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Stressful living in lower-quality habitats?Body mass,feeding behavior and physiological stress levels in wild wood mouse populations

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Integrative Zoology 2019年第1期14卷 114-126页

作者： Álvaro navarro-CASTILLA Isabel BARJA Department of Biology Unit of ZoologyFaculty of SciencesAutonomous University of MadridSpain

Wild populations are continuously subjected to changes in environmental factors that pose different challenges.Body condition and hormones have been commonly used as health indicators due to their potential correlation with fitness.In the present study,we analyzed whether habitats of different quality influenced body mass,food intake and physiological stress levels in wild wood mice(Apodemus sylvaticus).Field work was seasonally carried out in Holm oak woods and pine forests in central Spain.A total of 93 wood mice from 4 different populations(2 per habitat type)were live-trapped.From each captured individual we noted body mass and food intake,measured as the amount of bait remaining in each trap.The physiological stress levels were measured non-inva-sively in collected fresh feces by quantifying fecal corticosterone metabolites(FCM)with a 5a-pregnane-3ß,11ß,21-triol-20-one enzyme immunoassay.Wood mice abundances decreased from spring to summer,were higher in Holm oak woods than in pine forests and also resulted in different age-class distribution between both habitats.Individuals inhabiting pine forests showed a lower body mass and increased food intake,probably because of the comparatively lower food quality and availability in this habitat.Furthermore,these individuals showed increased physiological stress levels,likely due to the lower quality habitat in relation to both food and vegetation cover availability.Overall,besides affecting local wood mouse abundance,our study underscores the effect of habitat quality on body mass,food intake and the endocrine stress response.Considering the wood mouse’s piv-otal position in ecosystems,these results could help in the understanding of environmental traits hampering the viability of wild populations.

关键词： Apodemus sylvaticus body condition corticosterone environmental factors fecal corticosterone metabolites feeding behavior

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Changes in Mediterranean Coastline According to the Coastal Type and Land Cover under Climate Change:The Case of South-east Spain

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Journal of Geographical Research 2023年第2期6卷 34-47页

作者： Pedro Marcet Llorens josénavarro-Pedreño Departamento de Agroquímica y Medio Ambiente Universidad Miguel Hernández de ElcheAvd.de la Universidad SNElcheAlicante03202Spain

Coastline changes were analyzed considering the land cover types and the analysis of the causes that have determined these changes during the past decades.Through the overlapping of aerial photographs and GIS analysis,the results showed that the land surface increased with respect to the previous stage,gaining terrain to the sea,but this increment was caused by anthropogenic processes.In fact,without human pressure,the land surface beside the coastal line would have decreased,especially on the sandy beaches and coastal dunes.Therefore,the beaches are one of the most vulnerable ecosystems and geomorphological systems due to erosion and lack of sediment supply associated with the modified river courses(i.***.by the construction of reservoirs,concrete channeling,etc.),the inner land use changes,and the effects of global warming on the sea level.Climate change studies predict specific increases in the sea level along the coast.The aim of this work is to know if anthropic activity can reverse the effects of sea level rise and coastal erosion.In fact,it has been done for decades with measures aimed to correct impacts and favour economic activity(i.***.maintaining tourism resources)and not from the environmental issues.

关键词： Aerial photography Coastal changes Coastal erosion GIS analysis Sea level

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The effect of rippling on the mechanical properties of graphene

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Nano Materials Science 2022年第1期4卷 18-26页

作者： Guillermo Lopez-Polin Cristina Gomez-navarro Julio Gomez-Herrero Instituto de Ciencia de Materiales de Madrid CSICMadrid E 28049Spain Departamento de Física de La Materia Condensada Universidad Autónoma de MadridMadridE-28049Spain IFIMAC Condensed Matter Physics Center(IFIMAC).Universidad Autónoma de Madrid MadridE-28049Spain

Graphene is the stiffest material known so far but, due to its one-atom thickness, it is also very bendable.Consequently, free-standing graphene exhibit ripples that has major effects on its elastic properties. Here we will summarize three experiments where the influence of rippling is essential to address the results. Firstly, we observed that atomic vacancies lessen the negative thermal expansion coefficient(TEC) of free-standing graphene.We also observed an increase of the Young's modulus with global applied strain and with the introduction of small density defects that we attributed to the decrease of rippling. Here, we will focus on a surprising feature observed in the data: the experiments consistently indicate that only the rippling with wavelengths between 5 and 10 nm influences the mechanics of graphene. The rippling responsible of the negative TEC and anomalous elasticity is thought to be dynamic, i.e. flexural phonons. However, flexural phonons with these wavelengths should have minor effects on the mechanics of graphene, therefore other mechanisms must be considered to address our observations. We propose static ripples as one of the key elements to correctly understand the thermomechanics of graphene and suggest that rippling arises naturally due to a competition of symmetry breaking and anharmonic fluctuations.

关键词： Graphene Mechanical properties Atomic force microscopy Defects Ripples Stmain

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Classification of Some Nilpotent Class of Leibniz Superalgebras

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Acta Mathematica Sinica,English Series 2010年第5期26卷 799-816页

作者： Luisa M.CAMACHO josé R.GóMEZ Rosa M.navarro Bakhrom A.OMIROV Dpto. Matemática Aplicada I Universidad de Sevilla Dpto. de Matemáticas Universidad de Extremadura Institute of Mathemátics and Information Technologues Uzbekistan Academy of Science

The aim of this work is to present the description of Leibniz superalgebras up to isomorphism with characteristic sequence （n｜m - 1, 1） and nilindex n ＋ m.

关键词： Lie superalgebras Leibniz superalgebras nilindex charasteristic sequence

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Land Recycling,Food Security and Technosols

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Journal of Geographical Research 2021年第3期4卷 44-50页

作者： Teresa.rodríguez-Espinosa jose navarro-Pedreño Ignacio Gómez Lucas María Belén Almendro-Candel Department of Agrochemistry and Environment University Miguel Hernández of ElcheAvd.de la Universidad SN03202-ELCHEAlicanteSpain

The world population will grow up to 9.8 billion by 2050.The intensification in urban growth will occur on all continents and in all sizes of cities,especially in developing countries,experiencing a greater rising in urban agglomerations of 300,000 to 500,000 people,those of 500,000 to 1 million and those of 1 to 5 million,by 2035.In this way,the demand of soil to host human activities(land take)will increase,mainly affecting soils with greater agricultural potential close to cities,at the same time as the need for food will increase.Land rehabilitation can contribute to human food security,to enhance ecosystem services and,if made by waste Technosols,those are viable as substrate for urban agroforestry systems.Although the references for brownfield reclamation for urban agriculture,adding constructed Technosols and de-sealed soils can recover its ecosystem functions even food supply services and would be the solution in urban areas.

关键词： Brownfields Ecosystem services Land take Population growth Sealed soils Urban settlement

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Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV

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World Journal of Pediatrics 2019年第5期15卷 492-498页

作者： Isabel Cuéllar-Flores Talís Saínz Carlos Velo María Isabel González-Tomé Cristina García-navarro Caroclina Fernández-Mcphee Sara Guillén joséTomás Ramos Pilar Miralles Rafae Rubio joséIgnacio Bernardino Luis Prieto Pablo Rojo Santiago Jiménez de Ory Maria Luisa navarro CoRiSpe(FARO and NeuroCoRISpeS projects,RITIP-Traslational Research Network in Pediatric Infectious Diseases) Pediatric Department Hospital Clínico San CarlosMadridSpain Infectious Diseases Service Paed DepartmentHospital La PazMadridSpain La Paz Research Institute(IdiPAZ) MadridSpain Infectious Diseases Service Paed DepartmentHospital 12 de OctubreMadridSpain Infectious Diseases Service Paed DepartmentH.Gregorio MaranónMadridSpain Paed Department Hospital de GetafeMadridSpain Infectious Diseases Service H.Gregorio MaranónMadridSpain HIV Service Hospital 12 de OctubreMadridSpain Infectious Diseases Service Hospital La PazMadridSpain Instituto de Investigación Sanitaria Hospital Gregorio Maranón(IiSGM) MadridSpain Universidad Complutense de Madrid MadridSpain Translational Research Network in Pediatric Infectious Diseases(RITIP) MadridSpain 不详

Background Studies investigating health-related quality of life(HRQoL)in youth with perinatally acquired HIV(PHIV+)are scarce.This study aimed to compare HRQoL of PHIV+to sociodemographic-matched youth not living with HIV(HIV-),Spanish general youth population,and to explore associations between sociodemographic variables,drug consumption,and HRQoL.Methods PHIV+youth were randomly selected from CoRISpe database(Cohort of the Spanish Pediatric HIV Network).HRQoL was evaluated by SF-12v2.Results Thirty-nine PHIV+youth(mean age:23.36 years,SD=3.83)and thirty-nine HIV-youth(mean age:22.97 years,SD=3.80)participated in this study.PHIV+obtained lower scores in SF-12 physical health subscale(PCS)than HIV-(P=0.001)and Spanish general youth population(P=0.006).PHIV+had lower scores on the mental health subscale(MCS)than the Spanish general youth population(P<0.001).PHIV+who were at school obtained better scores than those were not at school.PHIV+youth who had used cocaine and cannabis had lower scores in MCS(P=0.002).Conclusions There is a need for HRQoL management in the associated medical follow-up.

关键词： Drug consumption Health-related quality of life Mental health Perinatally acquired HIV youth

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Intestinal pseudo-obstruction caused by herpes zoster:Case report and pathophysiology

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World Journal of Clinical Cases 2018年第6期6卷 132-138页

作者： Roberto Anaya-Prado josé V Pérez-navarro Ana Corona-Nakamura Michelle M Anaya-Fernández Roberto Anaya-Fernández Marian Eliza Izaguirre-Pérez Department of Surgery at Western Medical Center the Mexican Institute of Social Security Division of Research at Autonomous University of Guadalajara Department of Infectious Diseases at Western Medical Center the Mexican Institute of Social Security Division of Research at University of Guadalajara

Herpes zoster(HZ) infection occurs in approximately 10% to 30% of individuals. Visceral neuropathies secondary to HZ can cause cystitis and urinary retention. But colonic pseudo-obstruction can also occur. Peripheral neuropathy may reveal segmental motor paresis of either upper or lower limbs, the abdominal muscles or the diaphragm. We report the case of a 62-year-old male patient who presented with abdominal distention and cutaneous vesicular eruption on the left side of the abdominal wall. Plain X-rays and computed tomography scan showed distended small bowel. A diagnosis of intestinal pseudo-obstruction was made secondary to segmental paresis of the small intestine and visceral neuropathy. Conservative management was successful and the patient was discharged uneventfully. Intestinal pseudo-obstruction ought to be consideredwhen dealing with non-obstructive(adynamic) conditions of the digestive tract associated with HZ infection; since early recognition may help to avoid unnecessary surgery.

关键词： Ogilvie’s symdrome Herpes zoster virus Neuropathies Intestinal pseudo-obstruction

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Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

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Engineering 2021年第10期7卷 1393-1412页

作者： Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros rodrigo Sanz Jana Dziaková Javier rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-rodríguez Miren Alonso-navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García joséManuel Pingarrón Susana Campuzano rodrigo Barderas Chronic Disease Program(UFIEC) Carlos III Health InstituteMadrid E-28220Spain Department of Biochemistry and Molecular Biology Faculty of Optics and OptometryComplutense University of MadridMadrid E-28040Spain Gastroenterology Unit San Carlos Clinical HospitalMadrid E-28040Spain Surgical Pathology Department San Carlos Clinical HospitalMadrid E-28040Spain Translational Oncology Division OncoHealth InstituteJimenez Diaz Foundation University HospitalMadrid E-28040Spain Department of Biochemistry Faculty of MedicineAlberto Sols Institute of Biomedical ResearchCSIC-UAMMadrid E-28029Spain Department of Analytical Chemistry Faculty of Chemical SciencesComplutense University of MadridMadrid E-28040Spain Center for Biological Research Spanish National Research Council(CSIC)MadridE-28040Spain Molecular Pathology and Therapeutic Targets Group La Paz University Hospital(IdiPAZ)Madrid E-28046Spain

Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)de

关键词： Autoantibodies Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care Biosensors

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Enzymes of Entomopathogenic Fungi, Advances and Insights

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Advances in Enzyme Research 2014年第2期2卷 65-76页

作者： Lluvia de Carolina Sánchez-Pérez Juan Esteban Barranco-Florido Silvia.rodríguez-navarro josé Francisco Cervantes-Mayagoitia Miguel ángel Ramos-López Departamento de Producción Agrícola y Animal Universidad Autónoma Metropolitana México City México Departamento de Sistemas Biológicos Universidad Autónoma Metropolitana México City México Facultad de Química Universidad Autónoma de Querétaro Querétaro México

Entomopathogenic fungi (EF) are recognized biological control agents of insects. Basically, the entomopathogenic fungi pathogen activity depends on the ability of its enzymatic equipment, consisting of lipases, proteases and chitinases, which are in charge of breaking down the insect’s integument. Lipases are the first enzymes synthesized by the entomopathogenic fungi. Recently, a cytochrome P450 subfamily, referred as CYP52XI and MrCYP52 has been identified in Beauveria bassiana and Metarhizium robertsii, respectively. These break down long-chain alkenes and fatty acids to become initial nutrients. Subsequently, subtilisin type (Pr1) proteases sintetize;these enzymes are considered as virulence indicators and they are regulated by a signal transduction mechanism activated by the protein kinase A (PKA) mediated by AMPc. Through the employment of genetic engineering, it has been possible to increase virulence producing Pr1 recombinants with Androctonus australis neurotoxins or with chitinases, reducing the insect’s time of death. In the course of time, the Pr1 protease gene has presented evolutionary adaptations by gene duplication or horizontal transfer infecting different orders of insects. In the same way, the entomopathogenic fungi chitinases have presented a functional diversification. Currently, these have been phylogenetically classified into three subgroups, in accordance to the catalytic site domain and the chitin binding domain. The chitinolytic activity has increased through a directed evolution processes and genetic recombination with Bombyx mori chitinase. Recently, enzymes have been employed as control agents for insects and phytopathogenic fungi (disease originator) opening new potentialities in order to improve the entomopathogenic fungi use. Solid state fermentation is a bioprocess that would produce at great scale enzymes and some other metabolites in grade of increasing the entomopathogenic fungi virulence, in the control of insects and potentially in some diseases affecting plants.

关键词： Lipases Proteases Chitinases Host Evolution Biocontrol Agent

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Lipid bound extended release buprenorphine(high and low doses)and sustained release buprenorphine effectively attenuate post-operative hypersensitivity in an incisional pain model in mice(Mus musculus)

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Animal Models and Experimental Medicine 2021年第2期4卷 129-137页

作者： Kaela navarro Katechan Jampachaisri Monika Huss Cholawat Pacharinsak Department of Comparative Medicine Stanford UniversityStanfordCAUSA Department of Mathematics Naresuan UniversityPhitsanulokThailand

Background:Extended-release buprenorphine(XR)is indicated for pain management in rodents,but little is known about its use in mice.This study aimed to investigate whether high dose XR effectively attenuates post-operative hypersensitivity better than low dose XR in a mouse model of incisional pain.Methods:Mice(n 44)were randomly assigned to 1 of 4 treatment groups:(a)saline(1 ml/kg SC,once);(b)sustained release buprenorphine(Bup-SR,1 mg/kg SC,once);(c)low dose extended-release buprenorphine(XR-lo,3.25 mg/kg SC,once);(d)high dose extended-release buprenorphine(XR-hi,6.5 mg/kg SC,once).On days􀆴1,0(4 hours),1,2,and 3,mechanical and thermal hypersensitivities were evaluated,and plasma buprenorphine concentrations were measured.Results:Mechanical(days 0-2)and thermal(days 0-1)hypersensitivities were ob-served in the saline group.Bup-SR,XR-lo,and XR-hi attenuated mechanical hyper-sensitivity on days 0,1,and 2.None of the treatment groups,except XR-Lo on day 0,attenuated thermal hypersensitivity on days 0 or 1.Plasma buprenorphine concen-tration peaked at 4 hours(day 0)in all treatment groups and remained greater than 1 ng/mL on days 0-2.No abnormal clinical observations or gross pathologic findings were seen in any groups.Conclusion:The results indicate XR-hi did not effectively attenuate post-operative hypersensitivity better than XR-lo.Thus both 3.25 and 6.5 mg/kg XR are recom-mended for attenuating post-operative hypersensitivity for at least up to 48 hours in mice.

关键词： analgesia analgesics buprenorphine mouse pain management

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