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Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

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World Journal of Gastroenterology 2021年第11期27卷 1064-1075页

作者： josé carlos rodrigues nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá Department of Anesthesia and Surgery Liver Transplantation Fortaleza General HospitalFortaleza 60150-160CEBrazil Laboratory of the Biology of Tissue Healing Ontogeny and NutritionDepartment of Morphology and Institute of BiomedicineSchool of MedicineFederal University of CearáFortaleza 60430-270CEBrazil Department of Dental Clinic Federal University of CearáFortaleza 60430-270CEBrazil Department of Surgery Liver Transplant Unit of Federal University of CearáFortaleza 60430-270CEBrazil Transplantation Division Hospital Geral de FortalezaFortaleza 60175-742CEBrazil Institute of Virology CharitéUniversitätsmedizin BerlinBerlin 10117Germany UCL Medical School Royal Free CampusLondon NW32PFUnited Kingdom Department of Specialized Medicine Hepatology Liver Transplantation UnitAzienda Sanitaria Universitaria Integrata of UdineUdine I-33100Italy

BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular *** E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver *** To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)*** injury severity was assessed using different criteria,including METAVIR and models for endstage liver *** polymorphisms were analyzed by quantitative real-time polymerase chain *** The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to *** addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 *** fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.

关键词： Apolipoprotein E Polymorphism Liver cirrhosis Hepatitis C virus Hepatocellular carcinoma Liver transplantation

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Timing of breeding as a determinant of nest success of the vulnerable Chestnut Seedeater(Sporophila cinnamomea)in grasslands of southern South America

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Avian Research 2023年第1期14卷 126-135页

作者： Jonas Rafael rodrigues Rosoni Carla Suertegaray Fontana Caio josécarlos Programa de Pós-Graduacão em Biologia Animal Departamento de ZoologiaUniversidade Federal do Rio Grande do SulUFRGSAvenida Bento Gonçalves950091501-970Porto AlegreRio Grande do SulBrazil Laboratório de Ornitologia Museu de Ciências e TecnologiaPrograma de Pós-Graduacão em Ecologia e Evolucão da BiodiversidadePontifícia Universidade Católica do Rio Grande do SulPUCRSAvenida Ipiranga668190619-900Porto AlegreRio Grande do SulBrazil Departamen to de Ecologia Universidade Federal do Rio Grande do SulUFRGSAvenida Bento Gonçalves950091501-970Porto AlegreRio Grandedo SulBrazil

The breeding traits of Sporophila seedeaters have been relatively well studied in recent years;nevertheless,a group of ten species in the genus,known as southern capuchinos,remain *** is the case with Chestnut Seedeater(Sporophila cinnamomea),a species vulnerable to extinction,which breeds in the grasslands of southeast South America and,after reproduction,migrates towards the Cerrado region in central ***,we investigated breeding ecology and calculated average clutch size,productivity,the sex ratio of nestlings,and estimated nest *** we tested(1)whether there is a relationship between the number of active nests and environmental variables,(2)whether the nestling sex ratio deviates from the 1:1 ratio,(3)whether clutch size varies between breeding seasons,and(4)whether the nest success is related to starting date,nest age,plant support,nest height from the ground,and clutch *** two breeding seasons(October-March 2018-2020),we monitored 98 *** generated survival models with five interacting covariates to assess the survival of the *** recorded the entire breeding period for Chestnut Seedeater,which was estimated to be 4.6 months,similar to other migratory *** size did not differ between breeding *** sex ratio of nestlings was not significantly different from the 1:1 *** success was 31%,and predation was the leading cause of unsuccessful nests(83%).The daily survival rate was 0.95±*** main predictor of nest survival was the covariate starting *** findings,added to other aspects of the species’natural history described here,may help illuminate the ecology and behavior of Chestnut Seedeater and other southern endangered capuchinos,and grassland-dependent species of South America.

关键词： Brood parasitism Clutch size Neotropical grassl ands Nest age Nest predation Nest survival

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Catalytic Esterification of Oleic Acid Over SO42-/MCM-41 Nanostructured Materials

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Materials Sciences and Applications 2011年第6期2卷 706-709页

作者： Alexsandra rodrigues do nascimento Gicélia rodrigues joselaine Carvalho Santana Anne Michelle Garrido Pedrosa Marcelo josé Barros de Souza 不详

This paper deals a study concerning the synthesis and catalytic application of a series of SO42-/MCM-41 catalysts with different SO42-/Si ratios, in the catalytic esterification of oleic acid, aiming biofuels production. The catalysts were characterized by XRD and FT-IR. The catalytic tests were carried out in a batch reactor and the obtained results showed good catalytic activity with high degrees of conversions of oleic acid.

关键词： MCM-41 Sulphate Esterification Oleic Acid

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Gender Differences in Comorbidities and Sleep Patterns of Obese Patients with Obstructive Sleep Apnea

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World Journal of Neuroscience 2015年第1期5卷 49-57页

作者： Ricardo josé Benício Valadares Klayton Galante Sousa Marília nascimento Espindola carlos Eduardo Ventura Gaio dos Santos carlos Alberto Assis Viegas Postgraduate School of Medicine at the University of Brasilia (UNB) Brasilia Brazil

Objective: The aim of the study was to compare the comorbidities and sleep patterns most commonly associated with each gender in obstructive sleep apnea (OSA). Methods: This was a cross-sectional study of obese individuals with OSA.?The polysomnographies were carried out in a sleep laboratory environment, using a 15-channel polysomnography setup. Airflow was measured using a nasal pressure cannula/thermistor combination. A standard handbook was used for interpretation of PSG findings. Results: A total of 284 subjects were included in the study, (147 females). The mean age, body mass index and neck circumference were similar between females and males (p?= 0.9579,?p??p?< 0.0001, respectively). On polysomnography, females exhibited longer latency to REM sleep (146.50 ± 85.93 vs. 122.3 ± 68.28,?p?= 0.0210) and a higher percentage of?delta sleep (10.09 ± 7.48 vs. 7.55 ± 6.57,?p?= 0.0037);males had more frequent microarousals (38.37?± 27.44 vs. 28.07 ± 21.23,?p?= 0.0017) and a higher AHI score (30.56 ± 27.52 vs. 17.31 ± 21.23,?p?< 0.0001). The comorbidities most commonly associated with female gender were diabetes (29% vs. 9.49%,?p?= 0.0132), hypothyroidism (20% vs. 2.19%,?p?< 0.0001), and depression (81.63% vs. 51.22%,?p?< 0.0001). Male gender was associated with myocardial infarction (6.57% vs. 1.38%,?p?= 0.0245) and alcohol intake (33.88% vs. 11.34%,?p?< 0.0001). Obese males with OSA have a larger?neck circumference and higher AHI and arousal indices than females. Conclusions: There are genderdifferences both in the sleep patterns and in the comorbidities of patients with OSA. Men had a larger neck circumference, higher apnea and sleep fragmentation scores, were more likely to consume alcohol, and were more likely to have a history of myocardial infarction than women.

关键词： Obstructive Sleep Apnea Obesity Gender Comorbidity

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Effect of the Preparation Method on Co/Al2O3Catalyst Applied to Ethanol Steam Reforming Reaction Production of Hydrogen

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Modern Research in Catalysis 2012年第3期1卷 52-57页

作者： Silmara rodrigues Garcia josé Mansur Assaf Laboratory of Catalysis-Chemical Engineering Department-Federal University of Sao Carlos

Alumina supported cobalt catalysts were prepared, characterized and applied in ethanol steam reforming for hydrogen production. The support and the supported catalysts were prepared, respectively, by the solvothermal and precipitation, impregnation and deposition-precipitation methods. The cobalt was added by impregnation and deposition-precipitation in the Al2O3 supports using a Co(NO3)2·6H2O solution. The solids were characterized, Temperature-Programmed Re-duction with H2 (RTP-H2), X-Ray Diffraction (DRX), BET Nitrogen Adsorption and Temperature Programmed Oxida-tion (TPO). The results indicated that the preparation method and the treatment conditions of samples were appropriate for obtaining the wanted compounds. Co3O4 phase was verified for all catalysts through analyses of DRX and RTP-H2 results. Catalytic tests were performed by varying the temperature from 450?C to 600?C, with water: ethanol molar ratio of 3:1. The ethanol conversion was superior of 99%, with greater hydrogen yield at 600℃. The lower carbon deposition was observed in catalysts prepared with solvothermal/deposition-precipitation methods at 450℃.

关键词： Hydrogen Ethanol Reform Cobalt Alumina

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Freeze-dried jaboticaba(Myrciaria jaboticaba)peel powder,a rich source of anthocyanins and phenolic acids,mitigates inflammation-driven colorectal cancer in mice

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Food Bioscience 2023年第3期53卷 1060-1071页

作者： Roberto de Paula do nascimento Julia Soto Rizzato Gabriele Polezi Amanda Maria Tomazini Munhoz Moya Milena Ferreira Silva Ana Paula da Fonseca Machado Gilberto carlos Franchi Junior Renata Galhardo Borguini Manuela Cristina Pessanha de Araújo Santiago Ana Paula Ribeiro Paiotti joséAires Pereira carlos Augusto Real Martinez Mario Roberto Marostica Junior Laboratory of Nutrition and Metabolism(LANUM) Department of Food Science and Nutrition(DECAN)School of Food Engineering(FEA)University of Campinas(UNICAMP)CampinasSPBrazil Laboratory of Food Nutritionand HealthDepartment of Food Science and Nutrition(DECAN)School of Food Engineering(FEA)University of Campinas(UNICAMP)CampinasSPBrazil Laboratory of Cellular and Behavioral Pharmacology Federal University of São Paulo(UNIFESP)Diadema CampusDiademaSPBrazil Integrated Research Center for Onco-Hematological Childhood Diseases School of Medical Sciences(FCM)University of Campinas(UNICAMP)CampinasSPBrazil Brazilian Agricultural Research Corporation(EMBRAPA) Embrapa Food TechnologyRio de JaneiroRJBrazil Laboratory of Hepatology Molecular Applied-Discipline of GastroenterologyFederal University of S˜ao Paulo(UNIFESP)S˜ao Paulo CampusS˜ao PauloSPBrazil Postgraduate Program in Health Sciences S˜ao Francisco University(USF)Bragança Paulista CampusBragança PaulistaSPBrazil

This study aimed to characterize the peel of jaboticaba(Myrciaria jaboticaba(Vell.)***)by spectropho-tometry and chromatography,and investigate its effects on mice with inflammation-driven colorectal cancer(CRC).Freeze-dried jaboticaba peel(FDJP)showed a high antioxidant capacity in vitro,and to be mostly a source of cyanidin-3-O-glucoside,gallic acid,and ellagic *** the animal bioassay,FDJP added at 5%in the diet during 114 days completely abolished the formation of adenocarcinoma,which had an incidence of 75%in the non-treated *** consuming FDJP showed low histology damage regarding inflammatory infiltrate,edema,and crypt *** significantly reduced the colonic levels of proinflammatory markers interleukin-1beta and cyclooxygenase-2,and demonstrated a probability to decrease the expressions of inducible nitric oxide synthase and nuclear factor kappa *** summary,FDJP mitigated CRC,possibly by avoiding trig-gering *** benefit may come from its rich content in anthocyanins and phenolic acids.

关键词： Brazil Carcinogenesis Colitis Cyanidin-3-O-Glucoside Flavonoid Fruit

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Parsonage-Turner syndrome following chikungunya virus infection:A case report

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Asian Pacific Journal of Tropical Medicine 2019年第5期12卷 239-242页

作者： Luis Arthur Brasil Gadelha Farias Marina Vasconcelos Sampaio Ant?nio carlos Delgado Sampaio Roberto da Justa Pires Neto Jorge Luiz Nobre rodrigues School of Medicine,Federal University of Ceará School of Medicine,Universitary Center Christus(Unichristus) Orthopedic Department,S?o carlos Hospital Hospital S?o joséde Doen?as Infecciosas Infectology Service,Walter Cantídeo University Hospital School of Medicine Federal University of Ceará School of Medicine Universitary Center Christus(Unichristus) Orthopedic Department Sao Carlos Hospital Hospital Sao josé de Doencas Infecciosas Infectology Service Walter Cantídeo University Hospital

Rationale: Parsonage-Turner syndrome is a rare syndrome of unknown etiology, affecting mainly the lower motor neurons of the brachial *** fever is a mosquito-borne viral disease characterized by acute fever and polyarthritis/*** concerns: A 54-year-old Brazilian male patient who presented with a 2-day history of fever(temperature 38.8 ℃), arthralgia, erythematous rash, diffuse osteomuscular pain and headache, which evolved into left shoulder pain associated with morning ***: Parsonage-Turner syndrome and chikungunya ***: Symptomatic treatment(a combination of short-acting dypirone(500 mg every 6 h) and slow-release opioids(tramadol 100 mg every 4 h) and physiotherapy/rehabilitation with ***: The patient was improved and discharged, remaining with symptomatic treatment and physiotherapy/***: To the best of our knowledge, there were no reports of Parsonage-Turner syndrome following chikungunya virus *** of the possibility of this rare association is *** present case report highlights the importance of awareness of this association as a new cause of morbidity in patients with chikungunya virus infection.

关键词： Parsonage-Turner syndrome Chikungunya virus Chikungunya fever Brachial amyotrophy Case report

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Proposition of a Tool to Adjust the Inspired Oxygen Fraction in Anesthesia Devices during Prolonged Mechanical Ventilation in COVID-19 Patients

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Open Journal of Anesthesiology 2021年第10期11卷 299-305页

作者： Plínio de Oliveira Holanda Nely Marjollie Guanabara Teixeira Reis josé carlos R. nascimento Felipe Paiva Alencar Marilman Maciel Benício Department of Anesthesia Dr. Jose Frota Institute Fortaleza Brazil Unichristus University Fortaleza Brazil Department of Anesthesia Fortaleza General Hospital Fortaleza Brazil Laboratory of the Biology of Tissue Healing Ontogeny and Nutrition Department of Morphology and Institute of Biomedicine School of Medicine Federal University of Ceara Fortaleza Brazil Department of Computer Engineering Ceara State University Fortaleza Brazil

The COVID-19 pandemic has had a major impact on health care services, leading to a breakdown in public and private health systems worldwide. A major challenge was the scarcity of mechanical ventilators, which resulted in the use of anaesthesia devices for this purpose. However, they are quite different from mechanical ventilators used in Intensive Care Units and some adaptations, such as the use of high flow to reduce CO2 rebreathing, were necessary to ensure patient safety. The objective of this study was to present a mathematical formula and develop a tool that can be used to adjust the flow of oxygen and air in flow metres of anaesthesia devices that do not have oxygen analysers or these analysers are not operational. A literature review was conducted using the main health databases and libraries as research sources: PubMed, Virtual Health Library (VHL), SciELO, and Cochrane. The review included studies published in English, Spanish, and Portuguese. Animal studies were excluded. A total of 11 references were included to support this article.

关键词： Anaesthesia Ventilator Intensive Care Unit FiO2 Fresh Gas Flow Webpage

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Agronomic and Energetic Potential of Biomass Sorghum Genotypes

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American Journal of Plant Sciences 2015年第11期6卷 1862-1873页

作者： Fernanda Maria rodrigues Castro Adriano Teodoro Bruzi josé Airton rodrigues Nunes Rafael Augusto Costa Parrella Gabrielle Maria Romeiro Lombardi carlos Juliano Brant Albuquerque Maurício Lopes Agriculture Department Federal University of Lavras Lavras Brazil Biology Department Federal University of Lavras Lavras Brazil Embrapa Maize and Sorghum Sete Lagoas Brazil Epamig Uberlandia Brazil

The biomass sorghum [Sorghum bicolor (L.) Moench], is an interesting crop considering the necessity to invest in alternative sources to generate renewable energy. The objective of this experiment was to identify sorghum biomass genotypes with greatest agronomic and energetic potential, and verify if there is phenotypic association between agronomic and technological properties in the hybrids. The study was conducted in three cities of the Minas Gerais State, Brazil (Lavras, Uberlandia and Sete Lagoas). It was evaluated 16 genotypes of sorghum biomass, being 14 of them sensitive hybrids to photoperiod and two cultivars, as control, insensitive to photoperiod. The experimental design was a triple lattice 4 × 4, with plots formed by four linear rows of 5.0 m. The morphoagronomic characteristics evaluated for the three environments were: days to flowering (FLOW), plant height (PH), number of stems (NS) and green matter production (GMP). In the experiment conducted in Lavras, also it was evaluated the agronomic traits: stem diameter (SD) and dry matter production (DMP) besides the technological traits: higher heating value (HHV), crude fiber (CF), neutral detergent fiber (NDF) and acid detergent fiber (ADF). The genotype × environment interaction was significant for all traits. The hybrids had superior performance compared to the control genotypes. Biomass sorghum hybrids, sensitive to photoperiod, when compared with commercial hybrids of forage sorghum, insensitive to photoperiod, had an average production of 34 t ha-1 dry matter with 62% humidity and higher heating value of 4.400 Kcal/Kg. There was no phenotypic correlation between agronomic and technological characters evaluated.

关键词： Sorghum bicolor Bioenergy Alternative Source Phenotypic Correlation

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Growth and Photosynthetic Pigments of Cotton Cultivars Irrigated with Saline Water

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Agricultural Sciences 2019年第1期10卷 81-91页

作者： Elka Costa Santos nascimento Ronaldo do nascimento André Alisson rodrigues da Silva carlos Vailan de Castro Bezerra Mateus Costa Batista Luana Lucas de Sá Almeida Veloso Márcia Cristina de Araújo Pereira Hallyson Oliveira Federal University of Campina Grande Campina Grande Brazil

The cultivation of cotton is a relevant socioeconomic activity in the Brazilian agricultural scenario. In the Brazilian Northeast, however, production is limited by low rainfall, requiring water supplementation, a problem for the cotton cultivation practiced in the semi-arid region, due to the presence of saline ions in several water sources, from where the water is used for irrigation. It is necessary to identify cultivars that better tolerate saline stress in order to provide subsidies for their cultivation under such conditions. In this sense, the objective was to evaluate the tolerance of cotton cultivars to salinity. The experiment was conducted in a greenhouse, belonging to the Natural Resource Technology Center of the Federal University of Campina Grande, Campus I, Campina Grande, Brazil, in a completely randomized design in a 2 × 5 factorial scheme, with four replications, totaling 40 experimental units (BRS 368 RF and BRS SAFIRA) submitted to five saline levels (1.5, 3.0, 4.5, 6.0 and 7.5 dS·mˉ1). Irrigation with water saline of EC from 1.5 dS·mˉ1 affects adversely the growth of cotton cultivars, causing reductions in plant height, stem diameter, leaf area and number of leaves. Saline stress reduced the levels of the photosynthetic pigments of the cotton plants studied.

关键词： Gossypium hirsutum L. Salinity Chlorophyll

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