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World Journal of Gastroenterology 2023年第21期29卷 3379-3384页

作者： joséM Ramia Department of Surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Publication in a peer-reviewed journal is the goal of any research *** of the most important(and possibly the least understood)aspects of the publication process is the choice of a suitable journal that is likely to a... 详细信息

关键词： Research Journal Altmetrics Publication

There is life after coking for Ir nanocatalyst superlattices

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Nano Research 2022年第8期15卷 6969-6976页

作者： antonio J.Martínez-Galera Haojie Guo Mariano D.Jiménez-Sánchez Stefano Franchi Kevin C.Prince josé M.Gómez-Rodríguez Departamento de Física de la Materia Condensada Universidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Elettra-Sincrotrone Trieste S.C.p.A. in Area Science ParkBasovizza(Trieste)34149Italy Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de MadridMadrid E-28049Spain

Achieving superior performance of nanoparticle systems is one of the biggest challenges in *** major phenomena,occurring during the reactions,hinder the development of the full potential of nanoparticle catalysts:sintering and contamination with carbon containing species,sometimes called ***,we demonstrate that Ir nanocrystals,arranged into periodic networks on hexagonal boron nitride(h-BN)supports,can be restored without sintering after contamination by persistent *** restoration yields the complete removal of carbon from the nanocrystals,which keep their crystalline structure,allowing operation without *** findings,together with the possibility of fine tuning the nanocrystals size,confer this nanoparticle system a great potential as a testbed to extract key information about catalysis-mediated oxidation *** the case of the CO oxidation by O2,reaction of interest in environmental science and green energy production,the existence of chemical processes not observed before in other nanoparticle systems is demonstrated.

关键词： catalysis coke nanoparticles scanning tunneling microscopy(STM) X-ray photoemission spectroscopy(XPS)

Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

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Cellular & Molecular Immunology 2021年第4期18卷 905-918页

作者： Cristina Tecchio Marco antonio Cassatella Department of Medicine Section of Hem atology and Bone Marrow Transplant UnitUniversity of VeronaVeronaItaly Department of Medicine Section of General PathologyUniversity of VeronaVeronaItaly

Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow *** role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against ***,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered ***,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation ***,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC *** also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)***,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also *** on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial ***,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.

关键词： neutrophils allogeneic hematopoietic stem cell transplantation(alloHSCT) alloHSCT-associated complications lowdensity neutrophils(LDNs) normal-density neutrophils(NDNs)

Optimal Coordinated Operation of Distributed Static Series Compensators for Wide-area Network Congestion Relief

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1374-1384页

作者： Camilo Andres Ordonez M antonio Gomez-Exposito Guillermo EVinasco M jose Maria Maza-Ortega IEEE Smart Wires Union CityUSA Department of Electrical Engineering University of SevilleSevillaSpain Interconexion Electrica SA Intercolombia Sevilla Spain

Relieving network congestions is a critical goal for the safe and flexible operation of modern power systems, especially in the presence of intermittent renewables or distributed generation. This paper deals with the real-time coordinated operation of distributed static series compensators(DSSCs) to remove network congestions by suitable modifications of the branch reactance. Several objective functions are considered and discussed to minimize the number of the devices involved in the control actions, the total losses or the total reactive power exchanged, leading to a non-convex mixed-integer non-linear programming problem. Then, a heuristic methodology combining the solution of a regular NLP with k-means clustering algorithm is proposed to get rid of the binary variables, in an attempt to reduce the computational cost. The proposed coordinated operation strategy of the DSSCs is tested on several benchmark systems, providing feasible and sufficiently optimal solutions in a reasonable time frame for practical systems.

关键词： Distributed static series compensation(DSSC) flexible AC transmission system(FACTS) mixed-integer non-linear programming(MINLP) wide-area network control

Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics

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Journal of Pharmaceutical Analysis 2024年第2期14卷 196-210页

作者： Mariola Olkowicz Khaled Ramadan Hernando Rosales-solano Miao Yu Aizhou Wang Marcelo Cypel Janusz Pawliszyn Department of Chemistry University of WaterlooWaterlooONCanada Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian UniversityKrakowPoland Latner Thoracic Surgery Research Laboratories Toronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada The Jackson Laboratory JAX Genomic MedicineFarmingtonCTUSA Division of Thoracic Surgery Department of SurgeryUniversity Health NetworkUniversity of TorontoToronto Lung Transplant ProgramTorontoONCanada

Adjuvant chemotherapy improves the survival outlook for patients undergoing operations for lung metastases caused by colorectal cancer (CRC). However, a multidisciplinary approach that evaluates several factors related to patient and tumor characteristics is necessary for managing chemotherapy treatment in metastatic CRC patients with lung disease, as such factors dictate the timing and drug regimen, which may affect treatment response and prognosis. In this study, we explore the potential of spatial metabolomics for evaluating metabolic phenotypes and therapy outcomes during the local delivery of the anticancer drug, oxaliplatin, to the lung. 12 male Yorkshire pigs underwent a 3 h left lung in vivo lung perfusion (IVLP) with various doses of oxaliplatin (7.5, 10, 20, 40, and 80 mg/L), which were administered to the perfusion circuit reservoir as a bolus. Biocompatible solid-phase microextraction (SPME) microprobes were combined with global metabolite profiling to obtain spatiotemporal information about the activity of the drug, determine toxic doses that exceed therapeutic efficacy, and conduct a mechanistic exploration of associated lung injury. Mild and subclinical lung injury was observed at 40 mg/L of oxaliplatin, and significant compromise of the hemodynamic lung function was found at 80 mg/L. This result was associated with massive alterations in metabolic patterns of lung tissue and perfusate, resulting in a total of 139 discriminant compounds. Uncontrolled inflammatory response, abnormalities in energy metabolism, and mitochondrial dysfunction next to accelerated kynurenine and aldosterone production were recognized as distinct features of dysregulated metabolipidome. Spatial pharmacometabolomics may be a promising tool for identifying pathological responses to chemotherapy.

关键词： Pulmonary metastases Colorectal cancer Adjuvant chemotherapy In vivo lung chemo-perfusion Solid-phase microextraction(SPME)microprobes Spatial metabolomics

Vitamin D-dependent microbiota-enhancing tumor immunotherapy

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Cellular & Molecular Immunology 2024年第10期21卷 1083-1086页

作者： josé M.Izquierdo Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 128049MadridSpain

The antitumor immune response plays a crucial role in successful cancer *** a recent article in Science,Giampazolias et al.[1]reported a vitamin D(VitD)-mediated antitumor mechanism in murine intestinal epithelial cells(IECs)associated with a specific microbiota signature(Bacteroides fragilis)that enhances the antitumor immune *** strong positive association between VitD-dependent microbiota and the antitumor immune response provides a proof-of-concept for supplementing immunotherapy regimens with VitD to strengthen antitumor immunity and improve immunotherapysuccess.

关键词： immunotherapy immunity vitamin

Novel insights into the sexual dimorphism-associated immune response

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Cellular & Molecular Immunology 2024年第8期21卷 804-806页

作者： josé M.Izquierdo Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 128049MadridSpain

In their recent article in Science,Chi et al.[1]characterized a mechanism that regulates tissue/organ-specific immunity in *** findings revealed that the androgen type 2 innate lymphoid cell-dendritic cell axis played a prominent role in a microbiota-and sex hormone-dependent *** observations implicate sexual immune dimorphism as a molecular,cellular and tissue/organ-specific regulatory hub for the(im)balance between health and *** factors,including nutritional status,diet,vital light-dark rhythms(i.e.,circadian and infradian rhythms)and the microbiota,shape the development and function of the immune system differently in males and females,which can result in differences in susceptibility to autoimmune diseases,malignancies and infectious diseases and affect the outcome of vaccination[3](Fig.1).

关键词： immunity al. diseases

Canola and Oat Forage Potential Evaluation in Four Early Planting Dates

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Phyton-International Journal of Experimental Botany 2019年第4期88卷 435-448页

作者： Juan Isidro Sánchez-Duarte David Guadalupe Reta-Sánchez joséantonio Cueto-Wong Arturo Reyes-González Esmeralda Ochoa-Martínez Campo Experimental La Laguna Instituto Nacional de Investigaciones ForestalesAgrícolas y Pecuarias(INIFAP).Blvd.JoséSantos Valdez 1200 Pte.Col.CentroMatamorosCoahuilaCP 27440México

Canola and oat forage potential may be affected by climatic conditions when sown *** objective of this study was to evaluate the forage canola and oat potential in four early sowing dates(September 11 and 25;October 9 and 23)during the 2012-2013 and 2013-2014 cycles in Matamoros,Coahuila,*** cycle duration,chemical composition,dry matter(DM),crude protein(CP),and net energy for lactation(NEL)yields were *** temperatures and long photoperiods affected crops seeded on September 11,accelerating growth and reducing canola(26.6%-31.7%)and oat(15.8%)DM *** of September 25,canola cv IMC 205 reached DM yields(7746 kg ha^(-1)-9276 kg ha^(-1))similar to those obtained by oat(8115 kg ha^(-1)-9507 kg ha^(-1)),while canola cv Hyola 401 obtained such yields only until October *** chemical composition was better than that found in oat,with higher CP,but lower acid detergent fiber(ADF)and neutral detergent fiber(NDF)*** equaled oat CP yields(972 kg ha^(-1)-1215 kg ha^(-1))in the first sowing date,while in the other three other canola sowings reached higher yields(1193 kg ha^(-1)-1889 kg ha^(-1)).As for NEL yields,no difference was observed between both *** best sowing date for canola is from September 25 on,with CP production advantages over oat.

关键词： Avena sativa L. Brassica napus L.var.oleifera chemical composition dry matter yield nutrients

Spatial analysis and structure of a cross-timber stand in the TallGrass Prairie Preserve (Pawhuska, Oklahoma)

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Journal of Forestry Research 2013年第1期24卷 47-52页

作者： josé Ramón Arévalo Departamento de Ecología Facultad de BiologíaUniversidad de La LagunaLa Laguna 38206Spain

I analyzed the spatial distribution and structure of trees in a cross timber forest in the Tallgrass Prairie Preserve （Pawhuska, Oklahoma, USA）. I mapped and measured diameter of all stems, saplings （〉1.5 m tall） and dead trees in a 4-ha plot. The stand was dominated by Quercus stellata and Q. marilandica. In total, I mapped 7,636 trees, consisting of 6,785 Q. stellata, 846 Q. marilandica, 2 Celtis occidentalis, 1 Fraxinus pensilvanica and 2 Prunus americana. For saplings, I mapped 54 Q. stellata and 21 Q. marilandica. The size class distribution of the two dominant species did not differ. The dominant mortality class was “standing dead”, while I only found saplings less than 2 m tall. The spatial distribution of the species indicated segregation in the use of the environment, generating a clumped univariate distribution of stems of the same species within radii of 30 m, but repulsion outside 30 m. This segregation can be explained by the different ecological requirements of each species.

关键词： conservation point pattern analysis Quercus stellata Q.marilandica size class distribution