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The tip of the iceberg:ROP2 directly interacts with SYP121 to regulate root-hair polarization,elongation,and exocytosis

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Molecular Plant 2022年第7期15卷 1084-1086页

作者： Martiniano M.Ricardi jose M.estevez Instituto de Fisiología Biología Molecular y Neurociencias(IFIBYNE-UBA-CONICET)and Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaBuenos Aires C1428EHAArgentina Fundación Instituto Leloir and IIBBA-CONICET.Av.Patricias Argentinas 435 Buenos Aires C1405BWEArgentina Centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiago 8370146Chile ANID-Millennium Science Initiative Program-Millennium Nucleus for the Development of Super Adaptable Plants(MN-SAP) Santiago 8370146Chile

Root hairs(RHs)grow in a polar manner as cylindrical protrusions from the root epidermis.They significantly expand the root volume in the rhizosphere to search for water and nutrients,anchor the plant,and promote interactions with several kinds of microorganisms in the soil.Trichoblasts,the epidermis cell type responsible for RH development,switch from anisotropic cell elongation to tip growth through polarization of the growth machinery to a predefined RH initiation domain(RHID)at the plasma membrane.

关键词： tip polarization cylindrical

Hepatic abscess induced by foreign body:Case report and literature review

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World Journal of Gastroenterology 2007年第9期13卷 1466-1470页

作者： Sofia A Santos Sara CF Alberto Elsa Cruz Eduardo Pires Tomás Figueira lia Coimbra josé estevez Mário Oliveira Luís Novais Joo R Deus Department of Gastroenterology Fernando Fonseca Hospital IC19 Amadora 2720-276 Portugal Department of Radiology Fernando Fonseca Hospital IC19 Amadora 2720-276 Portugal Department of Surgery Fernando Fonseca Hospital IC19 Amadora 2720-276 Portugal Department of Pathology Fernando Fonseca Hospital IC19 Amadora 2720-276 Portugal Center for the Study of Esophageal Diseases Carnaxide Portugal

Hepatic abscess due to perforation of the gastrointestinal tract caused by ingested foreign bodies is uncommon. Pre-operative diagnosis is difficult as patients are often unaware of the foreign body ingestion and symptoms and imagiology are usually non-specific. The authors report a case of 62-year-old woman who was admitted with fever and abdominal pain. Further investigation revealed hepatic abscess, without resolution despite antibiotic therapy. A liver abscess resulting from perforation and intra-hepatic migration of a bone coming from the pilorum was diagnosed by surgery. The literature concerning foreign body-induced perforation of the gastrointestinal tract complicated by liver abscess is reviewed.

关键词：胃肠道穿孔异物诱发肝脓肿病例报告文献综述

Relativistic charged stellar modeling with a perfect fluid sphere

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Communications in Theoretical Physics 2023年第9期75卷 113-121页

作者： Joaquin estevez-Delgado Joel Arturo Rodríguez Ceballos Jorge Mauricio Paulin-Fuentes joséVega Cabrera Antonio Rendón Romero Facultad de Ciencias Físico Matemáticas de la Universidad Michoacana de San Nicolás de Hidalgo Edificio BCiudad UniversitariaMorelia MichoacánCP 58040Mexico Facultad de Químico Farmacobiología de la Universidad Michoacana de San Nicolás de Hidalgo Tzintzuntzan No.173Col.MatamorosMorelia MichoacánC.P.58240Mexico División Académica de Ciencias Básicas de la Universidad Juárez Autónoma de Tabasco Carretera Cunduacán-Jalpa Km.1Col.La Esmeralda86690CunduacánTabascoMexico Facultad de Ingenieria Mecanica de la Universidad Michoacana de San Nicolás de Hidalgo Edificio W Ciudad UniversitariaCP 58030Morelia MichoacánMexico

In this report we present the generalization of a solution to Einstein's equations with perfect fluid for the case of Einstein–Maxwell with perfect fluid.The effect of the charge is reflected by a parameter,ν,and its interval is determined by the positivity condition from the pressure in the interior of the star.It is shown that the solution is stable according to the Zeldovich criteria as well as in relation to the criteria of the adiabatic index.The compactness,u=GM/c^(2)R,of this charged model is greater than it is for the chargeless case as a result of the effect of the presence of the charge.This allows it to represent stars with a high compactness,in particular a graphic analysis is presented for the star SAX J1808.4-3658 with mass M=1.435M_(⊙)and radius R=7.07 km.From these data and employing the solution,we obtain that the total maximum charge for the star is Q=2.4085×10^(20)C.

关键词： general relativity exact solutions charged fluid stars models

The RALF1-FERONIA Complex Phosphorylates eIF4E1 to Promote Protein Synthesis and Polar Root Hair Growth

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Molecular Plant 2020年第5期13卷 698-716页

作者： Sirui Zhu jose Manuel estevez Hongdong Liao Yonghua Zhu Tao Yang Chiyu Li Yichuan Wang Lan Li Xuanming Liu Javier Martinez Pacheco Hongwei Guo Feng Yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Biologyand Hunan Key Laboratory of Plant Functional Genomics and Developmental RegulationHunan UniversityChangsha 410082P.R.China Fundacion Instituto Leloir Buenos Aires C1405BWEArgentina and IIBBA-CONICETBuenos Aires C1405BWEArgentina Centro de Biotecnologfa Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiago RM 8370146Chile National Engineering Laboratory for Rice and Byproduct Deep Processing Central South University of Forestry and TechnologyChangsha 410004P.R.China Institute of Plant and Food Science Department of BiologySouthern University of Science and TechnologyShenzhenGuangdong 518055P.R.China State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterChangsha 410125P.R.China

The molecular links between extracellular signals and the regulation of localized protein synthesis in plant cells are poorly understood.Here,we show that in Arabidopsis thaliana,the extracellular peptide RALF1 and its receptor,the FERONIA receptor kinase,promote root hair(RH)tip growth by modulating protein synthesis.We found that RALF1 promotes FERONIA-mediated phosphorylation of elF4E1,a eukaryotic translation initiation factor that plays a crucial role in the control of mRNA translation rate.Phosphorylated elF4E1 increases mRNA affinity and modulates mRNA translation and,thus,protein synthesis.The mRNAs targeted by the RALF1-FERONIA-elF4E1 module include ROP2 and RSL4,which are important regulators of RH cell polarity and growth.RALF1 and FERONIA are expressed in a polar manner in RHs,which facilitate elF4E1 polar丨ocalization and thus may control local f?OP2 translation.Moreover,we demonstrated that high-level accumulation of RSL4 exerts negative-feedback regulation of RALF1 expression by directly binding the RALF1 gene promoter,determining the final RH size.Our study reveals that the link between RALF1-FERONIA signaling and protein synthesis constitutes a novel component regulating cell expansion in these polar growing cells.

关键词： elF4E1 FER polar cell growth RALF1 root hairs RSL4

Safety and Efficacy of Racotumomab-Alum Vaccine as Second-Line Therapy for Advanced Non-Small Cell Lung Cancer

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International Journal of Clinical Medicine 2014年第14期5卷 844-850页

作者： Eduardo Santiesteban Leslie Perez Sailyn Alfonso Elia Neninger Soraida Acosta Yoana Flores Maurenis Hernandez Carmen Viada Robin García Meylán Cepeda Daymys estevez Yoisbel Moreno Amparo Macías Celestino Hernández Robau Hospital Villa Clara Cuba Center of Molecular Immunology Havana Cuba Hermanos Ameijeiras Hospital Havana Cuba josé Ramón López Tabranes Hospital Matanzas Cuba National Institute of Oncology and Radiobiology Havana Cuba Saturnino Lora Hospital Santiago de Cuba Cuba

Despite extensive clinical research in non-small cell lung cancer (NSCLC), overall survival is still poor. Racotumomab-alum is an anti-idiotypic cancer vaccine that targets NeuGcGM3 tumor associated ganglioside. The aim of this study was to evaluate safety and efficacy of racotumomab-alum in advanced NSCLC patients with progressive disease. This expanded access program included 86 histologically confirmed NSCLC patients, 18 years or older age, with advanced disease and without therapeutic option, with ECOG performance status ≤3, adequate organ functions and signed informed consent. The primary endpoint was overall survival and toxicity was measure assessed treatment-related toxicity according CTCAEv3. The study was approved by ethical review boards of participant institutions. Racotumomab-alum treatment consisted in 5 biweekly intradermal doses (1 mg/mL) during the induction phase of treatment (2 months). The maintenance phase consisted in monthly re-immunizations until unacceptable toxicity or PS worsening. The median overall survival time of all patients treated with racotumomab-alum was 8.96 months. The survival rates at 12 and 24 months were 42.8% and 28.0%, respectively. Patients that completed the induction phase of treatment (five doses or more) reached a median OS of 12.1 months. The most common adverse events were injection site reaction, bone pain, cough and asthenia. Racotumomab-alum cancer vaccine could be considered an effective and safe treatment option as second-line therapy for advanced NSCLC. Further clinical studies should be conducted to confirm this result.

关键词： Non-Small Cell Lung Cancer Cancer Vaccine Second-Line Treatment