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International Journal of Mining Science and Technology 2023年第5期33卷 555-571页

作者： Alberto Fernández joséa.sanchidrián Pablo Segarra Santiago Gómez Enming Li Rafael navarro Universidad Politécnica de Madrid–ETSI Minas y Energía Spain Universidad de Salamanca–GIR Charrock Spain

A procedure to recognize individual discontinuities in rock mass from measurement while drilling(MWD)technology is developed,using the binary pattern of structural rock characteristics obtained from in-hole images for *** from two underground operations with different drilling technology and different rock mass characteristics are considered,which generalizes the application of the methodology to different sites and ensures the full operational integration of MWD data *** approaches are followed for site-specific structural model building:a discontinuity index(DI)built from variations in MWD parameters,and a machine learning(ML)classifier as function of the drilling parameters and their *** prediction ability of the models is quantitatively assessed as the rate of recognition of discontinuities observed in borehole *** between the parameters involved in the models for each site,and differences in their weights,highlight the site-dependence of the resulting *** ML approach offers better performance than the classical DI,with recognition rates in the range 89%to 96%.However,the simpler DI still yields fairly accurate results,with recognition rates 70%to 90%.These results validate the adaptive MWD-based methodology as an engineering solution to predict rock structural condition in underground mining operations.

关键词： Drill monitoring technology Rock mass characterization Underground mining Similarity metrics of binary vectors Structural rock factor Machine learning

Mitochondria–cGAS–STInG axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez joséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal nLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the nLRP3(nOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the nLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal nLRP3 inflammasome complex and other nLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRnAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and nOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with nLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation nOD-,LRR-and pyrin domain-containing protein 3(nLRP3)

Spatial analysis and structure of a cross-timber stand in the TallGrass Prairie Preserve (Pawhuska, Oklahoma)

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Journal of Forestry Research 2013年第1期24卷 47-52页

作者： josé Ramón Arévalo Departamento de Ecología Facultad de BiologíaUniversidad de La LagunaLa Laguna 38206Spain

I analyzed the spatial distribution and structure of trees in a cross timber forest in the Tallgrass Prairie Preserve （Pawhuska, Oklahoma, USA）. I mapped and measured diameter of all stems, saplings （〉1.5 m tall） and dead trees in a 4-ha plot. The stand was dominated by Quercus stellata and Q. marilandica. In total, I mapped 7,636 trees, consisting of 6,785 Q. stellata, 846 Q. marilandica, 2 Celtis occidentalis, 1 Fraxinus pensilvanica and 2 Prunus americana. For saplings, I mapped 54 Q. stellata and 21 Q. marilandica. The size class distribution of the two dominant species did not differ. The dominant mortality class was “standing dead”, while I only found saplings less than 2 m tall. The spatial distribution of the species indicated segregation in the use of the environment, generating a clumped univariate distribution of stems of the same species within radii of 30 m, but repulsion outside 30 m. This segregation can be explained by the different ecological requirements of each species.

关键词： conservation point pattern analysis Quercus stellata Q.marilandica size class distribution

Past,present,and future of long-term treatment for hepatitis B virus

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World Journal of Gastroenterology 2023年第25期29卷 3964-3983页

作者： Teresa Broquetas josé A Carrión Liver Section Gastroenterology DepartmentHospital del MarBarcelona 08003Spain Institut Hospital del Mar D’Investigacions Mèdiques PSMARBarcelona 08003Spain Universitat Pompeu Fabra Facultat de Ciències de la Salut i de la VidaBarcelona 08003Spain

The estimated world prevalence of hepatitis B virus(HBV)infection is 316 *** infection was identified in 1963 and nowadays is a major cause of cirrhosis and hepatocellular carcinoma(HCC)despite universal vaccination programs,and effective antiviral ***-term administration of nucleos(t)ide analogues(nA)has been the treatment of choice for chronic hepatitis B during the last *** nA has shown a good safety profile and high efficacy in controlling viral replication,improving histology,and decreasing the HCC incidence,decompensation,and ***,the low probability of HBV surface antigen seroclearance made necessary an indefinite *** knowledge,in recent years,about the different phases of the viral cycle,and the new insights into the role of the immune system have yielded an increase in new therapeutic ***,several clinical trials evaluating combinations of new drugs with different mechanisms of action are ongoing with promising *** integrative literature review aims to assess the knowledge and major advances from the past of hepatitis B,the present of nA treatment and withdrawal,and the future perspectives with combined molecules to achieve a functional cure.

关键词： Hepatitis B Therapy Antigen Functional cure Antiviral agents Drug development

Minimization of methabenzthiazuron residues in leaching water using amended soils and photocatalytic treatment with TiO_2 and ZnO

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Journal of Environmental Sciences 2014年第4期26卷 757-764页

作者： jos Fenoll Pilar Flores Pilar Hellín Joaquín Hern'andez Simón navarro Department of Food Quality Murcia Institute of Agri-Food Research and Development Department of Agricultural Chemistry Geology and Pedology School of Chemistry University of Murcia Campus Universitario de Espinardo

In the present work, potential groundwater pollution by methabenzthiazuron （MTBU） and the effect of three different amendments （composted sheep manure, composted pine bark and spent coffee grounds） on its mobility were investigated under laboratory conditions. The efficiency of ZnO and TiO2 suspensions in the photocatalytic degradation of MTBU in leaching water was also investigated. The relative and cumulative breakthrough curves were obtained from disturbed soil columns. The presence and/or addition of organic matter drastically reduced the movement of the herbicide. On other hand, photocatalytic experiments showed that the addition of ZnO and TiO2 strongly enhances the degradation rate of this herbicide compared with the results of photolytic experiments under artificial light. ZnO appeared to be more effective in MTBU oxidation than TiO2. The results obtained point to the interest of using organic wastes and heterogeneous photocatalysis for reducing the pollution of groundwater by pesticide drainage.

关键词： groundwater pollution organic amendment pesticide movement photocatalytic oxidation semiconductor oxides

Coping with drought? The hidden microhabitat selection and underground movements of amphisbaenians under summer drought conditions

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Current Zoology 2024年第5期70卷 647-658页

作者： joséMartín Gonzalo Rodríguez-Ruiz joséJavier Cuervo Departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain

Habitat selection is a dynamic process that depends on many environmental variables that can vary with weather *** is important because,within a context of global change,extreme weather events,such as severe droughts,are predicted to become more *** examined the patterns of microhabitat selection and underground movements(using PIT-tag telemetry)of a strictly fossorial reptile,the north African checkboard amphisbaenian Trogonophis wiegmanni,during the summer drought *** aimed to test whether changes in strategies of habitat use and movements could allow this amphisbaenian to cope with unfavorable *** found that during the summer drought period,*** did not use the microhabitats in relationship to their availability,but particularly selected sites with high abundance of rocks but also areas under a high cover of bushes,where environmental conditions were more *** also found,using PIT-tag telemetry,that the numbers of *** individuals located under rocks and their activity(number of days with movements)decreased largely in ***,the animals were not entirely inactive,but,especially males were active below the ground under bushes and made some relatively long underground hidden movements between favorable areas.

关键词： arid environments fossoriality habitat selection movement ecology Trogonophis wiegmanni weather conditions

new strategies for ischemic stroke: internal photobiomodulation therapy

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neural Regeneration Research 2020年第9期15卷 1658-1659页

作者： Ramón Iglesias-Rey josé Castillo Clinical neurosciences Research Laboratory (LInC) Health Research Institute of Santiago de Compostela (IDIS) Clinical University Hospital Universidade de Santiago de Compostela

Epidemiology and physiopathology of ischemic stroke:Every year, around 15 million of people suffer a stroke event all around the world. Among those, around 6.7 million will die, and most of the survivors will suffer s... 详细信息

关键词： pathology Epidemiology ischemic

Appraising trapping efficiency of vegetative barriers in agricultural landscapes:Strategy based on a probabilistic approach based on a review of available information

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International Soil and Water Conservation Research 2024年第3期12卷 615-634页

作者： josé-Antonio Muñoz Gema Guzmán María-Auxiliadora Soriano josé A.Gómez Institute for Sustainable Agriculture(IAS)-CSIC Cordoba14004Spain Andalusian Institute of Agricultural and Fisheries Research and Training(IFAPA) Granada18004Spain Agronomy Department(DAUCO) University of CordobaCordoba14071Spain

Vegetative barriers have proven their effectiveness in controlling water erosion and enhancing other ecosystem services in agricultural *** characteristic has led to the conservation and promotion of vegetative barriers as landscape elements by the Common Agricultural Policy and other policy *** reviews have dealt with the trapping efficiency of vegetated barriers,although they usually focus on studies from humid climates where their implantation and survival are more ***,vegetated barriers are also an attractive alternative in arid and semi-arid *** limit competition for water and nutrients with crops to a reduced area compared to other best management practices,such as cover *** study presents a review of trapping efficiency of sediment,runoff,and nutrients(P and n)by vegetative barriers in regions of humid and arid,and semi-arid,climates,and a strategy based on sediment trapping efficiency probability,which in turn is based on the results obtained from our *** types of independent variables were grouped and identified for the review:related to the vegetative barrier dimension(buffer width,slope of the plot,and buffer area ratio),and related to the experimental conditions(type of vegetation in the buffer,soil protection of the non-buffered area,type of climate,type of experimental measurement and origin of rainfall).An explor-atory analysis evaluated the significance of the experimental variables,which identified the need to focus on experiments under natural rainfall since those carried out with simulated rainfall presented statis-tically significant *** general,average trapping efficiencies for runoff and sediment were 40.1 and 62.6%,*** nutrients,values of trapping efficiencies had an average of 44.9%for phosphorus and 38.4%for *** and sediment trapping efficiency in arid and semi-arid re-gions tended to be higher than in humid *** dimensional

关键词： Connectivity Sediment transport Runoff nutrients Experimental plots Buffer strip