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Climate-driven variations in productivity reveal adaptive strategies in Iberian cork oak agroforestry systems

Forest Ecosystems 2022年第1期9卷 83-93页

作者： josé carlos pérez-girón Emilio Rafael Díaz-Varela pedro Álvarez-Álvarez Department of Organisms and Systems Biology Polytechnic School of MieresUniversity of OviedoE-33600MieresAsturiasSpain Research Group on planning and Management in Complex Adaptive Socio-Ecological Systems(COMpASSES).School of Engineering University of Santiago de CompostelaE-27002LugoSpain

Background:Cork oak agroforestry systems(AFS)have been managed for centuries by humans to produce cork and other goods and services and have recently been recognised as an important reservoir for biodiversity improvement and ***,despite having recently been included as a natural habitat of community-wide interest within the EU Habitats Directive,these systems are in a critical situation of *** other factors,they are strongly threatened by climate change,the effects of which are also expected to be particularly severe in the Mediterranean *** this study,we aimed to evaluate the influence of climate variability by examining primary production indicators and also to analyse whether the geographical location may have a role in the incidence of the adverse effects of ***:Cork oak AFS were identified in the Forest Map of Spain and the Land use map of portugal and categorized on the basis of canopy *** climate data from 2001 to 2020 were used to model relationships with climate predictors and proximity to the *** analysis was conducted to identify significant spatial clusters of high-and low-efficiency ***:The responses to the influence of climatic conditions differed among the various cork oak AFS categories,particularly in the forest category,which was less dependent on climate *** humidity and water availability were the main drivers of net primary production(npp).Carbon use efficiency(CUE)was limited by relative humidity and spring temperature in open *** to the coast proved beneficial,especially in years with adverse weather conditions,but was not a limiting factor for survival of the ***,the results of the hotspot analysis supported the other findings,highlighting high-efficiency areas close to the coast and cold spots grouped in specific areas or dispersed ***:Canopy plays a key role in the influence of climatic conditions,particu

关键词： net primary production Carbon use efficiency Climate Quercus suber Agroforestry system

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Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

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Research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María pérez-Zabalza Antoni Oliver-Gelabert joséMaría Vallejo-Gil Javier Fañanás-Mastral Manuel Vázquez-Sancho Javier AndréBellido-Morales Alexánder Sebastián Vaca-núñez carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

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Inflammatory markers,oxidative stress,and mitochondrial dynamics:Repercussions on coronary artery disease in diabetes

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World Journal of Diabetes 2024年第9期15卷 1853-1857页

作者： josécarlos Tatmatsu-Rocha Luan Santos Mendes-Costa College of Medicine Postgraduate Program in Physiotherapy and FunctionalityFederal University of Ceará-UFCFortaleza 60430-450CearáBrazil physical Therapy Federal University of CearáFortaleza 60000-000CearáBrazil

Inflammatory markers and mediators that affect the development of cardiovascular diseases have been the focus of recent scientific ***,the purpose of this editorial is to promote a critical debate about the article titled“nε-carboxymethyl-lysine and inflammatory cytokines,markers,and mediators of coronary artery disease progression in diabetes”,published in the World Journal of Diabetes in *** work directs us to reflect on the role of advanced glycation end products,which are pro-inflammatory products arising from the metabolism of fatty acids and sugars whose main marker in tissues is nε-carboxymethyllysine(nML).Recent studies have linked high levels of pro-inflammatory agents with the development of coronary artery disease(CAD),especially tumor necrosis factor alpha,interleukins,and C-reactive *** inflammatory agents increase the production of reactive oxygen species(ROS),of which people with diabetes are known to have an increased *** increase in ROS promotes lipid peroxidation,which causes damage to myocytes,promoting myocardial ***,oxidative stress induces the binding of nML to its receptor RAGE,which in turn activates the nuclear factor-kB,and consequently,inflammatory *** inflammatory cytokines induce endothelial dysfunction,with increased expression of adhesion molecules,changes in endothelial permeability and changes in the expression of nitric *** this sense,the therapeutic use of monoclonal antibodies(inflammatory reducers such as statins and sodium-glucose transport inhibitors)has demonstrated positive results in the regression of atherogenic plaques and consequently *** the other hand,many studies have demonstrated a relationship between mitochondrial dynamics,diabetes,and cardiovascular *** link occurs since ROS have their origin in the imbalance in glucose metabolism that occurs in the mitochondrial matrix,and this imbalance can have its origin in inadequate diet as well as

关键词： Mitochondrial dynamics Diabetes Oxidative stress Coronary artery disease nε-carboxymethyl-lysine

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Risk Assessment of an Environmental Liability in the Commercialization of Hydrocarbons-A Secondary publication

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Journal of World Architecture 2024年第2期8卷 108-117页

作者： Yamila navarro Sosa josécarlos Rojas Acosta Lester Rivas Trasancos carlos C.Cañete pérez Yuletsis Díaz Rodríguez Center for petroleum Research(CEInpET) HavanaCuba Technological University of Havana joséAntonio Echeverría HavanaCuba

The risk analysis evaluates the probability of occurrence with the impact of said *** the hydrocarbon sector,an environmental liability is an improperly abandoned facility,soil contaminated by spills or *** objective of this work is to define a risk management *** characterization of the residue and the area was carried *** events were identified:overflow spill,soil contamination by infiltration,as well as radiant heat and suffocating and toxic fumes from a *** matrix method was applied considering the probability of occurrence against *** danger of infiltration implied a high level of *** risk management plan was drawn up,its main action being the liquidation of the pool and the sanitation of the area.

关键词： Hazardous events Environmental liability Waste Risk Vulnerability

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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in the brain

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neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： Yolanda Diz-Chaves Zainab Maastor carlos Spuch josé Antonio Lamas Lucas C.González-Matías Federico Mallo Biomedical Research Centre(CInBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational neuroscience Research Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research Centre(CInBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling pathways related to neuroprotection,like the support of cell growth/survival,enhancement promotion of synapse formation,autophagy,and inhibition of the secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic homeostasis and defe nse against pathogens in the central nervous *** brain insult,microglia are the first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or chemokines to react to the ***,under these circumstances,mic roglia can become chro nically inflammatory by losing their homeostatic molecular signature and,consequently,their functions during many *** processes promote the development of neurological disorders and influence their pathological evolution:like the formation of protein aggregates,the accumulation of abnormally modified cellular constituents,the formation and release by injured neurons or synapses of molecules that can dampen neural function,and,of critical impo rtance,the dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory pathologies,restoring brain cell homeostasis under inflammatory conditions,modulating mic roglia activity,and decreasing the inflammato ry *** review summarizes recent advances linked to the anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis,Alzheimer’s disease,parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

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Diabetes mellitus and comorbidities in elderly people from the Lugu community:A critical-reflective analysis

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World Journal of Diabetes 2024年第11期15卷 2162-2166页

作者： josécarlos Tatmatsu-Rocha josécarlos Gomes-pinto College of Medicine Postgraduate Program in Physiotherapy and FunctionalityFederal University of Ceará-UFCFortaleza 60810-786Brazil College of Medicine Postgraduate Program in Physiotherapy and FunctionalityFederal University of CearáFortaleza 60000-000Brazil

Ageing has a close relationship with chronic non-communicable diseases,such as diabetes mellitus and high blood *** pathologies are often associated with changes in eating habits and promote crucial physiological changes which act silently in the long term in the elderly *** to the speed of urban development and technological advances,there has been an increase in the population's life ***,it is essential to know the socio-demographic profile and prevalent comorbidities of the elderly population,which can provide a reliable and broad database to enable the outline of strategies and the promotion of efficient health *** this sense,the purpose of this editorial is to contribute to the debate surrounding the article that analysed epidemiological data from the Lugu *** mellitus,hypertension and cardiovascular pathologies and their comorbidities were the most prevalent conditions in this *** data could contribute to develop public policies constructively and assertively,allowing investments in the prevention and treatment of these pathologies.

关键词： Diabetes mellitus Quality indicators Health care Hypertension Comorbidity Exercise

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Health Vigilance and Risk Factors for Cervical Cancer: A Study in the State of Maranhão, Brazil

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Open Journal of Epidemiology 2024年第1期14卷 75-89页

作者： josé Márcio Soares Leite carlos Tomaz School of Medicine CEUMA University S&#227o Luís Brazil Master’s program in Environment CEUMA University S&#227o Luís Brazil

The purpose of this cross-sectional study was to investigate the importance of health vigilance in the prevention of cervical cancer. The sample consisted of 536 women. To identify which risk factors were associated with cervical cancer or with an increase in the mortality rate of this kind of cancer, a logistic regression model was used. The Odds Ratios (OR) and their respective 95% confidence intervals were also calculated. Most of them were at the age of highest incidence of cervical cancer (21 - 59 years old), had an unstable conjugal situation, minimal educational level (78.7%), low income (58.3%), consumed alcoholic beverages (56.4%), had a history of smoking (57.0%) and possessed limited knowledge about the prevention. These results are discussed in terms of a predictive model for cervical cancer that considers the importance of public health vigilance in the screening and precocious diagnosis.

关键词： Cancer Cervix Uteri public Health Surveillance Epidemiology

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María norte-Muñoz María portela-Lomba paloma Sobrado-Calvo Diana Simón Johnny Di pierdomenico Alejandro Gallego-Ortega Mar pérez joséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari joséEduardo Vargas Cláudia p Oliveira Carolina Uribe-Cruz carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho nacional de Desenvolvimento Científico e Tecnológico(Cnpq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUnD prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEn)in drinking water and Veh gavage],and RIF[HFCD,DEn and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRnAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(pn HCC compared to RIF(ppatic expression of Mmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(ppression of p62/SQSTM1 protein was lower in the RIF-group compared to the control(p=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and Mmp2(p>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(pn HCC compared to RIF,and the inverse was observed for miR-224(pno difference among groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(p>0.05).COnCLUSIOn RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

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Gravity-Driven Listric Growth Fault and Sedimentation in the Lagoa do peixe, Rio Grande do Sul Coastal plain, Brazil

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Open Journal of Geology 2024年第4期14卷 594-616页

作者： Bruno Silva da Fontoura Adelir josé Strieder Iran carlos Stalliviere Corrêa paulo Rogério Mendes Instituto de Geociê ncias UFRGS Porto Alegre Brazil Engenharia Geoló gica Centro de Engenharias UFPel Pelotas Brasil HIDROSERV— Servi&#231os Geol&#243gicos e Geof&#237sicos Ltda. Porto Alegre Brazil

High frequency, high resolution GpR surveys are successfully applied to investigate near-surface stratification architecture of sedimentary units in coastal plains and to define their depositional conditions. However, low frequency GpR surveys to investigate fault-related depositional systems at greater depths are scarce. This survey was designed investigate a > 100 km long linear escarpment that controls the northwest margin of the Lagoa do peixe, an important lagoon in Rio Grande do Sul Coastal plain (RGSCp, Brazil). The traditional approach points that RGSCp was developed by juxtaposition of four lagoons/barrier systems as consequence of sea level changes;no deformational structure is admitted to exist before. The low frequency GpR (50 MHz, RTA antenna) and geological surveys carried out in the RGSCp showed the existence of a large, gravity-driven listric growth fault controlling the Lagoa do peixe escarpment and hangingwall sedimentation. The radargrams in four subareas along the Lagoa do peixe Growth Fault could be interpreted following the seismic expression of rift-related depositional systems. The radargrams enabled to distinguish three main lagoonal deposition radarfacies. The lower lagoonal radarfacies is a convex upward unit, thicker close to growth fault;the radarfacies geometry indicates that fault displacement rate surpasses the sedimentation rate, and its upper stratum is aged ~3500 p>l4p>C years Bp. The second lagoonal radarfacies is a triangular wedge restricted to the lagoon depocenter, whose geometry indicates that fault displacement and the sedimentation rates kept pace. The upper lagoonal radarfacies is being deposited since 1060 ± 70 p>l4p>C years Bp, under sedimentation rate higher than fault displacement rate. The results indicate that low frequency GpR surveys can help in investigating fault-related depositional systems in coastal zones. They also point to a new approach in dealing with RGSCp stratigraphy.

关键词： GpR (Ground-penetrating Radar) Growth Fault Sedimentation Radarfacies Coastal plain

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