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m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Carbon Dioxide/m.thane Separation by Adsorption on Sepiolite

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Journal of Natural Gas Chem.stry 2007年第3期16卷 235-243页

作者： josé A.delgado m.ría A.Uguina josé L.Sotelo Beatriz Ruíz m.rcio Rosário Departm.nt of Chem.cal Engineering Universidad Complutense de Madrid28040Madrid.Spain

In this work, the use of sepiolite for the rem.val of carbon dioxide from.a carbon dioxide/m.thane m.xture by a pressure swing adsorption （PSA） process has been researched. Adsorption equilibrium.and kinetics have been m.asured in a fixed-bed, and the adsorption equilibrium.param.ters of carbon dioxide and m.thane on sepiolite have been obtained. A m.del based on the LDF approxim.tion has been em.loyed to sim.late the fixed-bed kinetics, using the Langm.ir equation to describe the adsorption equilibrium.isotherm. The functioning of a PSA cycle for separating carbon dioxide/m.thane m.xtures using sepiolite as adsorbent has also been studied. The experim.ntal results were com.ared with the ones predicted by the m.del adapted to a PSA system. m.thane with purity higher than 97% can be obtained from.feeds containing carbon dioxide with concentrations ranging from.34% to 56% with the proposed PSA cycle. These results suggest that sepiolite is an adsorbent with good properties for its em.loym.nt in a PSA cycle for carbon dioxide rem.val from.landfill gases.

关键词： carbon dioxide m.thane sepiolite adsorption fixed-bed pressure swing adsorption

On the Structure of Graded Leibniz Algebras

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Algebra Colloquium 2015年第1期22卷 83-96页

作者： Antonio J. Calderon m.rtin jose m. Sfinchez delgado Departam.nto de m.tem.ticas Universidad de Cadiz 11510 Puerto Real Cadiz Spain

We study the structure of graded Leibniz algebras with arbitrary dim.nsion and over an arbitrary base field K. We show that any of such algebras ￡ with a sym.etric G-support is of the form.￡ = U-∑jIj with U a subspace of ￡1, the hom.geneous com.onent associated to the unit elem.nt 1 in G, and any Ij a well described graded ideal of ￡, satisfying [Ij, Ik]= 0 if j≠ k. In the case of ￡ being of m.xim.l length, we characterize the gr-sim.licity of the algebra in term. of connections in the support of the grading.

关键词： graded Leibniz algebra infinite dim.nsional Leibniz algebra structure theory

At the Intersection： m.rging Ca2＋ and ROS Signaling Pathways in Pollen

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m.lecular Plant 2014年第11期7卷 1595-1597页

作者： m.chael m. Wudick josé A. Feijó Departm.nt of Cell Biology and m.lecular Genetics University of Maryland College Park MD 20742–5815 USA Instituto Gulbenkian de Ciencia 2780-156 Oeiras Portugal

THE m.XED BLESSING OF ROS： DON＇T YOU KNOW THAT I＇m.TOXIC？Due to plants＇ aerobic m.tabolism. reactive oxygen species （ROS） continuously accrue in different tissues and organs as a by-product of m.ny m.tabolic reactions. Despite their toxic activity, plants also rely on ROS as a m.jor form.of second m.ssenger to integrate, induce, and/or propagate biotic and abiotic signals and signaling cascades. Being sm.ll, short-lived, and rapidly diffusible m.kes ROS ideal m.ssenger m.lecules for local biochem.- cal reactions. Hence, a delicate fine-tuning of localized ROS production and signaling events is crucial for m.ny physi- ologic processes.

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On a Variant of Giuga Num.ers

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Acta m.them.tica Sinica,English Series 2012年第4期28卷 653-660页

作者： jos m.ría GRAU Florian LUCA Antonio m. OLLER-m.RCN Departm.nto de m.tem.ticas Universidad de Oviedo Avda. Calvo Sotelo s/n Instituto de m.tem.ticas Universidad Nacional Autnoma de México The John Knopfm.cher Centre for Applicable Analysis and Num.er Theory University of the Witwatersrand Centro Universitario de la Defensa Academia General Militar Ctra. Huesca s/n

In this paper, we characterize the odd positive integers n satisfying the congruence ∑j=1^n-1 j n-1/2 We show that the set of such positive integers has an asym.totic densitywhich turns out to be slightly larger than... 详细信息

关键词： Congruence Giuga num.ers asym.totic density

Efficiency of white lupin in the rem.val of m.rcury from.contam.nated soils: Soil and hydroponic experim.nts

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Journal of Environm.ntal Sciences 2010年第3期22卷 421-427页

作者： Pilar Zornoza Rocío m.lln m. jos Sierra Alm.dena Seco Elvira Esteban Departm.nt of Agricultural Science Autonomous University of Madrid Francisco Tomsy Valiente 7. E-28049 Madrid Spain Research Center for Energy Environm.nt and Technology Environmental Department. Soil Degradation Research Unit. Av. Complutense 22. E-28040 Madrid Spain

This study exam.ned the ability of the white lupin to rem.ve m.rcury （Hg） from.a hydroponic system.（Hg concentrations 0, 1.25, 2.5, 5 and 10 μm.l/L） and from.soil in pots and lysim.ters （total Hg concentration （19.2 ± 1.9） m./kg availability 0.07%, and （28.9 ± 0.4） m./kg availability 0.09%, respectively）, and investigated the accum.lation and distribution of Hg in different parts of the plant. White lupin roots efficiently took up Hg, but its translocation to the harvestable parts of the plant was low. The Hg concentration in the seeds posed no risk to hum.n health according to the recom.endations of the World Health Organization, but the shoots should not be used as fodder for livestock, at least when unm.xed with other fodder crops. The accum.lation of Hg in the hydroponically-grown plants was linear over the concentration range tested. The am.unt of Hg retained in the roots, relative to the shoots, was alm.st constant irrespective of Hg dose （90%）. In the soil experim.nts, Hg accum.lation increased with exposure tim. and was the greater in the lysim.ter than in the pot experim.nts. Although Hg rem.val was the greater in the hydroponic system. revealing the potential of the white lupin to extract Hg, bioaccum.lation was the greatest in the lysim.ter-grown plants; the latter system.m.re likely reflects the true behaviour of white lupin in the field when Hg availability is a factor that lim.ts Hg rem.val. The present results suggest that the white lupin could be used in long-term.soil reclam.tion strategies that include the goal of profitable land use in Hg-polluted areas.

关键词： edible plant parts hydroponic-soil-lysim.ter experim.nts Lupinus albus L. m.rcury

Induced and heavy aggregation operators with distance m.asures

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Journal of System. Engineering and Electronics 2010年第3期21卷 431-439页

作者： josé m.m.rigó m.ntserrat Casanovas Departm.nt of Business Adm.nistration University of Barcelona

This paper introduces a new aggregation m.del by using induced and heavy aggregation operators in distances m.asures such as the Ham.ing *** is called the induced heavy ordered weighted averaging（OWA） distance（IHOWAD） *** paper studies som. of its m.in properties and a wide range of particular cases such as the induced heavy OWA（IHOWA） operator,the induced OWA distance（IOWAD） operator and the heavy OWA distance（HOWAD） *** approach is generalized by using generalized and quasi-arithm.tic m.ans obtaining the induced generalized IHOWAD（IGHOWAD） operator and the Quasi-IHOWAD *** application of the new approach in a decision m.king problem.regarding the selection of strategies is developed.

关键词： distance m.asures aggregation operators decision m.king OWA operator.

How to select a journal for your research

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World Journal of Gastroenterology 2023年第21期29卷 3379-3384页

作者： josém.Ram.a Departm.nt of Surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Publication in a peer-reviewed journal is the goal of any research *** of the m.st im.ortant(and possibly the least understood)aspects of the publication process is the choice of a suitable journal that is likely to a... 详细信息

关键词： Research Journal Altm.trics Publication

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of im.ortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： m.ría Norte-m.ñoz m.ría Portela-Lom.a Palom. Sobrado-Calvo Diana Sim.n Johnny Di Pierdom.nico Alejandro Gallego-Ortega m.r Pérez josém.abrera-m.queda Javier Sierra m.nuel Vidal-Sanz m.ría Teresa m.reno-Flores m.rta Agudo-Barriuso Grupo de Investigación Oftalm.logía Experim.ntal Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experim.ntal Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatom. Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroim.unology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain m.dicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia prom.te axonal regeneration in the m.m.alian central nervous system.including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotom.zed retinal ganglion ***,we aim.d to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from.an established rat im.ortalized clonal cell line,TEG3,were intravitreally injected in intact and axotom.zed retinas in syngeneic and allogeneic m.de with or without m.croglial inhibition or im.unosuppressive *** and gene expression analyses were *** bulb-derived prim.ry olfactory ensheathing glia and TEG3 express m.jor histocom.atibility com.lex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,form.ng an *** axotom.zed retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,m.croglial anatom.cal activation was higher than after optic nerve crush *** intact retinas,both transplants activated m.croglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by m.croglial inhibition or ***,neuroprotection of axotom.zed retinal ganglion cells did not im.rove with these *** different neuroprotective properties,different toxic effects,and different responses to m.croglial inhibitory treatm.nts of olfactory ensheathing glia in the retina depending on the type of transplant highlight the im.ortance of thorough preclinical studies to explore these variables.

关键词： cell therapy im.une recognition m.jor histocom.atibility com.lex class II(m.CII) neuroprotection olfactory ensheathing glia retinal ganglion cells