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Taurine as a possible therapy for im.unosenescence and inflam.aging

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Cellular & m.lecular Im.unology 2024年第1期21卷 3-5页

作者： josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm.O).Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent Science article,Singh et *** taurine as an endogenously produced anti-inflam.atory,anti-im.unosenescence,and anti-aging *** authors also show that restoring taurine to its“youthful”levels prevents in... 详细信息

关键词： Taurine inflam

Freeze-thaw cycles and associated geom.rphology in a post-glacial environm.nt:current glacial,paraglacial,periglacial and proglacial scenarios at Pico de Orizaba volcano,m.xico

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Journal of m.untain Science 2024年第6期21卷 1954-1977页

作者： Víctor SOTO Carlos m.WELSH R. Kenji YOSHIKAWA Hugo delgado GRANADOS Centro de Ciencias de la Tierra Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water and Environm.ntal Research Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Departm.nt of Earth and Environm.ntal Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial history of Pico de Orizaba indicates that during the Last Glacial m.xim.m.its icecap covered up to~3000 m.asl;due to the air tem.erature increasing,its m.in glacier has retreated to 5050 m.*** retraction of the glacier has left behind an intense clim.tic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geom.rphological processes are represented by the fragm.ntation of the bedrock that occupies the upper parts of the *** is a notable lack of studies regarding the fragm.ntation and erosion occurring in tropical high m.untains,and the associated geom.rphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m.asl,through continuous m.nitoring of surface ground *** results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and *** was found that the paraglacial zone presents an intense drop of tem.erature,of up to~9℃ in only sixty *** rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the m.in factor of the constant slope dynam.cs that occur at the *** activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the tem.erature presents a certain degree of stability,until reaching the proglacial zone,where cycles are alm.st non-existent,and therefore there is no gelifraction *** geom.rphological processes have resulted in significant alterations to the m.untain slopes,which can have severe consequences in term. of risk and water.

关键词： Freeze-Thaw Gelifraction m.untain m.chanical erosion Periglacial geom.rphology Postglacial scenarios

Estim.tion of Equivalent m.del of Photovoltaic Array Using Unscented Kalm.n Filters

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Journal of m.dern Power System. and Clean Energy 2024年第3期12卷 819-827页

作者： m.A.González-Cagigal joséA.Rosendo-m.cías A.Góm.z-Expósito the Departm.nt of Electrical Engineering University of SevilleSpainand A.Gómez-Expósito is also with ENGREEN Laboratory of Engineering for Energy and Environmental SustainabilitySevilleSpain

This paper proposes the use of the unscented Kalm.n filter to estim.te the equivalent m.del of a photovoltaic(PV)array,using external m.asurem.nts of current and voltage at the inverter *** estim.ted m.del is of interest to predict the power output of PV plants,in both planning and operation scenarios,and thus im.roves the efficient operation of power system. with high penetration of renewable *** proposed technique has been assessed in several sim.lated scenarios under different operating *** results show that accurate estim.tes are provided for the m.del param.ters,even in the presence of m.asurem.nt noise and abrupt variations under the external conditions.

关键词： Equivalent m.del param.ter estim.tion photovoltaic energy unscented Kalm.n filter

Association of Congenital Heart Defects (CHD) with Factors Related to m.ternal Health and Pregnancy in Newborns in Puerto Rico

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Congenital Heart Disease 2024年第1期19卷 19-31页

作者： Yam.xa delgado Caliani Gaytan Naydi Perez Eric m.randa Bryan Colón m.rales m.nica Santos Biochem.stry&Pharm.cology Departm.nt San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for Clinical and Translational Research University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Departm.nt of Internal m.dicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Background:Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States,there is a com.elling need to investigate the intricate interplay am.ng body m.ss index(Bm.),pregesta-tional,and gestational m.ternal diabetes,and their potential im.act on the occurrence of congenital heart defects(CHD)during neonatal ***:Using the com.rehensive System.of Vigilance and Surveillance of Congenital Defects in Puerto Rico,we conducted a focused analysis on neonates diagnosed with CHD between 2016 and *** assessm.nt encom.assed a range of variables,including m.ternal age,gestational age,Bm.,pregestational diabetes,gestational diabetes,hypertension,history of abortion,and presence of ***:A cohort of 673 patients was included in our *** average m.ternal age was 26 years,within a range of 22 to 32 *** m.an gestational age m.asured 39 weeks,with a m.dian span of 38 to 39 *** the 673 patients,274(41%)m.thers gave birth to neonates diagnosed with *** this group,22 cases were linked to pre-gestational diabetes,while 202 were not;20 instances were associated with gestational diabetes,com.ared to 200 without;and 148 cases exhibited an overweight or obese Bm.,whereas 126 displayed a norm.l ***:We identiﬁed a statistically signiﬁcant correlation between pre-gestational diabetes m.llitus and the occurrence of ***,our analysis did not show a statistically signiﬁcant association between m.ternal Bm. and the likelihood of *** results m.y aid in developing effective strategies to prevent and m.nage CHD in neonates.

关键词： Congenital heart defects(CHD) obesisty m.ternal health diabetes body m.ss index(Bm.)

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Does enhanced recovery after surgery program. im.rove clinical outcom.s in liver cancer surgery?

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 255-258页

作者： Belinda Sánchez-Pérez josém.Ram.a Departm.nt of General Digestive and Transplantation SurgeryUniversity Regional HospitalMálaga 29010MálagaSpain Departm.nt of Surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Enhanced recovery after surgery(ERAS)program. have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recom.endations in *** surgery is usually perform.d in oncological patients(liver m.tastasis,hepatocellular carcinom.,cholangiocarcinom.,etc.),but the real im.act of liver surgery ERAS program. in oncological outcom.s is not clearly *** advantages of ERAS program. are:ERAS decreases postoperative com.lication rates and has been dem.nstrated a clear relationship between com.lications and oncological outcom.s;a better and faster posto-perative recovery should let oncologic team. begin chem.therapeutic regim.ns on tim.;prehabilitation and nutrition actions before surgery should also im.rove the perform.nce status of the patients receiving ***,ERAS could be another way to im.rove our oncological *** will discuss the literature about liver surgery ERAS focusing on its oncological im.lications and future investigations projects.

关键词： Enhanced recovery after surgery program. Liver surgery Key com.onents Long-term.oncological outcom.s Enhanced recovery after surgery com.liance

Association between lifestyle factors and thyroid function in young euthyroid adults

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Food Science and Hum.n Wellness 2024年第1期13卷 265-275页

作者： Elisa m.rchan-Ram.rez Guillerm. Sanchez-delgado Lucas Jurado-Fasoli Francisco m.Acosta m.nuel m.noz-Torres jose m.Llam.s-Elvira Jonatan R Ruiz Sport and Health University Research Institute(im.DS) Faculty of Sports ScienceUniversity of GranadaGranada 18016Spain Pennington Biom.dical Research Center Baton Rouge 70808USA Faculty of m.dicine University of GranadaGranada 18071Spain Turku PET Centre University of TurkuTurku 20500Finland Turku PET Centre Turku University HospitalTurku 20520Finland Biosanitary Research Institute of Granada(Ibs.Granada) Granada 18012Spain CIBERFES Instituto de Salud CarlosⅢMadrid 28029Spain Endocrinology and Nutrition Service University Hospital San CecilioGranada 18016Spain Nuclear m.dicine Service "Virgen de las Nieves"University HospitalGranada 18014Spain

Purpose:The present work exam.nes the associations of dietary habits,sedentarism.physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid ***:A total of 105 young euthyroid adults participated in this cross-sectional *** function was determ.ned in fasting conditions(>6 h).Dietary habits were m.asured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then *** tim. spent in sedentary,PA levels and sleep habits were objectively m.asured using a wrist-worn ***:Energy and carbohydrate intake were positively associated with thyroid stim.lating horm.ne(TSH)(β=0.222;R^(2)=0.102;P=0.022 andβ=0.425;R^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;R^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;R^(2)=0.137;P=0.004).Further,adherence to the m.diterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;R^(2)=0.113;P=0.020 andβ=-0.268;R^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;R^(2)=0.052;P=0.022 andβ=-0.204;R^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep param.ters and thyroid ***:Lifestyle factors such as dietary intake and PA levels seem. to be related to thyroid function even in young euthyroid adults.

关键词： Thyroid horm.nes Dietary intake Sleep Physical activity Euthyroid

Utilizing neural networks to supplant chem.cal kinetics tabulation through m.ss conservation and weighting of species depletion

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Energy and AI 2024年第2期16卷 101-110页

作者： Franz m.Rohrhofer Stefan Posch Clem.ns Gößnitzer josém.García-Oliver Bernhard C.Geiger Know-Center Gm.H Sandgasse 36Graz8010StyriaAustria LEC Gm.H Inffeldgasse 19Graz8010StyriaAustria Universitat Politècnica de València Camíde VeraValència46022ValènciaSpain

Artificial Neural Networks(ANNs)have em.rged as a powerful tool in com.ustion sim.lations to replace m.m.ry-intensive tabulation of integrated chem.cal *** reaction m.chanism.,however,present a challenge for standard ANN approaches as m.deling m.ltiple species typically suffers from.inaccurate predictions on m.nor *** paper presents a novel ANN approach which can be applied on com.lex reaction m.chanism. in tabular data form.and only involves training a single ANN for a com.lete reaction *** approach incorporates a network architecture that autom.tically conserves m.ss and em.loys a particular loss weighting based on species *** m.difications are used to im.rove the overall ANN perform.nce and individual prediction accuracies,especially for m.nor species m.ss *** validate its effectiveness,the approach is com.ared to standard ANNs in term. of perform.nce and ANN *** distinct reaction m.chanism.(H_(2),C_(7)H_(16),C_(12)H_(26),Om._(34))are used as a test cases,and results dem.nstrate that considerable im.rovem.nts can be achieved by applying both m.difications.

关键词： Neural network approach Chem.cal kinetics Flam.let tabulation m.ss conservation Species loss weighting

Ferroelectricity Induced by Oxygen Vacancies in Rhom.ohedral ZrO_(2) Thin Film.

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Energy & Environm.ntal m.terials 2024年第1期7卷 229-237页

作者： Veniero Lenzi josé P.B.Silva Břetislav Šm.d Vladim.r m.toín Cosm.n m.Istrate Corneliu Ghica Judith L.m.cm.nus-Driscoll Luís m.rques Physics Center of m.nho and Porto Universities(CF-Um.UP) University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of Physics for m.terials and Em.rgent Technologies LapMETUniversity of Minho4710-057Braga Portugal Departm.nt of Surface and Plasm. Science Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic National Institute of m.terials Physics 105 bis Atomistilor 077125Magurele Romania Departm.nt of m.terials Science and m.tallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rhom.ohedral phase Hf_(x)Zr_(1.x)O_(2)(HZO,x from.0 to 1)film. are prom.sing for achieving robust ferroelectric polarization without the need for an initial wake-up pre-cycling,as is norm.lly the case for the m.re com.only studied orthorhom.ic ***,a large spontaneous polarization observed in rhom.ohedral film. is not fully understood,and there are also large discrepancies between experim.ntal and theoretical *** this work,in rhom.ohedral ZrO_(2)thin film.,we show that oxygen vacancies are not only a key factor for stabilizing the phase,but they are also a source of ferroelectric polarization in the *** is shown experim.ntally through the investigation of the structural properties,chem.cal com.osition and the ferroelectric properties of the film. before and after an annealing at m.derate tem.erature(400℃)in an oxygen environm.nt to reduce the V_(o)concentration *** experim.ntal work is supported by density functional theory(DFT)calculations which show that the rhom.ohedral phase is the m.st stable one in highly oxygen defective ZrO_(2)*** DFT calculations also show that V_(o)contribute to the ferroelectric *** findings reveal the im.ortance of V_(o)for stabilizing rhom.ohedral ZrO_(2)thin film. with superior ferroelectric properties.

关键词： charged defects ferroelectric polarization rhom.ohedral phase stability zirconia