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Photosynthetic and Molecular Markers of CO_2-mediated Photosynthetic Downregulation in Nodulated Alfalfa

Journal of Integrative Plant Biology 2013年第8期55卷 721-734页

作者： Alvaro Sanz-Sez Gorka Erice Iker Aranjuelo Ricardo Aroca Juan manuel Ruíz-Lozano Jone Aguirreolea Juan jos Irigoyen manuel Sanchez-Diaz Department of Plant Biology University of NavarraPamplonaE-31008Spain Department of Plant Biology University of BarcelonaBarcelonaE-8028Spain Department of Plant Biology University of Illinois at Urbana-Champaign61801USA Agrobiotechnology Institute Public University of NavarraMutilva BajaE-31192Spain Department of Soil Microbiology and Symbiotic Systems Zaidin Experimental Station(CSIC)GranadaE-18008.Spain

Elevated CO2 leads to a decrease in potential net photosynthesis in long-term experiments and thus to a reduction in potential growth. This process is known as photosynthetic downregulation. There is no agreement on the definition of which parameters are the most sensitive for detecting CO2 acclimation. In order to investigate the most sensitive photosynthetic and molecular markers of CO2 acclimation, the effects of elevated CO2, and associated elevated temperature were analyzed in alfalfa plants inoculated with different Sinorhizobium meliloti strains. Plants （Medicago sativa L. cv. Aragon） were grown in summer or autumn in temperature gradient greenhouses （TGG）. At the end of the experiment, all plants showed acclimation in both seasons, especially under elevated summer temperatures. This was probably due to the lower nitrogen （N） availability caused by decreased N2-fixation under higher temperatures. Photosynthesis measured at growth CO2 concentration, rubisco in vitro activity and maximum rate of carboxylation were the most sensitive parameters for detecting downregulation. Severe acclimation was also related with decreases in leaf nitrogen content associated with declines in rubisco content （large and small subunits） and activity that resulted in a drop in photosynthesis. Despite the sensitivity of rubisco content as a marker of acclimation, it was not coordinated with gene expression, possibly due to a lag between gene transcription and protein translation.

关键词： Carbon dioxide Medicago sativa (alfalfa) photosynthetic downregulation RbcL and RbcS Sinorhizobium meliloti.

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Measuring the model risk-adjusted performance of machine learning algorithms in credit default prediction

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Financial Innovation 2022年第1期8卷 1930-1964页

作者： Andrés Alonso Robisco josémanuel CarbóMartínez Banco de España Calle de Alcalá4828014 MadridSpain

Implementing new machine learning(ML)algorithms for credit default prediction is associated with better predictive performance;however,it also generates new model risks,particularly concerning the supervisory validation *** industry surveys often mention that uncertainty about how supervisors might assess these risks could be a barrier to *** this study,we propose a new framework to quantify model risk-adjustments to compare the performance of several ML *** address this challenge,we first harness the internal ratings-based approach to identify up to 13 risk components that we classify into 3 main categories—statistics,technology,and market ***,to evaluate the importance of each risk category,we collect a series of regulatory documents related to three potential use cases—regulatory capital,credit scoring,or provisioning—and we compute the weight of each category according to the intensity of their mentions,using natural language processing and a risk terminology based on expert ***,we test our framework using popular ML models in credit risk,and a publicly available database,to quantify some proxies of a subset of risk factors that we deem *** measure the statistical risk according to the number of hyperparameters and the stability of the *** technological risk is assessed through the transparency of the algorithm and the latency of the ML training method,while the market conduct risk is quantified by the time it takes to run a post hoc technique(SHapley Additive exPlanations)to interpret the output.

关键词： Artificial intelligence Machine learning Credit risk Interpretability Bias Internal ratings based model IRB model Natural language processing NLP

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Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RICA registry

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Journal of Geriatric Cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel manuel Méndez-Bailón joséPérez-Silvestre joséMaría Fernández-Rodríguez Beatriz Cuesta García Adrián Argüelles-Curto Álvaro González-Franco Alicia Conde-Martel Sara Carrascosa-García Marta Sánchez-Marteles josémanuel Cerqueiro-González Noel Lorenzo-Villalba manuel Montero-Pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain Servicio de Medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain Servicio de Medicina Interna Consorcio Hospital General Universitario de ValenciaSpain Servicio de Medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain Servicio de Medicina Interna Hospital Universitario Central de AsturiasOviedoSpain Servicio de Medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain Servicio de Medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de Médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance Servicio de Medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BACKGROUND Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection *** PIONEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced NT-proBNP levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and ***-life studies in the elderly population are *** aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(ACEI)in elderly patients who initiate this treatment during hospitalization for acute *** We conducted a retrospective cohort study using the Spanish acute heart failure registry(RICA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with *** One hundred and ninety-nine patients hospitalized between October 2016 and November 2020 were included,with a median age of 82 years and high rate of *** these,107 were treated with sacubitril-valsartan and 92 with *** adjusted OR for readmission for HF at 3 months was 0.906(95%CI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%CI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%CI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%CI:0.325-1.612).CONCLUSION Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with ACEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission

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Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?

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World Journal of Pediatrics 2017年第1期13卷 76-83页

作者： Hoi Yan Tong Nicolás Medrano Alberto manuel Borobia joséAntonio Ruiz Ana María Martínez Julia Martín manuel Quintana Santos Garcfa Antonio jos6 Carcas Elena Ramirez Department of Clinical Pharmacology Hospital Universitario La PazIdiPAZSchool of MedicineUniversidad Autónoma de MadridMadridSpain Pediatric Emergency Department Hospital Universitario La PazIdiPAZMadridSpain General Emergency Department Hospital Universitario La PazIdiPAZMadridSpain

Background:There are few data Oll hepatotoxicity induced by acute or chronic paracetamol poisoning in the pediatric *** poisoning data can reveal the weakn嗍ofparacetamol poisoning management ***:We retrospectively studied the patients of less than 18 years old with measurable paracetamol levels,who were brought to the emergency department(ED)of La Paz University Hospital,Madrid,Spain,for suspected paracetamol overdoses between 2005 and 2010.

关键词： acute liver failure hepatotoxicity paracetamol poisoning

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Littoral-cell angioma of the spleen:A case report

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World Journal of Gastroenterology 2007年第48期13卷 6603-6604页

作者： ngel Cosme ngel Tejada Luis Bujanda manuel Vaquero josé Luis Elorza Evelia Ojeda Unai Goikoetxea Department of Gastroenterology Hospital Donostia Spain Department of Pathology Hospital Donostia Spain Departamet of Surgery Hospital Donostia Spain Department of Internal Medicine Hospital Donostia Spain

Littoral-cell angioma （LCA） is a primary splenic vascular tumor that arises from the normal littoral cells lining the sinus channels of the splenic red pulp. We report a case of LCA of the spleen, which has been infrequently communicated in the literature. A 76-year-old man with a 2-wk history of weight loss, abdominal pain and changes in bowel habits was admitted to our hospital. Imaging studies （CT and MR1） showed multiple lesions in the spleen. Splenectomy was performed. Lining cells were positive for CD31/CD68 markers. Our case was associated with a serrated colonic adenoma. LCA is a benign vascular tumor of the spleen that needs to be included in the differential diagnosis of multiple splenic nodules.

关键词： Littoral-cell angioma Spleen

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Association between vitamin D and hepatitis C virus infection: A meta-analysis

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World Journal of Gastroenterology 2013年第35期19卷 5917-5924页

作者： Livia Melo Villar josé Antonio Del Campo Isidora Ranchal Elisabeth Lampe manuel Romero-Gomez Laboratory of Viral Hepatitis Oswaldo Cruz Institute Fiocruz Rio de Janeiro RJ 210360-040 Brazil Unit for the Clinical Management of Digestive Diseases and CIBERehd Hospital Universitario de Valme41014 SevillaSpain

AIM:To evaluate the association between 25-hydroxyvitamin D[25(OH)D]and sustained virological response(SVR)in hepatitis C virus(HCV)infected ***:Relevant studies were identified by systematically searching MEDLINE databases up to March2012 and abstracts of the European and American Congress of Hepatology conducted in *** must provide information on SVR and the levels of 25(OH)D3and/or 25(OH)D2[henceforth referred to as 25(OH)D]in sera samples from HCV infected *** inclusion criteria were:clinical studies that included HCV infected patients aged older than 18 years regardless of HCV genotype or ethnic group;provided information on SVR rates;and were reported in the English languageas full *** to the heterogeneity of studies in categorizing serum vitamin D levels,a cut-off value of30 ng/mL of serum 25(OH)D was *** was assessed using *** summary odds ratios with their corresponding 95%CI were calculated based on a random-effects ***:Overall,11 studies(8 observational and 3interventional)involving 1575 individuals were included and 1117 HCV infected individuals(71%)showed low vitamin D *** of the studies included monoinfected HCV individuals with the mean age ranging from 38 to 56 *** studies were conducted in human immunodeficiency virus/HCV infected *** vitamin D measurement,most of the studies employed radioimmunoassays(n=5)followed by chemiluminescence(n=4)and just one study employed high performance/pressure liquid chromatography(HPLC).Basal vitamin D levels varied from 17 to43 ng/mL in the studies selected,and most of the HCV infected individuals had genotype 1(1068/1575)with mean viral load varying from log 4.5-5.9 UI/*** regard to HCV treatment,most of the studies(n=8)included HCV individuals without previous treatment,where the pooled SVR rate was 46.4%.High rates of SVR were observed in HCV individuals with vitamin D levels above 30 ng/mL(OR=1

关键词： Vitamin D Hepatitis C Therapy Metaanalysis Sustained virological response

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A comparative pattern of lectin-binding in the endometrial glands of the uterus and placenta of healthy buffaloes and bovines at early gestation

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BIOCELL 2021年第2期45卷 331-337页

作者： SERGIO GASTÓN CASPE josÉLUIS KONRAD DADIN PRANDO MOORE JUAN manuel SALA LILIAN LISCHINSKY CARLOS manuel CAMPERO CLAUDIO GUSTAVO BARBEITO Laboratory of Pathology Experimental Station MercedesInstituto Nacional de Tecnología AgropecuariaCorrientes3470Argentina Laboratory of Theriogenology School of Veterinary SciencesUniversidad Nacional del NordesteCorrientesW3402BKGArgentina Animal Health Group Experimental Station BalcarceInstituto Nacional de Tecnología AgropecuariaBalcarceB7620EMAArgentina Laboratory of Histology and Embryology School of Veterinary SciencesUniversidad Nacional de La PlataLa Plata1900Argentina

Water buffalo(Bubalus bubalis)and domestic cattle(Bos taurus)are closely related ***,embryo transfer interspecies has been attempted without any *** failure in hybrid embryo-implantation is associated with the glycocode in the maternal-fetal *** patterns have been studied in different species of ruminants;however,in ***,only the binucleated cells(BNC)have been *** glycocode is essential for a successful embryo-implantation and can be defined by Lectin-Histochemistry(LHC).The aim of this study is to compare the glycosylation pattern of placenta and uterus in water buffaloes and cattle by *** samples of placenta and uterus from pregnant Mediterranean female water buffaloes(Buf1)and Angus cows(Bov1)were *** animals were euthanized at 98 days of *** was carried out using twelve lectins(Con A,LCA,PSA,sWGA,PHA-e,SBA,UEA-1,WGA,RCA-1,PNA,DBA,BSA-1).The intensity of lectin binding was semiquantitatively scored using a scale of 0(negative)to 3(strongly positive).Difference between species was found in trophoblast layer by PSA,SWGA,PNA and BSA-1,in BNC,and in the mononuclear cells by LCA,PSA,PHA-e,DBA,BSA-1,*** utero,differences in the apical cellular membrane and the secretion of glands were identified by DBA and RCA-1,and in the cytoplasm of those glandular epithelial cells by PHA-e,BSA-1,WGA,and *** both species,BNC presented a strong positive reaction with DBA and SBA,a moderate response by LCA,PHA-e,BSA-1 and PNA lectin,and a low reaction by PSA,UEA-1,SWGA,WGA,Con A and *** results found in this study suggest that although both species are closely related,glycosylation patterns in the placenta and uterus are different,thus providing a possible reason for embryo transfer not being possible between these species.

关键词： Lectin-histochemistry Water buffalo Placenta Glycosylation pattern

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Trauma outcomes in nonfatal road traffic accidents:a Portuguese medico-legal approach

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Forensic Sciences Research 2022年第3期7卷 528-539页

作者： Flávia Cunha-Diniz Tiago Taveira-Gomes josémanuel Teixeira Teresa Magalhães CINTESIS—Faculty of Medicine University of PortoPortoPortugal IINFACTS—Institute of Research and Advanced Training in Health Sciences and Technologies Department of SciencesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal Fernando Pessoa University PortoPortugal Porto Healthcare Unity—Accidents Fidelidade—Insurance CompanyPortoPortugal

The objective of this study was to compare the outcomes of nonfatal road traffic accidents by the victims’age group and *** used the Portuguese medico-legal rules for personal injury assessment,in the scope of the Civil Law in that country,which includes a three-dimensional *** was a retrospective study including 667 victims of road traffic accidents aged 3–94 years *** final medico-legal reports all used the Portuguese methodology for personal injury *** were analysed by the victims’age group(children,working-age adults,and older people)and *** traffic accidents were generally serious(ISS mean 9.5),with higher severity in children and older *** most frequent body sequelae were musculoskeletal(64.8%),which were associated with functional and situational *** damage resulted in an average length of impairment of daily life of 199.6 days,171.7 days to return to work,and an average degree of quantum doloris(noneconomic damage related to physical and psychological harm)of 3.7/*** average permanent damage was 7.3/100 points for Permanent Functional Deficit,0.43/3 for Permanent Professional Repercussion,2/7 for Permanent Aesthetic Damage,3.9/7 for Permanent Repercussion on Sexual Activity and 3.2/7 for Permanent Repercussion on Sport and Leisure ***,19%of people became permanently dependent(10.6%needed third-party assistance).The medico-legal methodology used,considering victims’real-life situation,allows a comprehensive *** were several significant differences among the three age groups but none between *** differences and the impact of the more severe cases justify further detailed medico-legal studies in these specific situations on children,older people,and severely injured victims.

关键词： Forensic sciences traffic accident trauma injury damage outcome assessment legal medicine

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Site Characterization Index for Continuous Power Quality Monitoring Based on Higher-order Statistics

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 222-231页

作者： Olivia Florencias-Oliveros Juan-josé González-de-la-Rosa jose-María Sierra-Fernández Agustín Agüera-Pérez manuel-Jesús Espinosa-Gavira josé-Carlos Palomares-Salas Department of Automation Engineering ElectronicsArchitecture and Computers NetworksResearch Group TIC168Higher Polytechnic SchoolUniversity of CádizAlgeciras 11202Spain

The high penetration of distributed generation(DG)has set up a challenge for energy management and consequently for the monitoring and assessment of power quality(PQ).Besides,there are new types of disturbances owing to the uncontrolled connections of non-linear *** stochastic behaviour triggers the need for new holistic indicators which also deal with big data of PQ in terms of compression and scalability so as to extract the useful information regarding different network states and the prevailing PQ disturbances for future risk assessment and energy management *** and continuous monitoring would guarantee the report to claim for damages and to assess the risk of PQ *** this context,we propose a measurement method that postulates the use of two-dimensional(2D)diagrams based on higher-order statistics(HOSs)and a previous voltage quality index that assesses the voltage supply waveform in a continous monitoring *** suitable for both PQ and reliability applications,the results conclude that the inclusion of HOS measurements in the industrial metrological reports helps characterize the deviations of the voltage supply waveform,extracting the individual customers’pattern fingerprint,and compressing the data from both time and spatial *** method allows a continuous and robust performance needed in the SG ***,the method can be used by an average consumer as a probabilistic method to assess the risk of PQ deviations in site characterization.

关键词： Continuous statistical monitoring big data data compression higher-order statistics(HOSs) power quality(PQ)

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Dealing with Multisource Information for Estuarine Flood Risk Appraisal in Two Western European Coastal Areas

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International Journal of Disaster Risk Science 2022年第2期13卷 199-213页

作者： Ana Rodrigues Rilo Alexandre manuel de Oliveira Soares Tavares Paula Maria dos Santos Freire josé Luis Zêzere Estuarine and Coastal Zones Unit LNEC-National Civil Engineering Laboratory.1700-075 LisbonPortugal Centre of Geographical Studies Institute of Geography and Spatial PlanningUniversidade de Lisboa1700-066 LisbonPortugal Centre for Social Studies and Earth Sciences Department Coimbra University3030-790 CoimbraPortugal

Estuaries are usually affected by compound flooding triggers that cause diverse territorial *** fluvial flood risk assessment frameworks are well established in the literature,integrated management instruments that deal with estuarine flood risk remain incomplete and often *** research presents a methodology to extract relevant information from multiple sources post-event and a database building process that is applied to two contrasting estuaries(the Tagus River estuary in Portugal,and the Shannon River estuary in Ireland)in the Western European coastal ***,a total of 274 documents were analyzed and the information was stored in two *** correspondence analysis was applied to extract the most informative and relevant estuarine flood *** integrated estuarine flood risk assessment framework is presented and discussed based on the extracted *** framework is driven by two distinct dimensions(oceanic and hydrographic)and revealed the transversal position of triggers of estuarine floods,reflecting the compounding effects usually present in these *** results also highlight two levels of flood risk mostly based on damage typology.

关键词： Estuarine floods Estuarine flood indicators Multiple correspondence analysis Post-hazard multisource information Western Europe

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