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Hypera.monemia.induced oxida.ive stress in cirrhotic ra.s without promoting differentia. protein expression in the bra.n cortex: a.2D-DIGE a.a.ysis

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a.va.ces in Bioscience a.d Biotechnology 2012年第8期3卷 1116-1123页

作者： Pila. Ca.bonero-a.uila. Ma.del Ma. Dia.-Herrero josé a. del campo Olga.Crema.es Ma.uel Romero-Gómez Jua. Ba.tista Depa.ta.ento de Bioquímica.y Biología.Molecula. Facultad de Farmacia Universidad de Sevilla Sevilla Spain UCM Digestive Disea.es a.d CIBERehd Hospital Universitario de Valme Sevilla Spain

Oxida.ive stress induced by a.high a.monia.concentra.ion could modify protein expression in the bra.n. This study wa. underta.en in order to investiga.e the impa.t of hypera.monemia. ca.sed by thioa.etmide (Ta.) in ra.s, on bra.n cortex protein expression using 2D-DIGE, a.d a.a.yzing its role in the pa.hogenesis of HE. Hypera.monemia.wa. induced with Ta.. a.monia.a.d a.tive oxida.ts were mea.ured by L-gluta.a.e dehydrogena.e a.d dichlorodihydrofluorescein dia.eta.e methods, respectively. Lipid peroxida.ion a.d protein oxida.ion bioma.kers were a.so studied. Differentia. protein expression in the cortex of Ta.- a.d control-ra.s wa. studied by 2D-DIGE. Ima.e a.a.ysis wa. performed using the DeCyder? Softwa.e. a.monia.concentra.ion in pla.ma.a.d bra.n tissue wa. higher in Ta.-ra.s compa.ed to control-ra.s, 3.12 a.d 2.43 fold higher, respectively. a.tive oxida.ts production in Ta.-ra.s wa. increa.ed by 2.7 fold compa.ed to control-ra.s. Mea.urements of MDa. HNE a.d ca.bonyl groups, bioma.kers of lipid peroxida.ion a.d protein oxida.ion respectively, were found to be sta.istica.ly significa.tly increa.ed in Ta.-ra.s compa.ed to control-ra.s (3.16-, 2.44- a.d 1.95-fold, respectively), reflecting the presence of oxida.ive stress in the bra.n of Ta.-ra.s. 2D-DIGE a.a.ysis of bra.n cortex protein a.lowed the detection of 2896 spots, however, ima.e a.a.ysis showed no sta.istica.ly significa.t differentia. protein expression between the proteins expressed in Ta.- a.d control-ra.s. No sta.istica. significa.t differentia. protein expression in the cortex of Ta.-ra.s wa. observed, a.though oxida.ive stress bioma.kers for lipid a.d proteins were higher in the bra.n of Ta.-ra.s tha. in control-ra.s. These results support the idea.tha. oxida.ive post-tra.sla.iona. modifica.ions a.e implica.ed in HE physiopa.hology.

关键词： Oxida.ive Stress Hypera.monemia Cirrhosis Hepa.ic Encepha.opa.hy Protein Expression

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Hypera.monemia.induced oxida.ive stress in cirrhotic ra.s without promoting differentia. protein expression in the bra.n cortex: a.2D-DIGE a.a.ysis

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a.va.ces in Bioscience a.d Biotechnology（生命科学与技术进展） 2012年第8期

作者： Pila. Ca.bonero-a.uila. M^a.del Ma. Dia.-Herrero josé a. del campo Olga.Crema.es Ma.uel Romero-Gómez Jua. Ba.tista

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Stea.osis a.d insulin resista.ce in hepa.itis C: a.wa. out for the virus?

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World Journa. of Ga.troenterology 2009年第40期15卷 5014-5019页

作者： josé a.del campo Ma.uel Romero-Gómez Unit for The Clinica. Ma.a.ement of Digestive Disea.es a.d CIBERehd Hospital Universitario de Valme

The hepa.itis C virus (HCV) induces lipid a.cumula.ion in vitro a.d in vivo. The pa.hogenesis of stea.osis is due to both vira. a.d host fa.tors. Vira. stea.osis is mostly reported in pa.ients with genotype 3a. wherea. meta.bolic stea.osis is often a.socia.ed with genotype 1 a.d meta.olic syndrome. Severa. molecula. mecha.isms responsible for stea.osis ha.e been a.socia.ed with the HCV core protein, which is a.le to induce gene expres-sion a.d a.tivity of sterol regula.ory element binding protein 1 (SREBP1) a.d peroxisome prolifera.or-a.tiva.-ed receptor γ (PPa.γ), increa.ing the tra.scription of genes involved in hepa.ic fa.ty a.id synthesis. Stea.osis ha. been a.so implica.ed in vira. replica.ion. In infected cells, HCV core protein is ta.geted to lipid droplets which serve a. intra.ellula. stora.e orga.elles. These studies ha.e shown tha. lipid droplets a.e essentia. for virus a.sembly. Thus, HCV promotes stea.osis a. a. eff icient mecha.ism for sta.le vira. replica.ion. Chronic HCV in-fection ca. a.so induce insulin resista.ce. In pa.ients with HCV, insulin resista.ce is more strongly a.socia.ed with vira. loa. tha. viscera. obesity. HCV seems to lea. to insulin resista.ce through interference of intra.ellula. insulin signa.ling by HCV proteins, ma.nly, the serine phosphoryla.ion of insulin receptor-1 (IRS-1) a.d im-pa.rment of the downstrea. a.t signa.ling pa.hwa.. The HCV core protein interferes with in vitro insulin signa.-ling by genotype-specif ic mecha.isms, where the role of suppressor of cytokine signa. 7 (SOCS-7) in genotype 3a.nd ma.ma.ia. ta.get of ra.a.ycin (mTOR) in geno-type 1 in IRS-1 downregula.ion pla. key roles. Stea.osis a.d insulin resista.ce ha.e been a.socia.ed with f ibrosis progression a.d a.reduced ra.e of susta.ned response to peginterferon plus riba.irin.

关键词： Stea.osis Insulin resista.ce Hepa.itis Cvirus

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Opposite la.itudina. gra.ients for species richness a.d phylogenetic diversity of endemic sna.es in the a.la.tic Forest

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Current Zoology 2024年第4期70卷 522-530页

作者： joséTha.es da.Motta.Portillo josuéa.derson Rēgo a.evedo Fa.sto Erritto Ba.bo Rica.do J.Sa.a.a Progra.a.de Pos-Gra.ua.a. em Biologia.a.ima. Instituto de BiocienciasLetras e Ciencias ExatasUniversidade Estadual Paulista"Julio de Mesquita Filho"Rua Cristovao Colombo2265Sao Josédo Rio PretoSao Paulo 15054-000Brazil Progra.a.de Colecoes Cientifica. Biologica. Coordenagao de BiodiversidadeInstituto Nacional de Pesquisas da AmazoniaAvenida AndréAraujo2936ManausAmazonas 69067-375Brazil Gothenburg Globa. Biodiversity Centre University of GothenburgBox 461GothenburgVastra Gotaland SE-40530Sweden Instituto Federa. de Educa.a. Ciencia e Tecnologia de Minas GeraisRodovia Machado-Paraguacukm 3MachadoMinas Gerais 37750-000Rraizil Centro de Ciencia. Na.ura.s e Huma.a. UniversidadeFederaldo ABCRua Arcturus03Sao Bernardo do CampoSao Paulo09606-070Brazil

The decrea.e in species richness towa.d higher la.itudes is a. expected biogeogra.hica. *** pa.tern could be rela.ed to pa.ticula. envi-ronmenta. constra.nts a.d the evolutiona.y history of ***,species richness does not fully represent the evolutiona.y history of the cla.es behind their *** diversity better cla.ifies the role of historica. fa.tors in biogeogra.hica. *** a.a.yzed envi-ronmenta. a.d historica. drivers rela.ed to la.itudina. va.ia.ion in species richness a.d phylogenetic diversity of a.la.tic Forest endemic *** implemented species distribution models,from voucherba.ed loca.ity points,to ma. the sna.e ra.ges a.d *** used genera.ized a.ditive mixed models to eva.ua.e the rela.ionships a.ong the diversity metrics a.d a.ea.topogra.hica. roughness,a.d pa.t clima.e cha.ge velocity since the La.t Ma.imum Gla.ia. in the a.la.tic Forest la.itudina. *** to the expected genera. pa.tern,species richness wa. higher towa.d higher la.itudes,being positively rela.ed to pa.t clima.ic *** richness a.so increa.ed with tota. a.ea.a.d higher topogra.hica. *** diversity,on the other ha.d,showed opposite rela.ionships rela.ed to the sa.e *** diversity increa.ed with lower clima.ic sta.ility in lower ***,dimensions of diversity were a.fected in different wa.s by historica. a.d environmenta. constra.nts in this unique a.d threa.ened biodiversity hotspot.

关键词： biodiversity la.itudina. gra.ient neotropica. region phylogenetic diversity serpents species richness.

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Sea.ona. va.ia.ion a.d host sex a.fect ba.–ba. fly intera.tion networks in the a.a.onia. sa.a.na.s

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Integra.ive Zoology 2024年第3期19卷 400-416页

作者： Pa.lo MEJIa.Gusta.o Lima.URBIETa.Bruna.da.Silva.Xa.IER Isa.Jorge de Ca.TRO joséJúlio DE TOLEDO Gusta.o GRa.IOLLI Lucio a.dréVIa.a.DIa. Willia. Dougla. Ca.Va.HO Progra.a.de Pós-Gra.ua.ão em Biodiversida.e Tropica. Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Progra.a.de Pós-Gra.ua.ão em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil La.ora.ório de Ma.íferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Progra.a.de Pós-Gra.ua.ão em Biologia.a.ima. Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestria. Ecology Group(TEG-Ua.) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investiga.ión en Biodiversida. y Ca.bio Globa.(CIBC-Ua.) Universidad Autónoma de MadridMadridSpain

Ba.s a.e the second-most diverse group of ma.ma.s in the world,a.d ba. flies a.e their ma.n ***,significa.t knowledge ga.s rema.n rega.ding these a.ta.onistic intera.tions,especia.ly since diverse fa.tors such a. sea.ona.ity a.d host sex ca. a.fect their network ***,we explore the influence of such fa.tors by compa.ing species richness a.d composition of ba. flies on host ba.s,a. well a. specia.iza.ion a.d modula.ity of ba.–ba. fly intera.tion networks between sea.ons a.d a.ult host *** ca.tured ba.s a.d collected their ectopa.a.itic flies a. 10 sa.pling sites in the sa.a.na.s of a.a.áSta.e,northea.tern region of the Bra.ilia. *** fema.e ba.s being more pa.a.itized a.d recording grea.er ba. fly species richness in the wet sea.on,neither rela.ionship wa. sta.istica.ly *** pooled network could be divided into 15 compa.tments with 54 links,a.d a.l subnetworks comprised>12 *** tota. number of links ra.ged from 27 to 48(for the dry a.d wet sea.ons,respectively),a.d fema.e a.d ma.e subnetworks ha. 44 a.d 41 links,*** va.ues were very low for the pooled network a.d for a.l *** results revea.ed higher ba. fly species richness a.d a.unda.ce in the wet sea.on,wherea. specia.iza.ion a.d modula.ity were higher in the dry ***,the subnetwork for fema.e ba.s displa.ed higher specia.iza.ion a.d modula.ity tha. the ma.e ***,both sea.ona.ity a.d host sex contribute in different wa.s to ba.–ba. fly network *** studies should consider these fa.tors when eva.ua.ing ba.–ba. fly intera.tion networks.

关键词： a.a.á a.a.on biome ba. flies ba.s intera.tion networks

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Entry of hepa.itis C virus into the cell: a.thera.eutic ta.get

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World Journa. of Ga.troenterology 2012年第33期18卷 4481-4485页

作者： josé a.tonio del campo ngela.Roja. Ma.uel Romero-Gómez Unit for Medica. a.d Surgica. Ma.a.ement of Digestive Disea.es Center for Biomedical Research in Digestive and Liver Diseases Network (CIBERehd) Valme University Hospital University of Seville E-41014 Sevilla Spain

Severa. receptors ha.e been identified a. implica.ed on vira. entry into the hepa.ocyte; a.d, this intera.tion between the virus a.d potentia. receptors could modula.e infection, sponta.eous vira. clea.a.ce, persistence of the infection a.d the widesprea. of the virus a. outbrea.. Nevertheless, the pla.ing role of ea.h of them rema.ns controversia.. The Niema.nPick type C1 like 1 gene (NPC1L1) receptor ha. been recently implica.ed on hepa.itis C virus (HCV) entry into the cell a.d ezetimibe, a. a.ti-cholesterol drug seems to block tha., emerging the idea.to control hepa.itis C outbrea. modula.ing lipid-rela.ed receptors. Hepa.itis C infection seems to modula.e lipid meta.olism a.cording to host genetic ba.kground. Indeed, it circula.es like a.lipoviropa.ticle. The ma.n a.m of this field of vision would be to discuss the role of hepa.ocyte receptors implica.ed on virus entry, especia.ly NPC1L1 a.d the thera.eutic options derived from the better knowledge a.out HCV-lipidsreceptors intera.tion.

关键词： Hepa.itis C virus entry Niema.n-Pick type C1 like 1 gene Lipid meta.olism Ezetimibe

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Role of infla.ma.ory response in liver disea.es: Thera.eutic stra.egies

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World Journa. of Hepa.ology 2018年第1期10卷 1-7页

作者： josé a.del campo Pa.oma.Ga.lego Lourdes Gra.de Depa.tment of Digestive Disea.es Valme University Hospital and CIBERehd

Infla.ma.ion a.d tumorigenesis a.e tightly linked pa.hwa.s impa.ting ca.cer development. Infla.ma.omes a.e key signa.ling pla.forms tha. detect pa.hogenic microorga.isms, including hepa.itis C virus(HCV) infection, a.d sterile stressors(oxida.ive stress, insulin resista.ce, lipotoxicity) a.le to a.tiva.e pro-infla.ma.ory cytokines interleukin-1β a.d IL-18. Most of the infla.ma.ome complexes tha. ha.e been described to da.e conta.n a.NOD-like receptor sensor molecule. Redox sta.e a.d a.topha.y ca. regula.e infla.ma.ome complex a.d, depending on the conditions, ca. be either pro-or a.tia.optotic. a.ute a.d chronic liver disea.es a.e cytokinedriven disea.es a. severa. proinfla.ma.ory cytokines(IL-1α, IL-1β, tumor necrosis fa.tor-a.pha. a.d IL-6) a.e critica.ly involved in infla.ma.ion, stea.osis, fibrosis, a.d ca.cer development. NLRP3 infla.ma.ome ga.n of function a.gra.a.es liver disea.e, resulting in severe liver fibrosis a.d highlighting this pa.hwa. in the pa.hogenesis of non-a.coholic fa.ty liver disea.e. On the other ha.d, HCV infection is the prima.y ca.a.yst for progressive liver disea.e a.d development of liver ca.cer. It is well esta.lished tha. HCV-induced IL-1β production by hepa.ic ma.ropha.es pla.s a.critica. a.d centra. process tha. promotes liver infla.ma.ion a.d disea.e. In this review, we a.m to cla.ify the role of the infla.ma.ome in the a.gra.a.ion of liver disea.e, a.d how selective blocka.e of this ma.n pa.hwa. ma. be a.useful stra.egy to dela. fibrosis progression in liver disea.es.

关键词： Ca.pa.e-1 Fibrosis Hepa.itis C virus Infla.ma.ome Interleukin-1α Interleukin-1β Liver disea.e Non-a.coholic fa.ty liver disea.e NLRP3 Tumor necrosis fa.tor-a.pha

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Modula.ion of host lipid meta.olism by hepa.itis C virus: role of new thera.ies

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World Journa. of Ga.troenterology 2015年第38期21卷 10776-10782页

作者： josé a.del campo Ma.uel Romero-Gómez Digestive Disea.es a.d CIBERehd Valme University Hospital

It is well esta.lished tha. hepa.itis C virus(HCV) infection a.d replica.ion relies on host lipid meta.olism. HCV proteins intera.t a.d a.socia.e with lipid droplets to fa.ilita.e virion a.sembly a.d production. Besides,circula.ing infective pa.ticles a.e a.socia.ed with verylow-density lipoprotein. On the other ha.d,higher serum lipid levels ha.e been a.socia.ed with susta.ned vira. response to pegyla.ed interferon a.d riba.irin thera.y in chronic HCV infection,suggesting a.releva.t role in vira. clea.a.ce for host proteins. Host a.d vira. genetic fa.tors pla. a. essentia. role in chronic infection. Lipid meta.olism is hija.ked by vira. infection a.d could determine the success of vira. replica.ion. Recently development of direct a.ting a.tivira. a.ents ha. shown a.very high effica.y(> 90%) in susta.ned vira. response ra.es even for cirrhotic pa.ients a.d most of the vira. genotypes. HCV RNa.clea.a.ce induced by Sofosbuvir ha. been a.socia.ed with a. increa.ed concentra.ion a.d size of the low-density lipoprotein pa.ticles. In this review,host genetic fa.tors,vira. fa.tors a.d the intera.tion between them will be depicted to cla.ify the ma.or issues involved in vira. infection a.d lipid meta.olism.

关键词： Hepa.itis C virus Lipid meta.olism Direct a.ting a

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a.a.ysis of the rela.ion between orga.ic products consumption a.d box schemes use in a.ica.te (Spa.n)

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a.ricultura. Sciences 2011年第4期2卷 505-510页

作者： Ferna.do Vida. Da.id Berna.do López Fra.cisco josé del campo 不详

Box-schemes or orga.ic food subscription pla.s consist on a.regula. delivery of a.box of sea.ona. fruits a.d/or vegeta.les, prefera.ly orga.ic, cultiva.ed in the vicinity a. a.specified point using subscription, The object of the present work is trying to exa.ine whether there is a.rela.ionship between consumer knowledge a.out these short distribution cha.nels a.d the consumption of orga.ic products in the province of a.ica.te. a.survey ha. been conducted a.ong 400 usua. food buyers in this Spa.ish province. It ha. been found tha. the consumption of orga.ic products a.d the knowledge of such initia.ives a.e linked. We recommend to compa.ies tha. use this type of distribution cha.nel to publicize its benefits.

关键词： Box-Scheme Environmenta. Consumer Knowledge Distribution

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地基与海洋建筑物相互作用——以最近西班牙海岸线建筑物内部损坏为例(英文)

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工程地质学报 2011年第3期19卷 297-303页

作者： Ca.LOS delga.o jos M.del campo VICENTE Negro 马德里理工大学土木工程系

海洋工程通常是一个细长的线。我们通常看到的仅仅是建筑物狭长的表面,而不分析支撑他们的大量水下材料。毋庸置疑,海底地基将承受来自于海洋的周期性和交替的静力以及变化的动力。外部和内部的海上工程均在复杂的环境中运行。固态颗粒... 详细信息

海洋工程通常是一个细长的线。我们通常看到的仅仅是建筑物狭长的表面,而不分析支撑他们的大量水下材料。毋庸置疑,海底地基将承受来自于海洋的周期性和交替的静力以及变化的动力。外部和内部的海上工程均在复杂的环境中运行。固态颗粒(防波堤)可以吸入入射水流,并且通过颗粒之间的间距吸收海浪的能量。回流试图从固态颗粒中抽离物质,这样一个遵从太沙基原理的基于有效拉力和中性拉力之间的平衡建立起来。在某些情况下,防护层的液化已经造成了防波堤崩溃(Sines,葡萄牙,1978年2月)。在其他情况下,虹吸作用或液化导致巨石(垂直的防波堤)毁坏或崩溃(新巴塞罗那港口,西班牙,2001年11月)。结合复合设计工具的地基-作用力——结构相互作用的过程是一个复杂的分析,关于其研究刚刚开始。本文介绍了最近发生在西班牙的、由于地基失效导致的海上工程内部损坏的两个例子(马拉加,2004年7月,巴塞罗那,2007年1月),分析了其成因。

关键词：地基海洋建筑物破坏海岸线西班牙

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