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Can DNA fragmentation of neat or swim-up spermatozoa be used to predict pregnancy following ICsI of fertile oocyte donors？

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Asian Journal of Andrology 2013年第6期15卷 812-818,I0010页

作者： Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega josé Andrés Guijarro josé luís fernandez stephen D Johnston Rocio Nufiez-Calonge Faculty of Biology Autonomous University of Madrid Cantoblanco Madrid 28049 Spain CIfnica Tambre Madrid 28002 Spain GINIBIC-Complejo Hospitalario Universitario A CoruRa A Corufna15006 Spain school of Agriculture and Food science The University of Queensland Gatton 4343 Australia

This study compared the potential of assessing sperm DNA fragmentation （sDF） from neat semen and the subsequent swim-up （sU） procedure to predict pregnancy when conducting ICsI of fertile donor oocytes. Infertile females （n=81） were transferred embryos resulting from intracytoplasmic sperm injection （ICsI） of their partner＇s spermatozoa and proven donor oocytes. This model normalized the impact of female factor in putative sperm DNA repair. semen was blindly assessed for sDF using Halosperm immediately following ejaculation （Ns） and after swim-up at the time of ICsI fertilisation. There was a decrease in sDF values of the ejaculated semen sample following the swim-up protocol （P=0.000）. Interestingly, pregnancy could be equally predicted from sDF values derived from either neat or swim-up semen samples. Receiver operator curves and the derived Youden＇s indices determined sDF cutoff values for Ns and sU of 24.8% and 17.5%, respectively. Prediction of pregnancy from Ns sDF had a sensitivity of 75% and a specificity of 69%, whereas for sU sDF was 78% and 73%, respectively. While increased levels of sDF negatively impact reproductive outcome, we have shown that a reduction in sDF following sperm selection using ICsI with proven donor oocytes is not mandatory for achieving pregnancy. This suggests that a certain level of DNA damage that is not detectable using current technologies could be impacting on the relative success of assisted reproductive technology （ART） procedures. Consequently, we propose a modification of the so called ＇iceberg model＇ as a possible rationale for understanding the role of sDF in reproductive outcome.

关键词： assisted reproductive technology egg donation male factor sperm DNA fragmentation

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Mitochondria–cGAs–sTING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de Biología Molecular severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Complete fuzzy scheduling and fuzzy earned value management in construction projects

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Journal of Zhejiang University-science A(Applied Physics & Engineering) 2012年第1期13卷 56-68页

作者： josé luís PONZ-TIENDA Eugenio PELLICER Víctor YEPEs school of Building Engineering Universitat Politècnica de València school of Civil Engineering Universitat Politècnica de València Department of Construction Engineering ICITECHUniversitat Politècnica de València

This paper aims to present a comprehensive proposal for project scheduling and control by applying fuzzy earned *** goes a step further than the existing literature:in the formulation of the fuzzy earned value we consider not only its duration,but also cost and production,and alternatives in the scheduling between the earliest and latest *** mathematical model is implemented in a prototypical construction project with all the estimated values taken as fuzzy *** findings suggest that different possible schedules and the fuzzy arithmetic provide more objective results in uncertain environments than the traditional *** proposed model allows for controlling the vagueness of the environment through the adjustment of the α-cut,adapting it to the specific circumstances of the project.

关键词： Construction Earned value method(EVM) Fuzzy logic Fuzzy set Project management scheduling

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Touristic urbanization and greening of coastal dune fields:A long-term assessment of a temperate sandy barrier of Argentina

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Journal of Geographical sciences 2025年第1期 206-230页

作者： GARZO Pedro Andrés DADON josé Roberto IsLA Federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world. However, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization practices were considered necessary. The systematic introduction of fast-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. This complex region includes urban resorts, afforestation zones, and protected areas. A GIs-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. Furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native plant communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MsC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MsC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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REVIsITING THE sIMILAR PROCEss TO ENGINEER THE CONTEMPORARY sYsTEMs

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Journal of systems science and systems Engineering 2010年第3期19卷 321-350页

作者： Ana luísa RAMOs josé Vasconcelos FERREIRA Jaume BARCELó GOVCOPP-Department of Economics Management and Industrial EngineeringUniversity of Aveiro Department of statistics and Operations Research Technical University of Catalonia

This paper addresses the present-day context of systems Engineering, revisiting and setting up an updated framework for the sIMILAR process in order to use it to engineer the contemporary systems. The contemporary world is crowded of large interdisciplinary complex systems made of other systems, personnel, hardware, software, information, processes, and facilities. An integrated holistic approach is crucial to develop these systems and take proper account of their multifaceted nature and numerous interrelationships. As the system＇s complexity and extent grow, the number of parties involved （stakeholders and shareholders） usually also raises, bringing to the interaction a considerable amount of points of view, skills, responsibilities, and interests. The systems Engineering approach aims to tackle the complex and interdisciplinary whole of those socio-technical systems, providing the means to enable their successful realization. Its exploitation in our modern world is assuming an increasing relevance noticeable by emergent standards, academic papers, international conferences, and post-graduate programmes in the field. This work aims to provide ＂the picture＂ of modern systems Engineering, and to update the context of the sIMILAR process model in order to use this renewed framework to engineer the challenging contemporary systems. The emerging trends in the field are also pointed-out with particular reference to the Model-Based systems Engineering approach.

关键词： sIMILAR process systems engineering standards MBsE

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A Novel Approach to Measuring spatiotemporal Changes in social Vulnerability at the Local Level in Portugal

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International Journal of Disaster Risk science 2022年第6期13卷 842-861页

作者： Pedro Pinto santos joséluís Zêzere susana Pereira Jorge Rocha Alexandre Oliveira Tavares Centre for Geographical studies Institute of Geography and Spatial PlanningTERRAUniversity of Lisbon(CEG-IGOT-ULisboa)1600-276 LisboaLAPortugal Centre for social studies Earth Science DepartmentScience and Technology FacultyUniversity of Coimbra(CES/DCT-FCT-UCoimbra)3000-995 CoimbraPortugal

social vulnerability,as one of the risk components,partially explains the magnitude of the impacts observed after a *** this study,a spatiotemporally comparable assessment of social vulnerability and its drivers was conducted in Portugal,at the civil parish level,for three census *** first challenging step consisted of the selection of meaningful and consistent variables over *** were normalized using the Adjusted Mazziotta-Pareto Index(AMPI)to obtain comparable adimensional-normalized values.A joint principal component analysis(PCA)was applied,resulting in a robust set of variables,interpretable from the point of view of their self-grouping around vulnerability drivers.A separate PCA for each census was also conducted,which proved to be useful in analyzing changes in the composition and type of drivers,although only the joint PCA allows the monitoring of spatiotemporal changes in social vulnerability scores and drivers from 1991 to 2011.A general improvement in social vulnerability was observed for *** two main drivers are the economic condition(PC1),and aging and depopulation(PC2).The remaining drivers highlighted are uprooting and internal mobility,and daily *** data proved their value in the territorial,social,and demographic characterization of the country,to support medium-and long-term disaster risk reduction measures.

关键词： AMPI normalization Portugal social vulnerability spatiotemporal changes

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Checking procalcitonin suitability for prognosis and antimicrobial therapy monitoring in burn patients

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Burns & Trauma 2018年第1期6卷 39-48页

作者： luís Cabral Vera Afreixo Rita Meireles Miguel Vaz Catarina Chaves Marisa Caetano luís Almeida joséArtur Paiva Department of Plastic surgery and Burns Unit Unidade de QueimadosCoimbra University Hospital Centre(CHUC)Av.Bissaya Barreto s/n3000-075 CoimbraPortugal Autonomous section of Health sciences(sACs) University of AveiroAveiroPortugal CIDMA-Center for Research and Development in Mathematics and Applications iBiMEDInstitute for BiomedicineUniversity of AveiroAveiroPortugal Clinical Pathology Department Coimbra University Hospital Centre(CHUC)CoimbraPortugal Pharmacy Department Coimbra University Hospital Centre(CHUC)CoimbraPortugal MedinUP Department of Pharmacology and TherapeuticsFaculty of MedicineUniversity of PortoPortoPortugal Department of Emergency and Intensive Care Medicine Centro Hospitalar Sao JoaoPortoPortugal Faculty of Medicine University of PortoGrupo de Infeccao e SépsisPortoPortugal.

Background: Due to greater infection susceptibility, sepsis is the main cause of death in burn patients. Quick diagnosis and patient stratification, early and appropriated antimicrobial therapy, and focus control are crucial for patients’survival. On the other hand, superfluous extension of therapy is associated with adverse events and arousal of microbial resistance. The use of biomarkers, necessarily coupled with close clinical examination, may predict outcomes, stratifying patients who need more intensive care, and monitor the efficacy of antimicrobial therapy, allowing faster de-escalation or stop, reducing the development of resistance and possibly the financial burden, without increasing mortality. The aim of this work is to check the suitability of procalcitonin (PCT) to fulfill these goals in a large sample of septic burn patients. Methods: One hundred and one patients, with 15% or more of total body surface area (TBsA) burned, admitted from January 2011 to December 2014 at Coimbra Burns Unit (CBU), in Portugal were included in the sample. All patients had a diagnosis of sepsis, according to the American Burn Association (ABA) criteria. The sample was factored by survival (68 survivors and 33 non-survivors). The maximum value of PCT in each day was used for statistical analysis. Data were summarized by location measures (mean, median, minimum, maximum, quartiles) and dispersion measures (standard error and range measures). statistical analysis was performed with sPss?23.0 IBM? for Windows?. Results: There were statistically significant differences between PCT levels of patients from the survivor and non-survivor groups during the first and the last weeks of hospitalization as well as during the first week after sepsis suspicion, being slightly higher during this period. During the first 7 days of antimicrobial therapy, PCT was always higher in the non-survivor, still without reaching statistical significance, but when the analysis was extended till the 15th

关键词： Burns sepsis Procalcitonin Prognosis Antimicrobial stewardship

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FPGA sharing in the cloud: a comprehensive analysis

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Frontiers of Computer science 2023年第5期17卷 1-13页

作者： Jinyang GUO lu ZHANG joséROMERO HUNG Chao LI Jieru ZHAO Minyi GUO Department of Computer science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Micro/Nano Electronics Shanghai Jiao Tong UniversityShanghai 200240China

Cloud vendors are actively adopting FPGAs into their infrastructures for enhancing performance and *** cloud services continue to evolve,FPGA(field programmable gate array)systems would play an even important role in the *** this context,FPGA sharing in multi-tenancy scenarios is crucial for the wide adoption of FPGA in the ***,many works have been done towards effective FPGA sharing at different layers of the cloud computing *** this work,we provide a comprehensive survey of recent works on FPGA *** examine prior art from different aspects and encapsulate relevant proposals on a few key *** the one hand,we discuss representative papers on FPGA resource sharing schemes;on the other hand,we also summarize important sW/HW techniques that support effective ***,we further analyze the system design cost behind FPGA ***,based on our survey,we identify key opportunities and challenges of FPGA sharing in future cloud scenarios.

关键词： cloud FPGA FPGA sharing efficiency design cost

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Flow regimes in wet conical spouted beds using glass bead mixtures

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Particuology 2008年第2期6卷 72-80页

作者： Marcelo s.Bacelos jos Teixeira Freire Universidade Federal de sāo Carlos Centro de Ciências Exatas e de TecnologiaPrograma de Pós-Graduacāo em Engenharia QuímicaCentro de Secagem de PastasSuspensōes e SementesRod.Washington LuizKm 23513565-905CP 676Sāo CarlosSPBrazil

Using a high-viscosity Newtonian fluid, glycerol, an experimental investigation was carried out to evaluate the stable spouting regime in conical spouted beds using four particle mixtures： a reference （monoparticles）, a binary mixture, two ternary mixtures with flat and Gaussian distributions respectively. The mixtures were selected for particle diameters （dp） ranging from 1.09 to 4.98 mm and particle diameter ratios （dpL/dps） ranging from 1.98 to 4.0. Experimental data show that pressure fluctuation signals of the bed, as indicated by changes in their standard deviations, provide suitable information to identify the range of operational conditions for stable spouting. However, the analysis of skewness of curves of pressure fluctuation as a function of air velocity appears not sufficient to identify a particular flow regime. For glycerol in the spouting regime, the standard deviation is noted to increase with increasing glycerol concentration due to the growth of interparticle forces. The implications of these research findings on the drying of suspensions in conical spouted beds using glass bead mixtures are also discussed.

关键词： Conical spouted bed Binary and ternary mixtures Processing of pastes spouting regimes spouting stability Pressure fluctuation

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