Sports Medicine Norwegian School of Sport SciencesOslo 0806Norway Department of Chronic Diseases and Ageing Norwegian Institute of Public HealthOslo 0473Norway Geriatric Department Hospital Virgen del ValleToledo 45071Spain Geriatric Department Hospital Universitario de GetafeGetafe 28905Spain

Purpose:This study aimed to examine the associations of accelerometer-derived steps volume and intensity with hospitalizations and all-cause mortality in older ***:This prospective cohort study involved 768 community-dwelling Spanish older adults(78.8±4.9 years,mean±SD;53.9% females)from the Toledo Study for Healthy Aging(2012-2017).The number of steps per day and step cadence(steps/min) were derived from a hip-mounted accelerometer worn for at least 4 days at *** were followed-up over a mean period of 3.1 years for hospitalization and 5.7 years for all-cause *** proportional hazards regression models were used to estimate the individual and joint associations between daily steps and stepping intensity with hospitalizations and all-cause ***:Included participants walked 5835± 3445 steps/day with an intensity of 7.3± 4.1 steps/*** adjusting for age,sex,body mass index(BMI),education,income,marital status and comorbidities,higher step count(hazard ratio(HR)=0.95,95% confidence interval(95%CI:0.90-1.00,and HR=0.87,95%CI:0.81-0.95 per additional 1000 steps) and higher step intensity(HR=0.95,95%CI:0.91-0.99,and HR=0.89,95%CI:0.84-0.95 per each additional step/min) were associated with fewer hospitalizations and all-cause mortality risk,*** to the group having low step volume and intensity,individuals in the group having high step volume and intensity had a lower risk of hospitalization(HR=0.72,95%CI:0.52-0.98) and all-cause mortality(HR=0.60,95%CI:0.37-0.98).Conclusion:Among older adults,both high step volume and step intensity were significantly associated with lower hospitalization and all-cause mortality *** step volume and intensity may benefit older people.

关键词： Aging Follow-up Objective Physical activity Walking

Cost-effective synthesis of giant molecule acceptors(GMAs)for stable polymer solar cells

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Science China Chemistry 2024年第4期67卷 1041-1043页

作者： antonio Facchetti Department of Chemistry and the Materials Research Center Northwestern University2145 Sheridan Road60208 EvanstonIllinoisUSA School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive30332 AtlantaGeorgiaUSA

Polymer solar cells(PSCs)have emerged as a disruptive energy technology due to simple device architecture,earthabundant elemental composition,lightweight nature,and inherent mechanical flexibility[1,2].Via a strategic acceptordonor-acceptor(A-D-A)design of small-molecule acceptors(SMAs),device power conversion efficiency(PCE)has now increased>19%.

关键词： acceptor synthesis donor

Cohomology of Associative H-Pseudoalgebras

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Algebra Colloquium 2023年第4期30卷 541-554页

作者： josé I.Liberati Ciem-CONICET Medina Allende y Haya de la TorreCiudad Universitaria(5000)CórdobaArgentina

We define the cohomology of associative H-pseudoalgebras,and we show that it describes module extensions,abelian pseudoalgebra extensions,and pseudoalgebra first-order *** same results for the special case of associat... 详细信息

关键词： associative pseudoalgebra associative conformal algebra cohomology