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Is interferon-beta an alternative treatment for chronic hepatitis C?

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World Journal of gastroenterology 2006年第17期12卷 2730-2736页

作者： ricardo Moreno-Otero María Trapero-Mar.gán Elena gómez-Domínguez Luisa garcía-Buey joséA Moreno-Monteagudo Unit of Hepatology Hospital Universitario de La Princesa Universidad Autónoma de MadridSpain

The treatment of chronic hepatitis C （CHC） is still far from optimal, particularly for those subpopulations that do not respond to the standard combination therapy with Interferon-α （IFNα） plus ribavirin. Although in some cases the use of higher doses or longer treatment periods may be effective, these approaches are generally associated with a higher incidence of adverse events, which may either lead to a reduction in patient compliance or require dr.g withdrawal. IFNβ could represent an interesting alternative for treating CHC patients. Controversial data about IFNβ efficacy in CHC exist, the main reason being that many results stem from pilot studies with small cohorts of patients. However, promising results have been obtained in some subgroups of patients that fail to respond to IFNα. Additionally, the good tolerability of IFNβ represents an important advantage of the dr.g. The rates of dropouts in controlled clinical trials, as well as the need for dose reductions or treatment discontinuation are very low. It might be worth assessing the value of IFNβ plus ribavirin in randomized studies with a larger cohort of patients, not eligible or not tolerating standard therapy, and for non-responders.

关键词： Hepatitis C Hepatitis C virus Interferon beta ribavirin

Antenatal use of bosentan and/or sildenafil attenuates pulmonary features in rats with congenital diaphr.gmatic hernia

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World Journal of Pediatrics 2014年第4期10卷 354-359页

作者： María de Lourdes Lemus-Varela Amed Soliz Belinda Claudia gómez-Meda Ana Lourdes Zamora-Perez josé Manuel Ornelas-Aguirre Valery Melnikov Blanca Miriam Torres-Mendoza guillermo Moisés Zúñiga-gonzález Division of Neonatology High Specialty Medical UnitPediatric HospitalWestern National Medical CenterMexican Social Security InstituteGuadalajaraJaliscoMéxico Neonatal Intensive Care Unit Division of NeonatologyMiami Children's HospitalMiami FLDUSA Molecular Biology in Medicine Institute Molecular Biology and Genomic DepartmentHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Odontology research Institute Integrated Odontology Clinic DepartmentHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Pathology Department High Specialty Medical UnitNorth-western National Medical CenterMexican Social Security InstituteCiudad ObregónSonoraMéxico School of Medicine University of ColimaColimaMéxico Division of Neurosciences Western Biomedical Research CenterMexican Social Security Institute and Department of ClinicsHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Mutagenesis Laboratory Western Biomedical Research CenterMexican Social Security InstituteGuadalajaraJaliscoMéxico

Background:Lung hypoplasia,pulmonary persistent hypertension of the newborn and its morphological changes are the main features in congenital diaphr.gmatic hernia(CDH).This study was undertaken to investigate if antenatal use of sildenafil and/or bosentan attenuates vascular remodeling,promotes branching,and improves alveolarization in experimental nitrofeninduced ***:Nitrofen(100 mg)was gavage-fed to pr.gnant rats at post conception day(PCD)9 to induce *** rats were randomized to 5 groups:1)control;2)nitrofen;3)nitrofen+sildenafil 100 mg/kg per day at PCD 16-20;4)nitrofen+bosentan 30 mg/kg per day,at PCD 16-20,and 5)nitrofen+bosentan+sildenafil,same doses and administration *** cesarean delivery,the offsprings were sacrifi *** diaphr.gmatic defect and pulmonary hypoplasia were identified,and the lungs were *** wall thickness,bronchiolar density and alveolarization were ***:The offsprings with CDH were characterized by severe pulmonary hypoplasia(lung weight-to-body weight ratio:0.0263[95%confidence interval(CI)0.0242-0.0278)]in the nitrofen group versus 0.0385(95%CI 0.0355-0.0424)in the control group(P=0.0001).Pulmonary arterial wall thickness was decreased to 3.0(95%CI 2.8-3.7)μm in the nitrofen+sildenafil group versus 5.0(95%CI 4.1-4.9)μm in the nitrofen group(P=0.02).Terminal bronchioles increased to 13.7(95%CI 10.7-15.2)μm in the nitrofen+bosentan group in contrast to 8.7(95%CI 7.2-9.4)μm in the nitrofen group(P=0.002).More significant differences(P=0.0001)were seen in terminal bronchioles in the nitrofen+sildenafil+bosentan group than in the nitrofen group[14.0(95%CI 12.5-15.4)μm versus 8.5(95%CI 7.1-9.3)μm].Pulmonary arterial wall thickness was also decreased in the former ***:In this rat model,antenatal treatment with sildenafil attenuates vascular *** promotes the development of terminal bronchioles in nitrofen-induced CDH.

关键词： antenatal treatment bosentan congenital diaphr.gmatic hernia pulmonary hypoplasia sildenafil

Introduction, Establishment, and Invasion of Digitonthophagus gazella (Fabricius, 1787) (Coleoptera: Scarabaeinae) in the Savannas of Venezuela and Colombia

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Natural resources 2017年第5期8卷 370-381页

作者： Jorge Ari Noriega Oona Delgado Joffre Isnar Blanco Jorge gámez josé Clavijo Laboratorio de Zoología y Ecología Acuática—LAZOEA Universidad de Los Andes Bogotá Colombia Department of Biogeography and global Change National Museum of Natural Science (CSIC) Madrid Spain Museo del Instituto de Zoología Agrícola Francisco Fernández Yépez—MIZA Facultad de Agronomía Universidad Central de Venezuela Maracay Venezuela Laboratorio de Entomología Universidad Nacional Experimental del Táchira San Cristóbal Venezuela Fundación Entomológica Andina Mérida Venezuela

The invasion process involves overcoming certain barriers with negative effects on the biodiversity and ecosystem function. This is the case of the African dung beetle Digitonthophagus gazella, which was introduced in the United States and other countries in Central and South America to help in dung removal activity. The distribution of D. gazella has been documented in the Americas, but in Venezuela there is little information. Trying to understand the process of invasion of the Colombian-Venezuelan savannas and measure their potential impact, the information stored in collections and literature was collected. Five new state records were reported for Venezuela, as well as four scenarios of the process of introduction and establishment of this species in the r.gion. Although the amount of records has increased, the number of individuals sampled is still incipient. The possible areas of invasion and the potential negative effects that the presence of this species exerts in these r.gions are also discussed. In addition, potential areas of invasion and negative effects of this species are discussed. results emphasize the importance of generating models of the invasive process in order to design pr.grams that monitor the effects incurred by the presence of D. gazella on native species and propose control and mitigation mechanisms.

关键词： Anthropic Introduction Biodiversity Dung Beetles Invasive Species Scarabaeidae

Breakthrough on high-speed oscillation mode controlling in optoelectronic oscillator

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Science Bulletin 2018年第13期63卷 807-808页

作者： josécapmany Photonics research Labs ITEAM Research InstituteUniversitat Politecnica de ValendaCamino de Vera s/n46022 ValenciaSpain

The optoelectronic oscillator(OEO)is a hybrid electrical/photonic device that lever.ges on the use of a high Q-factor energy stor.ge element,such as a long and low loss fiber delay line to generate single frequency microwave signals with ultra-low phase noise[1–8].However,a long fiber delay line results in a long mode building time associated with the cavity round trip,which makes impossible to generate a

关键词：振荡器高速度动模控制微波信号长纤维 OEO 频率

Structural and optical properties of CZTS nanoparticles prepared by a colloidal process

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rare Metals 2021年第9期40卷 2602-2609页

作者： r.Aruna-Devi M.Latha S.Velumani joséÁlvaro Chávez-Carvayar Pr.gram on Nanoscience and Nanotechnology CINVESTAV-IPNSan Pedro Zacatenco07360 Mexico CityMexico CIICAp-UAEM Av.Universidad 1001.Col.Chamilpa62209 CuernavacaMorelosMexico Department of Electrical Engineering(SEES) CINVESTAV-IPNSan Pedro Zacatenco07360 Mexico CityMexico Instituto de Investigaciones en Materiales UNAM04510 Mexico CityMexico

This research presents the influence of copper(Cu) concentration on the properties of copper zinc tin sulfide(CZTS) nanoparticles(NPs) synthesized by a colloidal method, employing oleylamine as an organic solvent. From the structural analysis, a pure phase of CZTS was obtained at an optimized molar ratio of 1.8:1.1:1:4,and secondary phases were observed as the Cu concentration increased. The increment of the NPs size from 15 to50 nm was noticed as a function of Cu ***, the optical bandgap energy was tuned from1.35 to 1.68 eV with respect to Cu concentration. The sample synthesized at the molar ratio of 1.8:1.1:1:4 showed a pure phase CZTS with desired elemental composition and bandgap. Furthermore, CZTS thin films were prepared by a doctor-blade method using synthesized NPs followed by annealing under a sulfur/nitr.gen atmosphere. The annealed CZTS film showed a significant improvement in the morphological, electrical and optoelectronic ***, the annealed CZTS film can be efficiently used as an absorber layer in low-cost thin film solar cells.

关键词： CZTS Copper concentration Nanoparticles Thin film Annealing

Characterization of gromov Hyperbolic Short graphs

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Acta Mathematica Sinica,English Series 2014年第2期30卷 197-212页

作者： josé Manuel rODr.gUEZ Departamento de Matemticas Universidad Carlos III de MadridAvenida de la Universidad 30

To decide when a graph is gromov hyperbolic is,in general,a very hard *** this paper,we solve this problem for the set of short graphs（in an informal way,a graph g is r-short if the shortcuts in the cycles of g have length less than r）：an r-short graph g is hyperbolic if and only if S9r.g）is finite,where Sr.g）：=sup{L（C）：C is an r-isometric cycle in g}and we say that a cycle C is r-isometric if dC（x,y）≤dg（x,y）＋r for every x,y∈C.

关键词： Short graph gromov hyperbolicity gromov hyperbolic graph infinite graphs geodesics

Cohomology of Associative H-Pseudoalgebras

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Algebra Colloquium 2023年第4期30卷 541-554页

作者： josé I.Liberati Ciem-CONICET Medina Allende y Haya de la TorreCiudad Universitaria(5000)CórdobaArgentina

We define the cohomology of associative H-pseudoalgebras,and we show that it describes module extensions,abelian pseudoalgebra extensions,and pseudoalgebra first-order *** same results for the special case of associat... 详细信息

关键词： associative pseudoalgebra associative conformal algebra cohomology

Updates in immunotherapy for hepatocellular carcinoma

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Hepatoma research 2019年第10期5卷 19-31页

作者： Leonardo g.da Fonseca Flair joséCarrilho Medical Oncology São Paulo Clínicas Liver Cancer GroupHospital das Clínicas ComplexInstituto do Cancer do Estado de São PauloUniversity of São Paulo School of MedicineSão PauloSP 05403-000Brazil Department of gastroenterology São Paulo Clínicas Liver Cancer GroupHospital das Clínicas ComplexInstituto do Cancer do Estado de São PauloUniversity of São Paulo School of MedicineSão PauloSP 05403-000Brazil

Hepatocellular carcinoma(HCC)carries an unfavorable pr.gnosis and novel therapeutic strategies are *** now,only few systemic agents have improved survival in patients with advanced stage *** changed the landscape in several tumor types by producing unprecedented clinical outcomes with a favorable safety *** presents a particular immune-suppressive microenvironment and HCC develops in a background of chronic inflammation in the vast majority of *** this r.gard,immunotherapy may be a suitable *** research focused on therapies involving immune cells and anti-tumor immune response for HCC has shown encour.ging preliminary *** checkpoint inhibitors,such the anti-PD-1/PD-L1 monoclonal antibodies,have provided durable responses in patients with advanced stage disease,although the pioneers phaseⅢtrials did not confirm survival superiority over the available *** vaccines,adoptive cellular therapies and combinations of local modalities with immunotherapy are promising approaches under active research.

关键词： Hepatocellular carcinoma immunotherapy immunosuppression pr.gnosis immunology antibody vaccine

The effect of broadening the definition of generalized anxiety disorder on healthcare resource utilization and related costs in outpatient psychiatric clinics

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Open Journal of Psychiatry 2013年第1期3卷 158-167页

作者： josé M. Olivares josé L. Carrasco Enrique álvarez María Perez Vanessa López-gómez Javier rejas Department of Psychiatry Hospital de la Santa Creu i San Pau Universitat Autónoma de Barcelona Centro de Investigación Biomédica En Red de SAlud Mental (CIBERSAM) Barcelona Spain Department of Psychiatry Hospital Meixoeiro Complejo Hospitalario Universitario Vigo Spain Department of Psychiatry Instituto de Investigación Sanitaria Hospital Clínico San Carlos Centro de Investigación Biomédica En Red de SAlud Mental (CIBERSAM) Madrid Spain Health Economics and Outcomes research Department Pfizer S.L.U. Madrid Spain Medical Unit Pfizer S.L.U. Madrid Spain

Background: Patients with generalized anxiety disorder (gAD) are among the highest users of healthcare resources. The broadening of the DSM-IV criteria for.gAD has been a subject of controversy in the literature, but its consequences have not been analyzed to date. Objective: The purpose of this study was to analyze how the broadening of the DSM-IV criteria affects healthcare resource utilization and related costs. Methods: A multicentre, prospective, observational study was conducted in randomly selected outpatient psychiatric clinics between October 2007 and April 2008. Patients diagnosed according to DSM-IV or broader criteria (1 month of excessive or non-excessive worry and only 2 associated DSM-IV symptoms) for the first time were consecutively enrolled. Socio-demographic data, healthcare resources and corresponding costs were collected over a 6-month period. results: A total of 3549 patients were systematically recruited, 1815 in the DSM-IV criteria group (Dg) and1264 inthe broad criteria group (Bg). Treatments prescribed were similar for antidepressants in both groups (77.0% in the Dg vs. 75.3% in the Bg, p = 0.284), and slightly higher in the Dg for benzodiazepines (71.5% vs. 67.2% respectively, p = 0.011) and anticonvulsants (72.1% vs. 67.0% respectively, p = 0.002). Healthcare resource utilization was statistically reduced to a similar extent in both groups as a consequence of treatment, yielding a reduction in the cost of illness of €1196 (SD = 1158) and €1112 (SD = 874) respectively;p = 0.304, over a 6-month period. Conclusion: The broadening of the gAD criteria could lead to earlier diagnosis not necessarily associated with an increase in healthcare resource utilization or costs to the National Health System in the six-month follow-up.

关键词： generalized Anxiety Disorder Diagnosis DSM-IV Criteria Healthcare resource Utilization Costs