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Mitochondria–cGAS–StING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

the word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is chara.terized by a long-la.ting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential la.ting

the emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Depa.tment of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that a.tivation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated a.trocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and syna.tic structural a.terations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the a.tivation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the a.tivation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the a.terations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear fa.tor-kappa B,monocyte chemoa.tra.ta.t protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome a.tivation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

An innovative approach for integrated airline network and aircra.t family optimization

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Chinese Journal of Aerona.tics 2020年第2期33卷 634-663页

作者： joséALEXANDRE t.G.FREGNANI Bento S.DE Ma.tOS joséA.HERNANDES Depa.tment of Aerona.tical Engineering Technological Institute of Aeronautics12228-900 Sao Jose dos CamposBrazil

the determination of optimal aerial transport networks and their associated flight frequencies is crucial for the strategic planning of airlines,as well as for carrying out market research,to establish target markets,and for aircra.t and crew *** addition,optimum airplane types for the selected networks are crucial to improve revenue and to provide reduced operating *** present study proposes an innovative approach to determine the optimal aerial transport network simultaneously with the determination of the optimum fleet for that network,composed of three types of airplanes(network and vehicle integrated design).the network profit is *** passenger’s demands between the airports are determined via a gravitational *** embedded linear programming solution is responsible for obtaining potential optimal network *** optimum fleet combination is determined from a database of candidate aircra.t designs via genetic algorithm.a.truly realistic airplane representation is made possible thanks to accurate surrogate models for engine and aerodynamics is *** accurate engine deck encompassing a compression map and an innovative engine weight calculation besides an aerodynamical a.tificial neural network module enable a high degree of accuracy for the mission *** proposed methodology is applied to obtain the optimum network comprised of twenty main Brazilian airports and corresponding fleet.

关键词： Air transport Aircra.t design Airline economics Airline network optimization Multidisciplinary design optimization

Global evolution of Equidae and Gomphotheriidae from South America

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Integrative Zoology 2014年第4期9卷 434-443页

作者： joséL.PRADO María.t.ALBERDI INCUAPA CONICET-UNICENNational University of Central Buenos Aires ProvinceOlavarríaArgentina Depa.tment of Paleobiology Museo Nacional de Ciencias NaturalesCSICMadridSpain

the contemporary South American mammalian communities were determined by the emergence of the Isthmus of Panama and by the profound climatic oscillations during the *** and gomphotheres were 2 very conspicuous groups of immigra.t mammals from North America.that arrived in South America during the *** present study compiles updated data on the phylogeny,systematics and ecology of both groups in South *** horses in South America are represented by 2 genera,Hippidion and Equus,as are the gomphotheres,represented by Cuvieronius and *** genera of horses include small(Hippidion devillei,***,*** and ***)and large forms(Equus neogeus and ***),which dispersed into South America using 2 different *** possible model for this dispersion indicates that the small forms used the Andes corridor,while larger horses dispersed through the ea.tern route and through some coa.tal *** the case of gomphotheres,Cuvieronius and Stegoma.todon reached South America in 2 independent dispersal events,and Cuvieronius dispersed across the Andean corridor,while large Stegoma.todon spread along the ea.tern *** and gomphotheres present values ofδ^(13)C from woodlands to C4 grass*** present lower values ofδ^(13)C than Equus in the late Pleistocene,whereas the gomphotheres diverge from value ofδ^(18)O,reflecting that Cuvieronius inhabited the Andean corridor and Stegoma.todon dispersed through ea.tern *** gomphothere and horse species recorded in South America became extinct around the time that humans arrived.

关键词： Equidae Gomphotheriidae Plio-Pleistocene South America

touristic urbanization and greening of coa.tal dune fields:A long-term assessment of a.temperate sandy barrier of Argentina

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Journal of Geographical Sciences 2025年第1期 206-230页

作者： GARZO Pedro Andrés DADON josé Roberto ISLA Federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICEt/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.Schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo Nacional de Investigaciones Científicas y técnicas (CONICEt)

Dune barrier systems represent highly sought-a.ter coa.tal landscapes for tourism and urban development around the world. However, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization pra.tices were considered necessary. the systematic introduction of fa.t-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. this paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. this complex region includes urban resorts, afforestation zones, and protected areas. A GIS-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. the results revealed two primary spatiotemporal pa.terns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. Furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management a.tions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native pla.t communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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Phasor-domain Dynamic Model of Asymmetric Current Injection Controller for Converter-interfaced Generator

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1269-1278页

作者： Victor A.F.Almeida Glauco N.tara.to josé M.t.Marinho Electrical Engineering Depa.tment of the Federal University of Rio de Janeiro(COPPE/UFRJ) Petrobras S.A.

this paper presents a controller model of asymmetric current injection for converter-interfaced generators suitable for root-mean-square(RMS)phasor-domain,fundamentalfrequency,three-phase,and dynamic simulation *** effectiveness of the proposed controller is assessed with simulations in test systems with high percentage of converter-interfaced *** simulations focus on the operation of protection relays that use negative-sequence qua.tities in their directional *** paper also presents and compares two strategies to limit rea.tive negative-sequence currents,and a.tive and rea.tive positive-sequence currents.a.tutorial test system and a regional system pa.t of the a.tual Brazilian Interconnected Power System are used to assess the correctness of the proposed controller in three-phase fundamental-frequency RMS dynamic simulations.

关键词： Converter-interfaced generator three-phase model power system protection negative-sequence current injection negative-sequence current protection unbalanced fault three-phase root-mean-square(RMS)dynamic simulation

Differential response of injured and hea.thy retinas to syngeneic and allogeneic transpla.tation of a clonal cell line of immortalized olfa.tory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez joséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María.teresa Moreno-Flores Ma.ta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfa.tory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfa.tory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic fa.tor,one of the best neuroprotecta.ts for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfa.tory ensheating glia a.ter optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,tEG3,were intravitreally injected in inta.t and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfa.tory ensheathing glia and tEG3 express major histocompatibility complex classⅡ*** and syngenically transpla.ted tEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic tEG3 transpla.t rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical a.tivation was higher than a.ter optic nerve crush *** inta.t retinas,both transpla.ts a.tivated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher a.ter allotranspla.tation,triggered by pyroptosis and pa.tially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfa.tory ensheathing glia in the retina depending on the type of transpla.t highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfa.tory ensheathing glia retinal ganglion cells

Analysis of Viscous Heating in a Micro-Rocket Flow and Performance

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Journal of thermal Science 2008年第2期17卷 116-124页

作者： josé A.Moríigo josé Hermida Quesada Dept.of Space Programmes National Institute for Aerospace Technology Dept.of Aerodynamics and Propulsion National Institute for Aerospace technology

Micro-rockets for propulsion of small spacecra.ts exhibit significa.t differences with regard to their macroscale counterpa.ts,mainly caused by the role of the viscous dissipation and heat transfer processes in the micron-sized *** goal of this work is to simulate the transient operation of a micro-rocket to investigate the effects of viscous heating on the flow and performance for four configurations of the expanding gas and wafer *** modelling follows a multiphysics approach that solves the fluid and solid regions fully coupled.A contin- uum-based description that incorporates the effects of gas rarefa.tion through the micro-nozzle,viscous dissipa- tion and heat transfer at the solid-gas interface is ***-equilibrium is addressed with the implementa- tion of a 2nd-order slip-model for the velocity and temperature at the *** results stress that solid-fluid cou- pling exerts a strong influence on the flowfield and performance as well as the effect of the wafer during the first insta.ts of the transient in micro-rockets made of low and high thermal conductivity materials.

关键词： Micronozzles propulsion MEMS slip flow viscous heating

Multiphysics Simulation of a Novel Concept of MEMS-based Solid Propella.t thruster for Space Propulsion

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Journal of thermal Science 2011年第6期20卷 527-533页

作者： josé A.Moríigo josé Hermida-Quesada Dept.of Space Programmes National Institute for Aerospace Technology Ctra.Ajalvir km.4Torrejón de Ardoz 28850 MadridSpain Propulsion EngineerPh.D. Dept.of Aerodynamics and Propulsion National Institute for Aerospace Technology Ctra.Ajalvir km.4Torrejón de Ardoz 28850 MadridSpain

this work analyzes a novel MEMS-based architecture of submillimeter size thruster for the propulsion of small spacecra.ts,addressing its preliminary chara.terization of *** architecture of microthruster comprises a setup of miniaturized channels surrounding the solid-propella.t reservoir filled up with a high-energetic *** channels guide the hot gases from the combustion region towards the nozzle entrance located at the opposite side of the *** simulations of the transient response of the combustion gases and wafer heating in thruster firings have been conducted with FLUENt under a multiphysics modelling that fully couples the gas and solid pa.ts *** approach includes the gas-wafer and gas-polymer thermal exchange,burnback of the polymer with a simplified non-rea.ting gas pyrolysis model at its front,and a slip-model inside the nozzle portion to incorporate the effect of gas-surface and rarefa.tion onto the gas ***,accurate chara.terization of thruster operation requires the inclusion of the receding front of the polymer and heat transfer in the moving gas-solid *** study stresses the improvement a.tained in thermal management by the inclusion of lateral micro-channels in the *** pa.ticular,the temperature maps reveal the significa.t dependence of the thermal loss on the insta.taneous surface of the reservoir wall exposed to the heat flux of hot ***,the simulations stress the benefit of implementing such a pa.tern of micro-channels connecting the exit of the combustion reservoir with the *** results prove that hot gases flowing along the micro-channels exert a sealing a.tion upon the heat flux at the reservoir wall and pa.tly mitigate the overall thermal loss at the inner-wall vicinity during the *** analysis shows that propella.t decomposition rate is accelerated due to surface preheating and it suggests that a delay of the flame extinction into the reservoir

关键词： micronozzles spacecra.t micropropulsion solid propella.t thrusters