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Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Improvement in estimation of soil water deficit by integrating airborne imagery data into a soil water balance model

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International Journal of Agricultural and Biological Engineering 2017年第3期10卷 37-46页

作者： Huihui Zhang Ming Han josé L.chávez Yubin Lan Water Management and Systems Research Unit USDA-ARS2150 Centre AvenueBldg.D.Fort CollinsCO80526USA Department of Civil and Environmental Engineering Colorado State UniversityCampus Delivery 1372Fort CollinsCO80523USA College of Engineering South China Agricultural University/Engineering Research Center for Agricultural Aviation Application(ERCAAA)Guangzhou 510642China

In this study,an approach that integrates airborne imagery data as inputs was used to improve the estimation of soil water deficit(SWD)for maize and sunflower grown under full and deficit irrigation *** proposed model was applied to optimize the maximum total available soil water(TAWr)by minimizing the difference between a water stress coefficient ks and crop water stress index(1-CWSI).The optimal value of maximum TAWr was then used to calibrate a soil water balance model which in turn updated the estimation of soil water *** estimates of SWD in the soil profile of both irrigated maize and sunflower fields were evaluated with the crop root zone SWD derived from neutron probe measurements and the FAO-56 SWD *** results indicated a good agreement between the estimated SWD from the proposed approach and measured SWD for both maize and *** statistical analyses indicated that the maximum TAWr estimated from CWSI significantly improved the estimates of SWD,which reduced the mean absolute error(MAE)and root mean square error(RMSE)by 40%and 44%for maize and 22%for sunflower,compared with the FAO-56 *** proposed procedure works better for crops under deficit irrigation *** the availability of higher spatial and temporal resolution airborne imagery during the growing season,the optimization procedure can be further improved.

关键词： soil water deficit soil water balance model airborne imagery total available water CWSI deficit irrigation

In Vitro Propagation of Agave guiengola Gentry Using Semisolid Medium and Temporary Immersion Bioreactors

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Phyton-International Journal of Experimental Botany 2021年第3期90卷 1003-1013页

作者： Lucía Isabel chávez-Ortiz joséFrancisco Morales-Domínguez Araceli Rodríguez-Sahagún Eugenio Pérez-Molphe-Balch Departamento de Química Centro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientes20131México Laboratorio de Biología Molecular Vegetal Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán47820México

Agave guiengola Gentry is an endemic plant from a very small locality in Oaxaca,*** conservation status is fragile and can rapidly *** of its scarcity,this agave has been used solely for ornamental purposes,but it could have other uses if more plants were *** vitro propagation by enhanced axillary sprouting from stem segments was attained using Murashige and Skoog Basal Medium(MS)as well as basal medium supplemented with cytokinins 6-Benzylaminopurine(BA)or 6-(γ,γ-Dimethylallylamino)purine(2iP).The best treatment for shoot induction in semisolid medium consisted in MS supplemented with 2 mg l^(–1) BA,obtaining a mean of 3.7 shoots per *** interesting responses were observed,such as nodular callus induction using combinations of BA and 2,4-Dichlorophenoxyacetic acid(2,4-D);root induction without Plant Growth Regulators(PGR);and generation of shoot *** clusters constituted an excellent explant for micropropagation in temporary immersion bioreactors,obtaining a propagation rate of 43 shoots per explant with 1 min immersion and 6 h immersion *** new plants rooted and survived the transfer to *** study developed an in vitro propagation scheme to produce individuals that can be used either for reforestation,economical purposes,or to carry out studies in this species to assess its full potential,avoiding exploitation from wild plants.

关键词： Agavaceae temporary immersion systems callus induction micropropagation

Initial coin offerings(ICOs):Why do they succeed?

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Financial Innovation 2022年第1期8卷 233-267页

作者： joséCampino Ana Brochado Álvaro Rosa Instituto Universitário de Lisboa(ISCTE-IUL) Business Research Unit(BRU-IUL)LisbonPortugal Instituto Universitário de Lisboa(ISCTE-IUL) DINÂMIA’CETLisbonPortugal

Recent literature has addressed initial coin offering(ICO)projects,which are an innovative form of venture financing through cryptocurrencies using blockchain *** features of ICOs remain unexplored,leaving much room for additional research,including the success factors of ICO *** investigate the success of ICO projects,with our main purpose being to identify factors that influence a project’s *** a literature review,from which several potential variables were collected,we used a database comprising 428 ICO projects in the banking/financial sector to regress several econometric *** confirmed the impacts of several variables and obtained particularly valuable results concerning project and campaign *** confirmed the importance of a well-structured and informative *** proximity to certain markets with high availability of financial and human capital is also an important determinant of the success of an *** also confirm the strong dependency on cryptocurrency and the impact of cryptocurrency valuations on the success of a ***,we confirm the importance of social media in ICO projects,as well as the importance of human capital *** research contributes to the ICO literature by capturing most of the success factors previously identified and testing their impacts based on a large *** current research contributes to the building of systems theory and signaling theory by adapting their frameworks to the ICO *** results are also important for regulators,as ICOs are mainly unregulated and have vast future potential,and for investors,who can benefit from our analysis and use it in their due diligence.

关键词： Initial coin offering(ICO) Fintech Bank Financial services Technology Blockchain Innovation Venture capital Crowdfunding Success

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

Rebooting Synthetic Phage-Inducible chromosomal Islands:One Method to Forge Them All

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BioDesign Research 2020年第1期2020卷 34-47页

作者： Rodrigo Ibarra-chávez Andreas F.Haag Pedro Dorado-Morales Iñigo Lasa joséR.Penadés Institute of Infection Immunity and InflammationCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK Laboratory of Microbial Pathogenesis NavarrabiomedComplejo Hospitalario de Navarra-Universidad Pública de Navarra(UPNA)Instituto de Investigación Sanitaria de Navarra(IDISNA)31008 PamplonaSp

Phage-inducible chromosomal islands(PICIs)are a widespread family of mobile genetic elements,which have an important role in bacterial *** elements mobilize among bacterial species at extremely high frequencies,representing an attractive tool for the delivery of synthetic ***,tools for their genetic manipulation are limited and timing ***,we have adapted a synthetic biology approach for rapidly editing of PICIs in Saccharomyces cerevisiae based on their ability to excise and integrate into the bacterial chromosome of their cognate host *** proof of concept,we engineered several PICIs from Staphylococcus aureus and Escherichia coli and validated this methodology for the study of the biology of these elements by generating multiple and simultaneous mutations in different PICI *** biotechnological purposes,we also synthetically constructed PICIs as Trojan horses to deliver different CRISPR-Cas9 systems designed to either cure plasmids or eliminate cells carrying the targeted *** results demonstrate that the strategy developed here can be employed universally to study PICIs and enable new approaches for diagnosis and treatment of bacterial diseases.

关键词： proof eliminate generating

Recent trends and technical advancements in biosensors and their emerging applications in food and bioscience

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Food Bioscience 2022年第3期47卷 1023-1050页

作者： Oluwatosin E.Bankole Deepak Kumar Verma Mónica L.chávez González Juan Guzmán Ceferino joséSandoval-Cortés Cristóbal N.Aguilar Department of chemical Sciences Faculty of Science and Science EducationAnchor UniversityLagos StateNigeria Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpur721302West BengalIndia Bioprocesses Research Group Food Research DepartmentSchool of ChemistryUniversidad Autonoma de CoahuilaUnidad Saltillo25280CoahuilaMexico Los Ríos Multidisciplinary Academic Division Universidad Juárez Autónoma de TabascoTabascoMexico Department of Analytical chemistry School of ChemistryUniversidad Autonoma de CoahuilaUnidad Saltillo25280CoahuilaMexico

Biosensor development has recently advanced as a result of their strong and indisputable uses as analytical methods in a variety of sectors,including medicine,food industry,environmental monitoring,metabolism,agriculture,military,and *** popularity of biosensors as devices for a variety of applications may be ascribed to their distinct advantages of fast or rapid analysis,high sensitivity,minimal sample demand and preparation,and no need for the specific skill of operation that traditional analytical procedures *** attempted to update earlier studies in this study by incorporating other materials that have been in use but have received less attention,such as carbon nano-onions(CNOs),metal-organic frameworks(MOFs),and biopolymers for biosensor manufacturing and design based on their unique *** assessment also took into account applicable applications in many *** considerable progress has been made in the application of biosensors,there is still a need for research development and enhancement,particularly in transforming most of the laboratory experiments that have already been published into portable on-site and implementable in the public domains.

关键词： Biosensors Nanotechnology Nano-materials Food quality and safety Food snd biomedical industry Industrial application

Wheat ear carbon assimilation and nitrogen remobilization contribute significantly to grain yield

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Journal of Integrative Plant Biology 2016年第11期58卷 914-926页

作者： Bangwei Zhou Maria Dolores Serret Abdelhalim Elazab Jordi Bort Pie josé Luis Araus Iker Aranjuelo álvaro Sanz-Sáez Key Laboratory of Vegetation Ecology Ministry of EducationInstitute of Grassland ScienceNortheast Normal University Unit of Plant Physiology Faculty of BiologyUniversity of Barcelona Agrobiotechnology Institute Public University of Navarra-CSIC-Navarra GovernmentArrosadia Campus Department of Plant Biology University of the Basque Country Pharmacy Faculty

The role of wheat ears as a source of nitrogen （N） and carbon （C） in the grain filling process has barely been studied. To resolve this question, five wheat genotypes were labeled with 15N-enriched nutrient solution. N remobilization and absorption were estimated via the nitrogen isotope composition of total organic matter and Rubisco. Gas exchange analyses showed that ear photosynthesis contributed substantially to grain filling in spite of the great loss of C due to respiration. Of the total kernel N, 64.7% was derived from the N acquired between sowing and anthesis, while the remaining 35.3% was derived from the N acquired between anthesis and maturity. In addition, 1.87 times more N was remobilized to the developing kernel from the ear than from the flag leaf. The higher yielding genotypes showed an increased N remobflization to the kernel compared to the lower yielding genotypes. In addition, the higher yielding genotypes remobilized more N from the ears to the kernel than the lower yielding genotypes, while the lower yielding genotypes remobilized more N from the flag leaf to the kernel. Therefore, the ears contribute significantly toward fulfilling C and N demands during grain filling.

关键词： Carbon accumulation ear grain yield nitrogenaccumulation Rubisco

Optical Fiber Torsion Sensor with Mechanically Induced Long Period Fiber Gratings in Rare-Earth Doped Fibers

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Optics and Photonics Journal 2014年第6期4卷 129-135页

作者： Maria Pulido-Navarro josé álvarez-chávez Daniel Ceballos-Herrera Ponciano Escamilla-Ambrosio Instituto Politécnico Nacional Centro de Investigación e Innovación Tecnológica (CIITEC-IPN) Mexico City Mexico Instituto Politécnico Nacional Centro de Investigación en Computación (CIC-IPN) Mexico City Mexico Universidad Autónoma de Nuevo León (UANL) Nuevo León Mexico

In this work wavelength sensitivity in mechanically induced long period fiber gratings (MLPFG) is analyzed. This analysis is first carried out both in standard single-mode fiber SMF-28 and in Er-doped fibers. The mechanical analysis for both types of fibers under different torsion conditions is presented. In order to apply the torsion one of the fiber ends is fixed while torsion is applied on the other end. A MLPFG whose period is 503 μm is used to press the fiber after torsion is applied. This allows for micro curvatures to be formed on the fiber, which in turn generates a periodical index perturbation on it. Here, it was noted that the sensitive wavelength shift of the rejection bands is bigger for Er-doped fibers. For a torsion of 6 turns applied to 10 cm of doped fiber the wavelength peaks can be moved up to 25 nm, which is longer to what was detected on standard fibers. Therefore, by using Er-doped fibers to monitor torsion on structures will give more sensitive and accurate results than using standard fibers. These results can be employed for sensing applications, especially for small to medium size structures, which can be mechanical, civil or aeronautics.

关键词： Optical Fiber Sensors Fiber Bragg Gratingsensors Torsion Sensors Rare-Earth Doped Fibers