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Oligodendroctyes:the forgotten players of d.a.etes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan antonio López-Villodres Beatriz garcía-d.a. departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Bionand) MálagaSpain

Oligodendrocytes(OLs),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a d.a. ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,OLs provide trophic support to neurons and ***,OL metabolism is important for OL well-being and the proper accomplishment of their functions,and OL metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

Stress tensors and quantification of fracture patterns to analyze connectivity and potential fluid flow in a mesa landform of the Northern Andes

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Journal of Mountain Science 2024年第1期21卷 271-291页

作者： garcÍA-ARIAS Sergio VELANd.a.Francisco ALVAREZ Angélica SANABRIA-GÓMEZ joséd TARAZONA Yessenia VARGAS María Camila Escuela de Geología Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia Escuela de Física Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia

This work applies stress tensors inversions and quantification of fracture patterns along the Mesa de Los Santos, in the Eastern Cordillera of Colombia, to better understand the potential fluid flow. It thus contributes to the conceptual hydrogeological model. The area was subdivided into three blocks, separated by the NW Potreros and the Los Santos faults, having minor inner faults of different orientations. This separation facilitates the analysis of the fractures measured in the field, which in general show high dip angles and.a.conjugate geometry in the northern block, tension fractures(Mode I) in the central block, and.a.random distribution in the southwestern block. WinTensor treatment of slickensides yielded.a.maximum horizontal stress(SHmax) of 111o, which coincides with the WNW-ESE tensor observed from the conjugate and tension joints. We then used Frac Pa Q to generate interpolation maps of fracture intensity and density. The maps show the highest values in the central block and the lowest in the northern block,where the precipitation is higher, causing intensive rock weathering and homogenization of the fracture planes. Although the highest values of connectivity by line are found to the south of the mesa, we suggest the possibility of greater flow from the recharge zone(NE) along bedding planes and open NW-SE fractures.

关键词： Mesa de Los Santos Colombia Win-Tensor FracPaQ Strike-slip faults Fractured.a.uifers

Federated Network Intelligence Orchestration for Scalable and.a.tomated FL-Based.a.omaly detection in B5G Networks

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Computers, Materials & Continua 2024年第7期80卷 163-193页

作者： Pablo Fernández Saura josé M.Bernabé Murcia Emilio garcía de la Calera Molina Alejandro Molina Zarca Jorge Bernal Bernabé antonio F.Skarmeta Gómez department of Information and Communications Engineering University of MurciaMurcia30100Spain University Center of defense Spanish Air Force AcademySan Javier30720Spain

The management of network intelligence in Beyond 5G(B5G)networks encompasses the complex challenges of scalability,dynamicity,interoperability,privacy,and *** are essential steps towards achieving the realization of truly ubiquitous Artificial Intelligence(AI)-based.a.alytics,empowering seamless integration across the entire Continuum(Edge,Fog,Core,Cloud).This paper introduces a Federated Network Intelligence Orchestration approach aimed.a. scalable and.a.tomated Federated Learning(FL)-based.a.omaly detection in *** leveraging a horizontal Federated learning approach based on the FedAvg aggregation algorithm,which employs a deep autoencoder model trained on non-anomalous traffic samples to recognize normal behavior,the systemorchestrates network intelligence to detect and prevent *** into a B5G Zero-touch Service Management(ZSM)aligned Security Framework,the proposal utilizes multi-domain and multi-tenant orchestration to automate and scale the deployment of FL-agents and.a.-based.a.omaly detectors,enhancing reaction capabilities against *** proposed FL architecture can be dynamically deployed.a.ross the B5G Continuum,utilizing a hierarchy of Network Intelligence orchestrators for real-time anomaly and security threat *** includes FL enforcement operations for interoperability and extensibility,enabling dynamic deployment,configuration,and reconfiguration on *** validation of the proposed solution was conducted through dynamic orchestration,FL,and real-time anomaly detection processes using a practical test *** of key performance metrics,leveraging the 5G-NIdd dataset,demonstrates the system’s capability for automatic and near real-time handling of anomalies and.a.tacks,including real-time network monitoring and countermeasure implementation for mitigation.

关键词： Federated learning 6G orchestration anomaly detection security policy

Novel insights into d-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： dina Medina-Vera antonio Jesús López-Gambero Juan antonio Navarro Carlos Sanjuan Elena Baixeras Juan decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONANd UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bord.a.x INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid.a.cumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly med.a.ed by the phosphorylation and.a.gregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 d.a.etes d-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

Cost-effective synthesis of giant molecule acceptors(GMAs)for stable polymer solar cells

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Science China Chemistry 2024年第4期67卷 1041-1043页

作者： antonio Facchetti department of Chemistry and the Materials Research Center Northwestern University2145 Sheridan Road60208 EvanstonIllinoisUSA School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive30332 AtlantaGeorgiaUSA

Polymer solar cells(PSCs)have emerged.a. a disruptive energy technology due to simple device architecture,earthabundant elemental composition,lightweight nature,and inherent mechanical flexibility[1,2].Via a strategic acceptordonor-acceptor(A-d.a.design of small-molecule acceptors(SMAs),device power conversion efficiency(PCE)has now increased>19%.

关键词： acceptor synthesis donor

Using fused filament fabrication to improve the tribocorrosion behaviour of 17-4 PH SS in comparison to other metal forming techniques

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Friction 2024年第10期12卷 2325-2343页

作者： Cristina garcÍA-CABEZÓN Juan Alfonso NARANJO Celia garcÍA-HERNÁNdEZ Cristina BERGES Gemma HERRANZ Fernando MARTÍN-PEdROSA Materials Engineering E.I.I.Universidad de ValladolidValladolid 47011Spain INEI-Escuela Técnica Superior de Ingeniería Industrial(ETSII) Universidad de Castilla La ManchaCastilla-La Mancha 13071Spain

Fused filament fabrication(FFF)is one of the additive manufacturing processes which has gained more interest because of its simplicity and *** technology is similar to the conventional metal injection moulding(MIM)process,consisting of the feedstock preparation of metal powder and polymer binders,followed by layer-by-layer 3d printing(FFF)or injection(MIM)to create green parts and,finally,debinding and ***,both technologies provide near-dense *** work presents an in-depth study of the processing method’s *** porosity,microstructure,hardness,corrosion,and tribocorrosion behaviour are compared for 17-4 PH SS samples processed from powder by additive manufacturing using FFF and MIM,as well as conventional powder metallurgy(PM)*** samples exhibited the highest macro and microhardness,while corrosion behaviour was similar for both MIM and FFF samples,but superior in comparison to conventional PM ***,the FFF-as fabricated samples displayed.a.significant improvement in tribocorrosion resistance that could be explained by the higher proportion of delta ferrite and retained.a.stenite in their microstructure.

关键词： 17-4 PH SS fused filament fabrication(FFF) metal injection moulding(MIM) corrosion behaviour powder metallurgy(PM) tribocorrosion behaviour

Metabolomics for the d.a.nosis of bladder cancer: A systematic review

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Asian Journal of Urology 2024年第2期11卷 221-241页

作者： Herney Andrés garcía-Perdomo Angélica María dávila-Raigoza Fernando Korkes division of Urology/Urooncology Department of SurgerySchool of MedicineUniversidad del ValleCaliColombia UROGIV Research Group School of MedicineUniversidad del ValleCaliColombia Urologic Oncology Division of UrologyABC Medical SchoolSao PauloBrazil

Objective: Metabolomics has been extensively utilized in bladder cancer (BCa) research, employing mass spectrometry and nuclear magnetic resonance spectroscopy to compare various variables (tissues, serum, blood, and urine). This study aimed to identify potential biomarkers for early BCa ***: A search strategy was designed to identify clinical trials, descriptive and.a.alytical observational studies from databases such as Medline, Embase, Cochrane Central Register of Controlled Trials, and Latin American and Caribbean Literature in Health Sciences. Inclusion criteria comprised studies involving BCa tissue, serum, blood, or urine profiling using widely adopted metabolomics techniques like mass spectrometry and nuclear magnetic resonance. Primary outcomes included description of metabolites and metabolomics profiling in BCa patients and the association of metabolites and metabolomics profiling with BCa d.a.nosis compared to control patients. The risk of bias was assessed using the Quality Assessment of Studies of d.a.nostic ***: The search strategy yielded 2832 studies, of which 30 case-control studies were included. Urine was predominantly used.a. the primary sample for metabolite identification. Risk of bias was often unclear inpatient selection, blinding of the index test, and reference standard.a.sessment, but no applicability concerns were observed. Metabolites and metabolomics profiles associated with BCa d.a.nosis were identified in glucose, amino acids, nucleotides, lipids, and.a.dehydes ***: The identified metabolites in urine included citric acid, valine, tryptophan, taurine, aspartic acid, uridine, ribose, phosphocholine, and carnitine. Tissue samples exhibited elevated levels of lactic acid, amino acids, and lipids. Consistent findings across tissue, urine, and serum samples revealed downregulation of citric acid.a.d upregulation of lactic acid, valine, tryptophan, taurine, glutamine, aspartic acid, uridine, rib

关键词： Metabolite Metabolomics Bladder cancer Metabolomicsprofile

Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice

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Neural Regeneration Research 2024年第9期19卷 2068-2074页

作者： Carolina Aguado Sara Badesso joséMartínez-Hernández Alejandro Martín-Belmonte Rocío Alfaro-Ruiz Miriam Fernández Ana Esther Moreno-Martínez Mar Cuad.a.o-Tejedor Ana garcía-Osta Rafael Luján Synaptic Structure Laboratory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Therapy for Neurological disease Program Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Pharmacology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain Neuropharmacology and Pain Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain department of Pathology Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenoble Alpes Grenoble Institut des NeurosciencesGrenobleFrance

Plaques of amyloid-β(Aβ)and neurofibrillary tangles are the main pathological characteristics of Alzheimer’s disease(Ad).However,some older adult people with Ad pathological hallmarks can retain cognitive *** the factors that lead to this cognitive resilience to Ad offers promising prospects for identifying new therapeutic *** hypothesis focuses on the contribution of resilience to changes in excitatory synapses at the structural and molecular levels,which may underlie healthy cognitive performance in aged.a. *** the Morris Water Maze test,we selected resilient(asymptomatic)and cognitively impaired.a.ed Tg2576 *** the enzyme-linked immunosorbent assay showed similar levels of Aβ42 in both experimental groups,western blot analysis revealed differences in tau pathology in the pre-synaptic supernatant *** further investigate the density of synapses in the hippocampus of 16-18 month-old Tg2576 mice,we employed stereological and electron microscopic *** findings indicated.a.decrease in the density of excitatory synapses in the stratum rad.a.um of the hippocampal CA1 in cognitively impaired Tg2576 mice compared with age-matched resilient Tg2576 and non-transgenic ***,through quantitative immunoelectron microscopy in the hippocampus of impaired.a.d resilient Tg2576 transgenic Ad mice,we uncovered differences in the subcellular localization of glutamate ***,the density of GluA1,GluA2/3,and mGlu5 in spines and dendritic shafts of CA1 pyramidal cells in impaired Tg2576 mice was significantly reduced compared with age-matched resilient Tg2576 and non-transgenic ***,the density of GluA2/3 in resilient Tg2576 mice was significantly increased in spines but not in dendritic shafts compared with impaired Tg2576 and non-transgenic *** subcellular findings strongly support the hypothesis that dendritic spine plasticity and synaptic machinery in the hippocampus play cr

关键词： aging Alzheimer´s disease cognitive hippocampus immunoelectron microscopy resilience synapse

Boron-containing compounds as labels,drugs,and theranostic agents for d.a.etes and its complications

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World Journal of d.a.etes 2024年第6期15卷 1060-1069页

作者： Marvin A Soriano-Ursúa R Ivan Cordova-Chávez Eunice d Farfan-garcía George Kabalka department of Physiology Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico department of Physiology Instituto Politécnico NacionalMexico City 11340Mexico department of Biochemistry Instituto Politécnico NacionalMexico City 11340Mexico department of Chemistry The University of TennesseeKnoxvilleTN 37996United States

d.a.etes is a disease with a high global *** strategies have failed to limit the ad.a.cement and impact of the *** early d.a.nosis and treatment will require the development of new *** this sense,boroncontaining compounds have been reported.a. agents with the ability to reduce glycemia and *** have also been used for labeling and measuring carbohyd.a.es and other molecules linked to the initial stages of d.a.etes and its *** addition,certain boron compounds bind to molecules related to d.a.etes development and their biological activity in the regulation of elevated ***,it should be noted that some boron compounds appear to exert beneficial effects on d.a.etes complications such as accelerating wound healing while ameliorating pain in d.a.etic patients.

关键词： Boron Carbohyd.a.es Metabolism d.a.etes Boronodipyrromethene