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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Hunting for a viral proxy in bioaerosols of swine buildings using molecular detection and metagenomics

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Journal of Environmental Sciences 2025年第2期148卷 69-78页

作者： Valérie Létourneau marie-josée Gagné Jonathan m.Vyskocil Vincent Brochu Kim Robitaille martin Gauthier Julie Brassard Caroline Duchaine Quebec Heart and Lung Institute Research Centre-UniversitéLaval 2725 Chemin Sainte-FoyQuebecG1V 4G5Canada Saint-Hyacinthe Research and Development Centre Agriculture and Agri-Food Canada3600 Casavant Boulevard WestSaint-HyacintheJ2S 8E3Canada Department of Biochemistry Microbiologyand Bio-informaticsFaculty of Science and EngineeringUniversitéLaval1045 Avenue de la MédecineQuebecG1V 0A6Canada The Swine and Poultry Infectious Diseases Research Centre Faculty of Veterinary Medicine of Universitéde Montréal3200 Rue SicotteSaint-HyacintheJ2S 2M2Canada

There are limited biosecurity measures directed at preventing airborne transmission of viruses in *** effectiveness of dust mitigation strategies such as oil sprinkling,to decrease risk of airborne virus transmission are *** and qPCR for common fecal viruses were used to hunt for a ubiquitous virus to serve as a proxy when evaluating the efficiency of mitigation strategies against airborne viral infectious *** particles were collected from swine buildings using high-volume air *** DNA and RNA were used to perform specific RT-qPCR and qPCR and analyzed by highthroughput *** astroviruses group 2 were common(from 102 to 105 genomic copies per cubic meter of air or gc/m^(3),93%positivity)while no norovirus genogroup II was recovered from air *** torque teno sus virus were detected by qPCR in low concentrations(from 101 to 102 gc/m^(3),47%positivity).Among the identified viral families by metagenomics analysis,Herelleviridae,microviridae,myoviridae,Podoviridae,and Siphoviridae were *** phage vB_Avim_AVP of Aerococcus was present in all air samples and a newly designed qPCR revealed between 101 and 105 gc/m^(3) among the samples taken for the present study(97%positivity)and banked samples from5-and 15-year old studies(89%positivity).According to the present study,both the porcine astrovirus group 2 and the phage vB_Avim_AVP of Aerococcus could be proxy for airborne viruses of swine buildings.

关键词： Bioaerosols Viral metagenomics Astrovirus Aerococcus phage Swine buildings

A Complete Diophantine Characterization of the Rational Torsion of an Elliptic Curve

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Acta mathematica Sinica,English Series 2012年第1期28卷 83-96页

作者： Irene garcíA-SELFA jos m.TORNERO Departamento de matemáticas Universidad de HuelvaFacultad de Ciencias ExperimentalesCampus de El CarmenAvenida de las Fuerzas Armadass/n21071 HuelvaSpain Departamento de ' Algebra Universidad de SevillaP.O.116041080 SevillaSpain

We give a complete characterization for the rational torsion of an elliptic curve in terms of the （non-）existence of integral solutions of a system of diophantine equations.

关键词： Elliptic curves diophantine equations

Parallel droplet microfluidics for high throughput cell encapsulation and synthetic microgel generation

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microsystems & Nanoengineering 2018年第1期4卷 525-533页

作者： Devon m.Headen joséR.garcía Andrés J.garcía Woodruff School of mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA

Cells can be microencapsulated in synthetic hydrogel microspheres(microgels)using droplet microfluidics,but microfluidic devices with a single droplet generating geometry have limited throughput,especially as microgel diameter *** we demonstrate microencapsulation of human mesenchymal stem cells(hmSCs)in small(o100μm diameter)microgels utilizing parallel droplet generators on a two-layer elastomer device,which has 600% increased throughput ***-nozzle *** of microgel diameters were compared between products of parallel ***-nozzle configurations for two square nozzle widths,35 and 100μ*** produced on parallel nozzles were equivalent to those produced on single nozzles,with substantially the same *** of hmSCs was compared for parallel nozzle devices of each *** five micrometer wide nozzle devices could be operated at twice the cell concentration of 100μm wide nozzle devices but produced more empty microgels than predicted by a Poisson *** micrometer wide nozzle devices produced microgels as predicted by a Poisson *** of microgels did not increase with the addition of cells for either nozzle *** encapsulated on 35μm wide nozzle devices had reduced viability(~70%)and a corresponding decrease in vascular endothelial growth factor(VEGF)secretion compared to hmSCs cultured on tissue culture(TC)*** hmSCs using 100μm wide nozzle devices mitigated loss of viability and function,as measured by VEGF secretion.

关键词： droplets microencapsulation microgel multilayer parallel

multiple Chemical Sensitivity: A Sickness of Suffering, Not of Dying. Descriptive Study of 33 Cases

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Health 2025年第1期17卷 65-81页

作者： Blanca Navas-Soler Aarón Gutiérrez-Pastor Antonio Palazón-Bru Jorge Vallejo-Ortega Álex méndez-Jover Celia Santano-Pérez Carmen Seguí-Pérez marc Seguí-Pérez Sonia Cascant-Pérez Juan Carlos López-Corbalán míriam Pérez-Cardona Ramón Pérez-Doménech Antonio Hernández-garcía Patricia Lorca-Amorrich Ana Belén Llinares-Llinares Cristina Valverde-Cámara Rosa maría Bustos-martínez Juan manuel Núñez-Cruz Isidro Hernández-Isasi josé Juan martínez-Pérez josé manuel Santano-López maría Dolores Jover-Ríos Juan méndez-mora josé miguel Seguí-Ripoll Internal medicine Service University Hospital of San Juan de Alicante Alicante Spain Family and Community medicine Service University Hospital of San Juan de Alicante Alicante Spain Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO) University Hospital of San Juan de Alicante Alicante Spain Faculty of Physics University of Alicante Alicante Spain Department of Clinical medicine Medical School University Miguel Hernandez de Elche Alicante Spain CEU Veterinary School University Cardenal Herrera Alfara del Patriarca Campus Valencia Spain Secondary School Marist Brothers High School Alicante Spain Primary medicine Hospital Francesc Borgia of Gandia Valencia Spain Faculty of medicine CEU Cardenal Herrera University Alfara del Patriarca Campus Valencia Spain Faculty of Economics University of Alicante Alicante Spain Department of Internal medicine Hospital La Vega Baja of Orihuela Alicante Spain

Objective: We describe patients with mCS, the evolution of the Quick Environmental Exposure and Sensitivity Inventory (QEESI) score with a special focus on people whose fillings were removed. methods: We have conducted a retrospective longitudinal cohort study in patients diagnosed with mCS and attended in the outpatient Internal medicine department of the University Hospital of San Juan de Alicante, from January 1, 2008 to January 1, 2021. Sociodemographic, clinical, QEESI and treatment-related variables were collected. We performed descriptive and inferential analyses. mixed linear models were used to analyze the QEESI. Calculations were carried out with an α error of 5%. Results: Thirty-three patients were included (72.7% women, mean age 56.2). mCS was mainly triggered by mercury (N = 20) and food intolerance (N = 22). The mean interval from symptoms onset was 120 months (SD 81.6). 114 QEESIs were analyzed: 82 (N = 17 without amalgams) and 32 (N = 16 with amalgams). In patients without amalgams, severity scores increased across all subscales except the masking index (vs. with amalgams). mean scores for the group without amalgams (vs. with amalgams) were: chemical intolerance, 62.8 points (vs. 63.4 and 46.7);other intolerances, 52.7 points (vs. 62.8 and 50.3);symptom severity, 63.2 (vs. 76.7 and 63.3);masking index, 3.9 (vs. 3.2 and 2.8);and life impacts, 63.1 (vs. 58.4 and 49.8). Conclusion: The profile of patient with mCS is a middle-aged woman who is a frequent user of healthcare services, presents a long diagnostic delay and has borne a great personal, work and socioeconomic impact. The QEESI is useful for the clinical follow-up of patients, including the optimal treatment response in the case of amalgams. Clinical Significance: People affected by multiple Chemical Sensitivity deserve the attention, understanding and help of health professionals and family members, to face an invisible illness for those who do not suffer from it. Support is needed and doctors

关键词： Chemical Sensitivity Electromagnetic Sensitivity mercury Poisoning Amalgams QEESI

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría Norte-muñoz maría Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez josémCabrera-maqueda Javier Sierra manuel Vidal-Sanz maría Teresa moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(mHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Disturbance and forest recovery in the monarch Butterfly Biosphere Reserve,mexico

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Journal of Forestry Research 2020年第5期31卷 1551-1566页

作者： jose Lopez-garcıa Rafael m.Navarro-Cerrillo Instituto de Geografıa Universidad Nacional Autonoma de MexicoCiudad UniversitariaC.P.04510 CoyoacanDFMexico Departamento de Ingenierıa Forestal Universidad de CordobaCampus de RabanalesCarretera Nacional IV km 39614014 CordobaSpain

Analysis of the change in forest cover is important to determine stand dynamics and the processes involved in disturbance and *** of the core zone of the monarch Butterfly Biosphere Reserve were studied using photo interpretation techniques,considering biennial changes between 1999 and 2013 and changes over the whole period of study 1999–*** matrices were elaborated to determine the processes of change involved in both recovery and *** biennial changes for the whole period amounted to 2274 ha;343 ha accounted as degraded in more than one biennial *** total changes in forest cover between 1999 and 2013 involved 4902 ha,out of which,2912 ha were affected by disturbance,and 1990 ha were *** density and 2013 vegetation cover maps,the overall accuracy was 95.6%and 90.2%,*** combining both maps,gradual processes were revealed that were not evident in separate *** methodology is useful for the management and conservation of natural protected areas.

关键词： Illegal logging Forest density change Forest recovery Conifer forests monarch Butterfly Biosphere Reserve

An update on iron physiology

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World Journal of Gastroenterology 2009年第37期15卷 4617-4626页

作者： manuel muoz Isabel Villar josé Antonio garcía-Erce Transfusion medicine School of Medicine University of Málaga Málaga 29071 Spain Department of Hospital Pharmacy University Hospital Miguel Servet Zaragoza 50009 Spain Hematology and Hemotherapy University Hospital Miguel Servet Zaragoza 50009 Spain

Iron is an essential micronutrient, as it is required for adequate erythropoietic function, oxidative metabolism and cellular immune responses. Although the absorption of dietary iron (1-2 mg/d) is regulated tightly, it is just balanced with losses. Therefore, internal turnover of iron is essential to meet the requirements for erythropoiesis (20-30 mg/d). Increased iron requirements, limited external supply, and increased blood loss may lead to iron deficiency (ID) and iron-deficiency anemia. Hepcidin, which is made primarily in hepatocytes in response to liver iron levels, inflammation, hypoxia and anemia, is the main iron regulatory hormone. Once secreted into the circulation, hepcidin binds ferroportin on enterocytes and macrophages, which triggers its internalization and lysosomal degradation. Thus, in chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, which results in hypoferremia and iron-restricted erythropoiesis, despite normal iron stores (functional ID), and anemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD + ID). In contrast, low hepcidin expression may lead to iron overload, and vice versa. Laboratory tests provide evidence of iron depletion in the body, or reflect iron-deficient red cell production. The appropriate combination of these laboratory tests help to establish a correct diagnosis of ID status and anemia.

关键词： Iron metabolism Iron deficiency Functionaliron deficiency, Hepcidin Anemia of chronic disease

Blood transfusion for the treatment of acute anaemia in inflammatory bowel disease and other digestive diseases

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World Journal of Gastroenterology 2009年第37期15卷 4686-4694页

作者： josé Antonio garcía-Erce Fernando Gomollón manuel muoz Transfusion medicine and Apheresis Unit Haematology and Haemotherapy Regional Service "Miguel Servet" University Hospital Zaragoza 50009 Spain Gastroenterology Unit University Clinical Hospital and Biomedical Investigation Center at Digestive and Hepatic Disease Network c/San Juan Bosco 15 Zaragoza 50009 Spain Transfusion medicine School of Medicine University of Málaga Málaga 29071 Spain

Allogeneic blood transfusion (ABT) is frequently used as the first therapeutic option for the treatment of acute anaemia in patients with inflammatory bowel disease (IBD), especially when it developed due to gastrointestinal or perioperative blood loss, but is not risk-free. Adverse effects of ABT include, but are not limited to, acute hemolytic reaction (wrong blood or wrong patient), febrile non-hemolytic transfusional reaction, bacterial contamination, transfusion-related acute lung injury, transfusion associated circulatory overload, transfusion-related immuno-modulation, and transmission of almost all infectious diseases (bacteria, virus, protozoa and prion), which might result in increased risk of morbidity and mortality. Unfortunately, the main physiological goal of ABT, i.e. to increase oxygen consumption by the hypoxic tissues, has not been well documented. In contrast, the ABT is usually misused only to increase the haemoglobin level within a f ixed protocol [mostly two by two packed red blood cell (PRC) units] independently of the patient' s tolerance to normovolemic anaemia or his clinical response to the transfusion of PRC units according to a "one-by-one" administration schedule. Evidencebased clinical guidelines may promote best transfusion practices by implementing restrictive transfusion protocols, thus reducing variability and minimizing the avoidable risks of transfusion, and the use of autologous blood and pharmacologic alternatives. In this regard, preoperative autologous blood donation (PABD) consistently diminished the frequency of ABT, although its contribution to ABT avoidance is reduced when performed under a transfusion protocol. In addition, interpretation of utility of PABD in surgical IBD patients is hampered by scarcity of published data. However, the role of autologous red blood cells as drug carriers is promising. Finally, it must be stressed that a combination of methods used within wellconstructed protocols will offer better prospe

关键词： Anaemia Blood transfusion Autologous blood transfusion Inflammatory bowel diseases Risk assessment