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Applications of finite element simulation in orthopedic and trauma surgery

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World Journal of Orthopedics 2012年第4期3卷 25-41页

作者： Antonio Herrera Elena Ibarz josé Cego?ino Antonio lobo-Escolar Sergio puértolas Enrique lópez Jesús Mateo luis gracia Department of Orthopaedic and Trauma Surgery Miguel Servet University HospitalMedicine SchoolUniversity of Zaragoza Department of Mechanical Engineering University of Zaragoza

Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland picza captured together with computed tomography(CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element(FE) simulation lets us know the biomechanical changes that take place after hipprostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints applied

关键词： Finite element simulation Hip prosthesis lumbar spine lumbar fixations Osteoporotic fractures Splints

Forecast of the luminescent phenomena of Silicon Rich Oxide Films off Stoichiometry by Means of the Global Reaction Model

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Journal of Modern physics 2015年第11期6卷 1679-1694页

作者： Néstor David Espinosa-Torres josé álvaro David Hernández de la luz josé Francisco Javier Flores-gracia josé Alberto luna-lópez Javier Martínez-Juárez Gregorio Flores-Carrasco IC-CIDS Benemérita Universidad Autónoma de puebla Puebla México Ex Graduate Research Trainee at plasma processing laboratory Chemical Engineering Department McGill University Montreal Canada Department of Materials Science and Engineering and Chemical Engineering University Carlos III of Madrid and IAAB Madrid Spain

The Global Reaction Model describes a set of chemical reactions that can potentially occur during the process of obtaining silicon rich oxide (SRO) films, regardless of the technique used to grow such films which are an outside stoichiometry material. particularly, chemical reactions that occur during the process of growing of SRO films by lpCVD technique are highlighted in this model. We suggest and evaluate either some types of molecules or resulting nanostructures and we predict theoretically, by applying the density functional theory, the contribution that they may have to the phenomenon of luminescence which is measured in SRO films. Also, we have calculated the opto-electronic properties of SRO films. The suggested model provides enough information required to identify the molecular structures resulting from the presence of defects in SRO films and also those corresponding to charged structures. It is also possible to detect the molecular structures which are modified due to the effect of heat treatment, and identify the presence of different oxidation states inclusive the formation of siloxanes.

关键词： Global Reactions Model Silicon Rich-Oxide Defects lpCVD luminescence

liver dysfunction and SARS-CoV-2 infection

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World Journal of Gastroenterology 2021年第26期27卷 3951-3970页

作者： Abraham Edgar gracia-Ramos Joel Omar Jaquez-Quintana Raúl Contreras-Omaña Moises Auron Department of Internal Medicine General HospitalNational Medical Center"La Raza"Instituto Mexicano del Seguro SocialMexico City 02990Mexico Gastroenterology Service and Department of Internal Medicine Faculty of MedicineUniversity Hospital"Dr.JoséE.González"Universidad Autónoma de Nuevo LeónMonterrey 64460Mexico Centro de Estudio e Investigación en Enfermedades Hepáticas y Toxicológicas(CEIHET) Pachuca 42184Mexico Departments of Hospital Medicine and pediatric Hospital Medicine Cleveland ClinicClevelandOH 44195United States

Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019(COVID-19),which predominantly affects the respiratory system;it also causes systemic and multi-organic *** damage is among the main extrapulmonary ***-19-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease,and occurs in approximately one in five *** liver test results have been associated with a more severe course of COVID-19 and other complications,including *** linking COVID-19 to liver injury are *** consideration should be made for patients with pre-existing liver disease,such as metabolic dysfunction-associated fatty liver disease,chronic liver disease due to viral or autoimmune disease,liver transplant carriers,or cirrhosis,given the risk for more severe *** manuscript summarizes the current lines of evidence on COVID-19-associated liver injury regarding pathophysiology,clinical significance,and management in both patients with or without preexisting liver disease,to facilitate clinicians’access to updated information and patient ***,we mention the ideas and recommendations to be considered for future research.

关键词： SARS-CoV-2 Coronavirus COVID-19 liver liver diseases liver failure liver injury Cirrhosis

Comparative effects of different types of exercise on health-related quality of life during and after active cancer treatment:A systematic review and network meta-analysis

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Journal of Sport and Health Science 2023年第6期12卷 726-738页

作者： Vicente Martínez-Vizcaíno Iván Cavero-Redondo Sara Reina-Gutiérrez luis gracia-Marco joséJGil-Cosano Bruno Bizzozero-peroni Fernando Rodriguez-Artalejo Esther Ubago-Guisado Universidad de Castilla-la Mancha Health and Social Research CenterCuenca 16071Spain Facultad de Ciencias de la Salud Universidad Autónoma de ChileTalca 3460000Chile pROFITH(pROmoting FITness and Health through physical activity)Research Group Department of Physical Education and SportsFaculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18012Spain Higher Institute for physical Education Universidad de la RepúblicaRivera 40000Uruguay Department of preventive Medicine and public Health School of MedicineUniversidad Autónoma de MadridMadrid 28029Spain Idipaz(Instituto de Investigación Sanitaria Hospital Universitario la paz) Madrid 28029Spain g Epidemiology and Control of Chronic Diseases CIBER of Epidemiology and Public Health(CIBERESP)Madrid 28029Spain Cancer Registry of Granada Escuela Andaluza de Salud PúblicaGranada 18011Spain Cancer Epidemiology Group Instituto de Investigación BiosanitariaGranada 18012Spain

Background The positive influence of most types of exercise has been reported repeatedly,but what the most effective exercise approaches are for improving health-related quality of life(HRQol)in people with cancer remains *** aim of this systematic review and network meta-analysis was to synthesize the evidence from intervention studies to assess the effects of different types of exercise on HRQol during and after cancer *** MEDlINE,SpORTDiscus,the Cochrane library,Web of Science,and Scopus were searched for randomized controlled trials aimed at testing the effects of exercise interventions meant to improve HRQol in people with *** analyses were conducted for HRQol as measured by general and cancer-specific *** also evaluated whether the effects of exercise were different during and after cancer treatment in both the physical and mental HRQol *** In total,93 studies involving 7435 people with cancer were *** effect size estimates comparing exercise intervention *** care were significant for combined exercise(0.35,95%confidence interval(95%CI):0.14–0.56)for HRQol as measured by general questionnaires,and for combined(0.31,95%CI:0.13–0.48),mind–body exercise(0.54,95%CI:0.18–0.89),and walking(0.39,95%CI:0.04–0.74)for HRQol as measured by cancer-specific *** Exercise programs combining aerobic and resistance training can be recommended to improve HRQol during and after cancer *** scarcity and heterogeneity of these studies prevents us from making recommendations about other exercise modalities due to insufficient evidence.

关键词： Cancer Exercise HRQol physical activityTagedEnd

Candidate genes underlying QTl for flowering time and their interactions in a wide spring barley(Hordeum vulgare l.) cross

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The Crop Journal 2021年第4期9卷 862-872页

作者： Ana M.Casas Carlota R.Gazulla Arantxa Monteagudo Carlos p.Cantalapiedra Marian Moralejo Mpilar gracia Francisco J.Ciudad William T.B.Thomas jose l.Molina-Cano Scott Boden Bruno Contreras-Moreira Ernesto Igartua Department of Genetics and plant production Aula Dei Experimental Station(EEAD-CSIC)Avda Montanana 1005E-50059 ZaragozaSpain University of lleida-AGROTECNIO Center Avda.Rovira Roure 19125198 LleidaSpain Instituto de Tecnologia Agraria Junta de Castilla y LeonITACyLP.O.Box 17247071 ValladolidSpain The James Hutton Institute InvergowrieDundee DD25DAUK Institut de Recerca i Tecnologia Agroalimentaries(Udl-IRTA) Avda Rovira Roure 19125198 LleidaSpain John Innes Centre Norwich Research ParkNorwich NR47UHUK Fundacion ARAID calle Maria de Luna 1150018 ZaragozaSpain present address:Centro de Biotecnologia y Genomica de plantas Universidad Politecnica de Madrid(UPM)and Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)Madrid 28223Spain present address:School of Agriculture Food and WineWaite Research InstituteUniversity of AdelaideGlen OsmondSA 5064Australia present address:The European Bioinformatics Institute(EMBl-EBI) Wellcome Trust Genome CampusHinxtonUK

Response to vernalization and photoperiod are the main determinants controlling the time to flowering in temperate cereals. While the individual genes that determine a plant's response to these environmental signals are well characterized, the combinatorial effect on flowering time of allelic variants for multiple genes remains unresolved. This study investigated the genetic control of flowering-time in a biparental population of spring barley, derived from a wide cross between a late-flowering European and an early-flowering North-American cultivar. While the major flowering time genes are not segregating in the Beka ×logan cross, large variation in flowering was observed. We identified five QTl, with both parents found to contribute early alleles. The catalog of QTl discovered aligns with several candidate genes affecting flowering time in barley. The combination of particular alleles at HvCEN, HvElF3 and HvFT1 in logan are responsible for the earliness of this cultivar. Interestingly, earliness for flowering could be further enhanced, with Beka found to contribute three early alleles, including a QTl colocating with a HvFD-like gene, suggesting that there are diverse aspects of the flowering-time pathway that have been manipulated in these two cultivars. Epistatic interactions between flowering-time QTl or candidate genes were observed in field data and confirmed under controlled conditions. The results of this study link photoperiod-dependent flowering-time genes with earliness per se genes into a single model, thus providing a unique framework that can be used by geneticists and breeders to optimize flowering time in barley.

关键词： Barley Flowering HvElF3 HvCEN HvFT1

<i>Ab Initio</i>Molecular Orbital Calculation for Optical and Electronic properties Evaluation of Small and Medium Size Silicon Nano-Clusters Found in Silicon Rich Oxide Films

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Journal of Modern physics 2013年第11期4卷 1-26页

作者： Néstor David Espinosa Torres josé Francisco Javier Flores gracia josé Alberto luna lópez Juan Carlos Ramírez García Alfredo Morales Sánchez josé luis Sosa Sánchez David Hernández de la luz Francisco Morales Morales Research Center for Advanced Materials S.C. Unit Monterrey-pIIT Apodaca México Research Center for Semiconductor Devices CIDS-ICUAP-BUAP Puebla México The Faculty of Chemical Sciences BUAP Puebla México

In systems in atomic and nano scales such as clusters or agglomerates constituted of particles from a few to less than one hundred of atoms, quantum confinement effects are very important. Their optical and electronic properties are often dependent on the size of the systems and the way in which the atoms in these clusters are bonded. Generally, these nano-structures display optical and electronic properties significantly different of those found in corresponding bulk materials. Silicon agglomerates found in Silicon Rich Oxide (SRO) films have optical properties, which have reported as depended directly on nano-crystal size. Furthermore, the room temperature photoluminescence (pl) of Silicon Rich Oxides (SRO) has repeatedly generated a huge interest due to their possible applications in optoelectronic devices. However, a plausible emission mechanism has not yet widespread acceptance of the scientific community. In this research, we employed the Density Functional Theory with a functional B3lYp and a basis set 6 - 31G* to calculate the optical and electronic properties of small (six to ten silicon atoms) and medium size clusters of silicon (constituted of eleven to fourteen silicon atoms). With the theoretical calculation of the structural and optical properties of silicon clusters, it is possible to evaluate the contribution of silicon agglomerates in the luminescent emission mechanism experimentally found in thin SRO films.

关键词： Nano-Crystals Silicon Clusters Silicon-Rich Oxide luminescence Magic-Number

Analyzing the genomic and transcriptomic architecture of milk traits in Murciano-Granadina goats

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Journal of Animal Science and Biotechnology 2020年第3期11卷 649-666页

作者： Dailu Guan Vincenzo landi María gracia luigi-Sierra Juan Vicente Delgado Xavier Such Anna Castelló Betlem Cabrera Emilio Mármol-Sánchez Javier Fernández-Alvarez joséluis Ruiz de la Torre Casañas Amparo Martínez Jordi Jordana Marcel Amills Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Departamento de Genética Universidad de Córdoba14071 CórdobaSpain Departament de Ciència Animal i dels Aliments Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain Asociación Nacional de Criadores de Caprino de Raza Murciano-Granadina(CApRIGRAN) 18340 GranadaSpain Servei de Granges i Camps Experimentals Universitat Autònoma de Barcelona08193 BellaterraSpain

Background:In this study,we aimed to investigate the molecular basis of lactation as well as to identify the genetic factors that influence milk yield and composition in *** achieve these two goals,we have analyzed how the mRNA profile of the mammary gland changes in seven Murciano-Granadina goats at each of three different time points,i.e.78 d(T1,early lactation),216 d(T2,late lactation)and 285 d(T3,dry period)after ***,we have performed a genome-wide association study(GWAS)for seven dairy traits recorded in the 1st lactation of 822 Murciano-Granadina ***:The expression profiles of the mammary gland in the early(T1)and late(T2)lactation were quite similar(42 differentially expressed genes),while strong transcriptomic differences(more than one thousand differentially expressed genes)were observed between the lactating(T1/T2)and non-lactating(T3)mammary glands.A large number of differentially expressed genes were involved in pathways related with the biosynthesis of amino acids,cholesterol,triglycerides and steroids as well as with glycerophospholipid metabolism,adipocytokine signaling,lipid binding,regulation of ion transmembrane transport,calcium ion binding,metalloendopeptidase activity and complement and coagulation *** regard to the second goal of the study,the performance of the GWAS allowed us to detect 24 quantitative trait loci(QTls),including three genome-wide significant associations:QTl1(chromosome 2,130.72-131.01 Mb)for lactose percentage,QTl6(chromosome 6,78.90-93.48 Mb)for protein percentage and QTl17(chromosome 17,11.20 Mb)for both protein and dry matter ***,QTl6 shows positional coincidence with the casein genes,which encode 80%of milk ***:The abrogation of lactation involves dramatic changes in the expression of genes participating in a broad array of physiological processes such as protein,lipid and carbohydrate metabolism,calcium homeostasis,cell death and tissue remo

关键词： Casein genes Dairy traits GWAS lactation QTls RNA-Seq

Crop phenotyping in a context of global change:What to measure and how to do it

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Journal of Integrative plant Biology 2022年第2期64卷 592-618页

作者： jose luis Araus Shawn Carlisle Kefauver Omar Vergara-Díaz Adrian gracia-Romero Fatima Zahra rezzouk Joel Segarra Maria luisa Buchaillot Melissa Chang-Espino Thomas Vatter Rut Sanchez-Bragado joséArmando Fernandez-Gallego Maria Dolores Serret Jordi Bort Integrative Crop Ecophysiology Group Plant Physiology SectionFaculty of BiologyUniversity of BarcelonaBarcelonaSpain AGROTECNIO Center LleidaSpain plant Ecophysiology and Metabolism lab ITQB NovaPlant Sciences DivisionOeirasPortugal programa de Ingeniería Electrónica Facultad de IngenieríaUniversidad de IbaguéIbaguéColombia

High-throughput crop phenotyping,particularly under field conditions,is nowadays perceived as a key factor limiting crop genetic *** not only facilitates conventional breeding,but it is necessary to fully exploit the capabilities of molecular breeding,and it can be exploited to predict breeding targets for the years ahead at the regional level through more advanced simulation models and decision support *** terms of phenotyping,it is necessary to determined which selection traits are relevant in each situation,and which phenotyping tools/methods are available to assess such *** sensing methodologies are currently the most popular approaches,even when lab-based analyses are still relevant in many *** top of that,data processing and automation,together with machine learning/deep learning are contributing to the wide range of applications for *** review addresses spectral and red-green-blue sensing as the most popular remote sensing approaches,alongside stable isotope composition as an example of a lab-based tool,and root phenotyping,which represents one of the frontiers for field ***,we consider the two most promising forms of aerial platforms(unmanned aerial vehicle and satellites)and some of the emerging data-processing *** review includes three Boxes that examine specific case studies.

关键词： crop phenotyping deep learning models photosynthesis platforms remote sensing roots satellites sensors stable isotopes

Immunotherapy and immunoescape in colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain josé l perez-gracia Alvaro Gonzalez Ignacio Melero liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación Médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTlA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy Gene therapy interleukin-12 Dendritic cells CD137 indoleamine 2, 3 dioxygenase