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Polyphenols as potential enhancers of stem cell therapy against neurodegeneration

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Neural Regeneration Research 2022年第10期17卷 2093-2101页

作者： Diana Rodríguez-Vera Antonio Abad-garcía Nancy Vargas-Mendoza Rodolfo Pinto-Almazán Eunice D.Farfán-garcía josé A.morales-González Marvin A.Soriano-Ursúa Sección de Estudios de Posgrado e Investigación.Escuela Superior de Medicina Instituto Politécnico NacionalMéxico CityMéxico Unidad de Investigación Hospital Regional de Alta Especialidad IxtapalucaCarretera Federal México-Puebla km 34.5State of MéxicoMéxico

The potential of polyphenols for treating chronic-degenerative diseases(particularly neurodegenerative diseases)is attractive.However,the selection of the best polyphenol for each treatment,the mechanisms by which they act,and their efficacy are frequently discussed.In this review,the basics and the advances in the field,as well as suggestions for using natural and synthetic polyphenols alone or in a combinatorial strategy with stem cell assays,are compiled and discussed.Thus,stem cells exhibit several responses when polyphenols are added to their environment,which could provide us with knowledge for advancing the elucidation of the origin of neurodegeneration.But also,polyphenols are being included in the innovative strategies of novel therapies for treating neurodegenerative diseases as well as metabolic diseases related to neurodegeneration.In this regard,flavonoid compounds are suggested as the best natural polyphenols due to their several mechanisms for acting in ameliorative effects;but increasing reports are involving other polyphenols.Even if some facts limiting bioactivity prevent them from conventional use,some natural polyphenols and derivatives hold the promise for being improved compounds,judged by their induced effects.The current results suggest polyphenols as enhancers of stem cell therapy against the targeted diseases.

关键词： Alzheimer’s disease chronic degenerative diseases combinatorial therapy metabolism neurodegenerative diseases neuronal damage neuroprotection Parkinson’s disease polyphenols stem cell assays

Consensus Delphi study on guidelines for the assessment of anterior cruciate ligament injuries in children

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World Journal of Orthopedics 2022年第9期13卷 777-790页

作者： Angélica Campón Chekroun Jorge Velázquez-Saornil Isabel Guillén Vicente Zacarías Sánchez Milá David Rodríguez-Sanz Carlos Romero-morales Tomas Fernandez-Jaén joséIgnacio Garrido González MiguelÁngel Sánchez-Garrido Pedro Guillén garcía Campus San Jerónimo Guadalupe Universidad Católica de MurciaMurcia 30107MurciaSpain Department of Physiotherapy Universidad Católica deÁvilaÁvila 05005ÁvilaSpain Department of Orthopaedic and Trauma Surgery Clínica CemtroMadrid 28035MadridSpain Nursing Physiotherapy and PodiatryUniversidad Complutense de MadridMadrid 28040MadridSpain Department of Physical Therapy Universidad Europea de MadridMadrid 28023MadridSpain Department of Orthopaedic and Trauma Surgery Gabinete Médico GarridoSalamanca 37003SalamancaSpain

Background:Knee examination guidelines in minors are intended to aid decisionmaking in the management of knee instability.Clinical question:A Delphi study was conducted with a formal consensus process using a validated methodology with sufficient scientific evidence.A group consensus meeting was held to develop recommendations and practical guidelines for use in the assessment of instability injuries in children.Key findings:there is a lack of evidence to analyse anterior cruciate ligament injuries in children and their subsequent surgical management if necessary.Diagnostic guidelines and clinical assessment of the patient based on a thorough examination of the knee are performed and a guide to anterior cruciate ligament exploration in children is developed.Clinical application:In the absence of a strong evidence base,these established guidelines are intended to assist in that decision-making process to help the clinician decide on the most optimal treatment with the aim of benefiting the patient as much as possible.Following this expert consensus,surgical treatment is advised when the patient has a subjective sensation of instability accompanied by a pivot shift test++,and may include an anterior drawer test+and a Lachman test+.If these conditions are not present,the conservative approach should be chosen,as the anatomical and functional development of children,together with a physiotherapy programme,may improve the evolution of the injury.

关键词： Anterior cruciate ligament Diagnoses and examinations Sports injuries Knee Injury to minors

Liver disorders in COVID-19,nutritional approaches and the use of phytochemicals

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World Journal of Gastroenterology 2021年第34期27卷 5630-5665页

作者： Nancy Vargas-Mendoza Jazmín garcía-Machorro Marcelo Angeles-Valencia Marlet Martínez-Archundia Eduardo Osiris Madrigal-Santillán Ángel morales-González Liliana Anguiano-Robledo joséA morales-González Laboratorio de Medicina de Conservacion Instituto Politécnico NacionalMéxico 11340Mexico Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotécnológica Instituto Politécnico NacionalMéxico 11340Mexico Superior de Medicina Instituto Politécnico NacionalMéxico 11340Mexico Escuela Superior de Cómputo Instituto Politécnico NacionalMéxico 07738Mexico Laboratorio de Farmacología Molecular Instituto Politécnico NacionalMéxico 11340Mexico Laboratorio Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico NacionalMéxico 11340Mexico

Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),has affected millions of people globally.It was declared a pandemic by the World Health Organization in March 2020.The hyperinflammatory response to the entry of SARS-CoV-2 into the host through angiotensin-converting enzyme 2 is the result of a“cytokine storm”and the high oxidative stress responsible for the associated symptomatology.Not only respiratory symptoms are reported,but gastrointestinal symptoms(diarrhea,vomiting,and nausea)and liver abnormalities(high levels of aspartate aminotransferase,alanine aminotransferase transaminases,and bilirubin)are observed in at least 30%of patients.Reduced food intake and a delay in medical services may lead to malnutrition,which increases mortality and poor outcomes.This review provides some strategies to identify malnutrition and establishes nutritional approaches for the management of COVID-19 and liver injury,taking energy and nutrient requirements and their impact on the immune response into account.The roles of certain phytochemicals in the prevention of the disease or as promising target drugs in the treatment of this disease are also considered.

关键词： COVID-19 Infection Liver Nutrition therapy Phytochemicals

Use of δ^(18)O, δ^(13)C and NO_(3)^(-) to identify hydrogeochemical processes related to contamination in an aquifer located in central Mexico

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Acta Geochimica 2022年第3期41卷 367-392页

作者： joséIván morales-Arredondo María Aurora Armienta Hernández Fátima Juárez-Aparicio Jorge Federico Landa-Arreguín Itzamna Zaknite Flores-Ocampo Natural Resources Department Institute of GeophysicsNational Autonomous University of MexicoCiudad Universitaria No.3000Col.Copilco UniversidadCoyoacan Delegation04360 MexicoCDMXMexico Earth Sciences Postgraduate Program University National Autonomous of MexicoUniversity City No.3000Col.Copilco UniversityCoyoacán Delegation04510 MexicoCDMXMexico

In this work,an isotopic analysis of δ^(18)O,δ^(13)C,and NO_(3)^(-) concentrations was carried out to identify the origin and the processes related to the contamination of an aquifer located in the state of Guanajuato,Mexico.The research identified the possible sources of δ^(13)C in groundwater.During groundwater flow,CO_(2) participates in different hydrogeochemical reactions in which the dissolution of carbonates or biochemical processes related to biodegradation stand out.Isotopic data of δ^(13)C,δ^(18)O,and the hydrogeochemical behavior of NO_(3)^(-) and HCO_(3)^(-) in water,in addition to isotopic data and the chemical composition of limestones in the study area,were determined to establish the isotopic signature and the processes undergone by the rocks.The isotopic signature of rock and water samples indicated that metamorphic limestones contributed with carbon dioxide to deep groundwater,while in the upper aquifer,bacterial metabolic reactions during nitrification–denitrification could modify the isotopic signature of δ^(13)C in some wells,although atmospheric contribution also plays a role.The modification of the carbon isotopic component is related to the precipitation of calcite in specific regions of the study area,input of atmospheric CO_(2),and soil(e.***.the possible participation of C4-type plants in the assimilation-release of carbon).This process is not confirmed or completely ruled out in this study since agriculture is excessively developed throughout the region.The joint interpretation of isotopic values and the hydrogeochemical behavior of major and conservative elements help in identifying possible pollution processes in which different carbon sources are related.

关键词： ^(18)O and^(13)C isotopes Groundwater pollution Nitrate Limestone

Avian-power line interactions in the Gobi Desert of Mongolia:are mitigation actions effective?

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Avian Research 2021年第3期12卷 382-390页

作者： Adrian Orihuela-Torres Juan MPérez-garcía Zebensui morales-Reyes Lara Naves-Alegre joséASánchez-Zapata Esther Sebastián-González Área de Ecología Departamento de Biología AplicadaUniversidad Miguel Hernández de ElcheAvda.Universidad s/n03202 ElcheAlicanteSpain Departamento de Ecología Universidad de AlicanteCtra.San Vicente del Raspeig s/n03690 San Vicente del RaspeigAlicanteSpain

Background:Electrocution and collisions on power lines are among the leading causes of non-natural mortality for birds.Power lines are exponentially increasing,particularly in developing countries,but mitigation strategies to prevent bird mortality are questionable.Mongolia combines a recently increased power line network,an abundant raptor population,a dangerous crossarm configuration and a habitat with no natural perches,producing many bird-power line interactions.Our aim is to assess the bird mortality caused by power lines in the Gobi Desert of Mongolia,to determine the factors increasing the risk of bird electrocution,and to evaluate the effectiveness of used retrofitting measures.Methods:In July 2019 we covered 132.9 km of 15 kV power lines checking 1092 poles.We also conducted bird tran-sects to record raptor and corvid richness and abundance,to assess species vulnerability to electrocution.Results:We recorded 76 electrocuted birds of 7 species.Electrocution rate was 6.96 birds/100 poles.The most affected species were Common Raven(Corvus corax)and Upland Buzzard(Buteo hemilasius),highlighting the electro-cution of 5 endangered Saker Falcons(Falco cherrug).By contrast,we only recorded 8 individuals of 5 species collid-ing with wires,the most affected being Pallas’s Sandgrouse(Syrrhaptes paradoxus).About 76.1%of sampled poles had some mitigation measure.Of these,96.6%were brush perch deflectors and 3.4%rotating-mirrors perch deter-rents.We found differences in electrocution rates among crossarm configurations,with the strain insulator with one jumper being the most lethal.Additionally,we found no correlation between bird abundance and electrocution rates,suggesting that some species are more sensitive to electrocution.Although no differences in total bird electrocu-tion rates were detected between poles with and without perch deterrents,when bird size is considered,deterrents reduced the mortality rate of small birds,while they were ineffective for medium-sized birds.Conclusions:Despite the widespread use of

关键词： Collision Crossarm configuration Electrocution Electric infrastructures Perch deterrent Power line network Raptor

Stress,Burnout,and Resilience:Are Teachers at Risk?

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International Journal of Mental Health Promotion 2023年第2期25卷 207-222页

作者： joséLuis Moreno-Lucas Juan Pedro Martínez-Ramón Francisco Manuel morales-Rodríguez Cecilia Ruiz-Esteban e Inmaculada Méndez Department of Developmental and Educational Psychology Campus of Excellence Mare NostrumUniversity of MurciaEspinardoMurcia30100Spain Department of Developmental and Educational Psychology University Campus of CartujaUniversity of GranadaGranada18071Spain

It is increasingly common to find alarming news related to tragic events occurring in schools around the world.Being able to deal with these situations without getting hurt is a task not suitable for everyone.In general,teachers are the ones who must deal with this type of situation in addition to other daily problems that appear in any classroom that make the level of stress to which they are subjected can become dangerous.This research aims to know the current situation of teachers in a region of southeastern Spain in terms of their level of work stress,resilience,and other associated variables,for which an ex post facto quantitative approach study was designed.For this purpose,an ad hoc sociodemographic questionnaire,and questions based on the Teaching and Learning International Survey of the Organization for Economic Co-Operation and Development,the Maslach Burnout Inventory,and the Brief Resilient Coping Scale were applied.The participating sample consisted of 470 teachers.The main findings were that 6%of teachers had burnout(high emotional exhaustion,high cynicism,and low professional effectiveness simultaneously).Resilience correlated inversely with stress,emotional exhaustion,cynicism,excessive teaching,and difficulty maintaining classroom discipline.In conclusion,knowing the needs of teachers allows us to reflect on what kind of prevention and intervention programs are necessary to improve the well-being of teachers and thus improve the quality of education.

关键词： Burnout coping resilience stress teacher

Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender

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World Journal of Hepatology 2018年第2期10卷 297-307页

作者： josé A morales-González María de Lourdes Sernas-morales ángel morales-González Laura Ligía González-López Eduardo Osiris Madrigal-Santillán Nancy Vargas-Mendoza Tomás Alejandro Fregoso-Aguilar Liliana Anguiano-Robledo Eduardo Madrigal-Bujaidar Isela álvarez-González Germán Chamorro-Cevallos Laboratorio de Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico Nacional área Académica de Nutrición ICSa Universidad Autónoma del Estado de Hidalgo Depto. de Fisiología Laboratorio de Hormonas y Conducta ENCB campus Zacatenco Instituto Politécnico Nacional Laboratorio de Farmacología Molecular Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina-Instituto Politécnico Nacional Laboratorio de Genética Escuela Nacional de Ciencias Biológicas IPN Departamento de Farmacia Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional

AIM To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in rats.METHODS Wistar rats weighing 170-200 g were divided into groups as follows:(1) Control groups; and(2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations:(1) Group of males or females with a consumption of a solution of alcohol at 40%; and(2) group of males or females with a consumption of a solution of alcohol at 5%. At the end of the experiment, serum and liver samples were obtained. The following enzymes and metabolites were determined in serum: Alanine Aminotransferase(ALT), Aspartate Aminotransferase(AST), Lactate Dehydrogenase, and Gamma-Glutamyltransferase, and glucose, triglycerides, cholesterol, bilirubin, and albumin. Liver samples from each group were employed to analyze morphological abnormalities by light microscopy.RESULTS In all of the weekend alcohol-consumption groups, AST activity presented a significant, 10-fold rise. Regarding ALT activity, the groups with weekend alcohol consumption presented a significant increase that was six times greater. Bilirubin levels increased significantly in both groups of females. We observed a significant increase in the parameters of fatty change and inflammation due to weekend alcohol consumption. Only the group of females that consumed alcohol at 40% presented slight hepatocel ular disorganization CONCLUSION The results obtained herein provide solid evidence that weekend alcohol consumption gives rise to liver damage, demonstrated by biochemical and histological alterations, first manifested acutely, and prolonged weekend alcohol consumption can cause greater, irreversible damage.

关键词： Weekend alcohol consumption Liver morphology Transaminases Damage

Stochastic Computational Heuristic for the Fractional Biological Model Based on Leptospirosis

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Computers, Materials & Continua 2023年第2期74卷 3455-3470页

作者： Zulqurnain Sabir Sánchez-Chero Manuel Muhammad Asif Zahoor Raja Gilder-Cieza–Altamirano María-Verónica Seminario-morales Fernández Vásquez joséArquímedes Purihuamán Leonardo Celso Nazario Thongchai Botmart Wajaree Weera Department of Mathematics and Statistics Hazara UniversityMansehraPakistan Universidad Nacional de Frontera SullanaPiuraPerú Future Technology Research Center National Yunlin University of Science and Technology123 University RoadSection 3Douliou64002YunlinTaiwan Universidad Nacional Autónoma de Chota CajamarcaPerú Universidad Cesar Vallejo TrujilloLa LibertadPerú Universidad Señor de Sipán ChiclayoPerú Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen40002Thailand

The purpose of these investigations is to find the numerical outcomes of the fractional kind of biological system based on Leptospirosis by exploiting the strength of artificial neural networks aided by scale conjugate gradient,called ANNs-SCG.The fractional derivatives have been applied to get more reliable performances of the system.The mathematical form of the biological Leptospirosis system is divided into five categories,and the numerical performances of each model class will be provided by using the ANNs-SCG.The exactness of the ANNs-SCG is performed using the comparison of the reference and obtained results.The reference solutions have been obtained by using theAdams numerical scheme.For these investigations,the data selection is performed at 82%for training,while the statics for both testing and authentication is selected as 9%.The procedures based on the recurrence,mean square error,error histograms,regression,state transitions,and correlation will be accomplished to validate the fitness,accuracy,and reliability of the ANNs-SCG scheme.

关键词： Fractional leptospirosis biological model artificial neural networks scale conjugate gradient numerical performances

Modeling and multi-objective optimization of a gasoline engine using neural networks and evolutionary algorithms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 657-670页

作者： joséD. MARTíNEZ-morales Elvia R. PALACIOS-HERNáNDEZ Gerardo A. VELáZQUEZ-CARRILLO Faculty of Engineering Autonomous University of San Luis PotosiSan Luis Potosi 78290 Mexico Faculty of Science Autonomous University of San Luis PotosiSan Luis Potosi 78290 Mexico Mechatronics Department Monterrey Institute of Technology and Higher EducationMexico D. F. 01389 Mexico

In this paper, a multi-objective particle swarm optimization (MOPSO) algorithm and a nondominated sorting genetic algorithm Ⅱ (NSGA-Ⅱ) are used to optimize the operating parameters of a 1.6 L, spark ignition (SI) gasoline engine. The aim of this optimization is to reduce engine emissions in terms of carbon monoxide (CO), hydrocarbons (HC), and nitrogen oxides (NOx), which are the causes of diverse environmental problems such as air pollution and global warming. Stationary engine tests were performed for data generation, covering 60 operating conditions. Artificial neural networks (ANNs) were used to predict exhaust emissions, whose inputs were from six engine operating parameters, and the outputs were three resulting exhaust emissions. The outputs of ANNs were used to evaluate objective functions within the optimization algorithms: NSGA-Ⅱ and MOPSO. Then a decision-making process was conducted, using a fuzzy method to select a Pareto solution with which the best emission reductions can be achieved. The NSGA-Ⅱ algorithm achieved reductions of at least 9.84%, 82.44%, and 13.78% for CO, HC, and NOx , respectively. With a MOPSO algorithm the reached reductions were at least 13.68%, 83.80%, and 7.67% for CO, HC, and NOx , respectively.

关键词：人工神经网络汽油发动机多目标优化进化算法非支配排序遗传算法粒子群优化算法 Pareto解废气排放量