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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Partitioning a Graph into Defensive k-Alliances

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Acta mathematica Sinica,English Series 2011年第1期27卷 73-82页

作者： Ismael G.YERO Sergio BERmUDO Juan A.RODRiGUEZ-VELAZQUEZ jose m.sigarreta Department of Computer Engineering and mathematics Rovira i Virgili UniversityAv.Pai'sos Catalans 2643007 TarragonaSpain Department of Economy Quantitative Methods and Economic HistoryPablo de Olavide UniversityCarretera de Utrera Kin.141013-SevillaSpain Department of Computer Engineering and mathematics Rovira i Virgili UniversityAv.Paisos Catalans 2643007 TarragonaSpain Faculty of mathematics Autonomous University of GuerreroCarlos E.Adame 5Co1.La GaritaAcapulcoGuerreroMexico

A defensive k-alliance in a graph is a set S of vertices with the property that every vertex in S has at least k more neighbors in S than it has outside of S. A defensive k-alliance S is called global if it forms a dominating Set. In this paper we study the problem of partitioning the vertex set of a graph into （global） defensive k-alliances. The （global） defensive k-alliance partition number of a graph Г = （V, E）, ψkgd（F）） ψkd（F）, is defined to be the maximum number of sets in a partition of V such that each set is a （global） defensive k-alliance. We obtain tight bounds on ψkd（F） and ψkgd（F） in terms of several parameters of the graph including the order, size, maximum and minimum degree, the algebraic connectivity and the isoperimetric number. moreover, we study the close relationships that exist among partitions of F1 × F2 into （global） defensive （kl ＋ k2）-alliances and partitions of Fi into （global） defensive ki-alliances, i ∈ {1, 2}.

关键词： Defensive alliances dominating sets domination isoperimetric number

Symmetry and Transitive Properties of monohedral f-triangulations of the Riemannian Sphere

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Acta mathematica Sinica,English Series 2009年第10期25卷 1609-1616页

作者： Ana m.BREDA J.m.sigarreta Department of mathematics University of Aveiro Facultad de matematicas Universidad Autonoma de Guerrero

Here we give the complete description of the symmetry group and transitive properties of the set of all of monohedral triangulations of the Riemannian sphere by f-tilings. We shall also show that each monohedral f-tiling of the Riemannian sphere can be seen, up to a spherical isometry, as the singular set of a spherical isometric folding.

关键词： isometric folding monohedral tiling graphs combinatoric

Integral Representation Formulas Related to the Lamé–Navier System

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Acta mathematica Sinica,English Series 2020年第12期36卷 1341-1356页

作者： Ricardo ABREU-BLAYA Juan BORY-REYES marcos Antonio-HERRERA-PELáEZ josé maría sigarreta-ALmIRA Facultad de matemáticas Universidad Autónoma de GuerreroGuerreroMéxico Instituto Politécnico Nacional SEPI-ESImE-ZAC CD-MXMéxico

The paper provides integral representations for solutions to a certain first order partial differential equation natural arising in the factorization of the Lamé–Navier system with the help of Clifford analysis *** representations look like in spirit to the Borel–Pompeiu and Cauchy integral formulas both in three and higher dimensional setting.

关键词： Lamésystem Clifford analysis Dirac operator

Induced and heavy aggregation operators with distance measures

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Journal of Systems Engineering and Electronics 2010年第3期21卷 431-439页

作者： josé m.merigó montserrat Casanovas Department of Business Administration University of Barcelona

This paper introduces a new aggregation model by using induced and heavy aggregation operators in distances measures such as the Hamming *** is called the induced heavy ordered weighted averaging（OWA） distance（IHOWAD） *** paper studies some of its main properties and a wide range of particular cases such as the induced heavy OWA（IHOWA） operator,the induced OWA distance（IOWAD） operator and the heavy OWA distance（HOWAD） *** approach is generalized by using generalized and quasi-arithmetic means obtaining the induced generalized IHOWAD（IGHOWAD） operator and the Quasi-IHOWAD *** application of the new approach in a decision making problem regarding the selection of strategies is developed.

关键词： distance measures aggregation operators decision making OWA operator.

How to select a journal for your research

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World Journal of Gastroenterology 2023年第21期29卷 3379-3384页

作者： josém Ramia Department of Surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Publication in a peer-reviewed journal is the goal of any research *** of the most important(and possibly the least understood)aspects of the publication process is the choice of a suitable journal that is likely to a... 详细信息

关键词： Research Journal Altmetrics Publication

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría Norte-muñoz maría Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez josémCabrera-maqueda Javier Sierra manuel Vidal-Sanz maría Teresa moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(mHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Vitamin D-dependent microbiota-enhancing tumor immunotherapy

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Cellular & molecular Immunology 2024年第10期21卷 1083-1086页

作者： josé m.Izquierdo Centro de Biología molecular Severo Ochoa Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 128049MadridSpain

The antitumor immune response plays a crucial role in successful cancer *** a recent article in Science,Giampazolias et al.[1]reported a vitamin D(VitD)-mediated antitumor mechanism in murine intestinal epithelial cells(IECs)associated with a specific microbiota signature(Bacteroides fragilis)that enhances the antitumor immune *** strong positive association between VitD-dependent microbiota and the antitumor immune response provides a proof-of-concept for supplementing immunotherapy regimens with VitD to strengthen antitumor immunity and improve immunotherapysuccess.

关键词： immunotherapy immunity vitamin

Novel insights into the sexual dimorphism-associated immune response

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Cellular & molecular Immunology 2024年第8期21卷 804-806页

作者： josé m.Izquierdo Centro de Biología molecular Severo Ochoa Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 128049MadridSpain

In their recent article in Science,Chi et al.[1]characterized a mechanism that regulates tissue/organ-specific immunity in *** findings revealed that the androgen type 2 innate lymphoid cell-dendritic cell axis played a prominent role in a microbiota-and sex hormone-dependent *** observations implicate sexual immune dimorphism as a molecular,cellular and tissue/organ-specific regulatory hub for the(im)balance between health and *** factors,including nutritional status,diet,vital light-dark rhythms(i.e.,circadian and infradian rhythms)and the microbiota,shape the development and function of the immune system differently in males and females,which can result in differences in susceptibility to autoimmune diseases,malignancies and infectious diseases and affect the outcome of vaccination[3](Fig.1).

关键词： immunity al. diseases