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Multiphysics Simulation of a Novel Concept of MEMS-based Solid Propellant Thruster for Space Propulsion

Journal of Thermal Science 2011年第6期20卷 527-533页

作者： josé A.Moríigo josé hermida-quesada Dept.of Space Programmes National Institute for Aerospace Technology Ctra.Ajalvir km.4Torrejón de Ardoz 28850 MadridSpain Propulsion EngineerPh.D. Dept.of Aerodynamics and Propulsion National Institute for Aerospace Technology Ctra.Ajalvir km.4Torrejón de Ardoz 28850 MadridSpain

This work analyzes a novel MEMS-based architecture of submillimeter size thruster for the propulsion of small spacecrafts,addressing its preliminary characterization of *** architecture of microthruster comprises a setup of miniaturized channels surrounding the solid-propellant reservoir filled up with a high-energetic *** channels guide the hot gases from the combustion region towards the nozzle entrance located at the opposite side of the *** simulations of the transient response of the combustion gases and wafer heating in thruster firings have been conducted with FLUENT under a multiphysics modelling that fully couples the gas and solid parts *** approach includes the gas-wafer and gas-polymer thermal exchange,burnback of the polymer with a simplified non-reacting gas pyrolysis model at its front,and a slip-model inside the nozzle portion to incorporate the effect of gas-surface and rarefaction onto the gas ***,accurate characterization of thruster operation requires the inclusion of the receding front of the polymer and heat transfer in the moving gas-solid *** study stresses the improvement attained in thermal management by the inclusion of lateral micro-channels in the *** particular,the temperature maps reveal the significant dependence of the thermal loss on the instantaneous surface of the reservoir wall exposed to the heat flux of hot ***,the simulations stress the benefit of implementing such a pattern of micro-channels connecting the exit of the combustion reservoir with the *** results prove that hot gases flowing along the micro-channels exert a sealing action upon the heat flux at the reservoir wall and partly mitigate the overall thermal loss at the inner-wall vicinity during the *** analysis shows that propellant decomposition rate is accelerated due to surface preheating and it suggests that a delay of the flame extinction into the reservoir

关键词： micronozzles spacecraft micropropulsion solid propellant thrusters

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Analysis of Viscous Heating in a Micro-Rocket Flow and Performance

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Journal of Thermal Science 2008年第2期17卷 116-124页

作者： josé A.Moríigo josé hermida quesada Dept.of Space Programmes National Institute for Aerospace Technology Dept.of Aerodynamics and Propulsion National Institute for Aerospace Technology

Micro-rockets for propulsion of small spacecrafts exhibit significant differences with regard to their macroscale counterparts,mainly caused by the role of the viscous dissipation and heat transfer processes in the micron-sized *** goal of this work is to simulate the transient operation of a micro-rocket to investigate the effects of viscous heating on the flow and performance for four configurations of the expanding gas and wafer *** modelling follows a multiphysics approach that solves the fluid and solid regions fully coupled.A contin- uum-based description that incorporates the effects of gas rarefaction through the micro-nozzle,viscous dissipa- tion and heat transfer at the solid-gas interface is ***-equilibrium is addressed with the implementa- tion of a 2nd-order slip-model for the velocity and temperature at the *** results stress that solid-fluid cou- pling exerts a strong influence on the flowfield and performance as well as the effect of the wafer during the first instants of the transient in micro-rockets made of low and high thermal conductivity materials.

关键词： Micronozzles propulsion MEMS slip flow viscous heating

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Landform Instability and Land-use Dynamics in Tropical High Mountains, Central Mexico

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Journal of Mountain Science 2012年第3期9卷 414-430页

作者： GARCíA-ROMERO Arturo ACEVES-quesada josé Fernando ARREDONDO-LEóN Carlos Departamento de Geografía Física Instituto de Geografía Universidad Nacional Autónoma de México. Circuito exterior s/n Ciudad Universitaria 04510 Mexico Distrito Federal Mexico Unidad Académica de Estudios Regionales de la Coordinación de Humanidades Universidad Nacional Autónoma de México

This investigation is an analysis of the influence of landform instability on the distribution of land-use dynamics in a hydrographical basin, located in the Mexican Volcanic Belt mountain range (central Mexico), currently affected by substantial changes in land use and deforestation. A landform map was produced, in addition to seven attribute maps - altimetry, drainage density, slope, relief energy, potential erosion, geology and tectonics - which were considered as factors for determining landform instability through Multi-criteria Evaluation Analysis. Likewise, the direction and rhythm of land-use dynamics were analyzed in four dates - between 1976 and 2000 - and cross tabulations were made between them, in order to analyze the trends and processes of land-use dynamics. Afterwards, the databases obtained were cross tabulated with the landform variables to derive areas, percentages and correlation indices. In the study area, high-instability landforms are associated with most ancient volcanic and sedimentary landforms, where high altitude, drainage density, slope and potential to develop gravitational and fluvial processes are the major factors favouring a land-use pattern, dominated by the conservation of extensive forest land, abandonment of human land use and regeneration of disturbed areas. In contrast, low-instability landforms correspond to alluvial plains and lava hills covered by pyroclasts, where low potential erosion to develop fluvial processes, added to water and soil availability and accessibility, have favoured a land-use pattern dominated by the expansion of agroforestry plantations and human settlements, showing a marked trend towards either intensification or permanence of the current land use and with little abandonment and regeneration.

关键词： Landform instability Multi-criteriaEvaluation Analysis Land-use change and processes Tuxpan River Basin

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A Two-Scale Multi-Physics Deep Learning Model for Smart MEMS Sensors

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Journal of Materials Science and Chemical Engineering 2021年第8期9卷 41-52页

作者： josé Pablo quesada-Molina Stefano Mariani Department of Civil and Environmental Engineering Politecnico di Milano Milano Italy Department of Mechanical Engineering Universidad de Costa Rica Rodrigo Facio Brenes Campus San José Costa Rica

Smart materials and structures, especially those bio-inspired, are often characterized by a hierarchy of length- and time-scales. Smart Micro Electro-Mechanical Systems (MEMS) are also characterized by different physical phenomena affecting their properties at different scales. Data-driven formulations can then be helpful to deal with the complexity of the multi-physics governing their response to the external stimuli, and optimize their performances. As an example, Lorentz force micro-magnetometers working principle rests on the interaction of a magnetic field with a current flowing inside a semiconducting, micro-structured medium. If an alternating current with a properly set frequency is let to flow longitudinally in a slender beam, the system is driven into resonance and the sensitivity to the magnetic field may result largely enhanced. In our former activity, a reduced-order physical model of the movable structure of a single-axis Lorentz force MEMS magnetometer was developed, to feed a multi-objective topology optimization procedure. That model-based approach did not account for stochastic effects, which lead to the scattering in the experimental data at the micrometric length-scale. The formulation is here improved to allow for stochastic effects through a two-scale deep learning model designed as follows: at the material scale, a neural network is adopted to learn the scattering in the mechanical properties of polysilicon induced by its polycrystalline morphology;at the device scale, a further neural network is adopted to learn the most important geometric features of the movable parts that affect the overall performance of the magnetometer. Some preliminary results are discussed, and an extension to allow for size effects is finally foreseen.

关键词： Machine Learning Artificial Neural Networks Polysilicon MEMS Uncer-tainty Quantification Lorentz Force Magnetometer

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Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly

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World Journal of Stem Cells 2020年第12期12卷 1667-1690页

作者： Marta Camacho-Cardenosa joséManuel quesada-Gómez Alba Camacho-Cardenosa Alejo Leal GabrielDorado Bárbara Torrecillas-Baena Antonio Casado-Díaz Facultad Ciencias del Deporte Universidad De ExtremaduraCáceres 10003Spain CIBER De Fragilidad Y Envejecimiento Saludable(CIBERFES) Unidad De Gestión Clínica De Endocrinología Y NutriciónInstituto Maimónides De Investigación Biomédica De CórdobaHospital Universitario Reina SofíaCórdoba 14004Spain Servicio de Traumatología Hospital de CáceresCáceres 10004Spain Departamento Bioquímica y Biología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de Córdoba-CIBERFES14071 CórdobaSpain

BACKGROUND Mesenchymal stem cells(MSC)of bone marrow are the progenitor of osteoblasts and *** tend to differentiate into adipocytes,instead of osteoblasts,with *** favors the loss of bone mass and development of *** induces hypoxia inducible factor 1αgene encoding transcription factor,which regulates the expression of genes related to energy metabolism and *** allows a better adaptation to low O2 *** hypoxia has negative effects on bone metabolism,favoring bone ***,surprisingly,cyclic hypoxia(CH),short times of hypoxia followed by long times in normoxia,can modulate MSC differentiation and improve bone health in *** To evaluate the CH effect on MSC differentiation,and whether it improves bone mineral density in *** MSC cultures were induced to differentiate into osteoblasts or adipocytes,in CH(3%O2 for 1,2 or 4 h,4 d a week).Extracellular-matrix mineralization and lipid-droplet formation were studied in MSC induced to differentiate into osteoblast or adipocytes,*** addition,gene expression of marker genes,for osteogenesis or adipogenesis,have been quantified by quantitative real time polymerase chain *** in vivo studies with elderly(>75 years old;n=10)were carried out in a hypoxia chamber,simulating an altitude of 2500 m above sea level,or in normoxia,for 18 wk(36 CH sessions of 16 min each).Percentages of fat mass and bone mineral density from whole body,trunk and right proximal femur(femoral,femoral neck and trochanter)were assessed,using dual-energy X-ray *** CH(4 h of hypoxic exposure)inhibited extracellular matrix mineralization and lipid-droplet formation in MSC induced to differentiate into osteoblasts or adipocytes,***,both parameters were not significantly affected by the other shorter hypoxia times *** longest periods of hypoxia downregulated the expression of genes related to extracellular matrix

关键词： Normobaric cyclic hypoxia Mesenchymal stem cells Cellular differentiation Osteoblasts Adipocytes Bone health

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A Two-Scale Multi-Physics Deep Learning Model for Smart MEMS Sensors

A Two-Scale Multi-Physics Deep Learning Model for Smart MEMS...

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作者： josé Pablo quesada-Molina Stefano Mariani Department of Civil and Environmental Engineering Politecnico di Milano Department of Mechanical Engineering Universidad de Costa RicaRodrigo Facio Brenes Campus

Smart materials and structures, especially those bio-inspired, are often characterized by a hierarchy of length-and time-scales. Smart Micro Electro-Mechanical Systems（MEMS） are also characterized by different physical phenomena affecting their properties at different scales. Data-driven formulations can then be helpful to deal with the complexity of the multi-physics governing their response to the external stimuli, and optimize their performances. As an example, Lorentz force micro-magnetometers working principle rests on the interaction of a magnetic field with a current flowing inside a semiconducting, micro-structured medium. If an alternating current with a properly set frequency is let to flow longitudinally in a slender beam, the system is driven into resonance and the sensitivity to the magnetic field may result largely enhanced. In our former activity, a reduced-order physical model of the movable structure of a single-axis Lorentz force MEMS magnetometer was developed, to feed a multi-objective topology optimization procedure. That model-based approach did not account for stochastic effects, which lead to the scattering in the experimental data at the micrometric length-scale. The formulation is here improved to allow for stochastic effects through a two-scale deep learning model designed as follows: at the material scale, a neural network is adopted to learn the scattering in the mechanical properties of polysilicon induced by its polycrystalline morphology;at the device scale, a further neural network is adopted to learn the most important geometric features of the movable parts that affect the overall performance of the magnetometer. Some preliminary results are discussed, and an extension to allow for size effects is finally foreseen.

关键词： Machine Learning Artificial Neural Networks Polysilicon MEMS Uncertainty Quantification Lorentz Force Magnetometer

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Association between Hyperglycemia, C-Reactive Protein and Other Risk Factors in Patients at Cardiovascular Risk

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Journal of Diabetes Mellitus 2016年第1期6卷 16-24页

作者： Sandra Maria Barbalho Ricardo josé Toffano Marcelo Dib Bechara Karina Rodrigues quesada Marie Oshiiwa Claudemir Gregório Mendes Marcia Rocha Gabaldi Department of Biochemistry and Celular Biology Medical School of Marília UNIMAR Marília Brazil Food and Technology School of Marília (FATEC) Sao Paulo Brazil Department of the Cardiac Surgery Unit and Hemodynamics Medical School UNIMAR (Hospital Beneficente UNIMAR) Marília Brazil

Type 2 diabetes (DM2) is a syndrome characterized by postprandial hyperglycemia normally due to peripheral resistance to insulin and accounts for approximately 90% of diabetes cases worldwide and it is usually related to dyslipidemia, overweight/obesity and physical inactivity and increase in the risk of cardiovascular disease. This study aimed to compare the metabolic and inflammatory profile of hyperglycemic with non-hyperglycemic subjects in a group of patients undergoing coronary arteriography. Our group of patients showed that 63.16% presented glycaemia above 99 mg/dL (from the hyperglycemic patients, 31 individuals were classified as glucose intolerant and 29 as diabetic). Significant differences were found for glycaemia, LDL-c (Low Density Lipoprotein), and hs-CRP (high sensitivity C reactive protein) levels. Nevertheless it is possible to observe that patients with higher glycaemia showed increased values of Total Cholesterol, Triglycerides, LDL-c, Castelli Index I and II and estimative of LDL-c size particle and decreased HDL-c (High Density Lipoprotein) values. The comparison between hs-CRP levels and biochemical parameters shows significant differences for Body Mass Index, Triglycerides, HDL-c and the estimative of LDL-c particle. Also, the presence of Metabolic Syndrome is more prevalent in patients with high levels of hs-CRP. Diabetes patients have more significant increase in morbidity and mortality than the general population frequently due to further complications associated with the resistance to insulin. It is indispensable to outline the anthropometric and biochemical profile from hyperglycemic patients in order to work on secondary prevention of cardiovascular disease.

关键词： Hyperglycemia C-Reactive Protein Angiography Castelli Index Lipids

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Healthcare use among people with diabetes mellitus in Europe:a population-based cross-sectional study

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Family Medicine and Community Health 2022年第4期10卷 16-23页

作者： Álvaro Fuentes-Merlos joséAntonio quesada-Rico Raul Reina Domingo Orozco-Beltrán Faculty of Medicine Miguel Hernandez University of ElcheSant Joan D'AlacantSpain Department of Sports Sciences Sport Research CentreMiguel Hernandez University of ElcheElcheSpain

Objective This study aimed to determine the association of health determinants,lifestyle and socioeconomic variables on healthcare use in people with diabetes in *** A cross-sectional study was conducted using data from the European Health Interview Survey wave 2(ie,secondary analysis).Setting The sample included data from 25 European *** The sample included 16270 patients with diabetes aged 15 years or older(49.1%men and 50.9%women).Results The survey data showed that 58.2%of respondents had seen their primary care physician in the past month and 22.6%had been admitted to the hospital in the past *** of primary care was associated with being retired(prevalence ratio(PR)1.13,95%CI 1.07 to 1.19)and having very poor self-perceived health(PR 1.80,95%CI 1.51 to 2.15),long-standing health problems(PR 1.14,95%CI 1.04 to 1.24),high blood pressure(PR 1.06,95%CI 1.03 to 1.10)and chronic back pain(PR 1.07,95%CI 1.04 to 1.11).Hospital admission was associated with very poor self-perceived health(PR 3.03,95%CI 2.14 to 4.31),accidents at home(PR 1.54,95%CI 1.40 to 1.69),chronic obstructive pulmonary disease(COPD)(PR 1.34,95%CI 1.22 to 1.47),high blood pressure(PR 1.08,95%CI 1.01 to 1.17),chronic back pain(PR 0.91,95%CI 0.84 to 0.98),moderate difficulty walking(PR 1.33,95%CI 1.21 to 1.45)and severe difficulty walking(PR 1.67,95%CI 1.51 to 1.85).Conclusions In the European diabetic population,the high cumulative incidences of primary care visits and hospital admissions are associated with labour status,alcohol consumption,self-perceived health,long-standing health problems,high blood pressure,chronic back pain,accidents at home,COPD and difficulty walking.

关键词： admitted sectional difficulty

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Lipid Accumulation Product: Reliable Marker for Cardiovascular Risk Detection?

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Open Journal of Epidemiology 2021年第3期11卷 267-277页

作者： Lidiane Aparecida Vila Pires Ricardo josé Tofano Sandra Maria Barbalho Claudia Rucco Penteado Detregiachi Marcelo Dib Bechara Viviane Alessandra Capelluppi Tofano Jesselina Francisco dos Santos Haber Eduardo Federighi Baisi Chagas Ana Maria Gonçalvez Milla Karina quesada School of Medicine University of Marília (UNIMAR) Marília S&#227 o Paulo Brazil Postgraduate Program in Structural and Functional Interactions in Rehabilitation University of Marilia (UNIMAR) S&#227 o Paulo Brazil Cardiology Unit of the UNIMAR Beneficent Hospital (HBU) Marilia S&#227 o Paulo Brazil Department of Biochemistry and Nutrition Faculty of Food Technology of Marília Marília S&#227 o Paulo Brazil CENID (Interdisciplinary Center on Diabetes)—UNIMAR—Marília S&#227 o Paulo Brazil

The Lipid Accumulation Product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovascular risk and mortality. The aim of this study was to verify the association of LAP with anthropometric, biochemical, visceral adiposity index and IR in adults and the elderly. This single cross-section center clinical study, with experimental, analytical, primary, and observational design, included 210 participants. Anthropometric (Body Mass Index (BMI), Waist Circumference (WC), and Neck Circumference (NC)), LAP, Visceral Adipose Index (VAI), and biochemical parameters (fasting glycemia, insulinemia (to calculate the Homa-IR index), total cholesterol, LDL-c, HDL-c, and triglycerides) were evaluated. The results showed that by separating the sample into three groups (adequate BMI and WC, adequate BMI and elevated WC, and elevated BMI and WC), the group with high BMI and WC showed a high value of LAP and VAI compared to the other groups, with a significant difference. Still, the data show a positive and significant correlation when relating the LAP with VAI, HOMA-IR, BMI, WC, NC, total cholesterol, triglycerides, and Diastolic Blood Pressure. It also showed an inversely proportional relationship when associating LAP with HDL-c (p

关键词： Lipid Accumulation Product Obesity. Visceral Obesity Metabolic Syndrome Cardiovascular Risk

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Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda josé Yelamos josé Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P < 0.001); (3) academic year (P < 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P < 0.001); (6) attitude toward deceased donation (P < 0.001); (7) attitude toward living kidney donation (P < 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P < 0.001); (9) having discussed the subject with one’s family (P < 0.001) and friends (P < 0.001); (10) a partner’s opinion about the subject (P < 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

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