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macrolide-Clarithromycin Task-Force for the Treatment and prophylaxis of Covid-19 as a Single Agent

pharmacology & pharmacy 2020年第6期11卷 85-104页

作者： Eduardo mansilla Ricardo Rangel martínez Gustavo Horacio marín Idiberto Zotarelli Filho Elsa Rivas Jaime Rivas Katherine Athayde Teixeira de Carvalho mohammad reza Dayer Alí Samadikuchaksaraei Internal medicine School of Medical Sciences UNLP La Plata Argentina Exom.pharma Ciudad de México DF México pharmacology School of Medical Sciences UNLP La Plata Argentina Faceres medical School Sao José do Rio Preto Sao Paulo Brazil Intensive Care Units-Hospital de la Amistad perú Corea II Santa Rosa and Salvador University Hospital Piura Perú Intensive Care Unit Hospital de la Amistad Perú Corea II Santa Rosa Piura Perú pequeno príncipe Faculty & pelé pequeno príncipe Institute Curitiba Paraná Brazil department of Biology Faculty of Science Shahid Chamran University of Ahvaz Ahvaz Iran department of Tissue Engineering & Regenerative medicine Iran University of Medical Sciences Tehran Iran

SARS-CoV-2 is a novel RNA coronavirus responsible of a deadly pandemic: the clinical illness COVID-19. With only one authorized drug for emergency use in critically ill patients: Remdesivir, there is not any other approved drug or vaccine yet with proven potential to overcome this infection. We exposed here many scientific evidences to support our novel idea that a macrolide, basically Clarithromycin, could be effective as a single agent for treatment and prophylaxis of COVID-19. Clarithromycin could change the history of this pandemic. It could reduce the costs of treatment and the potential adverse effects when combining more than one drug such as with Hydroxychloroquine. Clarithromycin treatment and prophylaxis as a single agent could be much more simple, safe and cheaper as giving Chloroquine or Hydroxychloroquine alone or in combination with Azithromycin as well as other therapeutic options.

关键词： COVID-19 macrolides Clarithromycin Single Agent Therapy prophylaxis

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Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.maharachchikumbura Walter Rossi marco Leonardi Hyang Burm Lee Hye Yeon mun jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa phookamsak Nimali Ide Silva Kasun m.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard phukhamsakda Olinto L.pereira Vanessa p.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene mayrada Silva Soares Helio Longoni plautz Jr Helen maria pontes Sotao William Kalhy Silva Xavier Jadson Diogo pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina mariade Souza-motta Oliane maria Correia magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao milan C.Samarakoon Dhandevi pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.perera Vinit Kumar Shi-Ke Huang monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-mei Tian Armin mesic Sanjay K.Singh Kunthida phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage ming Zeng Thilini Chethana deping Wei martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.phillips Chang-Hsin Kuo Erio Camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones putarak Chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen paras Nath Singh Yusufjon Gafforov Itthayakorn promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao paul m Key laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand department of plant medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key laboratory of microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium.paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psamm.phila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,micarea squamulosa,muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,paramassaria samaneae,penicillium circulare,***,***-pumilae,***,***,phaeoisaria siamensis,phaeopoacea asparagicola,phaeosphaeria penniseti,plectocarpon galapagoense,porina sorediata,pseudoberkleasmium chiangmaiense,pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,prolixandromyces australi,***,***,***,p.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes pezizomycetes phylogeny Taxonomy

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Thyroid Nodule: Alpha Score 2.0 Classification for FNAB Selection, multicentric Study in latin America

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Open Journal of Radiology 2021年第4期11卷 160-174页

作者： Glenn mena maria Cristina Chammas Carlos mario Gonzalez Vasquez Lylian Rocío Villagómez marco Alfredo muñoz pico patricio Alejandro montalvo Santiago mena-Bucheli Julio Olmedo Elizabeth Quintero pedro Henrique de marqui moraes Osmar Cassio Saito Hubertino Diaz denise Romero Gabriela Velalcazar Angel Ramón Sosa Fleitas Yamil Oliver Quevedo Ontaneda Victor Ricardo Chara Alpha Imagen Radiología e Intervencionismo Quito Ecuador Hospital das Clínicas Faculdade de medicina da Universidade de Sã o paulo S&#227 o paulo Brasil Hospital pablo Tobón Uribe Medellin Colombia Hospital del Instituto Ecuatoriano de Seguridad Social Quito Sur Quito Ecuador Hospital San Francisco de Quito Quito Ecuador Hospital Edgardo Rebagliati martins Lima Perú Hospital Carlos Andrade marín Quito Ecuador Hospital de Clínicas San josé de San martín Buenos Aires Argentina Hospital Universitario de Los Andes Mérida Venezuela Hospital de la policía Quito Ecuador Hospital Sisol Tacna Perú

Introduction: To perform a latin-American multicentric study for the prediction of benign and malignant thyroid nodules using Alpha Score, and to compare it with ACR TIRADS® and Bethesda®. materials and methods: A pro... 详细信息

Introduction: To perform a latin-American multicentric study for the prediction of benign and malignant thyroid nodules using Alpha Score, and to compare it with ACR TIRADSp>®p> and Bethesdap>®p>. materials and methods: A prospective multicentric study in 10 radiological hospitals and institutions of latin America was performed and 818 thyroid nodules were analyzed by ultrasound and classified by using both ACR TIRADSp>®p> and Alpha Score;fine-needle aspiration biopsy was performed when needed and classified with Bethesda. The relationships between predictors were analyzed by using binary logistic regression, statistical significance was defined by a p-value of 0.05, with an error margin of 4% and 95% confidence intervals. Results: Alpha Score 2.0 establishes five types of malignant predictors: microcalcifications, irregular borders, taller-than-wide shape, predominant solid texture and hypoechogenicity;a diameter equal to or greater than 1.5 cm adds an extra point to the final score. Resulting classification divides TNs into 4 categories: benign (1.9%), low suspicion (8.7%), mild suspicion (13.6%) and high suspicion (75.7%) of malignancy probability;sensitivity of 82%, specificity of 74%, the positive predictive value of 94%, the negative predictive value of 51%, the statistical accuracy of 81%, odds ratio of 108.89 and correlation with ACR TIRADS of 0.77 and Bethesda of 0.91. Conclusions: Alpha Score 2.0 has superior diagnostic accuracy and performance compared to the previously published Alpha Score and is able to classify a benign TN in a precise, safe and accurate way, avoiding unnecessary FNABs or determining the necessity of FNAB in cases of moderate to high suspicion of malignancy.

关键词： Thyroid Cancer-Clinical Radiology-Imaging Thyroid Nodule Alpha Score TIRADS® Thyroid Ultrasonography

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胶质母细胞瘤的几何形态学分析:一项基于T1增强扫描的mRI研究

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国际医学放射学杂志 2017年第3期 357-357页

作者： p.B.Julián m.G.Alicia m.David A.S.mariano L.Belén A.Elena 王大伟 laboratory of mathematical Oncology Edificio Politécnico Institutode Matemática Aplicada a la Ciencia y la IngenieríaUniversidad de Castilla-La Mancha Avenida de Camilo José Cela

摘要背景通过mRI数据进行胶质母细胞瘤的肿瘤体积测量并预测病人预后一直存在争议,胶质母细胞瘤生长的数学模型表明肿瘤的形态特征与其浸润性密切相关。方法基于117例首发胶质母细胞瘤T1增强扫描影像,对肿瘤的体积及形态学参数进行多中... 详细信息

摘要背景通过mRI数据进行胶质母细胞瘤的肿瘤体积测量并预测病人预后一直存在争议,胶质母细胞瘤生长的数学模型表明肿瘤的形态特征与其浸润性密切相关。方法基于117例首发胶质母细胞瘤T1增强扫描影像,对肿瘤的体积及形态学参数进行多中心回顾性研究。对临床变量进行收集、肿瘤分割,测量参数包括:强化方式、坏死、体积、肿瘤最大直径、等效球径度增强宽幅及其他几个强化"边缘"的形态学参数。应用比例风险分析与Kaplan meier生存曲线进行

关键词：胶质母细胞瘤几何形态学初等数学 mRI T1

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