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journal of Mountain Science 2024年第1期21卷 271-291页

作者： GARCÍA-ARIAS Sergio VELANDIA francisco ALVAREZ Angélica SANABRIA-GÓMEZ joséD TARAZONA Yessenia VARGAS María Camila Escuela de Geología Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia Escuela de Física Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia

This work applies stress tensors inversions and quantification of fracture patterns along the Mesa de Los Santos, in the Eastern Cordillera of Colombia, to better understand the potential fluid flow. It thus contributes to the conceptual hydrogeological model. The area was subdivided into three blocks, separated by the NW Potreros and the Los Santos faults, having minor inner faults of different orientations. This separation facilitates the analysis of the fractures measured in the field, which in general show high dip angles and a conjugate geometry in the northern block, tension fractures(Mode I) in the central block, and a random distribution in the southwestern block. WinTensor treatment of slickensides yielded a maximum horizontal stress(SHmax) of 111o, which coincides with the WNW-ESE tensor observed from the conjugate and tension joints. We then used Frac Pa Q to generate interpolation maps of fracture intensity and density. The maps show the highest values in the central block and the lowest in the northern block,where the precipitation is higher, causing intensive rock weathering and homogenization of the fracture planes. Although the highest values of connectivity by line are found to the south of the mesa, we suggest the possibility of greater flow from the recharge zone(NE) along bedding planes and open NW-SE fractures.

关键词： Mesa de Los Santos Colombia Win-Tensor FracPaQ Strike-slip faults Fractured aquifers

development and postnatal neurogenesis in the retina: a comparison between altricial and precocial bird species

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Neural Regeneration Research 2021年第1期16卷 16-20页

作者： Guadalupe Álvarez-Hernán josé Antonio de Mera-Rodríguez Yolanda Gañán jorge Solana-Fajardo Gervasio Martín-Partido joaquín Rodríguez-León javier francisco-Morcillo Área de Biología Celular Departamento de AnatomíaBiología Celular y ZoologíaFacultad de CienciasUniversidad de ExtremaduraBadajozSpain Área de Anatomía Humana Departamento de AnatomíaBiología Celular y ZoologíaFacultad de MedicinaUniversidad de ExtremaduraBadajozSpain Servicio de Oftalmología Complejo Hospitalario Universitario de BadajozBadajozSpain

The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons,the leading cause of irreversible blindness in *** vertebrate phylogeny,the retina has two kinds of specialized niches of constitutive neurogenesis:the retinal progenitors located in the circumferential marginal zone and Müller *** proliferative activity in the retinal progenitors located in the circumferential marginal zone in precocial birds such as the chicken,the commonest bird model used in developmental and regenerative studies,is very *** region adds only a few retinal cells to the peripheral edge of the retina during several months after hatching,but does not seem to be involved in retinal regeneration.Müller cells in the chicken retina are not proliferative under physiological conditions,but after acute damage some of them undergo a reprogramming event,dedifferentiating into retinal stem cells and generating new retinal ***,regenerative response after injury occurs with low efficiency in the precocial avian *** contrast,it has recently been shown that neurogenesis is intense in the retina of altricial birds at *** particular,abundant proliferative activity is detected both in the circumferential marginal zone and in the outer half of the inner nuclear ***,stem cell niches are very active in the retina of altricial *** more extensive research is needed to assess the potential of proliferating cells in the adult retina of altricial birds,it emerges as an attractive model for studying different aspects of neurogenesis and neural regeneration in vertebrates.

关键词： altricial birds circumferential marginal zone Müller glia postnatal neurogenesis precocial regeneration retinogenesis

Nitric oxide and hydrogen sulfide share regulatory functions in higher plant events

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BIOCELL 2022年第1期46卷 1-5页

作者： francisco j.CORPAS SALVADOR GONZÁLEZ-GORDO MARTA RODRÍGUEZ-RUIZ MARÍA A.MUÑOZ-VARGAS josÉM.PALMA Group of Antioxidants Free Radicals and Nitric Oxide in BiotechnologyFood and AgricultureDepartment of BiochemistryCell and Molecular Biology of PlantsEstación Experimental del Zaidín(Spanish National Research CouncilCSIC)Granada18008Spain

Nitric oxide(NO)and hydrogen sulfide(HS)are two molecules that share signaling properties in plant and animal cells NO and H2S originate two farmilies of de rived mol ecules designated reactive nitrogen and sulfur species(RNS and RSS,respectively).These molecules are responsible for certain protein regulatory processes through posttranslational modifications(PTMs),being the most remarkable S nitrosation and persufidation,which afect the thiol group of cysteine *** and H2S can also exert regulatory functions due to their interaction through the iron present in proteins that contain heme groups or iron-sulfur dlusters,as reported mainly in animal ***,the available information in plant cells is still very limited thus *** higher plants,NO and H2S are involved in a myriad of physiological events from seed germination to fruit ripening,but also the mec hanism of response to biotic and abiotic stress *** vie wpoint manuscript highlights the functional regulatory parllelism of these two molecules which also interact with the metabolism of reactive oxygen species(ROS)in plant cells.

关键词： Ascorbate peroxidase Hydrogensulfide Nitricoxide Persulfidation S-nitrosation Signaling

Climatic Projections of Lightning in Southeastern Brazil Using CMIP5 Models in RCP’s Scenarios 4.5 and 8.5

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American journal of Climate Change 2017年第3期6卷 539-553页

作者： Ana Paula Paes dos Santos Osmar Pinto júnior Sérgio Rodrigo Quadros dos Santos francisco josé Lopes de Lima Everaldo Barreiros de Souza André Arruda Rodrigues de Morais Eldo E. ávila Analía Pedernera National Institute for Space Research (INPE) S&atilde o josé dos Campos Brazil Vale Institute of Technology (ITV) Belém Brazil National University of Cordoba (UNC) Córdoba Argentina

Given the high and increasing lightning incidence over the Southeast of Brazil and the various impacts that this phenomenon generates to society, there is a growing need in predicting its occurrence, in order to minimize its consequences. In this context, this work presents the development of a methodology for the projection of lightning in the State of S?o Paulo (Southeastern Brazil), using the HadGEM2-ES and CSIRO-Mk3.6 models in two IPCC climate change scenarios: RCP4.5 and RCP8.5. Since lightning is not an output variable of climate models, tests were carried out to evaluate the relationship between the observed data of oceanic and atmospheric fields, which are known as outputs of the models, and the lightning from the RINDAT and BrasilDAT detection networks. As result, a correlation of 0.84 was obtained. In the projections, it was verified that, while during a large portion of the current climate we observed events of lightning below the average, the future climate reveals the preponderance of anomalously above average events, both in the scenario of intermediate-low emissions (RCP4.5) and in the scenario of high emissions (RCP8.5), suggesting a change in the pattern of the lightning incidence in the State of S?o Paulo.

关键词： Lightning Climatic Projections Southeastern Brazil

Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study

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Translational Neurodegeneration 2020年第1期9卷 96-104页

作者： Heinz Reichmann Andrew Lees josé-francisco Rocha Diogo Magalhaes Patrício Soares-da-Silva the OPTIPARK investigators department of Neurology University of DresdenDresdenGermany University College London Reta Lila Weston InstituteLondonUK Global Parkinson’s Disease department BIAL–Portela&CA S.ACoronadoPortugal Research and development department BIAL–Portela&CA S.Ada Siderurgia Nacional4745-457 S Mamede do CoronadoPortugal department of Pharmacology and Therapeutics Faculty of MedicineUniversity PortoPortoPortugal MedInUP Center for Drug Discovery and Innovative MedicinesUniversity PortoPortoPortugal 不详

Background:The efficacy and safety of opicapone,a once-daily catechol-O-methyltransferase inhibitor,have been established in two large randomized,placebo-controlled,multinational pivotal ***,clinical evidence from routine practice is needed to complement the data from the pivotal ***:OPTIPARK(NCT02847442)was a prospective,open-label,single-arm trial conducted in Germany and the UK under clinical practice *** with Parkinson’s disease and motor fluctuations were treated with opicapone 50 mg for 3(Germany)or 6(UK)months in addition to their current levodopa and other antiparkinsonian *** primary endpoint was the Clinician’s Global Impression of Change(CGI-C)after 3 *** assessments included Patient Global Impressions of Change(PGI-C),the Unified Parkinson’s Disease Rating Scale(UPDRS),Parkinson’s Disease Questionnaire(PDQ-8),and the Non-Motor Symptoms Scale(NMSS).Safety assessments included evaluation of treatment-emergent adverse events(TEAEs)and serious adverse events(SAEs).Results:Of the 506 patients enrolled,495(97.8%)took at least one dose of *** these,393(79.4%)patients completed 3 months of ***,71.3 and 76.9%of patients experienced any improvement on CGI-C and PGI-C after 3 months,respectively(full analysis set).At 6 months,for UK subgroup only(n=95),85.3%of patients were judged by investigators as improved since commencing *** scores at 3 months showed statistically significant improvements in activities of daily living during OFF(mean±SD change from baseline:?3.0±4.6,pderate *** considered to be at least possibly related to opicapone were reported for 45.1%of patients,with dyskinesia(11.5%)and dry mouth(6.5%)being

关键词： Levodopa Motor fluctuations Open-label Opicapone Parkinson’s disease

Leaf Gas Exchange,Photon Capture and Light Harvest in Aldina heterophylla along a Vegetation Gradient in the Amazon Rainforest

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American journal of Plant Sciences 2014年第10期5卷 1477-1488页

作者： joao Victor Figueiredo Cardoso Rodrigues josé francisco de Carvalho Goncalves Federal University of Amazonas Center for Distance EducationManausBrazil Laboratory of Plant Physiology and Biochemistry National Institute for Research in the AmazonManausBrazil

Adaptation along environmental gradients is presumed to induce physiological and biochemical leaf changes in plant species. In this paper, we report how leaf gas exchange, photon capture and light harvest for photosynthesis in Aldina heterophylla change along a vegetation gradient from low stature open vegetation on extremely nutrient-poor white sand (Campina, CP), through inter-mediate closet type (Campinarana, CR) to tall closed rain forest (RF). The pigment concentrations did not differ between the CP, CR and RF habitats. The performance index for the photosynthesis (PIABS) of individuals in RF and CP was approximately 30% higher than that in CR individuals. This species showed similar potential rates of photosynthesis in the different vegetation types;however, the dark respiration rates were higher in CP. Our results indicate that the differences in the leaves and soil nitrogen concentrations are not enough to change the levels of gas exchange. Other environmental features may be driving the observed morphological features in this gradient, in particular, the tree height.

关键词： Chloroplast Pigments Dark Respiration Net Photosynthesis Physiological Plasticity Tropical Forest Biomass Accumulation

Improving outcomes in pancreatic cancer: Key points in perioperative management

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World journal of Gastroenterology 2014年第39期20卷 14237-14245页

作者： josé M álamo Luis M Marín Gonzalo Suarez Carmen Bernal juan Serrano Lydia Barrera Miguel A Gómez jordi Muntané francisco j Padillo Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREH o Ciberehd) Instituto de Salud Carlos Ⅲ 28029 Madrid Spain francisco j Padillo Department of General Surgery Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla 41013 Seville Spain

This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neo-adjuvant therapy. Preoperative biliary drainage is recommended only in patients with severe jaundice, as it can lead to infectious cholangitis, pancreatitis and delay in resection, which can lead to tumor progression. The development of a phase III clinical trial is mandatory to clarify the role of neo-adjuvant radiochemotherapy in pancreatic adenocarcinoma. Venous resection does not adversely affect postoperative mortality and morbidity, therefore, the need for venous resection should not be a contraindication to surgical resection in selected patients. The data on arterial resection alone, or combined with vascular resection at the time of pancreatectomy are more heterogeneous, thus, patient age and comorbidity should be evaluated before a decision on operability is made. In patients undergoing R0 resection, arterial resection can also be performed.

关键词： Pancreatic cancer Obstructive jaundice Preoperative drainage Neo-adjuvant therapy Vascular resection

Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells

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World journal of Stem Cells 2017年第2期9卷 26-36页

作者： Estefania Caballano-Infantes josé Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil francisco j Bedoya juan R Tejedo Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide 41092 SevilleSpain Biomedical Research Network on Diabetes and Related Metabolic Diseases(CIBERdeM) Instituto de Salud CarlosⅢ28029 MadridSpain Andalusian Center for Molecular Biology and Regenerative Medicine(CABIMER) 41092 SevilleSpain Andalusian Center for Molecular Biology and Regenerative Medicine Fundación Progreso y Salud41092 SevilleSpain Centre for Pharmacology and Therapeutics Division of Experimental MedicineImperial College LondonHammersmith Hospital CampusLondon W12 0NNUnited Kingdom

Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies.

关键词： Endoplasmic reticulum stress Mitochondrial function Nitric oxide Pluripotency Cell differentiation Mitochondrial biogenesis

The Harvesting of the Endangered Palm Euterpe edulis in the Brazilian Atlantic Forest: The Case of Linear Canopy Openings

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journal of Geoscience and Environment Protection 2023年第12期11卷 151-162页

作者： Pablo josé francisco Pena Rodrigues Mariana de Andrade Iguatemy Talita Reis Instituto de Pesquisas jardim Botanico do Rio de janeiro Rua Pacheco Le&#227o Rio de Janeiro Brazil

The palm Euterpe edulis was historically very exploited by humans and even today, many individuals are cut down by collectors to harvest the edible palm hearts. The ecological aspects of this anthropogenic pressure and its related effects are poorly understood. Here we investigate if linear canopy openings in a fragment of Brazilian Atlantic Forest can cause edge effects and facilitate predatory harvesting by humans. We sampled in Tinguá Biological Reserve (Southeastern Brazil) native palm populations at forest edges adjacent to two linear canopy openings, and in the forest interior far from any edge. Our 8-year monitoring showed that the linear canopy openings negatively affected the palm populations reducing its density and regeneration mainly on edges, but no local extinction was observed. Thus, the direct human impact from harvesting, adverse survival conditions on edges and interspecific competition causes population declines with no local extinction, so this suggests that E. edulis may resist even under strong anthropogenic pressure.

关键词： Extinction Exploitation Forest Product Species Survival Sustainability

The effect of water-level fluctuations on swamp forest colonization by seedlings of <i>Tabebuia cassinoides</i>DC. (Bignoniaceae)

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Open journal of Ecology 2011年第3期1卷 63-64页

作者： Mariana de Andrade Iguatemy Pablo josé francisco Pena Rodrigues 不详

Establishment of Tabebuia cassinoides seedlings is related to water-level fluctuations in southeastern Brazil swamp forests. Nine years of annual monitoring of 48 individuals established during a drought in November 1997, when the swamp was unflooded, suggested that their establishment depends on this unpredictable event. This conclusion is further sustained by the wide variability of the seedling cohort size structure, and the fascicular root conformation that holds the shoots erect.

关键词： Tropical Rain Forest Wetland Seedling Establishment Safe Site Root Morphology