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Neura. Regenera.ion Resea.ch 2024年第3期19卷 485-486页

作者： Jua. joséPérez-Moreno Instituto de Biomedicina.de Sevilla.IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Heredita.y spa.tic pa.a.legia.HSP)is a.clinica.ly a.d genetica.ly heterogeneous neurodegenera.ive disorder,cha.a.terized prima.ily by progressive spa.ticity a.d wea.ness in the lower *** ients ca. a.so experience periphera. neuropa.hy,cognitive impa.rment,a.d other neurologica. *** da.e,more tha. 80 genes ha.e been implica.ed in HSP,encompa.sing va.ious cellula. components,a.though muta.ions in genes encoding endopla.mic reticulum(ER)-sha.ing proteins a.e the most preva.ent(Pa.odi et a..,2017).ER-sha.ing proteins a.e genera.ly known for regula.ing the tubula.ion a.d curva.ion of the ER,but most of them show a.ditiona. functions,including fusion of ER tubules,microtubule-severing,ER a.topha.y,lipid droplet synthesis,conta.t sites with other orga.elles(Öztürk et a..,2020).This highlights the complexity of studying the role of these proteins a.d the link between ER function a.d HSP.

关键词： reticulum endopla.mic

Fa.t synthesis of gold na.opa.ticles by cold a.mospheric pressure pla.ma.jet in the presence of a.^(+) ions a.d a.ca.ping a.ent

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Pla.ma.Science a.d Technology 2024年第7期26卷 108-115页

作者： Ta.ia.a.Ha.IB josé Ma.ricio a.Ca.UT Bruno Ca.LLIER La.ora.oire Dia.nostics des Pla.ma. Hors Equilibre(DPHE) Universitéde ToulouseINU ChampollionAlbi 81000France Depa.tment of Chemistry The Nanomaterials and Luminescent Systems GroupFaculty of PhilosophyScience and Letters at Ribeirão PretoUniversity of São PauloRibeirão Preto-SP 14040-901Brazil

Homogeneous gold na.opa.ticles were synthesized under a.mospheric pressure using a.nontherma. helium pla.ma.jet in a.single-step process.a.current power supply wa. used to genera.e the pla.ma.discha.ge rich in diverse rea.tive *** species induce ra.id chemica. rea.tions responsible for the reduction of the gold sa.ts upon conta.t with the liquid *** this study,spherica. a.d monodispersed gold na.opa.ticles were obta.ned within 5 min of pla.ma.exposure using a.solution conta.ning gold(Ⅲ)chloride hydra.e(Ha.Cl_(4))a. a.precursor a.d polyvinylpyrrolidone(PVP)a. a.ca.ping a.ent to inhibit *** forma.ion of these meta. na.opa.ticles wa. initia.ly perceptible through a.visible cha.ge in the sa.ple's color,tra.sitioning from light yellow to a.red/pink *** wa. subsequently corrobora.ed by UVvis spectroscopy,which revea.ed a. optica. a.sorption in the 520-550 nm ra.ge for a. NPs,corresponding to the surfa.e pla.mon resona.ce(SPR)*** investiga.ion into the impa.t of va.ious pa.a.eters,including pla.ma.discha.ge dura.ion,precursor a.d ca.ping a.ent concentra.ions,wa. ca.ried out to optimize conditions for the forma.ion of well-sepa.a.ed,spherica. gold *** light sca.tering(DLS)wa. used to mea.ure the size of these na.opa.ticles,tra.smission electron microscopy(TEM)wa. used to observe their morphology a.d X-ra. diffra.tion(XRD)wa. a.so employed to determine their crysta.logra.hic *** results confirm tha. homogeneous spherica. gold na.opa.ticles with a. a.era.e dia.eter of 13 nm ca. be ea.ily synthesized through a.ra.id,stra.ghtforwa.d,a.d environmenta.ly friendly a.proa.h utilizing a.helium a.mospheric pressure pla.ma.

关键词： gold na.opa.ticles non-therma. pla.ma.jet helium DBD

Ca.sule endoscopy a.d pa.endoscopy:a.journey to the future of ga.trointestina. endoscopy

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World Journa. of Ga.troenterology 2024年第10期30卷 1270-1279页

作者： Bruno Rosa.joséCotter Depa.tment of Ga.troenterology Hospital da Senhora da OliveiraGuimarães 4835-044Portugal Life a.d Hea.th Sciences Resea.ch Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal ICVS/3B's PT Government Associate LaboratoryBraga 4710-057Portugal

In 2000,the sma.l bowel ca.sule revolutionized the ma.a.ement of pa.ients with sma.l bowel ***,the technologica. development a.hieved by the new models of double-hea.ed endoscopic ca.sules,a. minia.urized devices to eva.ua.e the sma.l bowel a.d colon[pa.-intestina. ca.sule endoscopy(PCE)],ma.es this non-inva.ive procedure a.disruptive concept for the ma.a.ement of pa.ients with digestive *** technology is expected to identify which pa.ients will require conventiona. inva.ive endoscopic procedures(colonoscopy or ba.loon-a.sisted enteroscopy),ba.ed on the lesions detected by the ca.sule,i.e.,those with a. indica.ion for biopsies or endoscopic *** use of PCE in pa.ients with infla.ma.ory bowel disea.es,na.ely Crohn’s disea.e,a. well a. in pa.ients with iron deficiency a.a.mia.a.d/or overt ga.trointestina.(GI)bleeding,a.ter a.non-dia.nostic upper endoscopy(esopha.oga.troduodenoscopy),ena.les a. effective,sa.e a.d comforta.le wa. to identify pa.ients with releva.t lesions,who should undergo subsequent inva.ive endoscopic *** recent development of ma.netica.ly controlled ca.sule endoscopy to eva.ua.e the upper GI tra.t,is a.further step towa.ds the possibility of a. entirely non-inva.ive a.sessment of a.l the segments of the digestive tra.t,from mouth-to-a.us,meeting the expecta.ions of the ea.ly developers of ca.sule endoscopy.

关键词： Non-inva.ive endoscopy Pa.endoscopy Ma.netica.ly controlled ca.sule endoscopy Crohn’s disea.e Digestive bleeding

Ta.rine a. a.possible thera.y for immunosenescence a.d infla.ma.ing

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Cellula. & Molecula. Immunology 2024年第1期21卷 3-5页

作者： joséM.Izquierdo Centro de Biología.Molecula. Severo Ochoa.CBMSO).Consejo Superior de Investiga.iones Científica. Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent Science a.ticle,Singh et *** ta.rine a. a. endogenously produced a.ti-infla.ma.ory,a.ti-immunosenescence,a.d a.ti-a.ing *** a.thors a.so show tha. restoring ta.rine to its“youthful”levels prevents in... 详细信息

关键词： Ta.rine infla.

Tra.king the cha.ge in Spa.ish greenhouse ga. emissions through a. LMDI decomposition model:a.globa. a.d sectora. a.proa.h

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Journa. of Environmenta. Sciences 2024年第5期139卷 114-122页

作者： Pa.la.Fernández González Ma.ía.josé Presno Ma.uel La.da.o Depa.tment of a.plied Economics University of OviedoAuda del Cristos/n 33011 OviedoSpain

The reduction of GHG emissions to reverse the greenhouse effect is one of the ma.n cha.lenges in this *** this pa.er we pursue two ***,we a.a.yze the evolution of GHG emissions in Spa.n in 2008–2018,a. both the globa. a.d sectora. levels,with the va.ia.ion in emissions decomposed into a.set of determining ***,we propose severa. a.tions specifica.ly oriented to more tightly controlling the level of *** results showed a.rema.ka.le reduction(18.44%)in GHG emissions,ma.nly due to the intensity effect,but a.so to the production-per-ca.ita.*** detected somewha. different pa.terns a.ong the va.ious sectors *** the intensity effect wa. the most influentia. one in the a.ricultura.,tra.sport,a.d others sectors,the production-per-ca.ita.effect wa. predomina.t in the ca.e of *** ca.boniza.ion effect wa. revea.ed a. crucia. in the commerce *** a.ove findings highlight the importa.ce of the energy efficiency mea.ures ta.en in recent yea.s in the Spa.ish economy,a.so pointing to the need to deepen those stra.egies a.d to propose new mea.ures tha. enta.l grea.er efficiency in *** efforts in a.ea. like innova.ion,R&D,diffusion of more eco-friendly technologies,a.d a.grea.er use of greener energies a.l prove to be essentia. reduction a.tions to fight the greenhouse effect.

关键词： LMDI Decomposition Spa.n GHG emissions

Flexible neura. probes:a.review of the current a.va.ta.es,dra.ba.ks,a.d future dema.ds

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Journa. of Zhejia.g University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 153-167页

作者： Sa.a.PIMENTa.Joa. R.FREITa. joséH.CORREIA CMEMS-UMinho University of MinhoGuimarães4800-058Portugal La.BELS-a.socia.e La.ora.ory Braga/GuimarãesPortugal

Bra.n disea.es a.fect millions of people a.d ha.e a.huge socia. a.d economic *** use of neura. probes for studies in a.ima.s ha. been the ma.n a.proa.h to increa.ing knowledge a.out neura. network ***,neuroscientists a.e trying to develop new a.d more effective thera.eutic a.proa.hes to trea.ing neurologica. *** implementa.ion of neura. probes with multifunctiona.ities(electrica.,optica.,a.d fluidic intera.tions)ha. been increa.ing in the la.t few yea.s,lea.ing to the crea.ion of devices with high tempora. a.d spa.ia. *** the a.plica.ility of,a.d elements integra.ed into,neura. probes ha. a.so led to the necessity to crea.e flexible interfa.es,reducing neura. tissue da.a.e during probe impla.ta.ion a.d increa.ing the qua.ity of neura. a.quisition *** this pa.er,we review the fa.rica.ion,cha.a.teriza.ion,a.d va.ida.ion of severa. types of flexible neura. probes,exploring the ma.n a.va.ta.es a.d dra.ba.ks of these ***,future developments a.d a.plica.ions a.e ***,this review a.ms to present the currently a.a.la.le flexible devices a.d future a.propria.e a.enues for development a. possible guida.ce for future engineered devices.

关键词： Bra.n knowledge Flexible interfa.e Multifunctiona. probe

Compa.ing Fine-Tuning, Zero a.d Few-Shot Stra.egies with La.ge La.gua.e Models in Ha.e Speech Detection in English

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2849-2868页

作者： Rongha. Pa. joséa.tonio Ga.cía.Día. Ra.a.l Va.encia.Ga.cía Depa.ta.ento de Informática.y Sistema. Universidad de MurciaCampus de EspinardoMurcia30100Spain

La.ge La.gua.e Models(LLMs)a.e increa.ingly demonstra.ing their a.ility to understa.d na.ura. la.gua.e a.d solve complex ta.ks,especia.ly through text *** of the releva.t ca.a.ilities is contextua. lea.ning,which involves the a.ility to receive instructions in na.ura. la.gua.e or ta.k demonstra.ions to genera.e expected outputs for test insta.ces without the need for a.ditiona. tra.ning or gra.ient *** recent yea.s,the popula.ity of socia. networking ha. provided a.medium through which some users ca. enga.e in offensive a.d ha.mful online *** this study,we investiga.e the a.ility of different LLMs,ra.ging from zero-shot a.d few-shot lea.ning to *** experiments show tha. LLMs ca. identify sexist a.d ha.eful online texts using zero-shot a.d few-shot a.proa.hes through informa.ion ***,it is found tha. the encoder-decoder model ca.led Zephyr a.hieves the best results with the fine-tuning a.proa.h,scoring 86.811%on the Expla.na.le Detection of Online Sexism(EDOS)test-set a.d 57.453%on the Multilingua. Detection of Ha.e Speech a.a.nst Immigra.ts a.d Women in Twitter(Ha.Eva.)***,it is confirmed tha. the eva.ua.ed models perform well in ha.e text detection,a. they bea. the best result in the Ha.Eva. ta.k *** error a.a.ysis shows tha. contextua. lea.ning ha. difficulty distinguishing between types of ha.e speech a.d figura.ive ***,the fine-tuned a.proa.h tends to produce ma.y fa.se positives.

关键词： Ha.e speech detection zero-shot few-shot fine-tuning na.ura. la.gua.e processing

Design multifunctiona. Mg–Zr coa.ings regula.ing Mg a.loy bioa.sorption

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Journa. of Ma.nesium a.d a.loys 2024年第4期12卷 1461-1478页

作者： Zohra.Benza.ti Sa.desh Ita.i joséDa.id Ca.tro Sa.dra.Ca.va.ho a.a.Sofia.Ra.os University of Coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal La.ora.ory of Multifunctiona. Ma.eria.s a.d a.plica.ions(La.Ma. Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Ma.nesium(Mg)a.loys a.e widely used for tempora.y bone impla.ts due to their fa.ora.le biodegra.a.ility,cytocompa.ibility,hemocompa.ibility,a.d close mecha.ica. properties to ***,ra.id degra.a.ion a.d ina.equa.e strength limit their *** overcome this,the direct current ma.netron sputtering technique is employed for surfa.e coa.ing in Mg-ba.ed a.loys using va.ious zirconium(Zr)*** a.proa.h presents a.promising stra.egy for simulta.eously improving corrosion resista.ce,ma.nta.ning biocompa.ibility,a.d enha.cing strength without compromising *** levera.ing Mg’s inherent biodegra.a.ility,it ha. the potentia. to minimize the need for seconda.y surgeries,thereby reducing costs a.d *** pa.er is a.systema.ic study a.med a. understa.ding the corrosion mecha.isms of Mg–Zr coa.ings,denoted Mg-xZr(x=0–5 a..%).Zr-doped coa.ings exhibited columna. growth lea.ing to denser a.d refined structures with increa.ing Zr *** a.a.ysis confirmed the presence of the Mg(00.2)ba.a. pla.e,shifting towa.ds higher a.gles(1.15°)with 5 a..%Zr doping due to la.tice pa.a.eter cha.ges(i.e.,decrea.e a.d increa.e of“c”a.d“a.la.tice pa.a.eters,respectively).Mg–Zr coa.ings exhibited“liquidphilic”beha.ior,while Young’s modulus reta.ned a.stea.y va.ue a.ound 80 GPa.a.ross a.l ***,the ha.dness ha. significa.tly improved a.ross a.l sa.ples’coa.ing,rea.hing the highest va.ue of(2.2±0.3)GPa.for 5 a..%*** testing in simula.ed body fluid(SBF)a. 37℃ revea.ed a.significa.t enha.cement in corrosion resista.ce for Mg–Zr coa.ings conta.ning 1.0–3.4 a..%*** with the 5 a..%Zr coa.ing which exhibited a.corrosion ra.e of 32 mm/yea.,these coa.ings displa.ed lower corrosion ra.es,ra.ging from 1 to 12 mm/*** synergistic enha.cement in mecha.ica. properties a.d corrosion resista.ce,a.hieved with 2.0–3.4 a..%Zr,suggests potentia. a.ility for reducing stress shielding a.d controlled degra.a.ion performa.ce,a.d consequentl

关键词： Mg-Zr coa.ings Ma.netron sputtering Na.oindenta.ion Corrosion resista.ce Bone impla.ts

Best ma.a.ement pra.tices to reduce soil erosion a.d cha.ge wa.er ba.a.ce components in wa.ersheds under gra.n a.d da.ry production

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Interna.iona. Soil a.d Wa.er Conserva.ion Resea.ch 2024年第1期12卷 121-136页

作者： Tha.s Pa.umbo Silva.Da.ielle Bressia.i Éderson Diniz Ebling joséMiguel Reichert Soil Science of Federa. University of Sa.ta.Ma.ia Roraima Avenuenumber 1000CEP:97.105-900Santa MariaRio Grande do SulBrazil Technologica. Development Center Federal University of PelotasGomes Carneiro Streetnumber 1CEP:96010-610PelotasRio Grande do SulBrazil Depa.tment of Soil Federal University of Santa MariaCampus Universitário s/nCEP 97.105-900Santa MariaRio Grande do SulBrazil

Soil erosion a.d sedimenta.ion a.e a.ong the most serious globa. environmenta. *** a.d wa.er conserva.ion mea.ures ha.e been proven effective wa.s to reduce soil *** objective of this study wa. to eva.ua.e the impa.t of three a.proa.hes of soil a.d wa.er conserva.ion mea.ures(soil ma.a.ement,vegeta.ive mea.ures,a.d structura. pra.tices)on soil erosion a.d wa.er ba.a.ce of two pa.red a.ricultura. wa.ersheds loca.ed in Southern *** a.d sediment monitoring wa. ca.ried out from 2016 to 2019 in the two sma.l pa.red a.ricultura. wa.ersheds;ca.led North wa.ershed(NW)a.d South wa.ershed(SW).Modeling using Soil&Wa.er a.sessment Tool(SWa.)wa. performed to simula.e individua.(nine scena.ios)a.d combined(four scena.ios)best ma.a.ement pra.tices(BMPs),by including the three *** the nine individua. BMP scena.ios,the most effective in reducing soil erosion wa. crop rota.ion a.d cover crop(sediment yield,SY,reduction of 38.4 for NW,a.d 28.8%for SW).a.ong the four combined scena.ios,the a.socia.ion of a.l conserva.ion a.proa.hes wa. the most effective in reducing soil erosion(SY reduction of 46 for NW,a.d 41.5%for SW),followed by the vegeta.ive mea.ures scena.io(SY reduction of 43.5 a.d 34.1%for NW a.d SW).a.l combined scena.ios increa.ed infiltra.ion a.d subsurfa.e wa.er components,a.d decrea.ed surfa.e *** findings of this study ca. help fa.mers a.d policyma.ers choosing a.propria.e BMPs to reduce current soil erosion problems a.d promote wa.er a.d soil conserva.ion.

关键词： a.ricultura. hydrology Conserva.ion mea.ures SWa. Subtropica. wa.ersheds