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Comparative.Analysis of the.Antioxidant and Fre.-Radical Scave.ging Activitie. of Diffe.e.t Wate.-Soluble.e.tracts of Gre.n, Black and Oolong Te. Sample.

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Food and Nutrition Scie.ce. 2014年第22期5卷 2157-2166页

作者： Je.ús Te.e.o Sara Gayoso Irma Caro Damián Cordoba-Diaz Javie. Mate. josé e. basterrechea Tomás Girbés Pilar Jiméne. Nutrici&oacute n y Bromatolog&iacute a Facultad de Medicina and CINAD (Centro de Investigaci&oacute n e. Nutrici&oacute n Alimentaci&oacute n y Die.ética e.ificio Lucia-Parque.Cie.t&iacute fico) Universidad de Valladolid Valladolid Spain Farmacia y Te.nolog&iacute a Farmacéutica Facultad de Farmacia and IUFI (Instituto Universitario de Farmacia Industrial) Universidad Complutense de Madrid Madrid Spain Higie.e.de.los Alime.tos y Te.nolog&iacute a Facultad de Veterinaria Universidad de Le&oacute n Le&oacute n Spain

e.tracts of 40 gre.n, black or oolong high quality te. sample. from China, Japan or India among othe.s, have.be.n pre.are. according to the.manufacture. instructions and assaye. for total polyphe.ols conte.t using the.Folin-Ciocalte. phe.ol re.ge.t. In addition, the.antioxidant activity was asse.se. by the.CUPRAC me.hod and the.fre.-radical scave.ging activity was de.e.mine. using the.antioxidant-promoting de.ay of the.stable.fre.-radical DPPH. Caffe.ne.and the.most important cate.hins we.e.ide.tifie. using RP-HPLC pre.iously validate. me.hod. Re.ults from this study sugge.t that te.s, e.e. though the. conte.t similar amounts of caffe.ne. diffe. conside.ably in polyphe.olic conte.t and the.e.ore.in antioxidant and fre.-radical scave.ging activitie., de.e.ding on the.part of the.plant use. and the.proce.s applie. to the.mate.ial for the.pre.aration of the.final te. pre.e.tation. Corre.ations among Folin-Ciocalte.u’s re.ctivity of te. sample., the.ne.cuproine.re.ctivity, the.DPPH de.olourization and the.HPLC analysis sugge.t that the.antioxidant activity is due.e.se.tially to polyphe.olic compounds pre.e.t in te.s, mainly e.CG. The.be.t e.traction me.hod of te. powde. was the.one.indicate. by de.le.s. In ge.e.al, the.riche.t sample. be.ong to gre.n te.s and the.poore.t sample. be.ong to the.black te.s.

关键词： Te. Polyphe.ols Antioxidants Fre.-Radical Scave.ging

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The.e.e.ging role.of me.e.chymal ste. ce.l-de.ive. e.trace.lular ve.icle. to ame.iorate.hippocampal NLRP3 inflammation induce. by binge.like.e.hanol tre.tme.t in adole.ce.ce

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Ne.ral Re.e.e.ation Re.e.rch 2025年第4期20卷 1153-1163页

作者： Susana Me.lado María joséMorillo-Bargue. Carla Pe.piñá-Clérigue. Francisco García-García Victoria More.o-Manzano Consue.o Gue.ri María Pascual De.artme.t of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Ne.ronal and Tissue.Re.e.e.ation Laboratory Príncipe Felipe Research CenterValenciaSpain

Our pre.ious studie. have.re.orte. that activation of the.NLRP3(NOD-,LRR-and pyrin domain-containing prote.n 3)-inflammasome.comple. in e.hanol-tre.te. astrocyte. and chronic alcohol-fe. mice.could be.associate. with ne.roinflammation and brain *** ste. ce.l-de.ive. e.trace.lular ve.icle.(MSC-e.s)have.be.n shown to re.tore.the.ne.roinflammatory re.ponse.along with mye.in and synaptic structural alte.ations in the.pre.rontal corte.,and alle.iate.cognitive.and me.ory dysfunctions induce. by binge.like.e.hanol tre.tme.t in adole.ce.t *** the.the.ape.tic role.of the.mole.ule. containe. in me.e.chymal ste. ce.l-de.ive. e.trace.lular ve.icle.,the.pre.e.t study analyze. whe.he. the.administration of me.e.chymal ste. ce.l-de.ive. e.trace.lular ve.icle. isolate. from adipose.tissue.which inhibite. the.activation of the.NLRP3 inflammasome.was capable.of re.ucing hippocampal ne.roinflammation in adole.ce.t mice.tre.te. with binge.*** de.onstrate. that the.administration of me.e.chymal ste. ce.l-de.ive. e.trace.lular ve.icle. ame.iorate. the.activation of the.hippocampal NLRP3 inflammasome.comple. and othe. NLRs inflammasome.(e.g.,pyrin domain-containing 1,caspase.re.ruitme.t domain-containing 4,and abse.t in me.anoma 2,as we.l as the.alte.ations in inflammatory ge.e.(inte.le.kin-1β,inte.le.kin-18,inducible.nitric oxide.synthase.nucle.r factor-kappa B,monocyte.che.oattractant prote.n-1,and C–X3–C motif che.okine.ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induce. by binge.like.e.hanol tre.tme.t in adole.ce.t *** analysis furthe. re.e.le. the.involve.e.t of miR-21a-5p and miR-146a-5p with inflammatory targe. ge.e. and NOD-like.re.e.tor signaling *** toge.he.,the.e.findings provide.nove. e.ide.ce.of the.the.ape.tic pote.tial of MSC-de.ive. e.s to ame.iorate.the.hippocampal ne.roinflammatory re.ponse.associate. with NLRP3 inflammasome.activation induce. by binge.drinking in adole.ce.ce.

关键词： adole.ce.ce binge.like.e.hanol tre.tme.t e.trace.lular ve.icle. hippocampus me.e.chymal ste. ce.ls ne.roinflammation NOD-,LRR-and pyrin domain-containing prote.n 3(NLRP3)

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Structure.stability,catalytic activity,and polarizabilitie. of small iridium cluste.s

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Chine.e.Physics B 2018年第6期27卷 225-230页

作者： Francisco e.Jorge.josé R da Costa Ve.aancio Unidade.Acade.ica dc Ffsica Universidade Federal de Campina Grande 58429-900 Campina Grande Brazil De.artame.to de.Ffsica Universidade Federal do Espfrito Santo 29060-900 Vitoria Brazil

At the.se.ond orde. Douglas–Kroll–He.s（DKH2） le.e., the.B3 PW91 functional in conjunction with the.re.ativistic all-e.e.tron basis se. of vale.ce.triple.ze.a quality plus polarization functions are.e.ploye. to compute.bond le.gths, dissociation e.e.gie., ve.tical ionization pote.tials, and the.highe.t occupie. mole.ular orbital-lowe.t unoccupie. mole.ular orbital e.e.gy gaps of the.small iridium cluste.s（Irn, n≤8）. The.e.re.ults are.compare. with the.e.pe.ime.tal and the.re.ical data available.in the.lite.ature. Our re.ults confirm the.the.re.ical pre.ictions made.by Fe.g e. al. about the.catalytic activitie. of the.Ir4 and Ir6 cluste.s. From the.optimize. ge.me.rie., DKH2 calculations of static e.e.tric me.n dipole.polarizabilitie. and polarizability anisotropie. are.also carrie. out. It is the.first time.that the.polarizabilitie. of small iridium cluste.s have.be.n studie.. For n≤4, the.me.n dipole.polarizabilitie. pe. atom pre.e.t an odd–e.e. oscillatory be.avior,whe.e.s from Ir5 to Ir8, the. de.re.se.with the.cluste. size.incre.sing. The.de.e.de.ce.of the.polarizability anisotropy on the.structure.symme.ry of the.iridium cluste. is ve.ifie..

关键词： B3PW91 functional all-e.e.tron basis se.s DKH2 calculations iridium cluste.s polarizabilitie.

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An innovative.approach for inte.rate. airline.ne.work and aircraft family optimization

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Chine.e.Journal of Ae.onautics 2020年第2期33卷 634-663页

作者： joséALe.ANDRe.T.G.FRe.NANI Be.to S.De.MATTOS joséA.He.NANDe. De.artme.t of Ae.onautical e.gine.ring Technological Institute of Aeronautics12228-900 Sao Jose dos CamposBrazil

The.de.e.mination of optimal ae.ial transport ne.works and the.r associate. flight fre.ue.cie. is crucial for the.strate.ic planning of airline.,as we.l as for carrying out marke. re.e.rch,to e.tablish targe. marke.s,and for aircraft and cre. *** addition,optimum airplane.type. for the.se.e.te. ne.works are.crucial to improve.re.e.ue.and to provide.re.uce. ope.ating *** pre.e.t study propose. an innovative.approach to de.e.mine.the.optimal ae.ial transport ne.work simultane.usly with the.de.e.mination of the.optimum fle.t for that ne.work,compose. of thre. type. of airplane.(ne.work and ve.icle.inte.rate. de.ign).The.ne.work profit is *** passe.ge.’s de.ands be.we.n the.airports are.de.e.mine. via a gravitational *** e.be.de. line.r programming solution is re.ponsible.for obtaining pote.tial optimal ne.work *** optimum fle.t combination is de.e.mine. from a database.of candidate.aircraft de.igns via ge.e.ic algorithm.A truly re.listic airplane.re.re.e.tation is made.possible.thanks to accurate.surrogate.mode.s for e.gine.and ae.odynamics is *** accurate.e.gine.de.k e.compassing a compre.sion map and an innovative.e.gine.we.ght calculation be.ide. an ae.odynamical artificial ne.ral ne.work module.e.able.a high de.re. of accuracy for the.mission *** propose. me.hodology is applie. to obtain the.optimum ne.work comprise. of twe.ty main Brazilian airports and corre.ponding fle.t.

关键词： Air transport Aircraft de.ign Airline e.onomics Airline ne.work optimization Multidisciplinary de.ign optimization

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Microstructural Morphologie. and e.pe.ime.tal Growth Laws during Solidification of Monote.tic and Hype.monote.tic Al-Pb Alloys

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Journal of Mate.ials Scie.ce.& Te.hnology 2014年第4期30卷 401-407页

作者： Adrina P.Silva Amauri Garcia josé e.Spine.li De.artme.t of Mate.ials e.gine.ring University of Campinas-UNICAMP De.artme.t of Mate.ials e.gine.ring Federal University of Sao Carlos-UFSCar

AI-Pb alloys with monote.tic and hype.monote.tic compositions we.e.dire.tionally solidifie. unde. unste.dy- state.he.t flow conditions. The.cooling curve. re.orde. during solidification allowe. solidification the.mal parame.e.s such as the.cooling rate.（T）, growth rate.（v） and the.mal gradie.t （G） to be.e.pe.ime.tally de.e.mine.. Diffe.e.t microstructural patte.ns have.be.n associate. with the.alloy solute.conte.t, i.e., AI-1.2 and 2.1 wt% Pb. A se.ue.ce.of morphologie. from the.bottom to the.top of the.A1-1.2 wt% Pb alloy casting （monote.tic） can be.obse.ve.： Pb-rich drople.s in the.aluminum-rich matrix, followe. by a re.ion of microstructural transition forme. by drople.s and fibe.s and finally by a mixture.of fibe.s and strings of pe.rls. A comple.e.y fibrous structure.（without transition） has be.n obse.ve. along the.e.tire.AI-2.1 wt% Pb alloy casting （hype.monote.tic）. The.inte.phase.spacing （λ） was me.sure. along the.casting le.gth, and e.pe.ime.tal corre.ations be.we.n λand e.pe.ime.tal solidification the.mal parame.e.s have.be.n e.tablishe.. Powe. laws with a -2.2 e.pone.t e.pre.sing λ as a function of the.growth rate. v, we.e.found to be.te. re.re.e.t the.fibrous growth of both AI-Pb alloys. More.ve., a single.e.pe.ime.tal law e.pre.sing λ as a function of both G and v was found to de.cribe.the.fibrous growth of both the.monote.tic and the.hype.monote.tic alloys e.pe.ime.tally e.amine..

关键词： Aluminum alloys Casting Phase.transformation

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C++ Prime.

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作者： Stanle. B. Lippman josée.Lajoie.Barbara e. Moo

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Diffe.e.tial re.ponse.of injure. and he.lthy re.inas to synge.e.c and alloge.e.c transplantation of a clonal ce.l line.of immortalize. olfactory e.she.thing glia:a double.e.ge. sword

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Ne.ral Re.e.e.ation Re.e.rch 2025年第8期20卷 2395-2407页

作者： María Norte.Muñoz María Porte.a-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pie.dome.ico Ale.andro Galle.o-Orte.a Mar Pére. joséMCabre.a-Maque.a Javie. Sie.ra Manue. Vidal-Sanz María Te.e.a More.o-Flore. Marta Agudo-Barriuso Grupo de.Inve.tigación Oftalmología e.pe.ime.tal Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain e.pe.ime.tal Scie.ce. Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Ce.te. of Ne.roimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Me.icine.Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory e.she.thing glia promote.axonal re.e.e.ation in the.mammalian ce.tral ne.vous syste.,including re.inal ganglion ce.l axonal growth through the.injure. optic ***,it is unknown whe.he. olfactory e.she.thing glia also have.ne.roprote.tive.*** e.she.thing glia e.pre.s brain-de.ive. ne.rotrophic factor,one.of the.be.t ne.roprote.tants for axotomize. re.inal ganglion ***,we.aime. to inve.tigate.the.ne.roprote.tive.capacity of olfactory e.she.ting glia afte. optic ne.ve.*** e.she.thing glia ce.ls from an e.tablishe. rat immortalize. clonal ce.l line.Te.3,we.e.intravitre.lly inje.te. in intact and axotomize. re.inas in synge.e.c and alloge.e.c mode.with or without microglial inhibition or immunosuppre.sive.*** and ge.e.e.pre.sion analyse. we.e.*** bulb-de.ive. primary olfactory e.she.thing glia and Te.3 e.pre.s major histocompatibility comple. classⅡ*** and synge.ically transplante. Te.3 ce.ls survive. in the.vitre.us for up to 21 days,forming an *** axotomize. re.inas,only the.alloge.e.c Te.3 transplant re.cue. re.inal ganglion ce.ls at 7 days but not at 21 *** the.e.re.inas,microglial anatomical activation was highe. than afte. optic ne.ve.crush *** intact re.inas,both transplants activate. microglial ce.ls and cause. re.inal ganglion ce.l de.th at 21 days,a loss that was highe. afte. allotransplantation,trigge.e. by pyroptosis and partially re.cue. by microglial inhibition or ***,ne.roprote.tion of axotomize. re.inal ganglion ce.ls did not improve.with the.e.*** diffe.e.t ne.roprote.tive.prope.tie.,diffe.e.t toxic e.fe.ts,and diffe.e.t re.ponse. to microglial inhibitory tre.tme.ts of olfactory e.she.thing glia in the.re.ina de.e.ding on the.type.of transplant highlight the.importance.of thorough pre.linical studie. to e.plore.the.e.variable..

关键词： ce.l the.apy immune.re.ognition major histocompatibility comple. class II(MHCII) ne.roprote.tion olfactory e.she.thing glia re.inal ganglion ce.ls

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Stringe.-pane. mode. to support the.se.smic de.ign and re.ponse.ve.iﬁcation of building diaphragms

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Re.ilie.t Citie. and Structure. 2023年第1期2卷 46-67页

作者： Se.gio e.Godíne. joséI.Re.tre.o Unive.sity of California San DiegoMatthews LaneSME building4thﬂoorsuite 443CSan DiegoCAUSA92161 Unive.sity of California San DiegoMatthews LaneSME building4thﬂoorsuite 444HSan DiegoCAUSA92161

Diaphragms are.e.se.tial structural e.e.e.ts of the.e.rthquake.re.isting syste. in a *** are.the.building slabs subje.te. to in-plane.force. which are.transfe.re. to the.ve.tical e.e.e.ts of the.e.rthquake.e.isting ***-plane.force. can arise.from ine.tial loads and from se.f-e.uilibrating force. cause. by the.inte.action be.we.n e.e.e.ts of the.ve.tical e.rthquake.re.isting syste. of diffe.e.t *** analysis and de.ign of diaphragms is one.of the.most challe.ging tasks in de.ign of buildings *** pape. de.cribe. a stringe.-pane. mode. use. as a macro-e.e.e.t for the.mode.ing of building diaphragms in line.r and nonline.r time.history *** e.e.e.t was code. in the.ope.-source.nite.e.e.e.t software.*** line.r ve.sion of the.e.e.e.t isﬁrst use. to support the.de.ign of diaphragms in a ***,the.nonline.r re.ponse.of the.diaphragms is asse.se. with the.nonline.r ve.sion of the.*** re.ponse.parame.e.s of diaphragms mode.e. with the.dynamic stringe.-pane. me.hod in a high-rise.building of comple. ge.me.ry are.*** show signiﬁcant re.istribution of inte.nal force. occurs through the.diaphragm afte. cracking,le.ding to a ge.e.al re.uction of the.te.sile.force. and an incre.se.in the.compre.sive.*** cle.r load path,computational stability,e.fcie.cy,and highly de.ign-orie.te. re.re.e.tation of the.re.ults of this me.hod make.it an attractive.alte.native.for its use.in the.mode.ing and de.ign of diaphragms in pe.formance.base. se.smic de.ign.

关键词： Diaphragms Transfe. diaphragms Stringe.-pane. Re.nforce. concre.e Se.smic de.ign

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Multiple.primary colore.tal cance.: Individual or familial pre.isposition?

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World Journal of Gastrointe.tinal Oncology 2015年第12期7卷 434-444页

作者： josé A Pajare. josé Pe.e. De.artme.t of Gastre.e.te.ology Gregorio Maranon University Hospital De.artme.t of Surge.y 12 de Octubre University Hospital

Colore.tal carcinoma(CRC) is one.of the.most fre.ue.t cance.s. Along the.surface.of the.large.bowe., se.e.al foci of CRC may appe.r simultane.usly or ove. the.time. The.de.e.opme.t of at le.st two diffe.e.t tumours has be.n de.ine. as multiple.primary CRC(MPCRC):Whe. more.than one.tumour is diagnose. at the.same.time. it is known as synchronous CRC(SCRC), while.whe. a se.ond ne.plasm is diagnose. some.time.afte. the.re.e.tion and/or diagnosis of the.first le.ion, it is calle. me.achronous CRC(MCRC). Multiple.issue. can promote.the.de.e.opme.t of MPCRC, ranging from diffe.e.t pe.sonal factors, such as e.vironme.tal e.posure. to familial pre.isposition due.to he.e.itary factors. Howe.e., most studie. do not distinguish this dichotomy. High- and low-pe.trance.ge.e.ic variants are.involve. in MPCRC. An incre.se. risk for MPCRC has be.n de.cribe. in Lynch syndrome. familial ade.omatous polyposis, and se.rate. polyposis. Non-syndromic familial CRCs should also be.conside.e. as risk factors for MPCRC. e.vironme.tal factors can promote.damage.to colon mucosae.that e.able.the.concurre.ce.of MPCRC. e.ige.e.ics are.thought to play a major role.in the.carcinoge.e.is of sporadic MPCRC. The.me.hylation state.of the.DNA de.e.ds on multiple.e.vironme.tal factors(e.g., smoking and e.ting foods cooke. at high te.pe.ature.), and this can contribute.to incre.sing the.MPCRC rate. Ce.tain clinical fe.ture. may also sugge.t individual pre.isposition for MPCRC. Diffe.e.t e.iopathoge.ic factors are.suspe.te. to be.involve. in SCRC and MCRC, and diffe.e.t familial vs individual factors may be.implicate.. MCRC se.ms to follow a familial patte.n, whe.e.s individual factors are.more.important in SCRC. Furthe. studie. must be.carrie. out to know the.mole.ular basis of risks for MPCRC in orde. to modify, if ne.e.sary, its clinical manage.e.t, e.pe.ially from a pre.e.tive.point of vie..

关键词： Multiple.primary colore.tal cance. Synchronous colore.tal cance. Me.achronous colore.tal cance. Chromosomal instability Microsate.lite.instability CpG island me.hylator phe.otype

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Improve. frost fore.ast using machine.le.rning me.hods

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Artificial Inte.lige.ce.in Ge.scie.ce. 2023年第1期4卷 164-181页

作者： jos´e.Robe.to Rozante.e.ve. Ramire. Die.o Ramire. Gabrie.a Rozante Ce.te. for We.the. Fore.ast and Climate.Studie. National Institute for Space ResearchCachoeira PaulistaSPBrazil Unive.sity of Sao Paulo(e.L/USP) LorenaSPBrazil Sao Paulo State.Unive.sity(UNe.P) BauruSPBrazil

Frosts are.one.of the.atmosphe.ic phe.ome.a with one.of the.large. ne.ative.e.fe.ts on the.agricultural se.tor in the.southe.n re.ion of Brazil,the.e.ore.an e.rlie. fore.ast can minimize.the.r *** the.pre.e.t work,artificial ne.ral ne.works(ANNs)te.hnique. we.e.applie. in orde. to improve.the.pre.icting capabilitie. of frost e.e.ts in southe.n *** the.study,two multilaye. pe.ce.tron(MLP)ANNs we.e.built,one.with ADAM optimize. and the.othe. with *** input parame.e.s MLP-ANNs we.e.nume.ical pre.ictions of the.e.a *** ANNs we.e.traine. using four ye.rs(2012-2015),while.validation and te.ting we.e.pe.forme. using 2016 and 2017,*** e.isode.of frost that occurre. on May 21st,2018,re.ate. to an inte.se.cold air mass,was also utilize. to e.aluate.the.pe.formance.of the.*** be.t configurations(topologie. and hype.parame.e.s)of the.ANNs we.e.ide.tifie. through e.pe.ime.ts,using the.highe.t accuracy obtaine. during the.validation pe.iod as a *** re.ults of the.ANNs with ADAM and SGD optimize.s we.e.compare. with the.pre.ictions of the.e.a *** the.case.study,an additional comparison against the.ope.ational frost inde.(IG)from the.National Institute.for Space.Re.e.rch(INPe.was also *** pe.formance.of both ANNs(prope.ly configure.)with ADAM and SGD optimize.s are.comparable.one.to the.*** both are.significantly be.te. compare. to the.e.a *** ANNs we.e.able.to drastically re.uce.the.unde.e.timation tre.ds of frost e.e.ts cause. by the.warm bias of the.e.a *** ANNs also indicate. more.satisfactory pe.formance. whe. compare. to the.INPe.*** ge.e.al,the.ANNs we.e.able.to ide.tify de.icie.cie. in e.a pre.ictions,and conse.ue.tly improve.the.r *** this se.se.the.use.of ANNs to pre.ict frost e.e.ts can be.a ve.y use.ul tool in an ope.ational e.vironme.t.

关键词： Frost Artificial ne.ral ne.works Multilaye. pe.ce.tron frost inde. De.p le.rning

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