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Gene expression changes in spleens of the wildlife reservoir species,Eurasian wild boar(Sus scrofa),naturally infected with Brucella suis biovar 2

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Journal of Genetics and Genomics 2010年第11期37卷 725-736页

作者： Ruth C.Galindo Pilar M.Muoz María J.de Miguel Clara M.Marin Javier labairu Miguel Revilla josé M.Blasco Christian Gortazar José de la Fuente Instituto de Investigación en Recursos Cinegéticos IREC(CSIC-UCLM-JCCM) Unidad de Sanidad Animal Centro de Investigación y Tecnología Agroalimentaria(CITA) ITG Ganadero Avda. Serapio Huici 2231610 VillabaNavarraSpain departamento de Patología Animal Facultad de VeterinariaUniversity of Zaragoza department of Veterinary Pathobiology Center for Veterinary Health SciencesOklahoma State University

Brucella suis is responsible for swine brucellosis worldwide. Of the five different B. suis biovars （by.）, bv. 2 appears restricted to Europe where it is frequently isolated from wild boar and hares, can infect pigs and can cause human brucellosis. In this study, the differ- ential gene expression profile was characterized in spleens of Eurasian wild boar naturally infected with B. suis bv. 2. Of the 20,201 genes analyzed in the microarray, 633 and 1,373 were significantly （fold change 〉 1.8; P 〈 0.01） upregulated and downregulated, respectively, in infected wild boar. The analysis was focused on genes that were over represented after conditional test for biological process gene ontology. Upregulated genes suggested that B. suis bv. 2 infection induced cell maturation, migration and/or proliferation in infected animals. The genes downregulated in infected wild boar impaired the activity of several important cellular metabolic pathways such as metabolism, cytoskeleton organization and biogenesis, immune response and lysosomal function and vesicle-mediated transport. In addition, the response to stress, sperm fertility, muscle development and apoptosis seemed to be also impaired in infected animals. These results suggested that B. suis bv. 2 may use strategies similar to other smooth brucellae to facilitate intracellular multiplication and the development of chronic infections. To our knowledge, this is the first report of the analysis of gene expression profile in hosts infected with B. suis bv. 2, which is important to understand the molecular mechanisms at the host-pathogen interface in the main reservoir species with possible implications in the zoonotic cycle of the pathogen.

关键词： Brucella suis boar genomics microarray systems biology

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Subjective experience and visual attention to a historic building:A real-world eyetracking study

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Frontiers of Architectural Research 2020年第4期9卷 774-804页

作者： Luis Alfonso de la fuente Suarez Architecture School Universidad Autonoma de Nuevo LeonSon Nicolos de los Garza(Monterrey)66455Mexico

The objective of this exploratory study is to discover the relations between visual attention to an architectural work and the subjective experiences produced during its observation.A subjective experience with a building is the specific manner in which an architectural element or the building as a whole are presented to a person.The qualities of the element as how they are perceived and the inner world of the observer are both considered in this subjective experience.The aims of this study are to describe the experience that a building generates in people,pinpoint what has attracted the participant's attention during each view of the building in an itinerary;and understand which aspects of this selected case study have made it an object of attend on.An eye-tracking study was carried out using a portable eye tracker.This tool allowed the participants to walk freely around the exterior of a historic train station in the city of Monterrey,Mexico.Two groups of participants,with routes starting from opposite sides of the building,contemplated it while using the eye tracker.Eye tracking allowed for the identification of the architectural elements that were objects of attention,the lengths of observation,and the points of view from which the elements were observed.Other data collection techniques,such as the think-aloud protocol and a special type of survey,were used to deeply understand the experiences that accompanied the visual exploration of the historic building.Results suggest that the participants observed the different architectural elements for a time that was neither influenced by the route used to explore the building nor the point where that route was initiated.The architectural elements identified as examples of high-quality architecture and perceived as aesthetically pleasing by the participants during the itinerary were observed for longer times.

关键词： Eye tracking Architecture Attention Subjective experience Data visualization

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霍克“暴风”战斗机

模型世界 2021年第12期 48-59+5页

作者： Tomás de la fuente

强大的霍克"暴风"战斗机可谓是第二次世界大战中最现代化、最令人印象深刻的飞机之一。它由空中野兽——霍克"台风"战斗机发展而来,在登陆后的日子里也有突出的表现。Tomás de la fuente为我们带来了这件细节满满的1/48比例模型,座舱...

强大的霍克"暴风"战斗机可谓是第二次世界大战中最现代化、最令人印象深刻的飞机之一。它由空中野兽——霍克"台风"战斗机发展而来,在登陆后的日子里也有突出的表现。Tomás de la fuente为我们带来了这件细节满满的1/48比例模型,座舱和其中一扇机翼上的弹舱为开启状态,呈现出丰富的直观细节。飞机身披当时英国皇家空军的典型迷彩,这种涂装一直都是表现大量污垢和磨损效果的良好平台。作者将逐步向我们讲述制作过程。

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Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages

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Cancer Biology & Medicine 2022年第7期19卷 1047-1060页

作者： Yu Han Yuming Yang Qiuyang Sun Bin Li Caixia Yue Yanlei Liu Jesús M.de la fuente Daxiang Cui Institute of Nano Biomedicine and Engineering Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of EducationShanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science&EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Engineering Center for Nanotechnology Collaborative Innovational Center for System BiologyShanghai 200241China department of Neurosurgery Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Instituto de Nanociencia de Aragon(INA) Universidad de ZaragozaZaragoza 50018Spain

Objective:Although great progress has been made in the field of siRNA gene therapy,safe,efficient,and targeted delivery of siRNA are still major challenges in siRNA therapeutics.Methods:We developed an up-conversion nanoparticle-based nanocage system.This system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites,due to modifications of targeted molecules on the surfaces of nanocages and local inhalation.Results:The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from degradation in transit to the tumor sites,where they accumulated.Compared with the passive target and control groups,the up-conversion nanoparticles based on the nanocage system showed a tumor suppressive effect after approximately 3 weeks of treatment.Conclusions:The up-conversion nanoparticle nanocages efficiently delivered vascular endothelial growth factor siRNAs to tumor sites.Mice with lung tumors treated with tumors targeting up-conversion nanoparticle nanocages showed steady body weight changes,high tumor inhibition ratios,and longer survival times.

关键词： Nanomaterials VEGF siRNA lung cancer gene therapy siRNA delivery

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FW-190 A-5——荷兰第1战斗机联队

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模型世界 2020年第9期 58-71页

作者： Tomás de la fuente

1/32长谷川(Hasegawa) Fw-190 A-5Fw-190是第二次世界大战最传奇的飞机之一。它的设计始于1937年,当时被设计为一线战斗机Me-10的继任者。事实上,Me-10从未被Fw-190取代,而是随着战争和前线的推进共存。一直到D型为止,它的主要特征是一...

1/32长谷川(Hasegawa) Fw-190 A-5Fw-190是第二次世界大战最传奇的飞机之一。它的设计始于1937年,当时被设计为一线战斗机Me-10的继任者。事实上,Me-10从未被Fw-190取代,而是随着战争和前线的推进共存。一直到D型为止,它的主要特征是一台14缸的BMW-801D-2径向发动机,拥有2100马力。使用这种径向发动机的机型有三种:A、F和G,

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雅克夫列夫YAK-3

模型世界 2020年第6期 56-65页

作者： Tomás de la fuente

SPECIAL HOBBY 1/32推出一款1/32的雅克-3在大比例模型圈内的呼声响了很久。该机的1/48比例模型曾由红星(ZVEZDA)和牛魔王(Eduard)出过,但大比例模型仍未出现。终于,Special Hobby推出了这套整体而言质量不错的套件,不过轮舱等部位开模...

SPECIAL HOBBY 1/32推出一款1/32的雅克-3在大比例模型圈内的呼声响了很久。该机的1/48比例模型曾由红星(ZVEZDA)和牛魔王(Eduard)出过,但大比例模型仍未出现。终于,Special Hobby推出了这套整体而言质量不错的套件,不过轮舱等部位开模过于繁琐。我觉得这款模型并不适合初学者。套件包含6板塑料件,排气管、轮子、无线电收发器等全为树脂件,以及一张预切成型的遮盖纸,一

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梅塞施密特Bf-109 E-4

模型世界 2018年第2期 66-74页

作者： Tomás de la fuente

Bf-109这一机型的鼎鼎大名早就已经不需要我去做过多的赘述了,所以我在此只介绍BF109家族中极为特殊的于1941年7月8月在Kln-Ostheim(科隆-奥斯特海姆)进行试飞的夜间作战型号。以BF-109 E-4为基础改造而成,通体被涂成了黑色涂装,加装... 详细信息

Bf-109这一机型的鼎鼎大名早就已经不需要我去做过多的赘述了,所以我在此只介绍BF109家族中极为特殊的于1941年7月8月在Kln-Ostheim(科隆-奥斯特海姆)进行试飞的夜间作战型号。以BF-109 E-4为基础改造而成,通体被涂成了黑色涂装,加装了Pei IG IV夜战天线,通过螺线管检测地面的无线电光束来进行导向。两个额外螺线管被加装在了机身底部并分别被一个泪滴状整流罩保护着。为了弥补这些夜战改造所带来的额外重量和对操

关键词：油画颜料螺线管 Bf-109 E-4 组合度 AK 驾驶舱施密特

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利比亚“铁面”

模型世界 2018年第12期 30-42页

作者： Tomás de la fuente

梅塞施密特Bf 110是二战最为有名的双引擎战斗机之一。它被设计成一种远程重型战斗机,然而它在不列颠之战的表现暴露了许多缺陷。由于缺乏机动性和加速性能,Bf 110跟英国单发战斗机根本无法匹敌。结果就是不仅没法给轰炸机护航,它们自... 详细信息

梅塞施密特Bf 110是二战最为有名的双引擎战斗机之一。它被设计成一种远程重型战斗机,然而它在不列颠之战的表现暴露了许多缺陷。由于缺乏机动性和加速性能,Bf 110跟英国单发战斗机根本无法匹敌。结果就是不仅没法给轰炸机护航,它们自己还得有飞机护航。但在另外一方面,Bf 110在对地攻击和夜间攻击中表现非常优秀。它的最终型号Bf 110 G-4型一直生

关键词：珐琅漆内部细节亮光漆组合度利比亚

Management of lung cancer in the COVID-19 pandemic:a review

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 145-157页

作者： Fernando Maroto Piñeiro Carmen Trinidad López Javier de la fuente Aguado department of Internal Medicine Hospital Povisa Ribera Salud Salamanca 5 Vigo 36211Spain Radiology Service Hospital Povisa Ribera Salud Salamanca 5 Vigo 36211Spain.

Since its inception,the COVID-19 pandemic has affected health care as a whole.Cancer patients in general and those suffering from lung cancer in particular are a vulnerable group because of their many intrinsic characteristics and care needs.How SARS-CoV-2(COVID-19)infection affects these patients regarding their risk of infection and outcome in this patient cohort is still to be determined.In this review,we tried to summarize our main concerns regarding COVID-19 in the context of cancer patients from a clinical and multidisciplinary approach.Different types of lung cancer treatments(chemotherapy,radiation therapy and immunotherapy)may also influence the risk of infection and condition the patient´s risk of having a worse outcome.Lung cancer patients require frequent radiologic study follow-ups,which may be affected by COVID-19 pandemic.COVID-19 related incidental radiologic findings can appear in routinely scheduled radiology tests,which may be difficult to interpret.Also cancer treatment induced pneumonitis may have similar radiologic features similar to those in acute SARS-CoV-2 pneumonia and lead to a wrong diagnosis.The different health care needs,the requirement for continuous health care access and follow-ups,and the clinical traials in which this patient population might be enrrolled are all being affected by the current COVID-19 health crisis.The COVID-19 pandemic has put health care providers and institutions in difficult situations and obliged them to face challenging ethical scenarios.These issues,in turn,have also affected the psychological well-being of health care workers.

关键词： COVID-19 cancer ethics CT thorax lung cancer cancer treatment chemotherapy immunotherapy