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Role of endothelium on the abnormal Angiotensin-mediated vascular functions in epileptic rats

Journal of Biophysical Chemistry 2012年第2期3卷 174-182页

作者： Carolina Restini Rosana Reis Claudio Costa-Neto Norberto Garcia-Cairasco josé cortes-de-oliveira Lusiane Bendhack Universidade de Ribeira&atildeo Preto—UNAERP. Curso de Medicina Ribeirāo Preto Brasil Faculdade de Ciências Farmacêuticas de Ribeiro Preto-USP Ribeiro Preto Brasil Faculdade de Medicina de Ribeir&atildeo Preto-USP Ribeir&atildeo Preto Brasil Faculdade de Medicina de Ribeiro Preto-USP Ribeiro Preto Brasil

Epidemiological studies have found that the risk for cardiovascular disease is increased in patients with epilepsy. The Renin Angiontensin System (RAS), an important player in vascular tone control, is also involved in many neurological disorders, including seizures and epilepsy. Although it has been reported that Angiotensin II (Ang II) release and Angiotensin receptors expression are altered in many cerebral areas in patients/animal models with neurological disorders, there are no data on the vascular function. We evaluated Ang I and Ang II-mediated vascular responses and to correlate their contractile responses to the pres- ence of endothelium and the protein levels of components of the RAS (AT1, AT2, Mas and ACE) in aorta isolated from genetically epileptic rats (WAR strain). The major finding was that the vascular contractile response induced by Ang I and Ang II is endothelium-dependent. Ang II induced contractions in aortas from Wistar rats either with intact endothelium (E+) (1.16 ± 0.04 g, n = 6) and endothelium-denuded (E-) (1.24 ± 0.04 g, n = 6). Maximum contractile response (ME) induced by Ang I was lower in Wistar E+ (0.45 ± 0.03 g, n = 6) compared with Wistar E- (1.13 ± 0.08 g, n = 6). Ang I and Ang II failed to induce contraction in WAR E+, whereas the ME induced by Ang I in WAR E- was lower (0.52 ± 0.04 g, n = 11) than in the Wistar. ME induced by Ang II in aortas from WAR was also lower (0.40 ± 0.03 g, n = 11) compared with Wistar. AT1 receptor expression in both E+ WAR and Wistar was lower than in both E- WAR and Wistar. AT2 and Mas receptor expression was higher in Wistar E- and E+ as compared to WAR E- and E+. ACE expression was higher in both E+ WAR and Wistar, but it was lower in both E- WAR and Wistar. Endothelium impairs the contractile response induced by Angiotensin in WAR, suggesting that endothelial relaxing factors play important role on the aorta contraction.

关键词： Endothelium Aorta Myogenic Tone Angiotensin Angiotensin II Receptor Epilepsy

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The dual role of necrostatin-1 in Parkinson’s disease models

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Neural Regeneration Research 2021年第10期16卷 2019-2020页

作者： Eva Alegre-cortes Guadalupe Martinez-Chacon jose M.Fuentes Sokhna M.S.Yakhine-Diop Universidad de Extremadura Depto.Bioquimica y Biologia Molecular y GeneticaFacultad de Enfermeria y Terapia OcupacionalAvda de la Universidad s/nCaceresSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED)Madrid Spain Instituto Universitario de Investigacion Biosanitaria de Extremadura(INUBE) CaceresSpain

Neuronal cell death is the main hallmark of Parkinson’s disease(PD).It is an irreversible process promoted by neurotoxins and/or genetic *** types of cell death have been associated with *** mechanisms by which neurons decide to specific type of cell death remain ***,it is well known that cell death can be either programmed or *** is a programmed cell death that involves the release of cytochrome c from damaged mitochondria to cytosol and the activation of caspases leading to nuclear *** is a caspase-independent cell death characterized by a gain in cell volume,rupture of plasma membrane and leak of cell contents,inflammation,and affects neighbouring *** was classified as a nonprogrammed cell death,but there are types of necrotic death triggered by a protein activation cascade,including necroptosis.

关键词： inflammation Necrosis rupture

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Hepatocyte transplantation program:Lessons learned andfuture strategies

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World Journal of Gastroenterology 2016年第2期22卷 874-886页

作者： Eugenia Pareja Ibars Miriam cortes Laia Tolosa Maria joséGómez-Lechón Slivia López joséVicente Castell joséMir Unidad de Terapia Celular Hepatica Instituto de Investigación Sanitaria La FeHospital Universitario y Politécnico La Fe de Valencia46026 ValenciaSpain Unidad de Cirugía Hepato-Bilio-Pancreática y Trasplante Hepático Hospital Universitario y Politécnico La Fe de Valencia46026 ValenciaSpain Liver transplantation Institute of Liver StudiesKing’s College HospitalInstitute of Liver StudiesSE5 9RS LondonUnited Kingdom Unidad de Hepatologıa Experimental Instituto de Investigación Sanitaria La FeHospital Universitario y Politécnico La Fe de Valencia46026 ValenciaSpain CIBERehd FIS08036 BarcelonaSpain

This review aims to share the lessons we learned over time during the setting of the hepatocyte transplantation(HT) program at the Hepatic Cell Therapy Unit at Hospital La Fe in Valencia. New sources of liver tissue for hepatocyte isolation have been explored. The hepatocyte isolation and cryopreservation procedures have been optimized and quality criteria for assessment of functionality of hepatocyte preparations and suitability for HT have been established. The results indicate that:(1) Only highly viable and functional hepatocytes allow to recover those functions lacking in the native liver;(2) Organs with steatosis(≥ 40%) and from elderly donors are declined since low hepatocyte yields, viability and cell survival after cryopreservation, are obtained;(3) Neonatal hepatocytes are cryopreserved without significant loss of viability or function representing high-quality cells to improve human HT;(4) Cryopreservation has the advantage of providing hepatocytes constantly available and of allowing the quality evaluation and suitability for transplantation; and(5) Our results from 5 adults with acute liver failure and 4 from children with inborn metabolic diseases, indicate that HT could be a veryuseful and safe cell therapy, as long as viable and metabolically functional human hepatocytes are used.

关键词： Hepatocyte transplantation Hepatocyteisolation Cell therapy Inborn errors of metabolism Neonatal hepatocytes Cryopreservation

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Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?

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World Journal of Gastroenterology 2017年第3期23卷 377-381页

作者： delia cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero joséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo department of General Surgery(Peritoneal Surface Surgical Oncolongy) Fundación Jiménez Díaz Hospital28050 MadridSpain department of Surgical Oncology Institut Gustave Roussy94805 VillejuifCédexFrance department of General Surgery(Peritoneal Surface Surgical Oncolongy) Virgen de la Arrixaca30120 MurciaSpain department of Medical Oncology Fundación Jiménez Díaz Hospital28050 MadridSpain

The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer.

关键词： Second-look surgery High-risk patients Peritoneal carcinomatosis Hyperthermic intraperitoneal chemotherapy Colo-rectal cancer

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Tuning of active disturbance rejection control for differentially flat systems under an ultimate boundedness analysis: a unified integer-fractional approach

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Control Theory and Technology 2021年第1期19卷 127-141页

作者： Jeisson E.Otero-Leal John cortes-Romero Efredy delgado Aguilera Felipe Galarza-Jimenez Alexander Jimenez-Triana departamento de Eléctricay Electrónica Facultad de IngeníeraUniversidad Nacional de ColombiaBogotáD.C..Colombia department of Control Engineering Universidad Distrital Francisco Joséde CaldasBogotáColombia

An adaptation of the active disturbance rejection control(AD RC)approach is applied to a fractional-order system with a flat *** the rather scarce information about the system,the conditions to establish an ultimate bound for a specific configuration of the system are found and compiled in a guideline for the tuning of the observer implemented in the ADRC.

关键词： ADRC Fractional-order system Ultimate bound Final value theorem

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Immunomodulatory therapy for the management of critically ill patients with COVID-19:A narrative review

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World Journal of Critical Care Medicine 2022年第4期11卷 269-297页

作者： David Andaluz-Ojeda Pablo Vidal-cortes Álvaro Aparisi Sanz Borja Suberviola Lorena del Río Carbajo Leonor Nogales Martín Estefanía Prol Silva Jorge Nieto del Olmo joséBarberán Ivan Cusacovich department of Critical Care Hospital Universitario HM SanchinarroHospitales MadridMadrid 28050Spain department of Intensive Care Complejo Hospitalario Universitario de OurenseOurense 32005Spain department of Cardiology Hospital del MarBarcelona 08003Spain department of Intensive Care Hospital Universitario Marqués de ValdecillaSantander 39008Spain department of Intensive Care Hospital Clínico Universitario de ValladolidValladolid 47005Spain department of Internal Medicine Hospital Universitario HM MontepríncipeHospitales MadridBoadilla del Monte 28860MadridSpain department of Internal Medicine Hospital Clínico Universitario de ValladolidValladolid 47005Spain

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the ongoing coronavirus disease 2019(COVID-19)*** the physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective *** To describe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of hyperinflammation and abnormal immune responses to disease progression together with a complete narrative review of the different immunoadjuvant treatments used so far in COVID-19 and their indication in severe and life-threatening *** A comprehensive literature search was *** reviewed the selected manuscripts following the PRISMA recommendations for systematic review and meta-analysis documents and selected the most ***,a recommendation of the use of each treatment was established based on the level of evidence of the articles and documents *** recommendation was made based on the consensus of all the *** A brief rationale on the SARS-CoV-2 pathogenesis,immune response,and inflammation was *** usefulness of 10 different families of treatments related to inflammation and immunopathogenesis of COVID-19 was reviewed and ***,based on the level of scientific evidence,a recommendation was established for each of *** Although several promising therapies exist,only the use of corticosteroids and tocilizumab(or sarilumab in absence of this)have demonstrated evidence enough to recommend its use in critically ill patients with *** including both,clinical and biological characteristics can constitute specific targets for better select certain therapies based on an individualized approach to treatment.

关键词： COVID-19 Critically ill patients Treatment Immunomodulary drugs Phenotype Immunosupression

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determination of Dihydromyricetin in Cassia ferruginea (Schrad.) DC. by Quantitative 1H NMR (qHNMR)

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Journal of Pharmacy and Pharmacology 2019年第5期7卷 255-264页

作者： Alene cortes de Queiroz e Silva Lilian Cherubin Correia Lucinéia Vizzotto Marconcini Alberto josé Cavalheiro Institute of Chemistry Department of Organic ChemistrySao Paulo State University (UNESP)AraraquaraSPBrazil

Cassia ferruginea (Schrad.) DC.(Fabaceae) is a native plant widely used as an ornamental tree and for the restoration of degraded areas in Brazil. Although no previous ethnopharmacological or chemical information was available, bioprospecting studies on this species found out a high concentration of dihydromyricetin (DHM) in different parts of the plant. DHM, also known as (+)-ampelopsin, is a flavonoid that presents important pharmacological and biological activities, including anticancer, cardioprotective and hepatoprotective effects. The aim of this study was to develop and validate a simple method for the determination of DHM in hydroethanolic extracts of C. ferruginea by quantitative 1H NMR (qHNMR) using the internal standard approach. The parameters as linearity, specificity and selectivity, accuracy, precision (repeatability and intermediate) and robustness showed satisfactory results. Five ethanolic extracts from different stages and organs of C. ferruginea were investigated, the DHM concentration ranges from 52.08 ± 3.95 to 201.83 ± 4.71 mg/g. The proposed method appears to be a suitable tool for fast quality control of herbal extracts, with no need of tedious sample preparation and chromatographic separations increasing the efficiency of natural products analysis. This is the first study reporting the presence and determination of DHM in Cassia ferruginea (Schrad.) DC.

关键词： qHNMR dihydromyricetin Cassia ferruginea

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Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz joséTuñón department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro Nacional de Investigaciones Cardiovasculares MadridSpain department of Cardiology Hospital Central de Asturias department of Cardiology Hospital Universitario Ruber-Quirónsalud department of Cardiology Hospital Universitario Infanta Leonor department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de Madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 *** AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,anddeath or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;Pdeath across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,Pderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKD GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Vascular Calcification： Current Genetics Underlying This Complex Phenomenon

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Chinese Medical Journal 2017年第9期130卷 1113-1121页

作者： Nonanzit Perez-Hernandez Gad Aptilon-Duque Ruben Blachman-Braun Gilberto Vargas-Alarcon Adrian Asael Rodriguez-cortes Shely Azrad-Daniez Rosalinda Posadas-Sanchez jose Manuel Rodriguez-Perez department of Molecular Biology National Institute of Cardiology "lgnacio Chavez" Mexico Mexico City 14080 Mexico 2department of Endocrinology National Institute of Cardiology "Ignacio Chavez" Mexico Mexico City 14080 Mexico

Objective： Vascular calcification is the consequence of the complex interaction between genetic, environmental, and vascular factors, which ultimately lead to the deposition of calcium in the tunica intima （atherosclerotic calcification） or tunica media （M6nckenberg＇s sclerosis）. Vascular calcification is also closely related to other pathologies, such as diabetes mellitus, dyslipidemia, and chronic kidney disease. It has been concluded that the degree of vascular calcification may vary from person to person, even if the associated pathologies and environmental factors are the same. Therefore, this suggests an important genetic contribution to the development of vascular calcification. This review aimed to find the most recent evidence about vascular calcification pathophysiology regarding the genetic aspects and molecular pathways. Data Sources： We conducted an exhaustive search in Scopus, EBSCO, and PubMed with the keywords ＂genetics and vascular calcification＂, ＂molecular pathways, genetic and vascular calcification＂ and included the main articles from January 1995 up to August 2016. We focused on the most recent evidence about vascular calcification pathophysiology regarding the genetic aspects and molecular pathways. Study Selection： The most valuable published original and review articles related to our objective were selected. Results： Vascular calcification is a multifactorial disease; thus, its pathophysiology cannot be explained by a single specific factor, rather than by the result of the association of several genetic variants, molecular pathway interactions, and environmental factors that promote its development. Conclusion： Although several molecular aspects of this mechanism have been elucidated, there is still a need for a better understanding of the factors that predispose to this disease.

关键词： Atherosclerosis Cardiovascular Risk Genetics Polymorphisms Vascular Calcification

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