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Chemical characterization UPLC-ESI-QToF-mSE,antibacterial and antibiofilm potential of Sarcomphalus joazeiro(mART.)Hauenschild

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Food Bioscience 2022年第6期50卷 1249-1259页

作者： Nara J.S.Araújo Ana Raquel P.Silva maria S.Costa Thiago S.Freitas josé m.barbosa filho Yedda m.L.S.matos maria Flaviana B.morais-Braga Francisco N.Pereira Junior C.A.P.Silva Erlânio O.Souza Paulo R.V.Ribeiro Bruna Caroline Gonçalves Vasconcelos de Lacerda Edlane martins de Andrade Henrique D.m.Coutinho Jacqueline C.Andrade-Pinheiro Programa de pós-graduação em Ciências da Saúde Universidade Federal do CaririUFCADivino Salvador284CEP63180-000BarbalhaCEBrazil Programa de pós-graduação em Biotecnologia Universidade Estadual do CearáUECEAv.Dr Munguba1700CEP60714-903FortalezaCEBrazil Departamento de Química Biológica Universidade Regional do CaririURCACel Antônio Luis1161CEP63105-000CratoCEBrazil Laboratório de Tecnologia Farmacêutica Universidade Federal da ParaíbaUFPBCidade Universitária5009CEP58051-970João PessoaPBBrazil Laboratório de Bioensaios – LABIO Universidade Federal do Cariri – UFCAR.Olegário Emidio de Araujos/nCEP63260-000Brejo SantoCEBrazil Faculdade de Tecnologia do Cariri FATECAmália Xavier de OliveiroCEP63040-000Juazeiro do NorteCEBrazil Embrapa Agroindústria Tropical R.Pernambuco2270 - Pici60511-110FortalezaCEBrazil CECAPE College.Av.Padre Cícero 3917 - São JoséJuazeiro do NorteCE63024-015Brazil

The present study aims to demonstrate the chemical composition of the ethanolic extract of Sarcomphalus joazeiro bark and to evaluate its antibacterial and antibiofilm *** that,the ethanolic extract of the stem bark was prepared,and chemical characterization was carried out in *** inhibitory concentration and antibiotic modification test were performed by the microdilution *** and antiformation assays were evaluated by the crystal violet *** the chemical characterization,the presence of 24 peaks was *** activity showed minimum inhibitory concentration≥2048μg/*** the evaluations of the potentiating activity,synergism was the most *** the formation analysis,it was observed that most strains showed moderate biofilm *** was concluded that saponin derivatives are the major secondary metabolites in the analyzed extract and that it presents relevant synergism with the antibiotics studied and a significant ability to inhibit bacterial biofilm formation.

关键词： Biofilm Saponins Synergism Inhibition

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría Norte-muñoz maría Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez josémCabrera-maqueda Javier Sierra manuel Vidal-Sanz maría Teresa moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(mHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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medicinal mushroom Growth as Affected by Non-Axenic Casing Soil

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Pedosphere 2011年第2期21卷 146-153页

作者： D.C.ZIED m.T.A.mINHONI J.KOPYTOWSKI-filho L.barbosa m.C.N.ANDRADE Departamento de Produc ao Vegetal (Defesa Fitossanit'aria) Faculdade de Ci encias Agron omicasUniversidade Estadual Paulista18603-970 Botucatu (Brazil) Departamento de Bioestat' stica Instituto de Bioci encia de BotucatuUniversidade Estadual Paulista18618-000 Botucatu (Brazil) Instituto Nacional de Pesquisa da Amaz onia INPA69060-001 Manaus (Brazil)

Ten different casing soils were collected from two soils at two depths （0.2 and 2.0 m below soil surface） to examine the relationships between the physical properties of non-axenic casing soil and yield, number and weight of the medicinal mushroom Agamcua blaaei ss. Heinemann. The results showed that soil clay content and bulk density were negatively correlated with the mushroom yield, respectively, but soil silt content and water-holding capacity were found to be positively correlated with the yield. The number of mushrooms was negatively correlated with soil water-holding capacity but positively correlated with soil clay, bulk density and porosity. The weight of mushroom was positively correlated with the content of soil fine sand and negatively correlated with the contents of soil coarse sand, total sand and clay. Neither soil depth nor different soil combinations affected the yield and number of mushrooms, but the mushroom weight was affected by the soil combinations and soil depth, so interplay in the fructification process with the physical characteristics of casing is complicated.

关键词： Agaricus blazei casing layer quality factors soil depth soil particles

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Tropical dendrochronology applied to invasive tree species in the Brazilian Atlantic Forest

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Journal of Forestry Research 2021年第1期32卷 91-101页

作者： Carolina Nogueira Xavier Daniela Granato-Souza Ana Carolina m.C.barbosa joséReinaldo moreira da Silva Forest Sciences Department Federal University of Lavras(UFLA)C.P.3037Lavras 37200-000Brazil Department of Geosciences University of ArkansasFayettevilleAR 72701USA

The Atlantic Forest is one of the largest and most biodiverse rainforests of South America but anthropogenic activities are drastically changing these *** invasion of alien or exotic species is one of the greatest threats to *** are few studies of invasive species in tropical Brazilian *** research examines growth and ecological aspects of Syzygium cumini and Clitoria fairchildiana,two invasive tree species in the Pedra Branca State Park,an Atlantic Forest remnant in southeastern *** species were successfully dated,indicating an average age of 58 and 31 years,respectively.A positive relationship between growth and precipitation of the previous growing season suggests an ecological adaptive strategy,which could be facilitating their invasion into the *** growth diameter curves indicate slow and fast growth rates for *** and ***,*** release episodes detected in the tree rings indicate increased anthropogenic disturbances over the last 50 years.

关键词： Atlantic Forest biome Invasive species Protected areas Tree rings

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The coppice-with-standards silvicultural system as applied to Eucalyptus plantations-a review

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Journal of Forestry Research 2014年第2期25卷 237-248页

作者： Antonio Carlos FERRAZ filho josé Roberto Soares SCOLFORO Blas mOLA-YUDEGO Departamento de Ciências Florestais Universidade Federal de Lavras (UFLA) School of Forest Sciences University of Eastern Finland (UEF)

We review the management of Eucalyptus species under a coppice-with-standards （CWS） silvicultural system. CWS management results in product diversification, permitting production of small and large scale timber from the same stand. Eucalyptus species are suitable candidates for CWS management because： there are large worldwide plantation areas, sprouting capacity is high, and eucalypts are multipur- pose species. We discuss （1） short rotation Eucalyptus coppice manage- ment for energy and pulping and （2） Eucalyptus seedling management for solid wood products. We review the literature and discuss experi- ences with Eucalyptus managed under the CWS system. We also assess projects dealing with Eucalyptus coppice management, stand density regulation, pruning, and stand and wood quality. The growth environ- ment of the standard trees （heavy competition up to the first harvest, free growth afterwards） coupled with long rotations （〉20 years） results in high quality logs for solid wood products. Early pruning should be ap- plied to enhance wood quality. We propose a system for the silvicultural management of Eucalyptus under the CWS system, elaborating on the consequences of initial planting density, site productivity, and standard tree densities as well as timing of basic silvicultural applications.

关键词： stand density regulation coppice management pruning silvicultural system stand production diversification CWS

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Rainfall partitioning in young clonal plantations Eucalyptus species in a subtropical environment,and implications for water and forest management

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International Soil and Water Conservation Research 2021年第3期9卷 474-484页

作者： Decio Oscar Cardoso Ferreto josémiguel Reichert Rosane barbosa Lopes Cavalcante Raghavan Srinivasan Soils Department Universidade Federal de Santa Maria(UFSM).Avenida Romima 1000Santa MariaRSBrazil Instituto Tecnoldgico Vale.Rua Boaventura da Silva 955UmarizalBelemPABrazil Department of Ecology and Conservation Biology Texas A&M University(TAMU)534 John Kimbrough Blvd.Room 305College StationTXUSA

Different canopy characteristics of industrial eucalyptus may lead to differences in water evaporation and availability to *** study aims to understand rainfall partitioning in a young clonal plantation(age of 2-4.5 years)of three eucalyptus species by relating tree parameters:diameter at breast height,total height,and leaf area *** measured rainfall,throughfall,stemflow and litter interception,along with the tree *** eucalyptus trees had rainfall interception varying between 22 mm(for 178 mm of rainfall)and 42 mm(for 87 mm of te rainfall),throughfall between 106 mm(for 186 mm of rainfall)and 44 mm(for 74 mm of rainfall),and stemflow between 0.5 mm(for 92 mm of rainfall)and 1.4 mm(for 24 mm of rainfall).For the three species,rainfall interception varied between 12 and 48%,throughfall between 57 and 90%,and stemflow between 0.3 and 5.4%.The coefficient of determination between interception and rainfall was 0.76,indicating interception depends on other variables,possibly including antecedent rainfall,rainfall intensity,and *** decreased with a reduction in leaf area index caused by eucalyptus *** *** had 0.75 mm of throughfall per 1 mm of rainfall,whereas in *** and E saligna,these ratios were 0.71 and 0.68,*** in *** and *** had a higher positive relationship with the diameter at breast height of the trees,whereas in *** the highest relationship was with the *** results contribute to establishing management strategies,such as choosing suitable eucalyptus species to local climate,and to improve the synchronization of crop-demand versus soil-water-supply while maintaining streamflow to fulfill ecological and production needs.

关键词： Water balance Blue-green water Forest hydrology Rainfall interception Rainfall throughfall

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Entropy model to assess sediment resuspension probability and trap efficiency of small dams

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International Journal of Sediment Research 2022年第5期37卷 675-686页

作者： Francisco Jairo Soares Pereira Antonio Viana da Silva filho josé Wellington Batista Lopes josé Carlos de Araújo Department of Agricultural Engineering Federal University of Ceará Campus Do Pici Rural Federal University of Pernambuco Federal University of Piauí

In the Brazilian drylands, there are tens of thousands of small dams. Despite their paramount importance to the rural population, they are rarely monitored. Water demand increases with time while, simultaneously, siltation reduces reservoir water capacity and availability. Reservoir siltation models are, therefore, mandatory to manage the numerous ungauged small dams in these *** objective of the current study is to improve sediment trap efficiency(TE) modeling by including resuspension as a key probabilistic process. The Shannon entropy was used to estimate the sediment resuspension probability, which was merged with the Camp model and generated the RETSED entropy model. To validate the RETSED model, an experimental check dam(ECD, 300 m3), located in the Gilbu es desertification site, Brazil, was monitored hourly during one hydrological year(July 2018-July 2019). measurements show that the annual volumetric decline of the check dam was 12%; and that the average trap efficiency equaled 86%. Only 9.5% of the hourly sediment concentration outflow exceeded the average plus one standard deviation, showing that the reservoir is well mixed; a fact which highlights the relevance of the resuspension process. Three empirical models failed to mimic the experimental results: Churchill(TE = 99%), Brune(TE = 75%), and maryland(TE = 94%). According to the RETSED entropy model, the resuspension probability during the experiment was 10%and TE = 81%, a value only 6% below the measured one. The Camp model simulated TE = 89%, only 3%higher than the measured value, but confirmed the Camp model’s tendency to overestimate TE due to a disregard of resuspension. The deterministic model showed low sensitivity concerning the hydrodynamic effects, whereas the entropy formulation proved to be more consistent with physical behavior: the resuspension probability clearly increased and trap efficiency decreased with rising reservoir discharge.

关键词： Erosion Check dam Sedimentation Ungauged basins Camp model

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Non-invasive diagnosis of liver fibrosis in chronic hepatitis C

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World Journal of Gastroenterology 2014年第11期20卷 2854-2866页

作者： Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon Roberto josé de Carvalho-filho Gastroenterology Division Department of Internal MedicineFederal University of Santa CatarinaFlorianópolisSC 88040-900Brazil Gastroenterology Division Department of MedicineFederal University of Sao PauloSao PauloSP 04023-900Brazil

Assessment of liver fibrosis in chronic hepatitis C virus(HCV)infection is considered a relevant part of patient care and key for decision *** liver biopsy has been considered the gold standard for staging liver fibrosis,it is an invasive technique and subject to sampling errors and significant intra-and inter-observer *** the last decade,several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection,with variable *** the clear advantage of being noninvasive,a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver *** addition,these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional ***,in general,these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic *** methods are either serum markers(usually combined in a mathematical model)or imaging modalities that can be used separately or combined in algorithms to improve *** this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C,their advantages,limitations and application in clinical practice.

关键词： Liver fibrosis Liver cirrhosis Hepatitis C Diagnosis Elasticity imaging techniques

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Induced and heavy aggregation operators with distance measures

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Journal of Systems Engineering and Electronics 2010年第3期21卷 431-439页

作者： josé m.merigó montserrat Casanovas Department of Business Administration University of Barcelona

This paper introduces a new aggregation model by using induced and heavy aggregation operators in distances measures such as the Hamming *** is called the induced heavy ordered weighted averaging（OWA） distance（IHOWAD） *** paper studies some of its main properties and a wide range of particular cases such as the induced heavy OWA（IHOWA） operator,the induced OWA distance（IOWAD） operator and the heavy OWA distance（HOWAD） *** approach is generalized by using generalized and quasi-arithmetic means obtaining the induced generalized IHOWAD（IGHOWAD） operator and the Quasi-IHOWAD *** application of the new approach in a decision making problem regarding the selection of strategies is developed.

关键词： distance measures aggregation operators decision making OWA operator.

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