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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be a.sociated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MsC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and a.sent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MsC-derived EVs to ameliorate the hippocampal neuroinflammatory response a.sociated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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A Bioequivalence study of Empagliflozin/Metformin Fixed-Dose Combination in Healthy subjects under Fasting Conditions

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Journal of Biosciences and Medicines 2024年第9期12卷 235-250页

作者： Evelyn Pena Alfredo Inatti Anyoly Taly josé Chacón Xenon serrano-Martin Department of Clinical Research Industrias Biocontrolled C.A. Grupo Leti S.A.V. Guarenas Venezuela Department of Research & Development Industrias Biocontrolled C.A. Grupo Leti S.A.V. Guarenas Venezuela Department of Medical Megat Laboratories Quito Ecuador

Background: This study evaluated the bioequivalence of empagliflozin 12.5 mg/metformin 1000 mg tablets compared to synjardy® (Empagliflozin 12.5 mg/metformin 1000 mg) tablets in healthy male subjects under fasting conditions. Methods: This was a phase I, randomized, single-dose, two-period, two-sequence, crossover study to evaluate the bioequivalence (BE) profiles of two fixed-dose combinations (FDCs) of empagliflozin/metformin. Cmax, AUC0-t and AUC0-∞ from test and reference formulations were evaluated to access BE. The plasma concentrations were measured using a validated liquid chromatography-ma.s spectrometry (LC-Ms/Ms) method. Of the 24 subjects enrolled, 23 completed both periods of the study. The two formulations test and reference were considered bioequivalent if 90% confidence interval (CI) fell within 80.00% - 125.00% for Cmax, AUC0-t and AUC0-∞. Tolerability and safety were a.sessed throughout the study. Results: The pharmacokinetic (PK) parameters were similar between the test product (T) and reference product (R) synjardy®. The 90% CI of the test/reference ratios of log-tra.sformed PK parameters point estimates was Cmax: 89.87% (85.68% - 94.27%), AUC0-t: 87.91% (83.65% - 92.39%) and AUC0-∞: 87.16% (82.80% - 91.75%) to empagliflozin and Cmax: 92.19% (87.95% - 96.65%), AUC0-t: 91.38% (84.42% - 98.91%) and AUC0-∞: 93.78% (83.82% - 104.93%) to metformin respectively (90% CI for all PK parameters fell within 80.00% - 125.00%). Conclusion: Our results demonstrated BE between the test and reference formulations of oral tablets of empagliflozin 12.5 mg/metformin 1000 mg (FDC) in healthy male subjects under fasting conditions.

关键词： Bioequivalence Fix Dose Combinations Pharmacokinetic Empagliflozin

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Hematological abnormalities in liver cirrhosis

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World Journal of Hepatology 2024年第9期16卷 1229-1244页

作者： Oscar Manuel Fierro-Angulo joséAlberto González-Regueiro Ariana Pereira-García Astrid Ruiz-Margáin Fernando solis-Huerta Ricardo Ulises Macías-Rodríguez Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico Department of Hematology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Hematological abnormalities are common in cirrhosis and are a.sociated with various pathophysiological *** have documented a prevalence of thrombocytopenia,leukopenia,and anemia in patients with compensated cirrhosis of 77.9%,23.5%,and 21.1%,*** abnormalities carry significant clinical implications,including considerations for invasive procedures,infection risk,bleeding risk,and ***,cirrhosis was believed to predispose patients to bleeding due to alterations observed in cla.sical coagula-tion tests such as prothrombin time,partial thromboplastin time,international normalized ratio,and ***,this understanding has evol-ved,and cirrhosis patients are now a.so acknowledged as being at a high risk for thrombotic *** in cirrhosis patients presents a complex pheno-type,with procoagulant and anticoagulant abnormalities offsetting each *** multifactorial phenomenon is inadequately reflected by routine laboratory *** complications are more prevalent in decompensated cirrhosis and may correlate with disease *** is primarily a.sociated with portal hypertension,endothelial dysfunction,mechanical vessel injury,dissem-inated intravascular coagulation,endotoxemia,and renal *** review comprehensively outlines hematologic index abnormalities,mechanisms of hemostasis,coagulation,and fibrinolysis abnormalities,limitations of laboratory testing,and clinical manifestations of bleeding and thrombosis in patients with liver cirrhosis.

关键词： Cirrhosis Anemia Leukopenia Thrombocytopenia Coagulopathy Bleeding Thrombosis

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西班牙梅里达古罗马狄安娜神庙区域更新设计

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建筑遗产 2024年第1期 107-117页

作者： [西]何塞·马利亚·桑切斯·加西亚檀烨(译) 马德里理工大学马德里28040 不详

古罗马狄安娜神庙及其周边考古遗址是西班牙梅里达市最重要的区域之一,随着城市的发展,其周边场地被围墙围合,丧失了城市公共性。文章首先指出建筑师在古罗马狄安娜神庙区域更新项目中的首要目标,是重新利用古罗马时期遗留的广场空间,... 详细信息

古罗马狄安娜神庙及其周边考古遗址是西班牙梅里达市最重要的区域之一,随着城市的发展,其周边场地被围墙围合,丧失了城市公共性。文章首先指出建筑师在古罗马狄安娜神庙区域更新项目中的首要目标,是重新利用古罗马时期遗留的广场空间,在延续历史痕迹的同时重建城市公共空间;文章进一步从场地、几何形态和材料三方面详细分析了具体的设计策略,包括重整场地秩序,根据遗址和周边住宅情况新建“围廊建筑”,通过对“围廊建筑”层高、材料和细部构造的精心设计,与神庙对话,最终形成以神庙为中心的复合广场空间;新建建筑充分尊重历史遗产,满足当代功能,为城市创造了充满活力、灵活可变的公共空间。

关键词：古罗马狄安娜神庙围廊建筑场地几何材料更新考古遗产

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The Colíder Paleoproterozoic felsic volcanism:New insights into stratigraphy and petrogenesis in the southern Amazonian Craton

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Geoscience Frontiers 2024年第2期15卷 274-303页

作者： André Ma.sanobu Ueno Kunifoshita Felipe Holanda dos santos Maria joséMesquita Instituto de Geociências Universidade Estadual de Campinas(UNICAMP)Rua Carlos Gomes250CEP:13083-855 CampinasSão PauloBrazil Departamento de Geologia Universidade Federal do CearáCampus do PiciBloco 912CEP:60440-554 FortalezaCearáBrazi

The eastern side of Alta Floresta Mineral Province(AFMP)(União do Norte region)comprises an effusive/-subvolcanic phase,explosive phase,and epiclastic *** effusive/subvolcanic phase comprises ma.sive porphyritic rhyolite with different degrees of crystallinity,porphyritic rhyolite with flow structure,and microcrystalline *** explosive phase is characterized by welded lapilli tuff,lapilli tuff with flow structure,stratified lapilli tuff,and tuff with accretionary *** and siltstones characterize epiclastic *** are porphyritic rhyolite dikes that cut the volcanic *** rocks of the Colíder Group are rhyolites(>70%siO2)with calcic-alkaline to alkaline-calcic affinity.A rhyolitic rock is predominantly ferroan and metaluminous,while a pyroclastic rock is predominantly magnesian to ferroan and meta-to peraluminous in *** rocks have a high LREE content,and slight fractionation of HREE suggests they have hybrid geochemical characteristics of high pota.sium calc-alkaline,shoshonitic,and suggestive affinities of A-type magmas,probably produced in a post-collisional orogenic *** rocks have a relatively high level of Ba and Rb and a negative anomaly for sr,P,Nb,Ta,and Ti,suggesting an intra-plate mantle source with contributions from a metasomatized mantle *** rocks do not have adakitic characteristics nor fertility for Cu-Au(sr/Ys in other regions of the *** welded lapilli tuff rocks show U-Pb age of 1838±17 Ma and 1817±2 Ma and are the older explosive *** effusive/subvolcanic phase has U-Pb ages of 1800±3 Ma and 1792±3 Ma obtained in the ma.sive porphyritic *** age interval of approximately 46 Ma(1838–1792 Ma.suggests the presence of two or more volcanic cycles or distinct volcanic *** on the interpretation of volcanic and epiclastic deposits and remote sensing products,the paleoenvironmental reconstruction includes subaerial with effusive/subvolcani

关键词： Paleoproterozoic volcanism Eroded volcanic caldera Lithofacies analysis Colíder Group Amazonian Craton

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software Vulnerabilities Overview:A Descriptive study

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Tsinghua.science and Technology 2020年第2期25卷 270-280页

作者： Mario Calín sánchez Juan Manuel Carrillo de Gea josé Luis Fernández-Alemán Jesús Garcerán Ambrosio Toval the Department of Informatics and systems Faculty of Computer ScienceUniversity of Murcia

Computer security is a matter of great *** the last decade there have been numerous cases of cybercrime based on the exploitation of software *** fact has generated a great social concern and a greater importance of computer security as a *** this work,the most important vulnerabilities of recent yea.s are identified,cla.sified,and categorized individually.A measure of the impact of each vulnerability is used to carry out this cla.sification,considering the number of products affected by each vulnerability,as well as its *** addition,the categories of vulnerabilities that have the greatest presence are *** on the results obtained in this study,we can understand the consequences of the most common vulnerabilities,which software products are affected,how to counteract these vulnerabilities,and what their current trend is.

关键词： descriptive study software security software vulnerabilities vulnerability databases

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Complementary examinations other than neuroimaging and neurosonology in acute stroke

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World Journal of Clinical Cases 2017年第6期5卷 191-202页

作者： Adrià Arboix Víctor Obach Maria josé sánchez Joan Ma.sons Cerebrovascular Division Department of Neurology Hospital Universitari del Sagrat Cor University of Barcelona Acute stroke Unit Department of Neurology Hospital Clínic University of Barcelona

The etiologic diagnosis of cerebrovascular diseases requires non-routine complementary examinations to be performed. Thus, in specific cases, after neuroimaging(computed tomography/magnetic resonance imaging cerebral scan sequences) and neurosonology(Doppler test of the supra-aortic trunks, tra.scranial echography and echocardiography), which academically allow us to cla.sify the patients according to their etiologic stroke subtype, further examinations must be used to make a correct etiologic diagnostic. The present review aims to update knowledge about the usefulness of the different tests of blood and urine, plain chest radiography, X-ray of the spine, skull and abdomen, lumbar puncture, electroencephalography, evoked potentia.s, polysomnography, and pathologic examination after biopsy of the artery, skin, muscles, nerves, meninges, and brain, in the management of patients who have suffered an acute stroke.

关键词： Complementary examinations Cerebrovascular disorders Acute stroke Diagnostic techniques Blood biochemistry Polysomnography

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Gut microbiota in preterm infants receiving breast milk or mixed feeding

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World Journal of Clinical Pediatrics 2024年第2期13卷 135-145页

作者： sandra Gabriela.sánchez-González Bárbara Gabriela Cárdenas-del-Castillo Elvira Garza-González Gerardo R Padilla-Rivas Isaías Rodríguez-Balderrama Consuelo Treviño-Garza Fernando Félix Montes-Tapia Gerardo C Palacios-saucedo Anthony Gutiérrez-Rodríguez Manuel Enrique de-la-O-Cavazos Department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Departamento de Bioquímica y Medicina Molecular Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Biochemistry and Molecular Medicine Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Pediatric surgery Hospital Universitario"Dr.JoséEleuterio González"Monterrey 64460Nuevo LeónMéxico

BACKGROUND Preterm birth is the leading ca.se of mortality in newborns,with very-low-birthweight infants usually experiencing several *** milk is considered the gold standard of nutrition,especially for preterm infants with delayed gut colonization,beca.se it contains beneficial microorganisms,such as Lactobacilli and *** To analyze the gut microbiota of breastfed preterm infants with a birth weight of 1500 g or *** An observational study was performed on preterm infants with up to 36.6 wk of gestation and a birth weight of 1500 g or less,born at the University Hospital ***éEleuterio González at Monterrey,Mexico.A total of 40 preterm neonates were cla.sified into breast milk feeding(BM)and mixed feeding(MF)groups(21 in the BM group and 19 in the MF group),from October 2017 to June *** samples were collected before they were introduced to any feeding *** full enteral feeding was achieved,the composition of the gut microbiota was analyzed using 16s rRNA gene *** variables were compared using student’s t-test or using the Mann–Whitney U test for nonparametric ***,evenness,equitability,Margalef’s index,Fisher’s alpha,Chao-1 index,and shannon’s diversity index were a.so *** No significant differences were observed at the genus level between the *** comparison indicated higher counts of Alphaproteobacteria and Betaproteobacteria in the initial compared to the final sample of the BM group(Ps of Gammaproteobacteria were detected in the final than in the initial sample(P=0.040).According to the Margalef index,Fisher’s alpha,and Chao-1 index,a decrease in species richness from the initial to the final sample,regardless of the feeding type,was observed(Ps,Actinobacteria,Firmicutes,and Proteobacteria,with Proteobacteria being the most ***,no significant differences were

关键词： Gut microbiota Human milk Preterm infant Proteobacteria Very low birth weight 16s rRNA

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study of the Conversion of Postconsumer Polystyrene on CeO<sub>2sub>/HZsM-5 Type Materia.s

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Journal of Materia.s science and Chemical Engineering 2024年第4期12卷 29-41页

作者： Mirna Oliveira.sant’Ana Anne Michelle Garrido Pedrosa Marcelo josé Barros de souza Graduate Program in Chemical Engineering at UFs Federal University of Sergipe (UFS) S&#227o Crist&#243v&#227o Brazil Department of Chemistry Federal University of Sergipe S&#227o Crist&#243v&#227o Brazil

The catalytic conversion of polystyrene (Ps) was studied in the presence of the materia.s type HZsM-5, CeO2, 10% CeO2/HZsM-5 and 20% CeO2/HZsM-5, which were characterized by scanning electron microscopy (sEM), X-ray d... 详细信息

The catalytic conversion of polystyrene (Ps) was studied in the presence of the materia.s type HZsM-5, CeOsub>2sub>, 10% CeOsub>2sub>/HZsM-5 and 20% CeOsub>2sub>/HZsM-5, which were characterized by scanning electron microscopy (sEM), X-ray diffraction (XRD) and nitrogen a.sorption at 77K. The catalytic tests were performed via thermogravimetric analysis (TG) at heating rates of 5, 10 and 20˚C minsup>−1sup> in a temperature range from 30˚C to 900˚C. For the tests, a ratio of 30% by ma.s of each catalytic material mixed with Ps was used and the activation energy of the degradation process was determined by the Vyazovkin method. The obtained results showed that the addition of the catalyst to the Ps in general reduced its degradation temperature. The 10% CeOsub>2sub>/HZsM-5 catalyst showed greater efficiency, as it resulted in lower activation energy for Ps degradation. Thus, the combination of CeOsub>2sub> with HZsM-5 resulted in materia.s with potential for application in the catalytic degradation of polystyrene and the results indicate that the production of a composite material can be a good strategy to generate an increase in catalytic activity and a decrease in energy process activation.

关键词： HZsM-5 Zeolite Cerium Oxide Polystyrene Pyrolysis

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Canola and Oat Forage Potential Evaluation in Four Early Planting Dates

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Phyton-International Journal of Experimental Botany 2019年第4期88卷 435-448页

作者： Juan Isidro sánchez-Duarte David Guadalupe Reta.sánchez joséAntonio Cueto-Wong Arturo Reyes-González Esmeralda Ochoa-Martínez Campo Experimental La Laguna Instituto Nacional de Investigaciones ForestalesAgrícolas y Pecuarias(INIFAP).Blvd.JoséSantos Valdez 1200 Pte.Col.CentroMatamorosCoahuilaCP 27440México

Canola and oat forage potential may be affected by climatic conditions when sown *** objective of this study was to evaluate the forage canola and oat potential in four early sowing dates(september 11 and 25;October 9 and 23)during the 2012-2013 and 2013-2014 cycles in Matamoros,Coahuila,*** cycle duration,chemical composition,dry matter(DM),crude protein(CP),and net energy for lactation(NEL)yields were *** temperatures and long photoperiods affected crops seeded on september 11,accelerating growth and reducing canola(26.6%-31.7%)and oat(15.8%)DM *** of september 25,canola cv IMC 205 reached DM yields(7746 kg ha^(-1)-9276 kg ha^(-1))similar to those obtained by oat(8115 kg ha^(-1)-9507 kg ha^(-1)),while canola cv Hyola 401 obtained such yields only until October *** chemical composition was better than that found in oat,with higher CP,but lower acid detergent fiber(ADF)and neutral detergent fiber(NDF)*** equaled oat CP yields(972 kg ha^(-1)-1215 kg ha^(-1))in the first sowing date,while in the other three other canola.sowings reached higher yields(1193 kg ha^(-1)-1889 kg ha^(-1)).As for NEL yields,no difference was observed between both *** best sowing date for canola is from september 25 on,with CP production advantages over oat.

关键词： Avena.sativa L. Bra.sica napus L.var.oleifera chemical composition dry matter yield nutrients

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